LOCUS       NM_173079               5280 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens RUN domain containing 1 (RUNDC1), transcript variant
            1, mRNA.
ACCESSION   NM_173079
VERSION     NM_173079.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5280)
  AUTHORS   Jalali,A., Amirian,E.S., Bainbridge,M.N., Armstrong,G.N., Liu,Y.,
            Tsavachidis,S., Jhangiani,S.N., Plon,S.E., Lau,C.C., Claus,E.B.,
            Barnholtz-Sloan,J.S., Il'yasova,D., Schildkraut,J., Ali-Osman,F.,
            Sadetzki,S., Johansen,C., Houlston,R.S., Jenkins,R.B., Lachance,D.,
            Olson,S.H., Bernstein,J.L., Merrell,R.T., Wrensch,M.R., Davis,F.G.,
            Lai,R., Shete,S., Aldape,K., Amos,C.I., Muzny,D.M., Gibbs,R.A.,
            Melin,B.S. and Bondy,M.L.
  TITLE     Targeted sequencing in chromosome 17q linkage region identifies
            familial glioma candidates in the Gliogene Consortium
  JOURNAL   Sci Rep 5, 8278 (2015)
   PUBMED   25652157
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5280)
  AUTHORS   Song,Q., Jing,H., Wu,H., Zhou,G., Kajiyama,T. and Kambara,H.
  TITLE     Gene expression analysis on a photodiode array-based
            bioluminescence analyzer by using sensitivity-improved SRPP
  JOURNAL   Analyst 135 (6), 1315-1319 (2010)
   PUBMED   20498880
REFERENCE   3  (bases 1 to 5280)
  AUTHORS   Llanos,S., Efeyan,A., Monsech,J., Dominguez,O. and Serrano,M.
  TITLE     A high-throughput loss-of-function screening identifies novel p53
            regulators
  JOURNAL   Cell Cycle 5 (16), 1880-1885 (2006)
   PUBMED   16929179
REFERENCE   4  (bases 1 to 5280)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055866.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_173079.4.
            
            Summary: This gene encodes a protein that contains a RUN (RPIP8,
            UNC-14 and NESCA) domain and a coiled coil domain. The encoded
            protein may negatively regulate p53 transcriptional activity. This
            gene is a potential candidate gene for predisposition to glioma in
            humans. [provided by RefSeq, May 2017].
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon in the 5' coding region compared to variant 2. The encoded
            isoform (1) is shorter than isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039247.1, AL831813.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361677.6/ ENSP00000354622.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-510               AC055866.19        164856-165365
            511-669             AC055866.19        171547-171705
            670-868             AC055866.19        173632-173830
            869-988             AC055866.19        174608-174727
            989-5280            AC055866.19        175142-179433
FEATURES             Location/Qualifiers
     source          1..5280
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..5280
                     /gene="RUNDC1"
                     /gene_synonym="RUND1"
                     /note="RUN domain containing 1"
                     /db_xref="GeneID:146923"
                     /db_xref="HGNC:HGNC:25418"
                     /db_xref="MIM:619250"
     exon            1..510
                     /gene="RUNDC1"
                     /gene_synonym="RUND1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1854
                     /gene="RUNDC1"
                     /gene_synonym="RUND1"
                     /note="isoform 1 is encoded by transcript variant 1; RUN
                     domain-containing protein 1"
                     /codon_start=1
                     /product="RUN domain-containing protein 1 isoform 1"
                     /protein_id="NP_775102.3"
                     /db_xref="CCDS:CCDS11448.1"
                     /db_xref="GeneID:146923"
                     /db_xref="HGNC:HGNC:25418"
                     /db_xref="MIM:619250"
                     /translation="MAAVEAAAEPVTVVAAVGPKAKDEEEEEEEPLPPCEAVRWAPVG
                     AVAEARPGATAFLEEATAEEPGAAPGSPPDSPGRTLRRLRAERRRLDSALLALSSHFA
                     QVQFRLRQVVRGAPAEQQRLLRELEDFAFRGCPHVLGYEGPGDPASDEGDGLPGDRPW
                     LRGEDQSEQEKQERLETQREKQKELILQLKTQLDDLETFAYQEGSYDSLPQSVVLERQ
                     RVIIDELIKKLDMNLNEDISSLSTEELRQRVDAAVAQIVNPARVKEQLVEQLKTQIRD
                     LEMFINFIQDEVGSPLQTGGGHCECKAGGKTGNGCSRTGSSRTPPGNSKTKAEDVKKV
                     RETGLHLMRRALAVLQIFAVSQFGCATGQIPPTLWQRVQADRDYSPLLKRLEVSVDRV
                     KQLALRQQPHDHVITSANLQDLSLGGKDELTMAVRKELTVAVRDLLAHGLYASSPGMS
                     LVMAPIACLLPAFSSAPEAMHPWELFVKYYHAKNGRAYVESPARKLSQSFALPVTGGT
                     VVTPKQSLLTAIHMVLTEHDPFKRSADSELKALVCMALNEQRLVSWVNLICKSGSLIE
                     PHYQPWSYMAHTGFESALNLLSRLSSLKFSLPVDLAVRQLKNIKDAF"
     exon            511..669
                     /gene="RUNDC1"
                     /gene_synonym="RUND1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..868
                     /gene="RUNDC1"
                     /gene_synonym="RUND1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..988
                     /gene="RUNDC1"
                     /gene_synonym="RUND1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..5280
                     /gene="RUNDC1"
                     /gene_synonym="RUND1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3081..3086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUNDC1"
                     /gene_synonym="RUND1"
                     /note="hexamer: AGTAAA"
     polyA_site      3108
                     /gene="RUNDC1"
                     /gene_synonym="RUND1"
                     /note="major polyA site"
     regulatory      3709..3714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUNDC1"
                     /gene_synonym="RUND1"
                     /note="hexamer: AATGAA"
     polyA_site      3715
                     /gene="RUNDC1"
                     /gene_synonym="RUND1"
     polyA_site      3825
                     /gene="RUNDC1"
                     /gene_synonym="RUND1"
                     /note="major polyA site"
     regulatory      5260..5265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUNDC1"
                     /gene_synonym="RUND1"
                     /note="hexamer: AATATA"
     polyA_site      5280
                     /gene="RUNDC1"
                     /gene_synonym="RUND1"
ORIGIN      
        1 gtttccggga agatggcggc tgtcgaagcg gctgcagagc cggtaacggt ggtggcggct
       61 gttgggccaa aggcgaaaga cgaagaggag gaggaagagg agccgctgcc accgtgcgag
      121 gcggtgcgct gggccccagt gggggcggtg gcggaggccc ggcctggggc aaccgcgttt
      181 ttagaagagg cgacggccga ggagcctggc gcggccccgg gctccccgcc ggattcgccg
      241 ggccggacgc tgcggcggct gcgggcagag cggcggcggc tggactcggc gctgctggcg
      301 ctgtcctcgc acttcgcgca ggtgcagttc cgcctgcgcc aggtggtgcg cggggcgccg
      361 gcggagcagc agcgccttct gcgggagctc gaagacttcg ccttccgcgg ctgccctcac
      421 gtcctaggtt acgaagggcc cggcgacccc gccagcgatg agggcgatgg gctgccaggg
      481 gaccggccat ggttgcgggg cgaggaccag agtgagcagg aaaagcaaga gcgtctggaa
      541 acccaaaggg agaagcagaa agaactgata ctgcagctca agacccagct agatgacctg
      601 gaaacgtttg cctatcaaga gggcagttat gactcgctgc cacagtccgt ggtgttggaa
      661 agacagcggg tgatcataga tgagttaata aagaaactgg acatgaatct gaatgaggac
      721 atcagttccc tgtccactga agagcttcgt cagcgtgtag atgcagcagt ggctcagatc
      781 gtcaacccag cccgagtcaa agaacagttg gttgagcaac tgaaaactca gatccgagac
      841 cttgagatgt ttatcaactt catccaagat gaagtgggaa gccccttgca gacaggtggt
      901 ggacactgtg agtgcaaggc cggtgggaag acaggaaatg gctgcagcag aacaggcagc
      961 agcagaacgc ctccaggaaa cagcaaaaca aaggcagagg atgtgaagaa agtccgggag
     1021 acggggctgc acctgatgcg gcgagcgctg gccgtgctcc agatctttgc tgttagccag
     1081 tttggttgtg ccacaggcca gatccctcca accctgtggc agagggtcca ggctgacaga
     1141 gactactctc ccttgctgaa gaggctggag gtgtcagtgg acagagtgaa gcagctagcc
     1201 ttgaggcagc agccacatga ccatgtcatc acctctgcca acctccagga cctctctctg
     1261 ggaggcaagg atgagctgac tatggctgtg cggaaggagc taacggtggc tgtgagggac
     1321 ctgctggccc atggactgta tgcctcctcc ccagggatga gccttgttat ggctcctatt
     1381 gcttgtttgc tgccagcctt ctcctcggcc ccagaggcca tgcacccgtg ggagctcttt
     1441 gtaaagtact accatgctaa gaacggccgt gcttatgtgg aatccccagc ccggaagctc
     1501 tcccagtcct tcgcccttcc tgttacggga ggcactgttg tcacccccaa acagagccta
     1561 ctgacagcca tccacatggt gctgacagag catgaccctt ttaagcgcag tgcagactca
     1621 gaattgaagg ccttggtgtg catggcactg aatgagcagc gtctggtgtc ctgggtgaac
     1681 ctcatctgca agtccgggtc actcatcgag cctcactacc agccctggag ctacatggca
     1741 cacacaggct ttgagagtgc cctcaacctg ctcagtcgcc tcagcagcct caagtttagc
     1801 ctccctgtag atctggctgt gcgccagctc aaaaacatca aagatgcctt ttgatgagag
     1861 tgccctaacc ccagacaagc tccttgttca gtagggatag atgtgctagt cttctagcat
     1921 aggagcaagg aatcagaggt ggggttaaag gcatttttcc cagaccctgc tcaggcagtc
     1981 ggccaaatga gtgcaaagtc tgttttcccc accaacttag ctctcggaaa gatgtgctgg
     2041 agggaccctc ttgttaagaa ggttctgcca ggccgggcgc ggtggctcac acctgtaatc
     2101 ccagcacttt gggaggccga ggcgggcgga tcacaaggtc aggagttcga gaccatcctg
     2161 tctaacacgg tgaaacccca tctctactaa aaatacaaaa aaattagtcg gacatggtgg
     2221 caggcacctg tagtcccagc tactcgggag gctgaggcag gagaatggcg tgaacccagg
     2281 aggcggagct tgcagtgagc caagatcgcg ccactgcact ccagcctggg cgacagagtg
     2341 agactccgtc tcaaaaaaaa aaagaaggtt gtacccacag tatacgtgtg ggcacttgtg
     2401 cttgagcctg tattaaagga atcaggccag gcacagtggc tcacgcctgt aatctcagca
     2461 cattgggagg ctgaggtggg cggatcacct gaggtcagga gttcaagacc agcctggcca
     2521 acatggtgaa accccatctc tactaaaaat acaaaaatta gctaggcggg gtagtgcatg
     2581 cctgtaatcc cagctactca ggaggctgag gccggagaat cgcttgagcc cgagaggtgg
     2641 agactgcagt aagccaagat catgccattg cactccagcc tgggcaacac agggagactc
     2701 catctcaaaa aaaaaaaaaa aaaaaaaaag acattcaact tgaggctcct gttagttaag
     2761 ctatcttctt tcacttgaag caggtttgag aggcctaggc cagaatttaa attcctttta
     2821 tgaatagatt tccctttctt cctgacccca aggtcagagg agactatata ttccatggct
     2881 gcctctaaga ctaggaatag gaatatctga aaacagcatt tctaagggtg gtaaccacag
     2941 gtcgatttta atacgagtcc tttttcttgt agaggtaagt aaaatcttcc tgacaaggta
     3001 gtcctctttt catggcacag acaatgggct ttctgtttat gaggggtgag aagtgatgtt
     3061 tgttactatg ttctccagca agtaaacatt cctctgctca cctcccaaca agactaacag
     3121 tctttttaga agtaaatata ttcaagacaa acgagaaaat cctggctacc caagtcgagt
     3181 atatacagga atacaaatcg gtaaccagca gctgttcctc aggttgtgac tcactgagca
     3241 ccacttgtcc tggaggctgg atgatggagg acatctggtt ataggtactg tagcagggat
     3301 aggtgccaca ggaggatagg aactacagca gatcgctgtt tccagaacgg ggaggagtat
     3361 ctcattgtga aacagactct agagtggttc tatttggtct tcagtgtttt agcctcgtta
     3421 gttcatattt ggcatgcagc ttgtggtgag tactgttcta ggactggcca aaaatgggca
     3481 aaatgtatca ctccaaacac tactgattca gcattgtttt catgtcttaa aattgccacc
     3541 tgcactttgt ttctgcacta ttatgtagtg cattttaact taaatttttt ccagcaacat
     3601 gttacttatt taagatacat tactgatatt tcattataat tagttcacct tccctgtgaa
     3661 acaagagaat tgtaaaatgt tgtggaaaat gatacatatg tggatgctaa tgaaatcata
     3721 gtattttgtg tagcttctct gaagacctta gagatctgca gctttggttt ataagtgttt
     3781 gggccttatc agcccatctg atccagatca atattttttt gaaaactgcc tgtatcctct
     3841 gtcctctgtt acggatcatc tcagctttgg tggtggtagt aggggttttt tgcctgaaaa
     3901 aattcactaa aaagtcccct tggcatgacc atctcctcct gcccacgcct gtagtccctc
     3961 cccacaacag atgtcatcac acatgctgct tttggaatgg agaccttttt tttttgagat
     4021 ggagtctcgc tctgttgtcc aggctggagt gcaatggcgt gatctcagct cactgcaacc
     4081 tccgcctcct gggttcaagc gattctcctt ccttagcctt ctgagtagct gggagtaccg
     4141 gcgcctgcca ccacgcctgg ctaatgtttg tatttttaat agagagggtt tcaccacatt
     4201 tgtcaggcta gtctcgaact cctgacctca ggtgatccac ccacttcagc ctcccaaagt
     4261 gctgggatta taggcgtgag ccaccacacc cagccaggat tggcactttt aaatccactt
     4321 gtctggatat cactttgggt ggtaactggt atagccatat ggcgtagccc agcgatcacc
     4381 ccagtattgc ctttttcaaa tcacaaaaac aaaacttgta ttaaggcttt gtgctagcat
     4441 tacaggaagc attttcattt gtctcattct aattaaattc tcactactta caaagtggga
     4501 cagtattatc cccactttac agctgaggaa actgaactgc agagaggtta aatattttgt
     4561 cctggtttac atgatgatgg aagacctgag atttggagtc aagttttctg aatccagagc
     4621 ccacagtcta tcttttcact tcattgtatc atgttgtttc tagattttgg tttctctttc
     4681 tcctttatcc accaccctca ttcctcccct cactttgggg aggagaaggt attttctaca
     4741 caactgccag aaatttcagc tgccaaagga caaggctgca gggagacagg ccggcagcca
     4801 tgactttcat gtctaagttc ttgaaaccta aatgtgtgta tcaactgaga caacccaaca
     4861 attccatcag catccctgca gtcagatatc tgctaagctc tgatatcatc tgtcattact
     4921 gagaacagag ctctgtcctt cacttagggt gagacaggac aagggaggag aggcaggcca
     4981 gtccacccag atccaaggat atgcaagaat ggaagggtca agagccacgg atatgtatgc
     5041 agtggaaatg tagggtgtgt tgtacaagta tgatctgcaa agtattgtta aagccgtcta
     5101 aggtgctctc caatcattca ttcactattg atcacttagc aactgcctgc ctagactaga
     5161 tgctaaagaa agagaaaagt aaacctaccc cgtgccctca acaaacacag tctagcaaag
     5221 gagataccat accaattgga gatttggaga gactgttaaa atatagattg ctgggtccca
//
