LOCUS       NM_001754               5971 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens RUNX family transcription factor 1 (RUNX1), transcript
            variant 1, mRNA.
ACCESSION   NM_001754
VERSION     NM_001754.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5971)
  AUTHORS   Kwon,N., Lu,Y.C., Thompson,E.N., Mancuso,R.I., Wang,L., Zhang,P.X.
            and Krause,D.S.
  TITLE     CDK9 phosphorylates RUNX1 to promote megakaryocytic fate in
            megakaryocytic-erythroid progenitors
  JOURNAL   Blood 144 (17), 1800-1812 (2024)
   PUBMED   39102635
  REMARK    GeneRIF: CDK9 phosphorylates RUNX1 to promote megakaryocytic fate
            in megakaryocytic-erythroid progenitors.
REFERENCE   2  (bases 1 to 5971)
  AUTHORS   Weiss,L.M., Warwick,T., Zehr,S., Gunther,S., Wolf,S.,
            Schmachtel,T., Izquierdo Ponce,J., Palfi,K., Teichmann,T.,
            Schneider,A., Stotzel,J., Knapp,S., Weigert,A., Savai,R.,
            Rieger,M.A., Oellerich,T., Wittig,I., Oo,J.A., Brandes,R.P. and
            Leisegang,M.S.
  TITLE     RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell
            functions
  JOURNAL   Commun Biol 7 (1), 1131 (2024)
   PUBMED   39271940
  REMARK    GeneRIF: RUNX1 interacts with lncRNA SMANTIS to regulate monocytic
            cell functions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5971)
  AUTHORS   Panaget,B., Mauvieux,L., Miguet,L., Fornecker,L.M., Lioure,B.,
            Ledoux,M.P., Rolland,D. and Mayeur-Rousse,C.
  TITLE     [Acute myeloid leukemia with mutated RUNX1 at the university
            hospitals of Strasbourg]
  JOURNAL   Ann Biol Clin (Paris) 82 (3), 266-280 (2024)
   PUBMED   39210855
  REMARK    GeneRIF: [Acute myeloid leukemia with mutated RUNX1 at the
            university hospitals of Strasbourg].
REFERENCE   4  (bases 1 to 5971)
  AUTHORS   Ji,Q., Tu,Z., Liu,J., Zhou,Z., Li,F., Zhu,X. and Huang,K.
  TITLE     RUNX1-PDIA5 Axis Promotes Malignant Progression of Glioblastoma by
            Regulating CCAR1 Protein Expression
  JOURNAL   Int J Biol Sci 20 (11), 4364-4381 (2024)
   PUBMED   39247813
  REMARK    GeneRIF: RUNX1-PDIA5 Axis Promotes Malignant Progression of
            Glioblastoma by Regulating CCAR1 Protein Expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5971)
  AUTHORS   Zheng,W., Guo,Y., Kahar,A., Bai,J., Zhu,Q., Huang,X., Li,Y., Xu,B.,
            Jia,X., Wu,G., Zhang,C. and Zhu,Y.
  TITLE     RUNX1-induced upregulation of PTGS2 enhances cell growth, migration
            and invasion in colorectal cancer cells
  JOURNAL   Sci Rep 14 (1), 11670 (2024)
   PUBMED   38778047
  REMARK    GeneRIF: RUNX1-induced upregulation of PTGS2 enhances cell growth,
            migration and invasion in colorectal cancer cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5971)
  AUTHORS   Deuitch,N., Broadbridge,E., Cunningham,L. and Liu,P.
  TITLE     RUNX1 Familial Platelet Disorder with Associated Myeloid
            Malignancies
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   33661592
REFERENCE   7  (bases 1 to 5971)
  AUTHORS   Nisson,P.E., Watkins,P.C. and Sacchi,N.
  TITLE     Transcriptionally active chimeric gene derived from the fusion of
            the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic
            cells
  JOURNAL   Cancer Genet Cytogenet 63 (2), 81-88 (1992)
   PUBMED   1423235
  REMARK    Erratum:[Cancer Genet Cytogenet. 1993 Mar;66(1):81.. PMID: 8467483]
REFERENCE   8  (bases 1 to 5971)
  AUTHORS   Avramopoulos,D., Cox,T., Blaschak,J.E., Chakravarti,A. and
            Antonarakis,S.E.
  TITLE     Linkage mapping of the AML1 gene on human chromosome 21 using a DNA
            polymorphism in the 3' untranslated region
  JOURNAL   Genomics 14 (2), 506-507 (1992)
   PUBMED   1427868
REFERENCE   9  (bases 1 to 5971)
  AUTHORS   Daga,A., Tighe,J.E. and Calabi,F.
  TITLE     Leukaemia/Drosophila homology
  JOURNAL   Nature 356 (6369), 484 (1992)
   PUBMED   1560822
REFERENCE   10 (bases 1 to 5971)
  AUTHORS   Miyoshi,H., Shimizu,K., Kozu,T., Maseki,N., Kaneko,Y. and Ohki,M.
  TITLE     t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are
            clustered within a limited region of a single gene, AML1
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10431-10434 (1991)
   PUBMED   1720541
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF015262.2, U19601.1 and
            AP000330.3.
            
            On Feb 12, 2020 this sequence version replaced NM_001754.4.
            
            Summary: Core binding factor (CBF) is a heterodimeric transcription
            factor that binds to the core element of many enhancers and
            promoters. The protein encoded by this gene represents the alpha
            subunit of CBF and is thought to be involved in the development of
            normal hematopoiesis. Chromosomal translocations involving this
            gene are well-documented and have been associated with several
            types of leukemia. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longest isoform
            (AML1c).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.453218.1,
                                           SRR14038191.2959294.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2149004
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000675419.1/ ENSP00000501943.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AF015262.2         61040-61174         c
            136-194             AF015262.2         60772-60830         c
            195-1357            U19601.1           1-1163
            1358-5971           AP000330.3         125336-129949       c
FEATURES             Location/Qualifiers
     source          1..5971
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.12"
     gene            1..5971
                     /gene="RUNX1"
                     /gene_synonym="AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2;
                     EVI-1; PEBP2aB; PEBP2alpha"
                     /note="RUNX family transcription factor 1"
                     /db_xref="GeneID:861"
                     /db_xref="HGNC:HGNC:10471"
                     /db_xref="MIM:151385"
     exon            1..135
                     /gene="RUNX1"
                     /gene_synonym="AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2;
                     EVI-1; PEBP2aB; PEBP2alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            136..252
                     /gene="RUNX1"
                     /gene_synonym="AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2;
                     EVI-1; PEBP2aB; PEBP2alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1637
                     /gene="RUNX1"
                     /gene_synonym="AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2;
                     EVI-1; PEBP2aB; PEBP2alpha"
                     /note="isoform AML1c is encoded by transcript variant 1;
                     core-binding factor, runt domain, alpha subunit 2;
                     AML1-EVI-1 fusion protein; PEA2-alpha B; PEBP2-alpha B;
                     oncogene AML-1; acute myeloid leukemia 1 protein; SL3-3
                     enhancer factor 1 alpha B subunit; SL3/AKV core-binding
                     factor alpha B subunit; polyomavirus enhancer-binding
                     protein 2 alpha B subunit; runt related transcription
                     factor 1; mutant RUNX1; AML1-ETO fusion; AML1-ETO fusion
                     protein"
                     /codon_start=1
                     /product="runt-related transcription factor 1 isoform
                     AML1c"
                     /protein_id="NP_001745.2"
                     /db_xref="CCDS:CCDS13639.1"
                     /db_xref="GeneID:861"
                     /db_xref="HGNC:HGNC:10471"
                     /db_xref="MIM:151385"
                     /translation="MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPS
                     TALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVL
                     PTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFND
                     LRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGS
                     LSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPS
                     PPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPR
                     QFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQ
                     GGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSALLNPSLPNQS
                     DVVEAEGSHSNSPTNMAPSARLEEAVWRPY"
     exon            253..291
                     /gene="RUNX1"
                     /gene_synonym="AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2;
                     EVI-1; PEBP2aB; PEBP2alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            292..545
                     /gene="RUNX1"
                     /gene_synonym="AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2;
                     EVI-1; PEBP2aB; PEBP2alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            546..702
                     /gene="RUNX1"
                     /gene_synonym="AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2;
                     EVI-1; PEBP2aB; PEBP2alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            703..807
                     /gene="RUNX1"
                     /gene_synonym="AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2;
                     EVI-1; PEBP2aB; PEBP2alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            808..999
                     /gene="RUNX1"
                     /gene_synonym="AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2;
                     EVI-1; PEBP2aB; PEBP2alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1161
                     /gene="RUNX1"
                     /gene_synonym="AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2;
                     EVI-1; PEBP2aB; PEBP2alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..5971
                     /gene="RUNX1"
                     /gene_synonym="AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2;
                     EVI-1; PEBP2aB; PEBP2alpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5468..5473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUNX1"
                     /gene_synonym="AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2;
                     EVI-1; PEBP2aB; PEBP2alpha"
                     /note="hexamer: AATAAA"
     polyA_site      5487
                     /gene="RUNX1"
                     /gene_synonym="AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2;
                     EVI-1; PEBP2aB; PEBP2alpha"
     regulatory      5941..5946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUNX1"
                     /gene_synonym="AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2;
                     EVI-1; PEBP2aB; PEBP2alpha"
                     /note="hexamer: AATAAA"
     polyA_site      5971
                     /gene="RUNX1"
                     /gene_synonym="AML1; AML1-EVI-1; AMLCR1; CBF2alpha; CBFA2;
                     EVI-1; PEBP2aB; PEBP2alpha"
                     /note="major polyA site"
ORIGIN      
        1 acttctttgg gcctcataaa caaccacaga accacaagtt gggtagcctg gcagtgtcag
       61 aagtctgaac ccagcatagt ggtcagcagg caggacgaat cacactgaat gcaaaccaca
      121 gggtttcgca gcgtggtaaa agaaatcatt gagtcccccg ccttcagaag agggtgcatt
      181 ttcaggagga agcgatggct tcagacagca tatttgagtc atttccttcg tacccacagt
      241 gcttcatgag agaatgcata cttggaatga atccttctag agacgtccac gatgccagca
      301 cgagccgccg cttcacgccg ccttccaccg cgctgagccc aggcaagatg agcgaggcgt
      361 tgccgctggg cgccccggac gccggcgctg ccctggccgg caagctgagg agcggcgacc
      421 gcagcatggt ggaggtgctg gccgaccacc cgggcgagct ggtgcgcacc gacagcccca
      481 acttcctctg ctccgtgctg cctacgcact ggcgctgcaa caagaccctg cccatcgctt
      541 tcaaggtggt ggccctaggg gatgttccag atggcactct ggtcactgtg atggctggca
      601 atgatgaaaa ctactcggct gagctgagaa atgctaccgc agccatgaag aaccaggttg
      661 caagatttaa tgacctcagg tttgtcggtc gaagtggaag agggaaaagc ttcactctga
      721 ccatcactgt cttcacaaac ccaccgcaag tcgccaccta ccacagagcc atcaaaatca
      781 cagtggatgg gccccgagaa cctcgaagac atcggcagaa actagatgat cagaccaagc
      841 ccgggagctt gtccttttcc gagcggctca gtgaactgga gcagctgcgg cgcacagcca
      901 tgagggtcag cccacaccac ccagccccca cgcccaaccc tcgtgcctcc ctgaaccact
      961 ccactgcctt taaccctcag cctcagagtc agatgcagga tacaaggcag atccaaccat
     1021 ccccaccgtg gtcctacgat cagtcctacc aatacctggg atccattgcc tctccttctg
     1081 tgcacccagc aacgcccatt tcacctggac gtgccagcgg catgacaacc ctctctgcag
     1141 aactttccag tcgactctca acggcacccg acctgacagc gttcagcgac ccgcgccagt
     1201 tccccgcgct gccctccatc tccgaccccc gcatgcacta tccaggcgcc ttcacctact
     1261 ccccgacgcc ggtcacctcg ggcatcggca tcggcatgtc ggccatgggc tcggccacgc
     1321 gctaccacac ctacctgccg ccgccctacc ccggctcgtc gcaagcgcag ggaggcccgt
     1381 tccaagccag ctcgccctcc taccacctgt actacggcgc ctcggccggc tcctaccagt
     1441 tctccatggt gggcggcgag cgctcgccgc cgcgcatcct gccgccctgc accaacgcct
     1501 ccaccggctc cgcgctgctc aaccccagcc tcccgaacca gagcgacgtg gtggaggccg
     1561 agggcagcca cagcaactcc cccaccaaca tggcgccctc cgcgcgcctg gaggaggccg
     1621 tgtggaggcc ctactgaggc gccaggcctg gcccggctgg gccccgcggg ccgccgcctt
     1681 cgcctccggg cgcgcgggcc tcctgttcgc gacaagcccg ccgggatccc gggccctggg
     1741 cccggccacc gtcctggggc cgagggcgcc cgacggccag gatctcgctg taggtcaggc
     1801 ccgcgcagcc tcctgcgccc agaagcccac gccgccgccg tctgctggcg ccccggccct
     1861 cgcggaggtg tccgaggcga cgcacctcga gggtgtccgc cggccccagc acccagggga
     1921 cgcgctggaa agcaaacagg aagattcccg gagggaaact gtgaatgctt ctgatttagc
     1981 aatgctgtga ataaaaagaa agattttata cccttgactt aactttttaa ccaagttgtt
     2041 tattccaaag agtgtggaat tttggttggg gtggggggag aggagggatg caactcgccc
     2101 tgtttggcat ctaattctta tttttaattt ttccgcacct tatcaattgc aaaatgcgta
     2161 tttgcatttg ggtggttttt atttttatat acgtttatat aaatatatat aaattgagct
     2221 tgcttctttc ttgctttgac catggaaaga aatatgattc ccttttcttt aagttttatt
     2281 taacttttct tttggacttt tgggtagttg tttttttttg ttttgttttg tttttttgag
     2341 aaacagctac agctttgggt catttttaac tactgtattc ccacaaggaa tccccagata
     2401 tttatgtatc ttgatgttca gacatttatg tgttgataat tttttaatta tttaaatgta
     2461 cttatattaa gaaaaatatc aagtactaca ttttcttttg ttcttgatag tagccaaagt
     2521 taaatgtatc acattgaaga aggctagaaa aaaagaatga gtaatgtgat cgcttggtta
     2581 tccagaagta ttgtttacat taaactccct ttcatgttaa tcaaacaagt gagtagctca
     2641 cgcagcaacg tttttaatag gatttttaga cactgagggt cactccaagg atcagaagta
     2701 tggaattttc tgccaggctc aacaagggtc tcatatctaa cttcctcctt aaaacagaga
     2761 aggtcaatct agttccagag ggttgaggca ggtgccaata attacatctt tggagaggat
     2821 ttgatttctg cccagggatt tgctcacccc aaggtcatct gataatttca cagatgctgt
     2881 gtaacagaac acagccaaag taaactgtgt aggggagcca catttacata ggaaccaaat
     2941 caatgaattt aggggttacg attatagcaa tttaagggcc caccagaagc aggcctcgag
     3001 gagtcaattt gcctctgtgt gcctcagtgg agacaagtgg gaaaacatgg tcccacctgt
     3061 gcgagacccc ctgtcctgtg ctgctcactc aacaacatct ttgtgttgct ttcaccaggc
     3121 tgagacccta ccctatgggg tatatgggct tttacctgtg caccagtgtg acaggaaaga
     3181 ttcatgtcac tactgtccgt ggctacaatt caaaggtatc caatgtcgct gtaaatttta
     3241 tggcactatt tttattggag gatttggtca gaatgcagtt gttgtacaac tcataaatac
     3301 taactgctga ttttgacaca tgtgtgctcc aaatgatctg gtggttattt aacgtacctc
     3361 ttaaaattcg ttgaaacgat ttcaggtcaa ctctgaagag tatttgaaag caggacttca
     3421 gaacagtgtt tgatttttat tttataaatt taagcattca aattaggcaa atctttggct
     3481 gcaggcagca aaaacagctg gacttattta aaacaacttg tttttgagtt ttcttatata
     3541 tatattgatt atttgtttta cacacatgca gtagcacttt ggtaagagtt aaagagtaaa
     3601 gcagcttatg ttgtcaggtc gttcttatct agagaagagc tatagcagat ctcggacaaa
     3661 ctcagaatat attcactttc atttttgaca ggattccctc cacaactcag tttcatatat
     3721 tattccgtat tacatttttg cagctaaatt accataaaat gtcagcaaat gtaaaaattt
     3781 aatttctgaa aagcaccatt agcccatttc ccccaaatta aacgtaaatg ttttttttca
     3841 gcacatgtta ccatgtctga cctgcaaaaa tgctggagaa aaatgaagga aaaaattatg
     3901 tttttcagtt taattctgtt aactgaagat attccaactc aaaaccagcc tcatgctctg
     3961 attagataat cttttacatt gaacctttac tctcaaagcc atgtgtggag ggggcttgtc
     4021 actattgtag gctcactgga ttggtcattt agagtttcac agactcttac cagcatatat
     4081 agtatttaat tgtttcaaaa aaaatcaaac tgtagttgtt ttggcgatag gtctcacgca
     4141 acacattttt gtatgtgtgt gtgtgtgcgt gtgtgtgtgt gtgtgtgaaa aattgcattc
     4201 attgacttca ggtagattaa ggtatctttt tattcattgc cctcaggaaa gttaaggtat
     4261 caatgagacc cttaagccaa tcatgtaata actgcatgtg tctggtccag gagaagtatt
     4321 gaataagcca tttctactgc ttactcatgt ccctatttat gatttcaaca tggatacata
     4381 tttcagttct ttctttttct cactatctga aaatacattt ccctccctct cttcccccca
     4441 atatctccct ttttttctct cttcctctat cttccaaacc ccactttctc cctcctcctt
     4501 ttcctgtgtt ctcttaagca gatagcacat acccccaccc agtaccaaat ttcagaacac
     4561 aagaaggtcc agttcttccc ccttcacata aaggaacatg gtttgtcagc ctttctcctg
     4621 tttatgggtt tcttccagca gaacagagac attgccaacc atattggatc tgcttgctgt
     4681 ccaaaccagc aaactttcct gggcaaatca caatcagtga gtaaatagac agcctttctg
     4741 ctgccttggg tttctgtgca gataaacaga aatgctctga ttagaaagga aatgaatggt
     4801 tccactcaaa tgtcctgcaa tttaggattg cagatttctg ccttgaaata cctgtttctt
     4861 tgggacattc cgtcctgatg atttttattt ttgttggttt ttatttttgg ggggaatgac
     4921 atgtttgggt cttttataca tgaaaatttg tttgacaata atctcacaaa acatatttta
     4981 catctgaaca aaatgccttt ttgtttaccg tagcgtatac atttgttttg ggatttttgt
     5041 gtgtttgttg ggaattttgt ttttagccag gtcagtattg atgaggctga tcatttggct
     5101 ctttttttcc ttccagaaga gttgcatcaa caaagttaat tgtatttatg tatgtaaata
     5161 gattttaagc ttcattataa aatattgtta atgcctataa ctttttttca atttttttgt
     5221 gtgtgtttct aaggactttt tcttaggttt gctaaatact gtagggaaaa aaatgcttct
     5281 ttctactttg tttattttag actttaaaat gagctacttc ttattcactt ttgtaaacag
     5341 ctaatagcat ggttccaatt ttttttaagt tcactttttt tgttctaggg gaaatgaatg
     5401 tgcaaaaaaa gaaaaagaac tgttggttat ttgtgttatt ctggatgtat aaaaatcaat
     5461 ggaaaaaaat aaactttcaa attgaaatga cggtataaca catctactga aaaagcaacg
     5521 ggaaatgtgg tcctatttaa gccagccccc acctagggtc tatttgtgtg gcagttattg
     5581 ggtttggtca caaaacatcc tgaaaattcg tgcgtgggct tctttctccc tggtacaaac
     5641 gtatggaatg cttcttaaag gggaactgtc aagctggtgt cttcagccag atgacatgag
     5701 agaatatccc agaaccctct ctccaaggtg tttctagata gcacaggaga gcaggcactg
     5761 cactgtccac agtccacggt acacagtcgg gtgggccgcc tcccctctcc tgggagcatt
     5821 cgtcgtgccc agcctgagca gggcagctgg actgctgctg ttcaggagcc accagagcct
     5881 tcctctcttt gtaccacagt ttcttctgta aatccagtgt tacaatcagt gtgaatggca
     5941 aataaacagt ttgacaagta catacaccat a
//
