LOCUS       NM_175634               7699 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens RUNX1 partner transcriptional co-repressor 1
            (RUNX1T1), transcript variant 2, mRNA.
ACCESSION   NM_175634
VERSION     NM_175634.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7699)
  AUTHORS   Lints,R., Walker,C.A., Delfi,O., Prouse,M., PohLui De Silva,M.,
            Bohlander,S.K. and Wood,A.C.
  TITLE     Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic
            NRAS in zebrafish myeloid leukaemia
  JOURNAL   Biol Open 13 (9) (2024)
   PUBMED   39177514
  REMARK    GeneRIF: Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and
            oncogenic NRAS in zebrafish myeloid leukaemia.
REFERENCE   2  (bases 1 to 7699)
  AUTHORS   Murray,J.E., Valli,E., Milazzo,G., Mayoh,C., Gifford,A.J.,
            Fletcher,J.I., Xue,C., Jayatilleke,N., Salehzadeh,F., Gamble,L.D.,
            Rouaen,J.R.C., Carter,D.R., Forgham,H., Sekyere,E.O., Keating,J.,
            Eden,G., Allan,S., Alfred,S., Kusuma,F.K., Clark,A., Webber,H.,
            Russell,A.J., de Weck,A., Kile,B.T., Santulli,M., De Rosa,P.,
            Fleuren,E.D.G., Gao,W., Wilkinson-White,L., Low,J.K.K.,
            Mackay,J.P., Marshall,G.M., Hilton,D.J., Giorgi,F.M., Koster,J.,
            Perini,G., Haber,M. and Norris,M.D.
  TITLE     The transcriptional co-repressor Runx1t1 is essential for
            MYCN-driven neuroblastoma tumorigenesis
  JOURNAL   Nat Commun 15 (1), 5585 (2024)
   PUBMED   38992040
  REMARK    GeneRIF: The transcriptional co-repressor Runx1t1 is essential for
            MYCN-driven neuroblastoma tumorigenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7699)
  AUTHORS   Tauziede-Espariat,A., Lew-Derivry,L., Abbou,S., Metais,A.,
            Pierron,G., Reynaud,S., Masliah-Planchon,J., Mariet,C., Hasty,L.,
            Dangouloff-Ros,V., Boddaert,N., Csanyi,M., Aline-Fardin,A.,
            Lamaison,C., Chretien,F., Beccaria,K., Puget,S. and Varlet,P.
  TITLE     CNS erythroblastic sarcoma: a potential emerging pediatric tumor
            type characterized by NFIA::RUNX1T1/3 fusions
  JOURNAL   Acta Neuropathol Commun 12 (1), 12 (2024)
   PUBMED   38243303
  REMARK    GeneRIF: CNS erythroblastic sarcoma: a potential emerging pediatric
            tumor type characterized by NFIA::RUNX1T1/3 fusions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7699)
  AUTHORS   Li,X.P., Dai,Y., Zhang,W.N., Pan,M.M., Mao,J., Zhao,B., Jiang,L.
            and Gao,Y.
  TITLE     Single-cell RNA-seq reveals novel immune-associated biomarkers for
            predicting prognosis in AML patients with RUNX1::RUNX1T1
  JOURNAL   Int Immunopharmacol 125 (Pt B), 111178 (2023)
   PUBMED   37951201
  REMARK    GeneRIF: Single-cell RNA-seq reveals novel immune-associated
            biomarkers for predicting prognosis in AML patients with
            RUNX1::RUNX1T1.
REFERENCE   5  (bases 1 to 7699)
  AUTHORS   Morohoshi,F., Mitani,S., Mitsuhashi,N., Kitabayashi,I.,
            Takahashi,E., Suzuki,M., Munakata,N. and Ohki,M.
  TITLE     Structure and expression pattern of a human MTG8/ETO family gene,
            MTGR1
  JOURNAL   Gene 241 (2), 287-295 (2000)
   PUBMED   10675041
REFERENCE   6  (bases 1 to 7699)
  AUTHORS   Calabi,F. and Cilli,V.
  TITLE     CBFA2T1, a gene rearranged in human leukemia, is a member of a
            multigene family
  JOURNAL   Genomics 52 (3), 332-341 (1998)
   PUBMED   9790752
REFERENCE   7  (bases 1 to 7699)
  AUTHORS   Wolford,J.K. and Prochazka,M.
  TITLE     Structure and expression of the human MTG8/ETO gene
  JOURNAL   Gene 212 (1), 103-109 (1998)
   PUBMED   9661669
REFERENCE   8  (bases 1 to 7699)
  AUTHORS   Era,T., Asou,N., Kunisada,T., Yamasaki,H., Asou,H., Kamada,N.,
            Nishikawa,S., Yamaguchi,K. and Takatsuki,K.
  TITLE     Identification of two transcripts of AML1/ETO-fused gene in t(8;21)
            leukemic cells and expression of wild-type ETO gene in
            hematopoietic cells
  JOURNAL   Genes Chromosomes Cancer 13 (1), 25-33 (1995)
   PUBMED   7541640
REFERENCE   9  (bases 1 to 7699)
  AUTHORS   van de Locht,L.T., Smetsers,T.F., Wittebol,S., Raymakers,R.A. and
            Mensink,E.J.
  TITLE     Molecular diversity in AML1/ETO fusion transcripts in patients with
            t(8;21) positive acute myeloid leukaemia
  JOURNAL   Leukemia 8 (10), 1780-1784 (1994)
   PUBMED   7523801
REFERENCE   10 (bases 1 to 7699)
  AUTHORS   Nisson,P.E., Watkins,P.C. and Sacchi,N.
  TITLE     Transcriptionally active chimeric gene derived from the fusion of
            the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic
            cells
  JOURNAL   Cancer Genet Cytogenet 63 (2), 81-88 (1992)
   PUBMED   1423235
  REMARK    Erratum:[Cancer Genet Cytogenet. 1993 Mar;66(1):81.. PMID: 8467483]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104339.10, DA787376.1,
            D14821.1 and AC103680.2.
            
            On Jun 2, 2019 this sequence version replaced NM_175634.2.
            
            Summary: This gene encodes a member of the myeloid translocation
            gene family which interact with DNA-bound transcription factors and
            recruit a range of corepressors to facilitate transcriptional
            repression. The t(8;21)(q22;q22) translocation is one of the most
            frequent karyotypic abnormalities in acute myeloid leukemia. The
            translocation produces a chimeric gene made up of the 5'-region of
            the runt-related transcription factor 1 gene fused to the 3'-region
            of this gene. The chimeric protein is thought to associate with the
            nuclear corepressor/histone deacetylase complex to block
            hematopoietic differentiation. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (2) utilizes two alternate exons
            in the 5' UTR and coding region compared to variant 1. The
            resulting protein (isoform B, also known as MTG8b) has a distinct
            N-terminus compared to isoform A. Variants 2 and 7-12 all encode
            isoform B.
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.3815361.1,
                                           SRR1803613.158742.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000523629.7/ ENSP00000428543.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AC104339.10        75446-75604         c
            160-530             DA787376.1         1-371
            531-2864            D14821.1           1-2334
            2865-7699           AC103680.2         131861-136695       c
FEATURES             Location/Qualifiers
     source          1..7699
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..7699
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /note="RUNX1 partner transcriptional co-repressor 1"
                     /db_xref="GeneID:862"
                     /db_xref="HGNC:HGNC:1535"
                     /db_xref="MIM:133435"
     exon            1..529
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            530..702
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     CDS             615..2429
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /note="isoform B is encoded by transcript variant 2;
                     core-binding factor, runt domain, alpha subunit 2;
                     translocated to, 1; cyclin D-related; acute myelogenous
                     leukemia 1 translocation 1, cyclin-D related; myeloid
                     translocation gene on 8q22; RUNX1 translocation partner 1;
                     eight twenty one protein; zinc finger MYND
                     domain-containing protein 2; runt related transcription
                     factor 1; translocated to, 1 (cyclin D related)"
                     /codon_start=1
                     /product="protein CBFA2T1 isoform B"
                     /protein_id="NP_783552.1"
                     /db_xref="CCDS:CCDS6256.1"
                     /db_xref="GeneID:862"
                     /db_xref="HGNC:HGNC:1535"
                     /db_xref="MIM:133435"
                     /translation="MISVKRNTWRALSLVIGDCRKKGNFEYCQDRTEKHSTMPDSPVD
                     VKTQSRLTPPTMPPPPTTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPS
                     SSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTL
                     TIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLL
                     LDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRY
                     SPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHG
                     TRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYW
                     IRRYSDAEDLKKGGGSSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAE
                     EAVNEVKRQAMTELQKAVSEAERKAHDMITTERAKMERTVAEAKRQAAEDALAVINQQ
                     EDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAQQQGDTPAV
                     SSSVTPNSGAGSPMDTPPAATPRSTTPGTPSTIETTPR"
     exon            703..840
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1082
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1172
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1354
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1605
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1691
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1893
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1962
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2153
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..7699
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6151..6156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /note="hexamer: AATAAA"
     polyA_site      6170
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /note="major polyA site"
     regulatory      7679..7684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /note="hexamer: AATAAA"
     polyA_site      7699
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
ORIGIN      
        1 gatgcgggcg ctctcggcgc acagcgcgcg gcgctcctgc tccccggcgg acgcccggcc
       61 gccctgcaga taaatgcgtc gccttcctcg agagtgagcg agggcgggcg agggagacgc
      121 agacgccgcc tgtgacagtg gcaattccct gcgccccaca tcacatttgt ctgccacagc
      181 agcaacaaca gaaaagcgga gggagggagg gaggcgggag gaggggagca gagctccgca
      241 agtcttgggc tctgcgtgga ggttgcgttt ggctggcgtc cccgaccccg ggctttttgc
      301 acggcagctc tctctgcgca gcgccgggcg gccgtagtcg ctccgcggcg cgactccgcg
      361 gtctcgtggc gagcgcgcgt gggcgagtgg ccgcggacac tctggcctcg cgagggaagc
      421 cgcgccgcgt cctcgccccg tcgccccgcg ggccggccga gacgacggga agttttattt
      481 gcagctcgga gcctgtggcg gatggtggga ctctccggcc ctgtgcagta aaagattgat
      541 ctctgggctg gtgaacataa tctctgtccc agtcagaaaa ggagagagga aattagcaga
      601 gcgattggtg gagaatgata tctgtcaaaa gaaacacttg gagagcactg agtttagtaa
      661 taggtgactg ccggaaaaaa gggaactttg aatattgtca agatcgtact gagaagcact
      721 ccacaatgcc agactcacct gtggatgtga agacgcaatc taggctgact cctccaacaa
      781 tgccacctcc cccaactact caaggagctc caagaaccag ttcatttaca ccgacaacgt
      841 taactaatgg cacgagccat tctcctacag ccttgaatgg cgccccctca ccacccaatg
      901 gcttcagcaa tgggccttcc tcttcttcct cctcctctct ggctaatcaa cagctgcccc
      961 cagcctgtgg tgccaggcaa ctcagcaagc tgaaaaggtt ccttactacc ctgcagcagt
     1021 ttggcaatga catttcaccc gagataggag aaagagttcg caccctcgtt ctgggactag
     1081 tgaactccac tttgacaatt gaagaatttc attccaaact gcaagaagct actaacttcc
     1141 cactgagacc ttttgtcatc ccatttttga aggccaactt gcccctgctg cagcgtgagc
     1201 tcctccactg cgcaagactg gccaaacaga accctgccca gtacctcgcc cagcatgaac
     1261 agctgcttct ggatgccagc accacctcac ctgttgactc ctcagagctg cttctcgatg
     1321 tgaacgaaaa cgggaagagg cgaactccag acagaaccaa agaaaatggc tttgacagag
     1381 agcctttgca ctcagaacat ccaagcaagc gaccatgcac tattagccca ggccagcggt
     1441 acagtccaaa taacggctta tcctaccagc ccaatggcct gcctcaccct accccacctc
     1501 cacctcagca ttaccgtttg gatgatatgg ccattgccca ccactacagg gactcctatc
     1561 gacaccccag ccacagggac ctcagggaca gaaacagacc tatggggttg catggcacac
     1621 gtcaagaaga aatgattgat cacagactaa cagacagaga atgggcagaa gagtggaaac
     1681 atcttgacca tctgttaaac tgcataatgg acatggtaga aaaaacaagg cgatctctca
     1741 ccgtactaag gcggtgtcaa gaagcagacc gggaagaatt gaattactgg atccggcggt
     1801 acagtgacgc cgaggactta aaaaaaggtg gcggcagtag cagcagccac tctaggcagc
     1861 agagtcccgt caacccagac ccagttgcac tagacgcgca tcgggaattc cttcacaggc
     1921 ctgcgtctgg atacgtgcca gaggagatct ggaagaaagc tgaggaggcc gtcaatgagg
     1981 tgaagcgcca ggcgatgacg gagctgcaga aggccgtgtc tgaggcggag cggaaagccc
     2041 acgacatgat cacaacagag agggccaaga tggagcgcac ggtcgccgag gccaaacggc
     2101 aggcggcgga ggacgcactg gcagttatca atcagcagga ggattcaagc gagagttgct
     2161 ggaattgtgg ccgtaaagcg agtgaaacct gcagtggctg taacacagcc cgatactgtg
     2221 gctcattttg ccagcacaaa gactgggaga agcaccatca catctgtgga cagaccctgc
     2281 aggcccagca gcagggagac acacctgcag tcagctcctc tgtcacgccc aacagcgggg
     2341 ctgggagccc gatggacaca ccaccagcag ccactccgag gtcaaccacc ccgggaaccc
     2401 cttccaccat agagacaacc cctcgctaga cgtgaactca gaactgtcgg aggaaagaca
     2461 acacaaccaa cgcgaaacca attcctcatc ctcagatgct caaagttgtt ttttttgttt
     2521 gtttgtttat tagatgaatt atcctatttc agtacttcag caagagagaa cctaactgta
     2581 tcttgaggtg gtagtaaaac acagagggcc agtaacgggt cgtaatgact tattgtggat
     2641 aacaaagata tcttttcttt agagaactga aaagagagca gagaatataa catgaaatga
     2701 tagatttgac ctcctccctg ttattttcaa gtagctggga ttttaaacta gatgacctca
     2761 ttaaccgatg ctttaccaaa cagcaaacca agagattgct aattgctgtt gaaagcaaaa
     2821 atgctaatat taaaagtcac aatgttcttt atatacaata atggaaaaaa aaaaaagagg
     2881 aaaaccctca agggcatgag cattggatac agcagtagac attttaacaa gaagatgaat
     2941 ggcgtccgtg ggttgctaac tgaactttga agacccgcta caaaacgcgc agatgtgcag
     3001 cagattggaa ggagacacag atgttcggtt tttttcctgt ttctgaaaag aaataataat
     3061 atccaggtca acagaatgaa aaatgaaaga tgatttgcaa tgggatgtat gaatacagca
     3121 gcaagaaaaa aaaatgccat aatacaaaag gctccatata tatatatata tatatatata
     3181 tacacacaca cacacgcaca tatacacaca cacacacaca cacacacaca cacacacaca
     3241 cacacacaca cacacacaag taagagactc agcctgcagt taattagcat tctggcagtt
     3301 ttgacatcag ccagctgccc taaataaccc ttcaacgttt cttcactttt gcaaggttcc
     3361 acagagtaag acattgggtc tattccagct cattcatttt atattgaaaa aaataatttt
     3421 aaaaatggtg gcttcagctc cagccccttt ccaaaatttt tcaaccccac cctgtttgga
     3481 tttttaatta aaaactagta gttctcttgg tgttaaaaca cttctgtcct gtgaggtttc
     3541 ccaatggtgt ttttcttgta aatgtgttgg acaaatgtga agatgcattg tagtttaacc
     3601 atatgcccac atttagtctc tttattccta gttggtgaga aacctgtatc tttctatgct
     3661 gcttttatat ctgtatgtat tagtgatatt tctctagtag ttaaaaaaaa aaaaaggaaa
     3721 aaaagactct ttttggttgt cctcaagaaa agaaaagaag aaaagctatc tttcggagct
     3781 gctatttcac tctcttatag gatttttttt tttcctgaaa accagcatgc ttcacggaat
     3841 gctaacatat tggtgttttt gtaagaggga tgtacataaa tgtattttgc actgtcacaa
     3901 tgactcccta ggcatgcttt ttgttttttt tttttttttt ttgagcaaat tctttttaaa
     3961 tatgctagag ccatttcatc aagtttagct gtagcataga gtagtcgtgg aatttttctt
     4021 tttttttttt ttaaatcatt attagggact tttttaaaaa aataaaataa caagatatcc
     4081 tactttaaaa aaaaaggaca gtgcatgcat attgctgtaa ggtcgtttaa gtatttctaa
     4141 ttttacaaaa gtaaaaatca ttagagctcc aaatgctgag gtgtagattg acagctttaa
     4201 cactgctgaa tgccaggtta tacagtattc ttacaaaaag ggaagtcagc caaagactga
     4261 tctgatggac caaaatcgga attttgaaaa gcaccagtac tactttccaa atgatcagca
     4321 ggttaaacat gttcagcaag gtatagtatg aatccattaa cccttcgttg tccagggtcc
     4381 agaccagaac tacttgttag ttttgaaaac agtagcccag gatgtggttg tgtgctttag
     4441 gaaagtcagc agtgctgcag gctgtgtaga caaccaaagt ttacaaggct gggaagacac
     4501 ttctccaaat acatatacac caggcatttc tttaaaatca aaaacaatcc attagctttg
     4561 gggcgggggg tggggggagg gttaaatgta ggccttggaa acagttttaa gtggctttta
     4621 agtatctgca tagaggcaat cctaaggttt gctttaagtc tcttaaatct aacattttta
     4681 aaagcatttc ttccctgtat tttcatatac aagttggttt taattttgtt tgggtggtgt
     4741 tatttttttt aaatgacttt ttagtttaga aagttctgat gagcaaataa atacatctat
     4801 ctacatgttg gaagtccatc tgccagcaca cctgcttaaa gtgaaatgaa agcacataac
     4861 caggctctga atgggttata ttttatcatg gtgctcccag aatcctttga cctcactctg
     4921 ctttctagtc tgcttgtgac actggacagt cctttcttac agagctatta tatgttctag
     4981 gctacgaagg gttaaataat cccaaaaatg aggtatgtca tacccacacg tctttatctc
     5041 tagaagctgt gatgtatgtg aaacagcact gttattctta acactagtgt gtaaaataag
     5101 gattagtaca gtacgtctca ttacttttta attcagggca ccctgagtga aaacaaatac
     5161 aaaaaaaaat ccctaactct gagctctatc tctgattcct cttcctcctt cccctcttcc
     5221 tcctcttcct ctcctcctgt tttgctacat tctcctcagt ggcaaaaagt ttcactctac
     5281 ctctgacagc atgtatattg caccagtagc taacaaaaac tggtctagtc aaaccaaatg
     5341 ggcacaaaag aaccaggata ccaaaagtta agctcataca gctgcaaacc atatcacttc
     5401 ttggtaacaa tgcagacctc ataaacctaa agaagagaaa gaaaagaaaa cttttgttac
     5461 tttccttttt tgcttgtcac ttatatacag gctatgtgag aatataattt gtaggtataa
     5521 cacattaaga aaaagttatc ttcattggat agaattgaat ggtggtcgct gataggaata
     5581 gggcgtcctc tagctcttat ctctgtctct tactcttttc tctttctctt tttctctgtc
     5641 atgagactgt gtgtgacagg gccacctgtc tttttttttt cttaaatttt tttttttttt
     5701 atgtgtaggt gcatgtcttg gggatttaaa aatttcaagg ctggtttact tatgcaaagc
     5761 atgcctacgt ctggaatact tagggaaaga aagcgactcc atgttgtccg aattcctcaa
     5821 gggacagaaa aaaaattgga gactgttgaa atgcagattt gaagtaattt ttttaaaata
     5881 ttattttggg ttctgcgaca ttgtgaaaaa ttaaagttgt tgtgcaatac ttaattcaga
     5941 catgtaccac aagttaatgg tagactaaca ctggggggtg gggtctaggc atcatgcttt
     6001 tgtcagcata ctcttgagct tttaagtcta ctatgtctga actgtggttt cttgtttatc
     6061 cttttttcct tagttggact gtaatgtatg gtctgtcaac ctgtgaatct ttaaagtatg
     6121 attcaggtat tgttgtattc tttactgtgt aataaaaaag ttgaaaaaaa tctggatcct
     6181 ctgtctccct cgtccccggt gtgccatggt tgcccaccag tgaccccagc ctgaggagtc
     6241 catcctccat ggtgctgaat caaatctgta gagtttattc agctacaaag cgtggctctg
     6301 taacaggagt tggcttatcc atgcgtgttg agtagggaat gatgtcagaa ctttgcaaaa
     6361 gtcgagctca ttcataaggg gatgtttctc aggcaggagg agtaggaaga gtgggaggag
     6421 aattactacc ttccatagga aaggagagct tggcttgcct agattagctg ctgcatagat
     6481 agcagaggcc cttttggctg tgttttgata aaattagaaa tgagtaccta aatctggatc
     6541 actctgctca gagaggttcg tgccaacctc atgaggctct gactcttgtc aggttgcttg
     6601 gctgccttgt gcatacccga atggcagatc agctgacatg acatggaact gctctatctg
     6661 ccttgtcccc tctcctctaa ttaaaagtcg ctaccattgt cactcttggt tatgtagtta
     6721 atatccactg tggctatctc caacttgctg ggacatccag ttatctcctc tgacacatat
     6781 tttttcattc tctagttaca aagtttgtta gagtttgaaa aacaaaccct tctcccctac
     6841 cctgtgaatg ctgttagttt ttatgtgtag ttttcaaaac acagattatc ttatatactg
     6901 tgttgtagca gaaattcctg tttcctctga atgttctgac tttatagacc aaaataatcg
     6961 ttgcaaaaaa tcaaggatgg cacagcaggt gcatgagccc gtgtctggag aaaggttatg
     7021 aaggtgaatg ctggttacat gggagggtga cttggagccc tctagtttcc ttcttgtgcc
     7081 agctgggttc ctgtttcaag gccaggcttc tctaacttgt cttcctggga aatgtagctt
     7141 ttccaagaat ttggtagtgc acaccaggaa aaactaggta tcagaacaga ttttttttta
     7201 aatagtggaa acaccctcac tcccacactt tggacagtta gggttggata tttaatttca
     7261 tagttactct ttttttccac agaagaaagg ccagcctgac ccaagttgcc tatttttaat
     7321 gtgttactgc atcttatttt ctcttcaaag tgaaaaaggc cagaaactag cagatagaaa
     7381 tggaacccgt tgacttagtt cccttataag aagttcttgc aaacacctct gtgacgtttt
     7441 cattcaagtg gatatgttgg acaaatagga aacagtttta gtttacgcga acagtatgag
     7501 acttccaggt ggtggacgcc atttttttag aagtgttgat gatgtatttg ataacattat
     7561 aaaagtatgt gtctcccgtg aaagaacatt gagctatttc cctggaatgg atggggaaga
     7621 aatgagcaaa ggagtgctgt tctgtatggg tgtctatacc cttattccaa ggtgaataaa
     7681 taaagttgtg tttgcctaa
//
