LOCUS       NM_001144825            2005 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RUN domain containing 3A (RUNDC3A), transcript variant
            1, mRNA.
ACCESSION   NM_001144825
VERSION     NM_001144825.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2005)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2005)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2005)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 2005)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   5  (bases 1 to 2005)
  AUTHORS   Janoueix-Lerosey,I., Pasheva,E., de Tand,M.F., Tavitian,A. and de
            Gunzburg,J.
  TITLE     Identification of a specific effector of the small GTP-binding
            protein Rap2
  JOURNAL   Eur J Biochem 252 (2), 290-298 (1998)
   PUBMED   9523700
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB209802.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001144825.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.782971.1, AB209802.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000426726.8/ ENSP00000410862.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2005              AB209802.1         27-2031
FEATURES             Location/Qualifiers
     source          1..2005
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2005
                     /gene="RUNDC3A"
                     /gene_synonym="RAP2IP; RPIP-8; RPIP8"
                     /note="RUN domain containing 3A"
                     /db_xref="GeneID:10900"
                     /db_xref="HGNC:HGNC:16984"
                     /db_xref="MIM:605448"
     exon            1..339
                     /gene="RUNDC3A"
                     /gene_synonym="RAP2IP; RPIP-8; RPIP8"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1573
                     /gene="RUNDC3A"
                     /gene_synonym="RAP2IP; RPIP-8; RPIP8"
                     /note="isoform 1 is encoded by transcript variant 1; RaP2
                     interacting protein 8; RUN domain-containing protein 3A;
                     rap2-interacting protein 8"
                     /codon_start=1
                     /product="RUN domain-containing protein 3A isoform 1"
                     /protein_id="NP_001138297.1"
                     /db_xref="CCDS:CCDS45698.1"
                     /db_xref="GeneID:10900"
                     /db_xref="HGNC:HGNC:16984"
                     /db_xref="MIM:605448"
                     /translation="MEASFVQTTMALGLSSKKASSRNVAVERKNLITVCRFSVKTLLE
                     KYTAEPIDDSSEEFVNFAAILEQILSHRFKACAPAGPVSWFSSDGQRGFWDYIRLACS
                     KVPNNCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITTALRDTRTTRRFYDSGA
                     IMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPYLKFTQSYDYLTDEE
                     ERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQKGYLEELVRLRE
                     SQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQEQLTGLIPSDHAPLAQGSK
                     ELTTPLVNQWPSLGTLNGAEGASNSKLYRRHSFMSTEPLSAEASLSSDSQRLGEGTRD
                     EEPWGPIGKDPTPSMLGLCGSLASIPSCKSLASFKSNECLVSDSPEGSPALSPS"
     exon            340..455
                     /gene="RUNDC3A"
                     /gene_synonym="RAP2IP; RPIP-8; RPIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            456..604
                     /gene="RUNDC3A"
                     /gene_synonym="RAP2IP; RPIP-8; RPIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            605..690
                     /gene="RUNDC3A"
                     /gene_synonym="RAP2IP; RPIP-8; RPIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            691..780
                     /gene="RUNDC3A"
                     /gene_synonym="RAP2IP; RPIP-8; RPIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            781..861
                     /gene="RUNDC3A"
                     /gene_synonym="RAP2IP; RPIP-8; RPIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1027
                     /gene="RUNDC3A"
                     /gene_synonym="RAP2IP; RPIP-8; RPIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1185
                     /gene="RUNDC3A"
                     /gene_synonym="RAP2IP; RPIP-8; RPIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1323
                     /gene="RUNDC3A"
                     /gene_synonym="RAP2IP; RPIP-8; RPIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1430
                     /gene="RUNDC3A"
                     /gene_synonym="RAP2IP; RPIP-8; RPIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..2005
                     /gene="RUNDC3A"
                     /gene_synonym="RAP2IP; RPIP-8; RPIP8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1986..1991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUNDC3A"
                     /gene_synonym="RAP2IP; RPIP-8; RPIP8"
                     /note="hexamer: AATAAA"
     polyA_site      2005
                     /gene="RUNDC3A"
                     /gene_synonym="RAP2IP; RPIP-8; RPIP8"
                     /note="major polyA site"
ORIGIN      
        1 gccccggctc agcacctcgg agagctccct ccccggcctt gttttgctct ggcatcgccg
       61 ccgggggagg gagcgagggg gccgggcacc gggcgcaaag gcagggggat ggccatggaa
      121 gggttgaggg gccccgtcgg acagagggcc cagccgtgat ccagcgacgg gtttggggct
      181 ccgggagggg tgggggggca gcgggcggcg gcagcagtgg ccgcacatct ggatggaagc
      241 gagctttgtc cagaccacca tggctctggg gctgtcctcc aagaaagcgt cctctcgcaa
      301 cgtggctgtg gagcgtaaga acctgatcac cgtgtgcagg ttctctgtga aaacgctgct
      361 ggagaagtac acagcggagc ccatcgatga ctcatcggag gagtttgtca attttgcagc
      421 cattttagag cagatcctca gccaccgctt caaagcctgt gccccagcag gtccagtgag
      481 ctggttcagc tcagacgggc agcggggctt ttgggactat atccggctgg cctgcagcaa
      541 agtgcccaac aactgtgtga gcagcatcga gaacatggag aacatcagca cagcccgggc
      601 caagggccgg gcatggatcc gggtggcact gatggagaag cgcatgtcag aatacatcac
      661 cacggctctg cgtgacaccc ggaccaccag acggttctat gactctggag ccatcatgct
      721 gcgggatgaa gccaccatcc tcaccggaat gctgatcgga ctgagcgcca tcgacttcag
      781 cttctgtcta aagggggaag tcctggacgg gaagaccccc gtggtcatcg attacacgcc
      841 ctacctaaag ttcacgcaga gctacgacta cctgacggac gaggaggagc ggcacagcgc
      901 cgagagcagc acgagcgagg acaactcgcc cgagcacccg tacctcccgc tcgtcaccga
      961 tgaggacagc tggtacagca agtggcacaa gatggagcag aagttccgca tcgtctacgc
     1021 gcagaagggc tacctggagg agctggtgcg tctgcgcgag tcgcagctga aggacctgga
     1081 ggcggagaac cggcggcttc agctgcagct ggaggaggcg gcggcgcaga accagcgcga
     1141 gaaacgggag ctggaaggcg tgatcctgga gctgcaggag cagctgacag gtctgatccc
     1201 cagtgaccac gcccctctgg cccagggttc caaggagctc actacacccc tggtcaatca
     1261 atggccctca ctgggaacgc ttaatggggc cgagggcgcc agcaactcca agctctaccg
     1321 gagacacagc ttcatgagca cggagccgct gtcagctgaa gccagtctga gctcggactc
     1381 ccagcgcctg ggagagggca cgcgggacga ggagccctgg ggtcccatcg ggaaggaccc
     1441 cacgccctcc atgctgggcc tctgcggctc cctggcctcc attcccagct gcaagtccct
     1501 ggcgagcttc aaatccaacg agtgcctggt gagcgacagt cccgagggca gcccagcact
     1561 gagccccagc tgaggaacag catgggcagt gccagcccca cctgccaggg gccatggaca
     1621 cctgccacct ttcttcaaca agagtccccc aatccaggct acccttccag agaacgctac
     1681 ccacccagcc agggttctct cggggaagat ctcgtctgct caccttagct ttctgccttg
     1741 gcagcacggg ctgcggaaga aagcacgctg ggccaggagg caggggtgcc caagccacag
     1801 ggagcccctg gggaagcctg ctccattctt ctggtgacct tggcgctcct tcactcatct
     1861 cccctgcccc ctcaggaact ggtggcccag cttccacacc cccacctccc agtctctagc
     1921 ctctccatct gtctgtgtat ggcctggagt cactccttcc tcagccccca gggcaagaga
     1981 gctcaaataa aaaccagagg actga
//
