LOCUS       NM_014806               5218 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RUN and SH3 domain containing 2 (RUSC2), transcript
            variant 2, mRNA.
ACCESSION   NM_014806 XM_048462
VERSION     NM_014806.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5218)
  AUTHORS   Guardia,C.M., Jain,A., Mattera,R., Friefeld,A., Li,Y. and
            Bonifacino,J.S.
  TITLE     RUSC2 and WDR47 oppositely regulate kinesin-1-dependent
            distribution of ATG9A to the cell periphery
  JOURNAL   Mol Biol Cell 32 (21), ar25 (2021)
   PUBMED   34432492
  REMARK    GeneRIF: RUSC2 and WDR47 oppositely regulate kinesin-1-dependent
            distribution of ATG9A to the cell periphery.
REFERENCE   2  (bases 1 to 5218)
  AUTHORS   Sakurai,S., Shimizu,T. and Ohto,U.
  TITLE     Crystal structure of the FYCO1 RUN domain suggests possible
            interfaces with small GTPases
  JOURNAL   Acta Crystallogr F Struct Biol Commun 76 (Pt 8), 326-333 (2020)
   PUBMED   32744243
  REMARK    GeneRIF: Crystal structure of the FYCO1 RUN domain suggests
            possible interfaces with small GTPases.
REFERENCE   3  (bases 1 to 5218)
  AUTHORS   Tom,E.C., Mushtaq,I., Mohapatra,B.C., Luan,H., Bhat,A.M.,
            Zutshi,N., Chakraborty,S., Islam,N., Arya,P., Bielecki,T.A.,
            Iseka,F.M., Bhattacharyya,S., Cypher,L.R., Goetz,B.T., Negi,S.K.,
            Storck,M.D., Rana,S., Barnekow,A., Singh,P.K., Ying,G., Guda,C.,
            Natarajan,A., Band,V. and Band,H.
  TITLE     EHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell
            Surface Expression and Recycling
  JOURNAL   Mol Cell Biol 40 (7), e00434-19 (2020)
   PUBMED   31932478
  REMARK    GeneRIF: RUSC2 and EHD1 function in a common pathway to positively
            regulate the basal traffic of Epidermal growth factor receptor from
            the Golgi compartment to the cell surface to ensure optimal surface
            receptor levels for subsequent ligand-mediated activation and
            cellular responses.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5218)
  AUTHORS   Sun,J., Zhang,Z. and Yang,S.
  TITLE     Circ_RUSC2 upregulates the expression of miR-661 target gene SYK
            and regulates the function of vascular smooth muscle cells
  JOURNAL   Biochem Cell Biol 97 (6), 709-714 (2019)
   PUBMED   31199889
  REMARK    GeneRIF: Circ_RUSC2 upregulates the expression of miR-661 target
            gene SYK and regulates the function of vascular smooth muscle cells
REFERENCE   5  (bases 1 to 5218)
  AUTHORS   Lin,L., Shi,Y., Wang,M., Wang,C., Zhu,J. and Zhang,R.
  TITLE     Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular
            Basis for Effector Recognition by Rab35 GTPase
  JOURNAL   Structure 27 (5), 729-740 (2019)
   PUBMED   30905672
  REMARK    GeneRIF: analysis of structural basis for effector recognition in
            Rab35/ACAP2 and Rab35/RUSC2 complexes
REFERENCE   6  (bases 1 to 5218)
  AUTHORS   Duan,B., Cui,J., Sun,S., Zheng,J., Zhang,Y., Ye,B., Chen,Y.,
            Deng,W., Du,J., Zhu,Y., Chen,Y. and Gu,L.
  TITLE     EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex
            formation to stabilize GIT2 during directional lung cancer cell
            migration
  JOURNAL   Cancer Lett 379 (1), 70-83 (2016)
   PUBMED   27238570
  REMARK    GeneRIF: Short-term EGF stimulation if of lung tumor cells can
            increase the interaction between RUSC2 and GIT2, prolonged
            stimulation leads to a decrease of their interaction through
            activating Rab35.
REFERENCE   7  (bases 1 to 5218)
  AUTHORS   Sarhadi,V.K., Lahti,L., Scheinin,I., Ellonen,P., Kettunen,E.,
            Serra,M., Scotlandi,K., Picci,P. and Knuutila,S.
  TITLE     Copy number alterations and neoplasia-specific mutations in MELK,
            PDCD1LG2, TLN1, and PAX5 at 9p in different neoplasias
  JOURNAL   Genes Chromosomes Cancer 53 (7), 579-588 (2014)
   PUBMED   24664538
REFERENCE   8  (bases 1 to 5218)
  AUTHORS   Fukuda,M., Kobayashi,H., Ishibashi,K. and Ohbayashi,N.
  TITLE     Genome-wide investigation of the Rab binding activity of RUN
            domains: development of a novel tool that specifically traps
            GTP-Rab35
  JOURNAL   Cell Struct Funct 36 (2), 155-170 (2011)
   PUBMED   21737958
REFERENCE   9  (bases 1 to 5218)
  AUTHORS   Bayer,M., Fischer,J., Kremerskothen,J., Ossendorf,E., Matanis,T.,
            Konczal,M., Weide,T. and Barnekow,A.
  TITLE     Identification and characterization of Iporin as a novel
            interaction partner for rab1
  JOURNAL   BMC Cell Biol 6 (1), 15 (2005)
   PUBMED   15796781
  REMARK    GeneRIF: conclude that Iporin might function as a link between the
            targeting of ER derived vesicles, triggered by the rab1 GTPase and
            a signaling pathway regulated by molecules containing SH3 and/or
            poly-proline regions
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 5218)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Characterization of RUSC1 and RUSC2 genes in silico
  JOURNAL   Oncol Rep 12 (4), 933-938 (2004)
   PUBMED   15375525
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133476.17.
            
            On Nov 23, 2018 this sequence version replaced NM_014806.4.
            
            Summary: This gene encodes a RUN and SH3 domain containing protein
            that interacts with Rab1b and Rab1-binding protein GM130.
            Alternatively spliced transcript variants have been observed for
            this gene. [provided by RefSeq, Jun 2012].
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon and thus differs in the 5' UTR, compared to variant
            1. Both variants 1 and 2 encode the same protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002373.2, SRR1803611.150051.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361226.8/ ENSP00000355177.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AL133476.17        50046-50107
            63-2168             AL133476.17        106365-108470
            2169-2810           AL133476.17        114995-115636
            2811-2996           AL133476.17        115887-116072
            2997-3137           AL133476.17        116243-116383
            3138-3214           AL133476.17        117849-117925
            3215-3389           AL133476.17        118132-118306
            3390-3495           AL133476.17        118397-118502
            3496-3542           AL133476.17        119161-119207
            3543-4365           AL133476.17        119964-120786
            4366-4503           AL133476.17        120895-121032
            4504-5218           AL133476.17        121116-121830
FEATURES             Location/Qualifiers
     source          1..5218
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..5218
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /note="RUN and SH3 domain containing 2"
                     /db_xref="GeneID:9853"
                     /db_xref="HGNC:HGNC:23625"
                     /db_xref="MIM:611053"
     exon            1..62
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /inference="alignment:Splign:2.1.0"
     exon            63..2168
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..4705
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /note="isoform 1 is encoded by transcript variant 2;
                     interacting protein of Rab1; RUN and SH3 domain-containing
                     protein 2; AP-4 complex accessory subunit RUSC2"
                     /codon_start=1
                     /product="AP-4 complex accessory subunit RUSC2 isoform 1"
                     /protein_id="NP_055621.2"
                     /db_xref="CCDS:CCDS35008.1"
                     /db_xref="GeneID:9853"
                     /db_xref="HGNC:HGNC:23625"
                     /db_xref="MIM:611053"
                     /translation="MDSPPKLTGETLIVHHIPLVHCQVPDRQCCGGAGGGGGSTRPNP
                     FCPPELGITQPDQDLGQADSLLFSSLHSTPGGTARSIDSTKSRSRDGRGPGAPKRHNP
                     FLLQEGVGEPGLGDLYDDSIGDSATQQSFHLHGTGQPNFHLSSFQLPPSGPRVGRPWG
                     TTRSRAGVVEGQEQEPVMTLDTQQCGTSHCCRPELEAETMELDECGGPGGSGSGGGAS
                     DTSGFSFDQEWKLSSDESPRNPGCSGSGDQHCRCSSTSSQSEAADQSMGYVSDSSCNS
                     SDGVLVTFSTLYNKMHGTPRANLNSAPQSCSDSSFCSHSDPGAFYLDLQPSPFESKMS
                     YESHHPESGGREGGYGCPHASSPELDANCNSYRPHCEPCPAVADLTACFQSQARLVVA
                     TQNYYKLVTCDLSSQSSPSPAGSSITSCSEEHTKISPPPGPGPDPGPSQPSEYYLFQK
                     PEVQPEEQEAVSSSTQAAAAVGPTVLEGQVYTNTSPPNLSTGRQRSRSYDRSLQRSPP
                     VRLGSLERMLSCPVRLSEGPAAMAGPGSPPRRVTSFAELAKGRKKTGGSGSPPLRVSV
                     GDSSQEFSPIQEAQQDRGAPLDEGTCCSHSLPPMPLGPGMDLLGPDPSPPWSTQVCQG
                     PHSSEMPPAGLRATGQGPLAQLMDPGPALPGSPANSHTQRDARARADGGGTESRPVLR
                     YSKEQRPTTLPIQPFVFQHHFPKQLAKARALHSLSQLYSLSGCSRTQQPAPLAAPAAQ
                     VSVPAPSGEPQASTPRATGRGARKAGSEPETSRPSPLGSYSPIRSVGPFGPSTDSSAS
                     TSCSPPPEQPTATESLPPWSHSCPSAVRPATSQQPQKEDQKILTLTEYRLHGTGSLPP
                     LGSWRSGLSRAESLARGGGEGSMATRPSNANHLSPQALKWREYRRKNPLGPPGLSGSL
                     DRRSQEARLARRNPIFEFPGSLSAASHLNCRLNGQAVKPLPLTCPDFQDPFSLTEKPP
                     AEFCLSPDGSSEAISIDLLQKKGLVKAVNIAVDLIVAHFGTSRDPGVKAKLGNSSVSP
                     NVGHLVLKYLCPAVRAVLEDGLKAFVLDVIIGQRKNMPWSVVEASTQLGPSTKVLHGL
                     YNKVSQFPELTSHTMRFNAFILGLLNIRSLEFWFNHLYNHEDIIQTHYQPWGFLSAAH
                     TVCPGLFEELLLLLQPLALLPFSLDLLFQHRLLQSGQQQRQHKELLRVSQDLLLSAHS
                     TLQLARARGQEGPGDVDRAAQGERVKGVGASEGGEEEEEEEETEEVAEAAGGSGRARW
                     ARGGQAGWWYQLMQSSQVYIDGSIEGSRFPRGSSNSSSEKKKGAGGGGPPQAPPPREG
                     VVEGAEACPASEEALGRERGWPFWMGSPPDSVLAELRRSREREGPAASPAENEEGASE
                     PSPGGIKWGHLFGSRKAQREARPTNRLPSDWLSLDKSMFQLVAQTVGSRREPEPKESL
                     QEPHSPALPSSPPCEVQALCHHLATGPGQLSFHKGDILRVLGRAGGDWLRCSRGPDSG
                     LVPLAYVTLTPTPSPTPGSSQN"
     exon            2169..2810
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2996
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3137
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3214
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3389
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3495
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /inference="alignment:Splign:2.1.0"
     exon            3496..3542
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /inference="alignment:Splign:2.1.0"
     exon            3543..4365
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /inference="alignment:Splign:2.1.0"
     exon            4366..4503
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /inference="alignment:Splign:2.1.0"
     exon            4504..5218
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5193..5198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /note="hexamer: AATAAA"
     polyA_site      5218
                     /gene="RUSC2"
                     /gene_synonym="Iporin; MRT61"
                     /note="major polyA site"
ORIGIN      
        1 gagacacgcc gccgccgccg ccgccgccgg cgcggaagga cgaggctgag gcgagaaacg
       61 aggtgccaag ctctcctgat gaaatgtgtt ctgccccact gggctccagg gacagtgtct
      121 ggtgctgttg aagcccttat tcgaactttc cagaatggat agtcccccaa agctgactgg
      181 agagaccctc atcgttcatc acatccccct ggtgcactgc caagtcccag acaggcagtg
      241 ctgtggaggg gcaggtggag gtggtgggag cacaagacct aatcccttct gcccacctga
      301 gctgggcatc acccagcccg atcaagacct aggacaagct gactccctgc tattcagcag
      361 cctgcactct actccaggag gaactgcacg gtctatagac agcaccaaga gtaggagtcg
      421 ggatggaaga ggccctggag cccccaaacg acacaacccc ttcttgctgc aggagggtgt
      481 gggtgagcca ggacttggtg acctgtatga tgacagcatt ggtgacagtg ccacccagca
      541 gtccttccac ctgcatggca ctggccagcc caactttcat ctatcctctt tccagctgcc
      601 accatctggc cccagagtgg gcaggccatg ggggacaaca cgcagtcggg ctggagtggt
      661 ggaagggcag gaacaggagc cagtgatgac cttggatact cagcagtgcg gcaccagcca
      721 ctgctgccgg ccagagctgg aagcagagac tatggagctg gatgagtgtg ggggacctgg
      781 tgggagtggc agtgggggtg gagccagcga tacctctggc ttttcctttg accaggaatg
      841 gaagctcagt tcagatgaat ccccaaggaa ccctggatgc tccggctcag gggaccagca
      901 ctgccgctgc agtagcacat ccagtcagtc cgaggcagct gaccagtcca tgggctatgt
      961 gagcgactcc tcctgcaaca gttcagatgg tgtgctggtc accttcagca ccctctacaa
     1021 caagatgcat ggcacccccc gtgccaatct caactctgcc ccacagtcct gcagcgactc
     1081 ttccttctgc agccactcag accctggcgc cttctatctg gatctgcagc cctccccatt
     1141 tgagtctaag atgtcttatg agtcccatca ccctgaaagt ggaggaaggg aagggggcta
     1201 tggttgccct catgcctctt ctcctgagct tgatgccaac tgcaactcct accgcccaca
     1261 ctgtgagccg tgcccagcag tggctgacct cacagcctgc ttccaaagcc aggcccgtct
     1321 tgttgtggcc acacaaaatt actataaact tgtcacctgt gacctatctt cccaatcatc
     1381 cccaagccct gctggctctt ccatcactag ctgctctgag gaacacacca agataagtcc
     1441 cccaccaggc cctggcccag acccaggccc cagccagccc tctgagtatt acctattcca
     1501 gaagccagaa gtccagccag aggaacaaga agcagtgagt tcctccaccc aagcagcagc
     1561 tgctgtgggc cccactgtgc ttgagggaca agtatacacg aatacttcac cccccaacct
     1621 cagcactgga cgtcagcgct cccgcagcta tgatcgcagc ctgcagcgca gccctcctgt
     1681 ccgcctgggc tcgctggaac gtatgttgag ttgcccagtg cgcttgagtg agggccctgc
     1741 agccatggcc gggcctggct ccccacccag gagggtcacc tcctttgccg agctggccaa
     1801 gggccggaag aaaactggag gctctggctc gcccccactt cgtgtgagtg ttggggactc
     1861 ctcccaggag ttctcaccca tccaagaagc ccagcaagat cggggggccc cactggatga
     1921 gggcacttgc tgtagccata gcctgccacc catgcctttg gggccaggca tggacctact
     1981 tggcccagac ccaagtccac cctggtccac ccaggtctgt cagggacccc actccagtga
     2041 gatgcctcct gctggcctca gagctactgg gcaaggcccc ctggctcagc tgatggatcc
     2101 agggcctgct ctcccaggga gcccagccaa cagccatacc cagagggatg caagagctag
     2161 agctgacggg ggtggcaccg agagccgacc agtccttcgc tacagcaagg aacagaggcc
     2221 aaccacactg cccatccagc ccttcgtgtt ccagcaccac ttccccaagc agctggccaa
     2281 ggcccgggcc ctccacagcc tttcccagct ctacagcctc tcaggctgca gccgtacaca
     2341 gcagcctgcc ccactggctg cccctgctgc tcaagtctca gtcccagctc cctcagggga
     2401 accgcaggca tccactcccc gagccactgg cagaggtgcc aggaaagctg ggtctgagcc
     2461 agagacctct cggccatcgc ccctgggcag ctactccccc atccggagtg ttggcccctt
     2521 tgggcccagc actgactctt ctgcctccac ttcgtgctcc cctcccccag agcagcccac
     2581 agccacagaa agcctgcccc catggagcca ctcctgtcct tctgctgtcc ggcctgccac
     2641 ctcccagcag ccgcagaagg aggatcagaa gatactgacc ttgactgagt accggctcca
     2701 tggaacagga agcttgccgc ctctgggctc ctggcgatct ggcctcagcc gagcagagag
     2761 cctggcccgg ggaggtggtg agggcagcat ggccaccagg cccagtaatg ccaaccacct
     2821 atcccctcaa gccctcaagt ggcgggaata caggaggaag aacccactag ggccacctgg
     2881 tttgtcaggg agcctagacc gaagatcaca agaagctcgg ctggcccgaa gaaaccctat
     2941 ctttgagttc cctggctccc tcagtgctgc cagccatctg aactgccggc tgaatggcca
     3001 agcagtgaag ccgttaccac tgacctgccc tgacttccag gacccctttt ccttgacgga
     3061 gaagcctcca gctgagtttt gtctgtcccc agatggcagc tcagaggcca tttccattga
     3121 cctgcttcag aaaaaagggc tggtaaaagc tgttaacatc gctgtggacc tcattgtggc
     3181 tcattttggc acaagccggg atcccggggt gaaggcaaag ctgggaaaca gttctgtgag
     3241 ccccaatgtg ggccacctgg ttctgaagta cttgtgccct gccgtccgcg ccgtgctgga
     3301 ggatgggctc aaggcctttg tactggacgt catcatcggg cagcgtaaga acatgccatg
     3361 gagtgtggtt gaggcttcca cacagctagg cccatccacc aaggtcctgc atggcctcta
     3421 caacaaagtc agccaattcc cagagctcac cagtcatacc atgcgcttca acgccttcat
     3481 cctcggcctg ctcaacatcc ggtccctgga gttctggttt aatcacctct ataaccacga
     3541 agacatcatc cagacccact accagccctg gggcttcctg agtgcagctc ataccgtgtg
     3601 tcccggcctc tttgaagagc tgctgctgct gctacagccc ctggccctgc tgcccttcag
     3661 cctcgacttg ctgttccagc accggctgct gcaaagtggg cagcagcagc ggcagcacaa
     3721 ggaactgctg cgggtgtccc aggacctgct gctgtctgcc cactccacgc tgcagctggc
     3781 ccgggcccgg ggccaggagg gccctggaga cgtggacagg gcagcccaag gggagcgggt
     3841 gaagggtgtg ggtgcctcag aaggtggaga agaggaagag gaagaagagg agacagaaga
     3901 ggtggcagag gcagccgggg gctcagggcg tgccaggtgg gcccgaggtg ggcaggccgg
     3961 ctggtggtac cagctcatgc agagctccca ggtctacatc gatggctcca ttgagggttc
     4021 caggttccct cgtggtagca gcaacagcag cagcgagaaa aagaaagggg caggaggtgg
     4081 gggacctccc caggctccac caccccgaga gggagtagtg gagggggctg aggcctgccc
     4141 tgcctctgag gaggccctgg gccgggaaag gggctggccc ttctggatgg ggagcccccc
     4201 tgactctgtg ctggccgagc tgaggcgcag tcgggagagg gaagggcccg ctgcctcgcc
     4261 agcagaaaat gaggaagggg cctcagagcc ttcacctgga ggcatcaagt ggggacacct
     4321 ctttggctcc cgaaaagccc agcgggaggc ccggcccaca aataggctcc cctcggactg
     4381 gctgagcctg gacaagtcca tgttccaact agtggcgcag acagtgggtt cccgccggga
     4441 gccagagccc aaggagagcc tgcaggagcc acactcccca gccctgccct ccagtcctcc
     4501 gtgtgaggtg caggcactgt gccaccacct ggccaccggc cctggacagc tgagcttcca
     4561 caaaggagac atcctacgag tgctggggcg agctggagga gactggctgc gctgcagccg
     4621 tggccccgac tctggcctgg tgcccctggc ctacgtgaca ttgaccccaa ctccaagtcc
     4681 aacccctgga agcagccaaa actgaggccc tgtgcatgct ggtggcctca gggaccctca
     4741 taacccccag actcagagcc cgagagccct tcccaagcca ttggcttggc tgcagagtag
     4801 actgagagct ggggccacgt atccctgtgc tggcacctgc tccctgtgct cagtattaat
     4861 tacgccccct taactgtccc agtgaccttg tccagacctc cacccaggag agggatggga
     4921 cacagcactg ggctgccagg attcccctgg cccgtctggg ccaacccttc catgggtgaa
     4981 gacaagcaag tccccctgga ggcgggtggc ccagaaagcc atctacaggg ttccctaggc
     5041 caggtggaga tgaggatggg taacagtatt ggggccagat ccctaagccc cccagctgta
     5101 aataggctgt ggccagtgcc tggtcatcag aagagggagg aggagcccag gcgtctgttt
     5161 atgtatttat ttatttattt attataccta ttaataaaaa aggtgctcag cctccaaa
//
