LOCUS       NM_001134405            4063 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RUN domain containing 3B (RUNDC3B), transcript variant
            2, mRNA.
ACCESSION   NM_001134405
VERSION     NM_001134405.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4063)
  AUTHORS   Burmeister,D.W., Smith,E.H., Cristel,R.T., McKay,S.D., Shi,H.,
            Arthur,G.L., Davis,J.W. and Taylor,K.H.
  TITLE     The expression of RUNDC3B is associated with promoter methylation
            in lymphoid malignancies
  JOURNAL   Hematol Oncol 35 (1), 25-33 (2017)
   PUBMED   26011749
  REMARK    GeneRIF: RUNDC3B expression has a role in promoter methylation in
            lymphoid malignancies
REFERENCE   2  (bases 1 to 4063)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4063)
  AUTHORS   Balaguer,T.M., Gomez-Martinez,A., Garcia-Morales,P., Lacueva,J.,
            Calpena,R., Reverte,L.R., Riquelme,N.L., Martinez-Lacaci,I.,
            Ferragut,J.A. and Saceda,M.
  TITLE     Dual regulation of P-glycoprotein expression by trichostatin A in
            cancer cell lines
  JOURNAL   BMC Mol Biol 13, 25 (2012)
   PUBMED   22846052
  REMARK    GeneRIF: The ABCB1 nested gene RUNDC3B expression, although
            upregulated by TSA, is independent of the ABCB1 alternative
            promoter used.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4063)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 4063)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4063)
  AUTHORS   Raguz,S., De Bella,M.T., Slade,M.J., Higgins,C.F., Coombes,R.C. and
            Yague,E.
  TITLE     Expression of RPIP9 (Rap2 interacting protein 9) is activated in
            breast carcinoma and correlates with a poor prognosis
  JOURNAL   Int J Cancer 117 (6), 934-941 (2005)
   PUBMED   15986426
  REMARK    GeneRIF: activation of Rap2-binding protein 9 (RPIP9) occurs during
            the malignant breast epithelial transformation and increases with
            progression toward an invasive phenotype
REFERENCE   7  (bases 1 to 4063)
  AUTHORS   Wang,S., Zhang,Z., Ying,K., Chen,J.Z., Meng,X.F., Yang,Q.S., Xie,Y.
            and Mao,Y.M.
  TITLE     Cloning, expression, and genomic structure of a novel human Rap2
            interacting gene (RPIP9)
  JOURNAL   Biochem Genet 41 (1-2), 13-25 (2003)
   PUBMED   12645870
  REMARK    GeneRIF: During a large-scale screen of a human fetal brain cDNA
            library, a full-length cDNA encoding a novel Rap2-interacting
            protein was isolated and sequenced. The gene was mapped to human
            chromosome 7q21-q22 and has 9 exons and 8 introns.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002457.2, AK055233.1, AK294039.1 and AC003083.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001134405.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (b) has the same
            N- and C-termini but is shorter compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.174801.1, AK294039.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394654.4/ ENSP00000378149.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC002457.2         64065-64079
            16-217              AK055233.1         1-202
            218-1170            AK294039.1         1-953
            1171-2207           AK055233.1         1205-2241
            2208-4063           AC003083.2         88927-90782
FEATURES             Location/Qualifiers
     source          1..4063
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.12"
     gene            1..4063
                     /gene="RUNDC3B"
                     /gene_synonym="RPIB9; RPIP9"
                     /note="RUN domain containing 3B"
                     /db_xref="GeneID:154661"
                     /db_xref="HGNC:HGNC:30286"
                     /db_xref="MIM:617295"
     exon            1..548
                     /gene="RUNDC3B"
                     /gene_synonym="RPIB9; RPIP9"
                     /inference="alignment:Splign:2.1.0"
     CDS             427..1797
                     /gene="RUNDC3B"
                     /gene_synonym="RPIB9; RPIP9"
                     /note="isoform b is encoded by transcript variant 2; RUN
                     domain-containing protein 3B; Rap2-interacting protein 9;
                     Rap2 binding protein 9; rap2-binding protein 9"
                     /codon_start=1
                     /product="RUN domain-containing protein 3B isoform b"
                     /protein_id="NP_001127877.1"
                     /db_xref="CCDS:CCDS47635.1"
                     /db_xref="GeneID:154661"
                     /db_xref="HGNC:HGNC:30286"
                     /db_xref="MIM:617295"
                     /translation="MASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSV
                     KTLIDRSCFETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGYESPRSFWDYIRVACR
                     KVSQNCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGA
                     IVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDE
                     EELRTLGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLR
                     ENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLTVLKNNDLRSRQELT
                     AHLTNQWPSPGALDVNAVALDTLLYRKHNKQWYEKSYQSLDQLSAEVSLSQTSLDPGQ
                     SQEGDGKQDTLNVMSEGKEDTPSLLGLCGSLTSVASYKSLTSLKSNDYLASPTTEMTS
                     PGLTPS"
     exon            549..664
                     /gene="RUNDC3B"
                     /gene_synonym="RPIB9; RPIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            665..798
                     /gene="RUNDC3B"
                     /gene_synonym="RPIB9; RPIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            799..884
                     /gene="RUNDC3B"
                     /gene_synonym="RPIB9; RPIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            885..974
                     /gene="RUNDC3B"
                     /gene_synonym="RPIB9; RPIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1055
                     /gene="RUNDC3B"
                     /gene_synonym="RPIB9; RPIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1224
                     /gene="RUNDC3B"
                     /gene_synonym="RPIB9; RPIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1382
                     /gene="RUNDC3B"
                     /gene_synonym="RPIB9; RPIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1529
                     /gene="RUNDC3B"
                     /gene_synonym="RPIB9; RPIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1651
                     /gene="RUNDC3B"
                     /gene_synonym="RPIB9; RPIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..4063
                     /gene="RUNDC3B"
                     /gene_synonym="RPIB9; RPIP9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4044..4049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUNDC3B"
                     /gene_synonym="RPIB9; RPIP9"
                     /note="hexamer: ATTAAA"
     polyA_site      4063
                     /gene="RUNDC3B"
                     /gene_synonym="RPIB9; RPIP9"
                     /note="major polyA site"
ORIGIN      
        1 gccgctgcct cccgggctgg ggcacgagtg gctgcggagt gtgggtggtt gggcgtgagg
       61 ggccgacggg ctcgcgcgcg cgccgtctgc tgaggtccct cgggaaggag gagagcgcct
      121 gacgccgacc cgcaggcgca gcccggcagt cggcggcgcg ccgagggcgg aggtggtgcg
      181 tgcgtgcgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgga gctcgggtgc
      241 caagggcgag ccgtcagtcc ccgggtgcga gtccctgctg tcttccacac ccttcctccc
      301 tccaggctcc tttcctacat ccttcccgcg cccccacggt tgcggaccga gcgagaaccc
      361 ccttaagcag gtgtgggggg cgtgcggggt ggcacgagac aaaaggggca cgggggtaag
      421 cccgccatgg cctcccggag cctggggggc ctgagcggga tccgcggcgg tggcggcgga
      481 ggcggcaaga aaagcctgag cgcccgcaat gctgcggtgg agaggaggaa cctgatcacc
      541 gtgtgcaggt tttctgtgaa gaccctgatt gatcggtctt gctttgagac aattgatgat
      601 tcttctcctg aatttaacaa ttttgcagct attttggaac agattttaag ccaccggcta
      661 aaaggtcaag taacctggtt tggttatgaa agtcctcgta gcttctggga ctatatcaga
      721 gtggcttgcc ggaaagtttc acagaattgt atctgcagca ttgaaaatat ggaaaatgtc
      781 agttcttcta gagctaaggg tagagcctgg atcagagtag cactcatgga aaaacattta
      841 tctgaataca tctctacagc tctgagagac ttcaaaacaa ccaggagatt ttatgaagat
      901 ggagcaattg tcttgggtga agaagcaaat atgcttgctg gcatgcttct aggactcaat
      961 gctattgatt tcagtttctg cctaaaggga gaggggctgg atggcagttt tcctgctgta
     1021 atagactata caccatattt gaagtatatc caaagttctg atagtatcag cagtgatgag
     1081 gaggagctaa ggactttggg aagcagtggt agcgaaagca gtactccaga gaatgtcgga
     1141 cctcctttcc tcatggatga gaacagttgg ttcaacaagt gtaagagagt taaacaaaag
     1201 tatcagctta ccctggaaca gaagggttac cttgaagaac tcttacgact tcgagagaac
     1261 caactatctg aatctgtctc ccagaataaa atactacttc aaaggattga agattccgat
     1321 ctggctcata aactggagaa ggaacaatta gaatatataa ttgtggagct tcaagatcag
     1381 ctgactgtgc taaagaataa tgatttaaga tcgagacaag agttaactgc ccatctcacc
     1441 aaccagtggc cttctccagg agctctggat gtcaatgctg ttgccttgga tacgttgctt
     1501 taccgaaaac acaataaaca gtggtatgag aaaagttatc aaagtcttga ccagttatca
     1561 gcagaagtta gcctttctca gacttcacta gatccaggcc agtcacaaga aggagatgga
     1621 aaacaagaca cattaaatgt aatgagtgaa ggtaaggaag atactccctc attacttggc
     1681 ctctgtggat ctctaacgtc agtggcaagt tacaagtctc taacaagctt aaaatctaat
     1741 gactaccttg caagtcctac aacagagatg acaagtccag gcctaactcc atcctgaaaa
     1801 tttttgtgta aaagccaaaa ctttttatgt tgtaaatgtt taatttacat gtttgactgc
     1861 tgggaagacc tttgaaattt tatattgttc tggtacatgt ctgaaattct attgcttgga
     1921 gagaatcccc tccagataag agattttgag tgaaaaacat aatgatcctg ccatttttca
     1981 tttttaaaat tcttacattt gtcattgaga aagttcaaaa tggaataggc tttaaaaaaa
     2041 aaaaaacttt caaagatccg ccaaatcatt catagcaaat tgtacatatt gttcagctga
     2101 tttttatata tttaaataca ccttagtggc cagagactga cttcaaggtt ttattccaga
     2161 gactccagag acttaagcta agtatttttt cattctttca gattttcaaa aaaaaaaaaa
     2221 aaaaaagtta atttcatttt ttcattaatg tcttcctaag ttctatgctt taaatgcctt
     2281 gtttttaata acgggaaagt tctcagctgc attttcacag tggcttattc agtttttctt
     2341 taatatttac catttggtat caattcagca ttccacttaa cattttataa attccatagg
     2401 aacatgcctg ttttggtagt tactgactta atttgttagt gccacaagga aaatatttta
     2461 cagtatttta tgccatttag gcaaaatgaa taaactgttt tccaagattt tcttaaaaga
     2521 ttatcaattt aaaagtatga tcaagtatgc ctcaaaaact agaaacattt caaaatgtag
     2581 aacaaacgtt gaaaaattgt tttgccagga aagagttcaa gttcagttaa ggatttgaga
     2641 ggcttttaaa caaggatcag taggatagtt atcatattta cttaatatat gtctgatatt
     2701 cagtgctggt tctttttcct gtttgtgcaa caatgaagtg tgtcatgtgt gttttatagc
     2761 ctctatcatt aatcacacca gagtctcatt ttaaaacatt ttaatgttaa aacatcccca
     2821 cacttataca caggtaaaat tagttttttt ttttttaaag ttgtaatctg tacttttttt
     2881 tttttgcaat ttttgaaaca gctacattaa tccctaaaaa tcccaccata ctgaaaatgt
     2941 atggcgtgta ttttctatag taagtaatat gaggaaaaca tgattagctg tgccaaagaa
     3001 attttataca ttgtttacat gatgaggcca cagtacttac tgaggacttc atatggtttt
     3061 tttgtttatt attattgaga aaagagctga ggttaccaca ttcattcttt gtgttagaaa
     3121 tgtaggagtg tggtggtttt ctgcaatatt tagagcttag tctcataatt tggaatttaa
     3181 gataataagt agtaacaagg caagtctttt atgtaagaca gtcaaacagt gtcacttcag
     3241 ggacaaaggc ctggaagccc ttaaaataag ttatcttaga tgtgccagaa catattcaga
     3301 gctttattcc tttaagctta aggcttcaat acttgtagaa atgcaaatat tcttgagaaa
     3361 tgatacattt tttgttctca atttctcaat tctacatacc tgattatgag tgaagtatcc
     3421 aaagcaggtt ttcatcagca tgggggatgg aaggtaggta taatatgagg acaatggaaa
     3481 ctttgggaga agggagtgag gaaatggata aagagaaatt tgaaaatttt aggctggact
     3541 tgagcactat tgctgctttc ctatgaacta tcagaatgtt taaatgcttt atcattcatg
     3601 gtccactctc aaccaacatt tattatcctt tagtaattaa acaatggttt tacatacatt
     3661 tttataatgt agaaggaaat tcaagattcc ataatcgtaa aatttttcag atttgtctaa
     3721 tgtgtaattt gtgcatcttc acatgctgct aaatgcagat ttaaacatta catctgagga
     3781 tcatgacttt tcctcctttc ttggagatct tggtataaaa ttcatctgct gttataaaat
     3841 caggtttcta cagagttcgt ttcacactaa aggtagtttg ttactgtttg catgaggaaa
     3901 ccatgtatgt ctcaatcttt aattttaggt ggtagtgttt attgttcacc ctccctcttg
     3961 cctccaaaag aatgctgaat tatacgccaa tatttccatg tgtattctgt tgccttgatg
     4021 cgtactatac ttgttgcatg tatattaaaa attttgtact atg
//
