LOCUS       NM_001105203            3436 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RUN and SH3 domain containing 1 (RUSC1), transcript
            variant 1, mRNA.
ACCESSION   NM_001105203
VERSION     NM_001105203.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3436)
  AUTHORS   Tong,C.J., Deng,Q.C., Ou,D.J., Long,X., Liu,H. and Huang,K.
  TITLE     LncRNA RUSC1-AS1 promotes osteosarcoma progression through
            regulating the miR-340-5p and PI3K/AKT pathway
  JOURNAL   Aging (Albany NY) 13 (16), 20116-20130 (2021)
   PUBMED   34048366
  REMARK    GeneRIF: LncRNA RUSC1-AS1 promotes osteosarcoma progression through
            regulating the miR-340-5p and PI3K/AKT pathway.
REFERENCE   2  (bases 1 to 3436)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3436)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3436)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3436)
  AUTHORS   Zhou,P., Liu,P. and Zhang,J.
  TITLE     Long noncoding RNA RUSC1-AS-N promotes cell proliferation and
            metastasis through Wnt/beta-catenin signaling in human breast
            cancer
  JOURNAL   Mol Med Rep 19 (2), 861-868 (2019)
   PUBMED   30569097
  REMARK    GeneRIF: The present study demonstrated that lncRNA RUSC1ASN
            promoted cell viability and metastasis via Wnt/betacatenin
            signaling in human breast cancer.
REFERENCE   6  (bases 1 to 3436)
  AUTHORS   Sun,Q., Han,C., Liu,L., Wang,Y., Deng,H., Bai,L. and Jiang,T.
  TITLE     Crystal structure and functional implication of the RUN domain of
            human NESCA
  JOURNAL   Protein Cell 3 (8), 609-617 (2012)
   PUBMED   22821014
  REMARK    GeneRIF: RUN domain of NESCA can bind H-Ras, a downstream signaling
            molecule of TrkA, with high affinity. Moreover, NESCA RUN can
            directly interact with TrkA.
REFERENCE   7  (bases 1 to 3436)
  AUTHORS   MacDonald,J.I., Dietrich,A., Gamble,S., Hryciw,T., Grant,R.I. and
            Meakin,S.O.
  TITLE     Nesca, a novel neuronal adapter protein, links the molecular motor
            kinesin with the pre-synaptic membrane protein, syntaxin-1, in
            hippocampal neurons
  JOURNAL   J Neurochem 121 (6), 861-880 (2012)
   PUBMED   22404429
  REMARK    GeneRIF: Nesca functions as an adapter involved in neuronal
            vesicular transport
REFERENCE   8  (bases 1 to 3436)
  AUTHORS   Napolitano,G., Mirra,S., Monfregola,J., Lavorgna,A., Leonardi,A.
            and Ursini,M.V.
  TITLE     NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein
  JOURNAL   J Cell Physiol 220 (2), 410-417 (2009)
   PUBMED   19365808
  REMARK    GeneRIF: Data show that NESCA and NEMO interact by their N-terminal
            region, that NESCA directly associates with TRAF6, which in turn
            catalyzes NESCA polyubiquitination, and that NESCA overexpression
            strongly inhibits TRAF6-mediated polyubiquitination of NEMO.
REFERENCE   9  (bases 1 to 3436)
  AUTHORS   MacDonald,J.I., Kubu,C.J. and Meakin,S.O.
  TITLE     Nesca, a novel adapter, translocates to the nuclear envelope and
            regulates neurotrophin-induced neurite outgrowth
  JOURNAL   J Cell Biol 164 (6), 851-862 (2004)
   PUBMED   15024033
REFERENCE   10 (bases 1 to 3436)
  AUTHORS   Matsuda,S., Miyazaki,K., Ichigotani,Y., Kurata,H., Takenouchi,Y.,
            Yamamoto,T., Nimura,Y., Irimura,T., Nakatsugawa,S. and Hamaguchi,M.
  TITLE     Molecular cloning and characterization of a novel human gene
            (NESCA) which encodes a putative adapter protein containing SH3
  JOURNAL   Biochim Biophys Acta 1491 (1-3), 321-326 (2000)
   PUBMED   10760598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA099897.1 and BC025680.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001105203.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025680.1, SRR3476690.687070.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368352.10/ ENSP00000357336.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-494               DA099897.1         46-539
            495-3436            BC025680.1         462-3403
FEATURES             Location/Qualifiers
     source          1..3436
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3436
                     /gene="RUSC1"
                     /gene_synonym="NESCA"
                     /note="RUN and SH3 domain containing 1"
                     /db_xref="GeneID:23623"
                     /db_xref="HGNC:HGNC:17153"
                     /db_xref="MIM:617318"
     exon            1..98
                     /gene="RUSC1"
                     /gene_synonym="NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            99..1541
                     /gene="RUSC1"
                     /gene_synonym="NESCA"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..2893
                     /gene="RUSC1"
                     /gene_synonym="NESCA"
                     /note="isoform a is encoded by transcript variant 1; new
                     molecule containing SH3 at the carboxy-terminus; RUN and
                     SH3 domain-containing protein 1; AP-4 complex accessory
                     subunit RUSC1"
                     /codon_start=1
                     /product="AP-4 complex accessory subunit RUSC1 isoform a"
                     /protein_id="NP_001098673.1"
                     /db_xref="CCDS:CCDS41410.1"
                     /db_xref="GeneID:23623"
                     /db_xref="HGNC:HGNC:17153"
                     /db_xref="MIM:617318"
                     /translation="MLSPQRALLCNLNHIHLQHVSLGLHLSRRPELQEGPLSTPPPPG
                     DTGGKESRGPCSGTLVDANSNSPAVPCRCCQEHGPGLENRQDPSQEEEGAASPSDPGC
                     SSSLSSCSDLSPDESPVSVYLRDLPGDEDAHPQPSIIPLEQGSPLASAGPGTCSPDSF
                     CCSPDSCSGASSSPDPGLDSNCNALTTCQDVPSPGLEEEDERAEQDLPTSELLEADDG
                     KIDAGKTEPSWKINPIWKIDTEKTKAEWKTTENNNTGWKNNGNVNSSWKSEPEKFDSG
                     WKTNTRITDSGSKTDAGKIDGGWRSDVSEEPVPHRTITSFHELAQKRKRGPGLPLVPQ
                     AKKDRSDWLIVFSPDTELPPSGSPGGSSAPPREVTTFKELRSRSRAPAPPVPPRDPPV
                     GWALVPPRPPPPPVPPRRKKNRPGLQPIAEGQSEEGRAVSPAAGEEAPAAKEPGAQAG
                     LEVRSSWSFAGVPGAQRLWMAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNL
                     VQKAQLGDSRLSPDVGHLVLTTLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEAS
                     VKPGSSTRSLGTLYSQVSRLAPLSSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLS
                     LLYLPTGFFSLARGGCPSLSTELLLLLQPLSVLTFHLDLLFEHHHHLPLGPPQAPAPP
                     GPPPALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLPTPGSWWEQLTQASRVY
                     ASGGTEGFPLSRWAPGRHGTAAEEGAQERPLPTDEMAPGRGLWLGRLFGVPGGPAENE
                     NGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMVQTHRAVRALCDHT
                     AARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPVGYTSLVL"
     exon            1542..1640
                     /gene="RUSC1"
                     /gene_synonym="NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1717
                     /gene="RUSC1"
                     /gene_synonym="NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1892
                     /gene="RUSC1"
                     /gene_synonym="NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..1998
                     /gene="RUSC1"
                     /gene_synonym="NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2045
                     /gene="RUSC1"
                     /gene_synonym="NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2598
                     /gene="RUSC1"
                     /gene_synonym="NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2724
                     /gene="RUSC1"
                     /gene_synonym="NESCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..3436
                     /gene="RUSC1"
                     /gene_synonym="NESCA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3417..3422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUSC1"
                     /gene_synonym="NESCA"
                     /note="hexamer: AATAAA"
     polyA_site      3436
                     /gene="RUSC1"
                     /gene_synonym="NESCA"
                     /note="major polyA site"
ORIGIN      
        1 gtgctagtgc ccctcccctc ccgctctgtg ccccgccggg cggggaccgt gggagccgcg
       61 gacaagccca aggccggagc ggttccagga ggaccctggt ctgcacctgt ggttgccagg
      121 taggtggatg tgagagaccc tacccttctg gttctctaga agccatccca tcgccgctag
      181 catcatgctg tcccctcaga gagctttact ctgcaacctc aaccacatcc acctccagca
      241 cgtctccctg ggcctgcact tgtcccgccg tcctgagcta caggaggggc ctttgagcac
      301 accccctcct ccaggagaca ctgggggcaa ggagagcagg ggcccctgca gtggcaccct
      361 ggtggacgcc aattccaaca gcccagctgt gccctgccgg tgctgccagg agcacggtcc
      421 gggcctagaa aaccggcagg acccgtcaca ggaggaagag ggggctgcct ctccctcaga
      481 cccaggctgc tcctcctcac tcagctcctg ctcagatctt agccccgatg agtcccctgt
      541 ctcagtctac ttgcgggacc tccctggtga tgaggatgcc caccctcagc ccagtatcat
      601 ccccctggag cagggctccc cactggcttc agcaggccct ggcacctgct caccggacag
      661 cttctgctgc tctcctgatt cctgctccgg agcttcttct tcacccgatc ctggcctgga
      721 ctcgaactgc aacgccctga ccacctgcca ggacgtccct tccccaggct tggaggaaga
      781 ggacgagagg gcggagcagg atctccctac ctctgagctc ttagaggcgg atgatgggaa
      841 aatcgacgct gggaaaacgg agcccagttg gaagattaac ccaatttgga aaattgacac
      901 agagaaaact aaagctgaat ggaaaaccac tgaaaacaat aacactggtt ggaaaaacaa
      961 cgggaatgtt aactctagct ggaaaagtga acctgaaaaa ttcgactctg gttggaaaac
     1021 caacacaaga ataactgatt ctggctcgaa aacagatgca gggaaaattg atggaggatg
     1081 gagaagtgac gtcagcgagg agccggtgcc ccaccggaca atcacgtcct tccacgagct
     1141 ggcccagaag cgcaagcggg gcccagggct gccccttgtc ccgcaggcga agaaagatcg
     1201 cagtgactgg ctcatagtct tctcgcccga caccgagctc cccccctcgg ggtcgccggg
     1261 cggctcctcg gcacctcctc gggaagtcac caccttcaag gaactccggt cccgaagccg
     1321 ggccccagcc ccgccagtcc cgcctcgaga ccccccagtt ggctgggctt tggtcccgcc
     1381 ccggccccca cccccgcctg tccctccccg aaggaagaag aaccgacctg gactgcagcc
     1441 catagcggag gggcagtccg aggagggccg ggctgtcagc ccagcggctg gcgaggaggc
     1501 cccagccgcg aaggagccgg gcgcgcaggc cggcctggag gtccgtagtt cgtggtcctt
     1561 cgccggtgtc cccggagccc agcggctgtg gatggcagaa gcccagagtg ggactggtca
     1621 gctgcaggag cagaagaaag gtcttctgat agccgtcagc gtctccgttg ataaaatcat
     1681 ctcgcatttc ggggccgccc ggaacttggt gcagaaggcc cagttgggtg atagccggct
     1741 gagcccggat gtggggcacc tggtgctgac caccctctgc ccggccctcc acgccctggt
     1801 ggcggacggg ctgaagcctt tccggaagga cctcatcacc gggcagcgca ggagcagccc
     1861 ctggagcgtg gtggaggcgt cggtgaagcc aggctccagc acccgctccc ttggaaccct
     1921 gtatagccag gtcagccgtc tagccccgct gagcagcagc cgtagccgct tccatgcctt
     1981 tatcctgggc ctcctcaaca ccaagcagtt ggagctgtgg ttttccagtc tccaggaaga
     2041 tgcaggcctg ctctccctcc tgtacctgcc aacaggattt ttctccctgg cccgcggtgg
     2101 ttgtccctcc ctgtccacag agctgctgct cctgctgcag ccattgtcgg tgctcacttt
     2161 ccacctggac ctgctctttg agcaccacca ccacctgccc ctgggcccac ctcaggcccc
     2221 tgcccctcca ggcccacctc cagctctgca gcagactatg caagccatgc tgcactttgg
     2281 gggccggctg gcccagagcc ttcgggggac ttccaaggaa gctgcttcag acccctctga
     2341 ctctccaaac cttcccacac cagggagctg gtgggagcag ttgacccagg cctcccgggt
     2401 ctatgcctct gggggcactg agggctttcc tctttcccga tgggcaccgg ggcgtcatgg
     2461 gactgcagct gaagaaggtg cacaggagag acccctgccc acagatgaga tggcaccagg
     2521 caggggcctc tggttgggaa gactatttgg agtgcctggg ggccccgcag aaaatgagaa
     2581 tggagcccta aagtccagga gaccatctag ctggctgccc ccgacagtga gtgtgttggc
     2641 tcttgtgaag cggggggcac ctcccgagat gccttctcct caggagcttg aggcctcagc
     2701 acccaggatg gtgcaaaccc atagggcagt gcgggctctc tgtgatcaca ctgctgcaag
     2761 acctgaccag ttgagcttcc ggcgtgggga agtgctgcgt gtcatcacca cagtggatga
     2821 ggactggctc cgctgtgggc gggatggcat ggagggtctg gtgcctgtgg ggtatacctc
     2881 ccttgttctg tagccctggg accctttcct gcgtatgtgt ctccttcctg tcacctggga
     2941 atggaatggc cagtgaacac catcccagaa gcattttccc tctgcaaaat gacgtttctt
     3001 cccacgtctg tttctgctaa tatttaaaat aaactttcct tcttccctcc tatacccacc
     3061 tgtaaggtga aatctgctct tcttccaaat atataaaaaa ggaattgccc tccaggtaat
     3121 ccctttcctt tttcccgtct atataaggga atgtcttcct tcctatctat ctgcaaaatg
     3181 gaaatctaga cctccttctt catccataag tggactgtgc cagtacaata catgcctcag
     3241 cccccaagcc tagaaggacc tctagtctcc ttcctgtgtg gaatcttccc cactccatcc
     3301 ctcccaagtt gcctgtattg ataatgtact cactcatgct gtactaggtg ctgaagcctg
     3361 gacacccttg gtgggtgggc ctgtggtgat ggtttgcatc cttcctcctt tgtcccaata
     3421 aagtatggga gttgaa
//
