LOCUS       NM_001395209            7670 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens RUNX1 partner transcriptional co-repressor 1
            (RUNX1T1), transcript variant 16, mRNA.
ACCESSION   NM_001395209 XM_017013930
VERSION     NM_001395209.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7670)
  AUTHORS   Lints,R., Walker,C.A., Delfi,O., Prouse,M., PohLui De Silva,M.,
            Bohlander,S.K. and Wood,A.C.
  TITLE     Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic
            NRAS in zebrafish myeloid leukaemia
  JOURNAL   Biol Open 13 (9) (2024)
   PUBMED   39177514
  REMARK    GeneRIF: Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and
            oncogenic NRAS in zebrafish myeloid leukaemia.
REFERENCE   2  (bases 1 to 7670)
  AUTHORS   Murray,J.E., Valli,E., Milazzo,G., Mayoh,C., Gifford,A.J.,
            Fletcher,J.I., Xue,C., Jayatilleke,N., Salehzadeh,F., Gamble,L.D.,
            Rouaen,J.R.C., Carter,D.R., Forgham,H., Sekyere,E.O., Keating,J.,
            Eden,G., Allan,S., Alfred,S., Kusuma,F.K., Clark,A., Webber,H.,
            Russell,A.J., de Weck,A., Kile,B.T., Santulli,M., De Rosa,P.,
            Fleuren,E.D.G., Gao,W., Wilkinson-White,L., Low,J.K.K.,
            Mackay,J.P., Marshall,G.M., Hilton,D.J., Giorgi,F.M., Koster,J.,
            Perini,G., Haber,M. and Norris,M.D.
  TITLE     The transcriptional co-repressor Runx1t1 is essential for
            MYCN-driven neuroblastoma tumorigenesis
  JOURNAL   Nat Commun 15 (1), 5585 (2024)
   PUBMED   38992040
  REMARK    GeneRIF: The transcriptional co-repressor Runx1t1 is essential for
            MYCN-driven neuroblastoma tumorigenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7670)
  AUTHORS   Tauziede-Espariat,A., Lew-Derivry,L., Abbou,S., Metais,A.,
            Pierron,G., Reynaud,S., Masliah-Planchon,J., Mariet,C., Hasty,L.,
            Dangouloff-Ros,V., Boddaert,N., Csanyi,M., Aline-Fardin,A.,
            Lamaison,C., Chretien,F., Beccaria,K., Puget,S. and Varlet,P.
  TITLE     CNS erythroblastic sarcoma: a potential emerging pediatric tumor
            type characterized by NFIA::RUNX1T1/3 fusions
  JOURNAL   Acta Neuropathol Commun 12 (1), 12 (2024)
   PUBMED   38243303
  REMARK    GeneRIF: CNS erythroblastic sarcoma: a potential emerging pediatric
            tumor type characterized by NFIA::RUNX1T1/3 fusions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7670)
  AUTHORS   Li,X.P., Dai,Y., Zhang,W.N., Pan,M.M., Mao,J., Zhao,B., Jiang,L.
            and Gao,Y.
  TITLE     Single-cell RNA-seq reveals novel immune-associated biomarkers for
            predicting prognosis in AML patients with RUNX1::RUNX1T1
  JOURNAL   Int Immunopharmacol 125 (Pt B), 111178 (2023)
   PUBMED   37951201
  REMARK    GeneRIF: Single-cell RNA-seq reveals novel immune-associated
            biomarkers for predicting prognosis in AML patients with
            RUNX1::RUNX1T1.
REFERENCE   5  (bases 1 to 7670)
  AUTHORS   Morohoshi,F., Mitani,S., Mitsuhashi,N., Kitabayashi,I.,
            Takahashi,E., Suzuki,M., Munakata,N. and Ohki,M.
  TITLE     Structure and expression pattern of a human MTG8/ETO family gene,
            MTGR1
  JOURNAL   Gene 241 (2), 287-295 (2000)
   PUBMED   10675041
REFERENCE   6  (bases 1 to 7670)
  AUTHORS   Calabi,F. and Cilli,V.
  TITLE     CBFA2T1, a gene rearranged in human leukemia, is a member of a
            multigene family
  JOURNAL   Genomics 52 (3), 332-341 (1998)
   PUBMED   9790752
REFERENCE   7  (bases 1 to 7670)
  AUTHORS   Wolford,J.K. and Prochazka,M.
  TITLE     Structure and expression of the human MTG8/ETO gene
  JOURNAL   Gene 212 (1), 103-109 (1998)
   PUBMED   9661669
REFERENCE   8  (bases 1 to 7670)
  AUTHORS   Era,T., Asou,N., Kunisada,T., Yamasaki,H., Asou,H., Kamada,N.,
            Nishikawa,S., Yamaguchi,K. and Takatsuki,K.
  TITLE     Identification of two transcripts of AML1/ETO-fused gene in t(8;21)
            leukemic cells and expression of wild-type ETO gene in
            hematopoietic cells
  JOURNAL   Genes Chromosomes Cancer 13 (1), 25-33 (1995)
   PUBMED   7541640
REFERENCE   9  (bases 1 to 7670)
  AUTHORS   van de Locht,L.T., Smetsers,T.F., Wittebol,S., Raymakers,R.A. and
            Mensink,E.J.
  TITLE     Molecular diversity in AML1/ETO fusion transcripts in patients with
            t(8;21) positive acute myeloid leukaemia
  JOURNAL   Leukemia 8 (10), 1780-1784 (1994)
   PUBMED   7523801
REFERENCE   10 (bases 1 to 7670)
  AUTHORS   Nisson,P.E., Watkins,P.C. and Sacchi,N.
  TITLE     Transcriptionally active chimeric gene derived from the fusion of
            the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic
            cells
  JOURNAL   Cancer Genet Cytogenet 63 (2), 81-88 (1992)
   PUBMED   1423235
  REMARK    Erratum:[Cancer Genet Cytogenet. 1993 Mar;66(1):81.. PMID: 8467483]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104339.10, AF181450.5 and
            AC103680.2.
            
            On Jun 11, 2021 this sequence version replaced XM_017013930.2.
            
            Summary: This gene encodes a member of the myeloid translocation
            gene family which interact with DNA-bound transcription factors and
            recruit a range of corepressors to facilitate transcriptional
            repression. The t(8;21)(q22;q22) translocation is one of the most
            frequent karyotypic abnormalities in acute myeloid leukemia. The
            translocation produces a chimeric gene made up of the 5'-region of
            the runt-related transcription factor 1 gene fused to the 3'-region
            of this gene. The chimeric protein is thought to associate with the
            nuclear corepressor/histone deacetylase complex to block
            hematopoietic differentiation. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.2633333.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-529               AC104339.10        75076-75604         c
            530-673             AC104339.10        67247-67390         c
            674-811             AF181450.5         65904-66041         c
            812-1053            AF181450.5         63257-63498         c
            1054-1143           AF181450.5         59680-59769         c
            1144-1325           AF181450.5         53794-53975         c
            1326-1576           AF181450.5         40317-40567         c
            1577-1662           AF181450.5         35565-35650         c
            1663-1864           AF181450.5         34802-35003         c
            1865-1933           AF181450.5         24583-24651         c
            1934-2124           AC103680.2         147547-147737       c
            2125-7670           AC103680.2         131861-137406       c
FEATURES             Location/Qualifiers
     source          1..7670
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..7670
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /note="RUNX1 partner transcriptional co-repressor 1"
                     /db_xref="GeneID:862"
                     /db_xref="HGNC:HGNC:1535"
                     /db_xref="MIM:133435"
     exon            1..529
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     CDS             502..2400
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /note="isoform G is encoded by transcript variant 16;
                     core-binding factor, runt domain, alpha subunit 2;
                     translocated to, 1; cyclin D-related; acute myelogenous
                     leukemia 1 translocation 1, cyclin-D related; myeloid
                     translocation gene on 8q22; RUNX1 translocation partner 1;
                     eight twenty one protein; zinc finger MYND
                     domain-containing protein 2; runt related transcription
                     factor 1; translocated to, 1 (cyclin D related)"
                     /codon_start=1
                     /product="protein CBFA2T1 isoform G"
                     /protein_id="NP_001382138.1"
                     /db_xref="GeneID:862"
                     /db_xref="HGNC:HGNC:1535"
                     /db_xref="MIM:133435"
                     /translation="MVGLSGPVQSGGENLHLKISRVRKRNLPFVVWGEEEASTPGLDA
                     ISHHLCYPDRTHRDRTEKHSTMPDSPVDVKTQSRLTPPTMPPPPTTQGAPRTSSFTPT
                     TLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTT
                     LQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLP
                     LLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRT
                     KENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLDDMA
                     IAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCI
                     MDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGGSSSSHSRQQSPVNPD
                     PVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMIT
                     TERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSF
                     CQHKDWEKHHHICGQTLQAQQQGDTPAVSSSVTPNSGAGSPMDTPPAATPRSTTPGTP
                     STIETTPR"
     exon            530..673
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            674..811
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1053
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1143
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1325
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1576
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1662
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1864
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1933
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2124
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..7670
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6122..6127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /note="hexamer: AATAAA"
     polyA_site      6141
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /note="major polyA site"
     regulatory      7650..7655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
                     /note="hexamer: AATAAA"
     polyA_site      7670
                     /gene="RUNX1T1"
                     /gene_synonym="AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8;
                     ZMYND2"
ORIGIN      
        1 gatgcgggcg ctctcggcgc acagcgcgcg gcgctcctgc tccccggcgg acgcccggcc
       61 gccctgcaga taaatgcgtc gccttcctcg agagtgagcg agggcgggcg agggagacgc
      121 agacgccgcc tgtgacagtg gcaattccct gcgccccaca tcacatttgt ctgccacagc
      181 agcaacaaca gaaaagcgga gggagggagg gaggcgggag gaggggagca gagctccgca
      241 agtcttgggc tctgcgtgga ggttgcgttt ggctggcgtc cccgaccccg ggctttttgc
      301 acggcagctc tctctgcgca gcgccgggcg gccgtagtcg ctccgcggcg cgactccgcg
      361 gtctcgtggc gagcgcgcgt gggcgagtgg ccgcggacac tctggcctcg cgagggaagc
      421 cgcgccgcgt cctcgccccg tcgccccgcg ggccggccga gacgacggga agttttattt
      481 gcagctcgga gcctgtggcg gatggtggga ctctccggcc ctgtgcagtc tggcggagag
      541 aatttacatt taaagattag cagagtgaga aagagaaatc tgccttttgt tgtgtggggt
      601 gaggaggagg catctacccc tggccttgac gctatctccc atcacctctg ctatccagac
      661 aggactcacc gagatcgtac tgagaagcac tccacaatgc cagactcacc tgtggatgtg
      721 aagacgcaat ctaggctgac tcctccaaca atgccacctc ccccaactac tcaaggagct
      781 ccaagaacca gttcatttac accgacaacg ttaactaatg gcacgagcca ttctcctaca
      841 gccttgaatg gcgccccctc accacccaat ggcttcagca atgggccttc ctcttcttcc
      901 tcctcctctc tggctaatca acagctgccc ccagcctgtg gtgccaggca actcagcaag
      961 ctgaaaaggt tccttactac cctgcagcag tttggcaatg acatttcacc cgagatagga
     1021 gaaagagttc gcaccctcgt tctgggacta gtgaactcca ctttgacaat tgaagaattt
     1081 cattccaaac tgcaagaagc tactaacttc ccactgagac cttttgtcat cccatttttg
     1141 aaggccaact tgcccctgct gcagcgtgag ctcctccact gcgcaagact ggccaaacag
     1201 aaccctgccc agtacctcgc ccagcatgaa cagctgcttc tggatgccag caccacctca
     1261 cctgttgact cctcagagct gcttctcgat gtgaacgaaa acgggaagag gcgaactcca
     1321 gacagaacca aagaaaatgg ctttgacaga gagcctttgc actcagaaca tccaagcaag
     1381 cgaccatgca ctattagccc aggccagcgg tacagtccaa ataacggctt atcctaccag
     1441 cccaatggcc tgcctcaccc taccccacct ccacctcagc attaccgttt ggatgatatg
     1501 gccattgccc accactacag ggactcctat cgacacccca gccacaggga cctcagggac
     1561 agaaacagac ctatggggtt gcatggcaca cgtcaagaag aaatgattga tcacagacta
     1621 acagacagag aatgggcaga agagtggaaa catcttgacc atctgttaaa ctgcataatg
     1681 gacatggtag aaaaaacaag gcgatctctc accgtactaa ggcggtgtca agaagcagac
     1741 cgggaagaat tgaattactg gatccggcgg tacagtgacg ccgaggactt aaaaaaaggt
     1801 ggcggcagta gcagcagcca ctctaggcag cagagtcccg tcaacccaga cccagttgca
     1861 ctagacgcgc atcgggaatt ccttcacagg cctgcgtctg gatacgtgcc agaggagatc
     1921 tggaagaaag ctgaggaggc cgtcaatgag gtgaagcgcc aggcgatgac ggagctgcag
     1981 aaggccgtgt ctgaggcgga gcggaaagcc cacgacatga tcacaacaga gagggccaag
     2041 atggagcgca cggtcgccga ggccaaacgg caggcggcgg aggacgcact ggcagttatc
     2101 aatcagcagg aggattcaag cgagagttgc tggaattgtg gccgtaaagc gagtgaaacc
     2161 tgcagtggct gtaacacagc ccgatactgt ggctcatttt gccagcacaa agactgggag
     2221 aagcaccatc acatctgtgg acagaccctg caggcccagc agcagggaga cacacctgca
     2281 gtcagctcct ctgtcacgcc caacagcggg gctgggagcc cgatggacac accaccagca
     2341 gccactccga ggtcaaccac cccgggaacc ccttccacca tagagacaac ccctcgctag
     2401 acgtgaactc agaactgtcg gaggaaagac aacacaacca acgcgaaacc aattcctcat
     2461 cctcagatgc tcaaagttgt tttttttgtt tgtttgttta ttagatgaat tatcctattt
     2521 cagtacttca gcaagagaga acctaactgt atcttgaggt ggtagtaaaa cacagagggc
     2581 cagtaacggg tcgtaatgac ttattgtgga taacaaagat atcttttctt tagagaactg
     2641 aaaagagagc agagaatata acatgaaatg atagatttga cctcctccct gttattttca
     2701 agtagctggg attttaaact agatgacctc attaaccgat gctttaccaa acagcaaacc
     2761 aagagattgc taattgctgt tgaaagcaaa aatgctaata ttaaaagtca caatgttctt
     2821 tatatacaat aatggaaaaa aaaaaaagag gaaaaccctc aagggcatga gcattggata
     2881 cagcagtaga cattttaaca agaagatgaa tggcgtccgt gggttgctaa ctgaactttg
     2941 aagacccgct acaaaacgcg cagatgtgca gcagattgga aggagacaca gatgttcggt
     3001 ttttttcctg tttctgaaaa gaaataataa tatccaggtc aacagaatga aaaatgaaag
     3061 atgatttgca atgggatgta tgaatacagc agcaagaaaa aaaaatgcca taatacaaaa
     3121 ggctccatat atatatatat atatatatat atacacacac acacacgcac atatacacac
     3181 acacacacac acacacacac acacacacac acacacacac acacacacaa gtaagagact
     3241 cagcctgcag ttaattagca ttctggcagt tttgacatca gccagctgcc ctaaataacc
     3301 cttcaacgtt tcttcacttt tgcaaggttc cacagagtaa gacattgggt ctattccagc
     3361 tcattcattt tatattgaaa aaaataattt taaaaatggt ggcttcagct ccagcccctt
     3421 tccaaaattt ttcaacccca ccctgtttgg atttttaatt aaaaactagt agttctcttg
     3481 gtgttaaaac acttctgtcc tgtgaggttt cccaatggtg tttttcttgt aaatgtgttg
     3541 gacaaatgtg aagatgcatt gtagtttaac catatgccca catttagtct ctttattcct
     3601 agttggtgag aaacctgtat ctttctatgc tgcttttata tctgtatgta ttagtgatat
     3661 ttctctagta gttaaaaaaa aaaaaaggaa aaaaagactc tttttggttg tcctcaagaa
     3721 aagaaaagaa gaaaagctat ctttcggagc tgctatttca ctctcttata ggattttttt
     3781 ttttcctgaa aaccagcatg cttcacggaa tgctaacata ttggtgtttt tgtaagaggg
     3841 atgtacataa atgtattttg cactgtcaca atgactccct aggcatgctt tttgtttttt
     3901 tttttttttt tttgagcaaa ttctttttaa atatgctaga gccatttcat caagtttagc
     3961 tgtagcatag agtagtcgtg gaatttttct tttttttttt tttaaatcat tattagggac
     4021 ttttttaaaa aaataaaata acaagatatc ctactttaaa aaaaaaggac agtgcatgca
     4081 tattgctgta aggtcgttta agtatttcta attttacaaa agtaaaaatc attagagctc
     4141 caaatgctga ggtgtagatt gacagcttta acactgctga atgccaggtt atacagtatt
     4201 cttacaaaaa gggaagtcag ccaaagactg atctgatgga ccaaaatcgg aattttgaaa
     4261 agcaccagta ctactttcca aatgatcagc aggttaaaca tgttcagcaa ggtatagtat
     4321 gaatccatta acccttcgtt gtccagggtc cagaccagaa ctacttgtta gttttgaaaa
     4381 cagtagccca ggatgtggtt gtgtgcttta ggaaagtcag cagtgctgca ggctgtgtag
     4441 acaaccaaag tttacaaggc tgggaagaca cttctccaaa tacatataca ccaggcattt
     4501 ctttaaaatc aaaaacaatc cattagcttt ggggcggggg gtggggggag ggttaaatgt
     4561 aggccttgga aacagtttta agtggctttt aagtatctgc atagaggcaa tcctaaggtt
     4621 tgctttaagt ctcttaaatc taacattttt aaaagcattt cttccctgta ttttcatata
     4681 caagttggtt ttaattttgt ttgggtggtg ttattttttt taaatgactt tttagtttag
     4741 aaagttctga tgagcaaata aatacatcta tctacatgtt ggaagtccat ctgccagcac
     4801 acctgcttaa agtgaaatga aagcacataa ccaggctctg aatgggttat attttatcat
     4861 ggtgctccca gaatcctttg acctcactct gctttctagt ctgcttgtga cactggacag
     4921 tcctttctta cagagctatt atatgttcta ggctacgaag ggttaaataa tcccaaaaat
     4981 gaggtatgtc atacccacac gtctttatct ctagaagctg tgatgtatgt gaaacagcac
     5041 tgttattctt aacactagtg tgtaaaataa ggattagtac agtacgtctc attacttttt
     5101 aattcagggc accctgagtg aaaacaaata caaaaaaaaa tccctaactc tgagctctat
     5161 ctctgattcc tcttcctcct tcccctcttc ctcctcttcc tctcctcctg ttttgctaca
     5221 ttctcctcag tggcaaaaag tttcactcta cctctgacag catgtatatt gcaccagtag
     5281 ctaacaaaaa ctggtctagt caaaccaaat gggcacaaaa gaaccaggat accaaaagtt
     5341 aagctcatac agctgcaaac catatcactt cttggtaaca atgcagacct cataaaccta
     5401 aagaagagaa agaaaagaaa acttttgtta ctttcctttt ttgcttgtca cttatataca
     5461 ggctatgtga gaatataatt tgtaggtata acacattaag aaaaagttat cttcattgga
     5521 tagaattgaa tggtggtcgc tgataggaat agggcgtcct ctagctctta tctctgtctc
     5581 ttactctttt ctctttctct ttttctctgt catgagactg tgtgtgacag ggccacctgt
     5641 cttttttttt tcttaaattt tttttttttt tatgtgtagg tgcatgtctt ggggatttaa
     5701 aaatttcaag gctggtttac ttatgcaaag catgcctacg tctggaatac ttagggaaag
     5761 aaagcgactc catgttgtcc gaattcctca agggacagaa aaaaaattgg agactgttga
     5821 aatgcagatt tgaagtaatt tttttaaaat attattttgg gttctgcgac attgtgaaaa
     5881 attaaagttg ttgtgcaata cttaattcag acatgtacca caagttaatg gtagactaac
     5941 actggggggt ggggtctagg catcatgctt ttgtcagcat actcttgagc ttttaagtct
     6001 actatgtctg aactgtggtt tcttgtttat ccttttttcc ttagttggac tgtaatgtat
     6061 ggtctgtcaa cctgtgaatc tttaaagtat gattcaggta ttgttgtatt ctttactgtg
     6121 taataaaaaa gttgaaaaaa atctggatcc tctgtctccc tcgtccccgg tgtgccatgg
     6181 ttgcccacca gtgaccccag cctgaggagt ccatcctcca tggtgctgaa tcaaatctgt
     6241 agagtttatt cagctacaaa gcgtggctct gtaacaggag ttggcttatc catgcgtgtt
     6301 gagtagggaa tgatgtcaga actttgcaaa agtcgagctc attcataagg ggatgtttct
     6361 caggcaggag gagtaggaag agtgggagga gaattactac cttccatagg aaaggagagc
     6421 ttggcttgcc tagattagct gctgcataga tagcagaggc ccttttggct gtgttttgat
     6481 aaaattagaa atgagtacct aaatctggat cactctgctc agagaggttc gtgccaacct
     6541 catgaggctc tgactcttgt caggttgctt ggctgccttg tgcatacccg aatggcagat
     6601 cagctgacat gacatggaac tgctctatct gccttgtccc ctctcctcta attaaaagtc
     6661 gctaccattg tcactcttgg ttatgtagtt aatatccact gtggctatct ccaacttgct
     6721 gggacatcca gttatctcct ctgacacata ttttttcatt ctctagttac aaagtttgtt
     6781 agagtttgaa aaacaaaccc ttctccccta ccctgtgaat gctgttagtt tttatgtgta
     6841 gttttcaaaa cacagattat cttatatact gtgttgtagc agaaattcct gtttcctctg
     6901 aatgttctga ctttatagac caaaataatc gttgcaaaaa atcaaggatg gcacagcagg
     6961 tgcatgagcc cgtgtctgga gaaaggttat gaaggtgaat gctggttaca tgggagggtg
     7021 acttggagcc ctctagtttc cttcttgtgc cagctgggtt cctgtttcaa ggccaggctt
     7081 ctctaacttg tcttcctggg aaatgtagct tttccaagaa tttggtagtg cacaccagga
     7141 aaaactaggt atcagaacag attttttttt aaatagtgga aacaccctca ctcccacact
     7201 ttggacagtt agggttggat atttaatttc atagttactc tttttttcca cagaagaaag
     7261 gccagcctga cccaagttgc ctatttttaa tgtgttactg catcttattt tctcttcaaa
     7321 gtgaaaaagg ccagaaacta gcagatagaa atggaacccg ttgacttagt tcccttataa
     7381 gaagttcttg caaacacctc tgtgacgttt tcattcaagt ggatatgttg gacaaatagg
     7441 aaacagtttt agtttacgcg aacagtatga gacttccagg tggtggacgc cattttttta
     7501 gaagtgttga tgatgtattt gataacatta taaaagtatg tgtctcccgt gaaagaacat
     7561 tgagctattt ccctggaatg gatggggaag aaatgagcaa aggagtgctg ttctgtatgg
     7621 gtgtctatac ccttattcca aggtgaataa ataaagttgt gtttgcctaa
//
