LOCUS       NM_001037442            4433 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens RUN and FYVE domain containing 3 (RUFY3), transcript
            variant 1, mRNA.
ACCESSION   NM_001037442
VERSION     NM_001037442.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4433)
  AUTHORS   Xu,H., Zheng,Y., Wu,J., Zhang,R., Zhao,Q., Chen,S., Peng,W.,
            Cai,D., Gao,Y., Chen,X., Li,D., Yuan,S., Li,G. and Nan,A.
  TITLE     circSORBS1 inhibits lung cancer progression by sponging miR-6779-5p
            and directly binding RUFY3 mRNA
  JOURNAL   J Transl Med 22 (1), 590 (2024)
   PUBMED   38915053
  REMARK    GeneRIF: circSORBS1 inhibits lung cancer progression by sponging
            miR-6779-5p and directly binding RUFY3 mRNA.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4433)
  AUTHORS   Khumukcham,S.S., Penugurti,V., Bugide,S., Dwivedi,A., Kumari,A.,
            Kesavan,P.S., Kalali,S., Mishra,Y.G., Ramesh,V.A.,
            Nagarajaram,H.A., Mazumder,A. and Manavathi,B.
  TITLE     HPIP and RUFY3 are noncanonical guanine nucleotide exchange factors
            of Rab5 to regulate endocytosis-coupled focal adhesion turnover
  JOURNAL   J Biol Chem 299 (11), 105311 (2023)
   PUBMED   37797694
  REMARK    GeneRIF: HPIP and RUFY3 are noncanonical guanine nucleotide
            exchange factors of Rab5 to regulate endocytosis-coupled focal
            adhesion turnover.
REFERENCE   3  (bases 1 to 4433)
  AUTHORS   Angarita,F.A., Oshi,M., Yamada,A., Yan,L., Matsuyama,R., Edge,S.B.,
            Endo,I. and Takabe,K.
  TITLE     Low RUFY3 expression level is associated with lymph node metastasis
            in older women with invasive breast cancer
  JOURNAL   Breast Cancer Res Treat 192 (1), 19-32 (2022)
   PUBMED   35018543
  REMARK    GeneRIF: Low RUFY3 expression level is associated with lymph node
            metastasis in older women with invasive breast cancer.
REFERENCE   4  (bases 1 to 4433)
  AUTHORS   Zhang,Y., Ni,W. and Qin,L.
  TITLE     RUFY3 promotes the progression of hepatocellular carcinoma through
            activating NF-kappaB-mediated epithelial-mesenchymal transition
  JOURNAL   Aging (Albany NY) 13 (17), 21283-21293 (2021)
   PUBMED   34510031
  REMARK    GeneRIF: RUFY3 promotes the progression of hepatocellular carcinoma
            through activating NF-kappaB-mediated epithelial-mesenchymal
            transition.
REFERENCE   5  (bases 1 to 4433)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4433)
  AUTHORS   Zhu,H., Dai,W., Li,J., Xiang,L., Wu,X., Tang,W., Chen,Y., Yang,Q.,
            Liu,M., Xiao,Y., Zhang,W., Lin,J., Wang,J., Liu,G., Sun,Y.,
            Jiang,P., Li,G., Li,A., Liu,S., Chen,Y. and Wang,J.
  TITLE     HOXD9 promotes the growth, invasion and metastasis of gastric
            cancer cells by transcriptional activation of RUFY3
  JOURNAL   J Exp Clin Cancer Res 38 (1), 412 (2019)
   PUBMED   31547840
  REMARK    GeneRIF: HOXD9 directly associated with the RUFY3 promoter to
            increase the transcriptional activity of RUFY3 in gastric cancer.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4433)
  AUTHORS   Xie,R., Wang,J., Liu,X., Wu,L., Zhang,H., Tang,W., Li,Y., Xiang,L.,
            Peng,Y., Huang,X., Bai,Y., Liu,G., Li,A., Wang,Y., Chen,Y., Ren,Y.,
            Li,G., Gong,W., Liu,S. and Wang,J.
  TITLE     RUFY3 interaction with FOXK1 promotes invasion and metastasis in
            colorectal cancer
  JOURNAL   Sci Rep 7 (1), 3709 (2017)
   PUBMED   28623323
  REMARK    GeneRIF: our results uncovered a novel, unexpected regulatory
            function of RUFY3. We identified FOXK1 as a new RUFY3-binding
            protein. This study shed light on the critical role of RUFY3 in
            inducing EMT and in the migration and invasion phenotypes caused by
            abnormal FOXK1 expression.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4433)
  AUTHORS   Wang,G., Zhang,Q., Song,Y., Wang,X., Guo,Q., Zhang,J., Li,J.,
            Han,Y., Miao,Z. and Li,F.
  TITLE     PAK1 regulates RUFY3-mediated gastric cancer cell migration and
            invasion
  JOURNAL   Cell Death Dis 6 (3), e1682 (2015)
   PUBMED   25766321
  REMARK    GeneRIF: these findings provide important evidence that PAK1 can
            positively regulate RUFY3 expression, which contribute to the
            metastatic potential of gastric cancer cells
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4433)
  AUTHORS   Yoshida,H., Okumura,N., Kitagishi,Y., Shirafuji,N. and Matsuda,S.
  TITLE     Rab5(Q79L) interacts with the carboxyl terminus of RUFY3
  JOURNAL   Int J Biol Sci 6 (2), 187-189 (2010)
   PUBMED   20376209
  REMARK    GeneRIF: Rab5(Q79L) interacts with the carboxyl terminus of RUFY3
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4433)
  AUTHORS   Mori,T., Wada,T., Suzuki,T., Kubota,Y. and Inagaki,N.
  TITLE     Singar1, a novel RUN domain-containing protein, suppresses
            formation of surplus axons for neuronal polarity
  JOURNAL   J Biol Chem 282 (27), 19884-19893 (2007)
   PUBMED   17439943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA248021.1, BC053837.1,
            AK302637.1, DC299541.1, AC009570.13, AC021989.8 and AA435606.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001037442.3.
            
            Summary: This gene encodes a RPIP8, UNC-14, and NESCA
            domain-containing protein that is required for maintenance of
            neuronal polarity. In addition, it has been implicated in mediation
            of gastric cancer cell migration and invasion via interaction with
            P21-activated kinase-1, which promotes its expression. The encoded
            protein localizes to F-actin-enriched invadopodia to induce
            formation of protrusions, thereby facilitating cell migration.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.8983.1,
                                           SRR1803617.237418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381006.8/ ENSP00000370394.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-465               DA248021.1         70-534
            466-2101            BC053837.1         418-2053
            2102-2370           AK302637.1         1492-1760
            2371-2750           DC299541.1         51-430
            2751-2916           AK302637.1         2141-2306
            2917-3683           AC009570.13        1-767               c
            3684-4416           AC021989.8         13114-13846
            4417-4433           AA435606.1         14-30               c
FEATURES             Location/Qualifiers
     source          1..4433
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..4433
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /note="RUN and FYVE domain containing 3"
                     /db_xref="GeneID:22902"
                     /db_xref="HGNC:HGNC:30285"
                     /db_xref="MIM:611194"
     exon            1..788
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     CDS             611..2473
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /note="isoform 1 is encoded by transcript variant 1;
                     single axon-related 1; rap2 interacting protein x; single
                     axon-regulated protein"
                     /codon_start=1
                     /product="protein RUFY3 isoform 1"
                     /protein_id="NP_001032519.1"
                     /db_xref="CCDS:CCDS34001.1"
                     /db_xref="GeneID:22902"
                     /db_xref="HGNC:HGNC:30285"
                     /db_xref="MIM:611194"
                     /translation="MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRE
                     LDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQ
                     QFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPV
                     GRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVI
                     DANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNA
                     TVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQD
                     RTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALV
                     SLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQA
                     ERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIP
                     GRGSQKSESKMDGKHKMQEENVKLKKPLEESHRLQPHPMDEQDQLLLSEKPQLCQLCQ
                     EDGSLTKNVCKNCSGTFCDACSTNELPLPSSIKLERVCNPCHKHLMKQYSTSPS"
     exon            789..962
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1080
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1182
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1306
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1368
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1434
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1504
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1597
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1681
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1849
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1947
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2067
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2167
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2232
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2260
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2329
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..4433
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2665..2670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /note="hexamer: AATAAA"
     polyA_site      2685
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /note="major polyA site"
     regulatory      4301..4306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /note="hexamer: AATAAA"
     polyA_site      4329
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /note="major polyA site"
     regulatory      4409..4414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /note="hexamer: AATAAA"
     polyA_site      4433
                     /gene="RUFY3"
                     /gene_synonym="RIPX; SINGAR1; ZFYVE30"
                     /note="major polyA site"
ORIGIN      
        1 agttcattag tcagccattt tggtcaacac cctgcttact gcgcacggcc aatcctatga
       61 gaactcagca tcccagctca tctgagcaga tcctggaagt gatttctgca gctcaggatt
      121 ttttttttaa gctacattga aaatataggt ttattttttg ttcaggtttt tcttttatat
      181 tttttttctg cacaaaggag gaggattttt cacttactca tatcgaggcc agatttttaa
      241 agccagctaa ggcagcatca gctgtgcggg atttaaagcc tatagctcag ctgaaaaaaa
      301 aggtgggggg cagggaaggg aagataaaag gagaggaagc tgggagaaga caagcatcat
      361 cttattttgc tatgtggtag gaactgtcta taagatagtg tagaattgtt tatcttgagc
      421 agtttgttct taacctataa ggtatttttc cttttttttt tttttaaacc tcccccaccc
      481 ttttcctgaa agctttgttt cagagctttg tattgggttt ttttggtgag gaggttgtat
      541 ttattttttt ggtgtgtgtg tgtgagtgtg tgtgtgtctg tgtgtgtgtt gtggtcccag
      601 ctgagtcatc atgtctgctc tgacgcctcc gaccgatatg ccaaccccca ccactgacaa
      661 gatcacacag gctgccatgg agaccatcta cctttgcaaa ttccgagtgt ccatggatgg
      721 agaatggctc tgcctgcgag agctggatga catctcactt acacctgacc cagagcctac
      781 ccatgaagat cctaattatc tcatggctaa tgaacgcatg aacctcatga acatggccaa
      841 gctgagtatc aagggcttga ttgaatcagc tctgaacctg gggaggactc ttgactctga
      901 ctatgcacct ctccagcaat tctttgtggt gatggagcac tgtctgaaac atggcttgaa
      961 agctaaaaaa acttttctcg gacaaaataa atccttctgg gggcctctag aactggtaga
     1021 aaagcttgtt ccagaagccg cagagataac agcaagtgtt aaagatcttc caggacttaa
     1081 gacaccagta ggtagaggaa gagcctggct tcgtttggca ttaatgcaaa agaaactttc
     1141 agaatatatg aaagctttga tcaataagaa agaacttctc agtgaattct acgaacccaa
     1201 tgccctcatg atggaagaag aaggagccat aattgctggt ctgttggtgg gtctgaatgt
     1261 cattgatgcc aatttctgta tgaaaggaga agacttggac tctcaggttg gagttataga
     1321 tttttcaatg tatctcaagg acgggaacag cagtaaaggt actgaaggag acggtcagat
     1381 tactgcaatt ctggaccaga agaactatgt agaagaactg aacagacatt tgaatgctac
     1441 tgtaaacaac cttcaggcaa aagtagatgc attagaaaaa tccaacacta aactgacaga
     1501 ggagcttgca gttgcaaaca acaggatcat taccttacaa gaagaaatgg aacgagttaa
     1561 agaggaaagt tcctacatac tggaatccaa tcggaagggt cccaagcaag acagaactgc
     1621 agaagggcaa gcactaagtg aagcaagaaa gcatttaaaa gaagagacac aattacgatt
     1681 ggatgttgag aaagaactgg agatgcagat cagcatgagg caggagatgg aattggctat
     1741 gaagatgctg gagaaggatg tctgtgagaa gcaggatgcc ctggtatctc ttcggcagca
     1801 gctggatgac ctcagagctc tcaagcatga acttgccttt aagctgcaga gttcagactt
     1861 aggagtaaaa cagaaaagtg aactaaacag tcgcttggaa gagaagacta atcagatggc
     1921 tgctaccatt aaacaacttg aacaaagatt gcgccaggct gagcgaagcc gccaatctgc
     1981 tgagttggac aaccggctct tcaaacagga ctttggagac aagatcaaca gtctgcagct
     2041 ggaagtcgag gagctcacca ggcagcggaa ccagcttgag ttagaactaa aacaggaaaa
     2101 agaaagaaga ttacaaaacg acaggagcat cccaggaagg ggttcccaga agtcagaatc
     2161 caagatggat gggaagcaca aaatgcaaga ggaaaatgtt aaactaaaaa agcccctgga
     2221 agaaagccac aggctgcaac cccaccctat ggatgaacag gatcagctgc tgctctctga
     2281 aaagccacag ttgtgtcagc tatgccagga agacggcagc ctaacaaaga atgtgtgtaa
     2341 gaactgcagc ggaaccttct gtgatgcctg ttcaacaaat gaactgcctc ttccttcaag
     2401 tatcaagctt gagcgagttt gcaatccctg tcacaagcat ctgatgaagc aatattctac
     2461 cagcccatca taagactgga ggccaagacc tggaccaaaa cgtttatgca ggctcctctg
     2521 tacctgtgtt ttagctgtca ggatctcata gagcccagtt cttagagtca actaaagagt
     2581 tgataggaat ttactaggtc cagggagaaa aggcagtggt tggggttact ggaaattttg
     2641 ctcattttct ctaatgactg tatgaataaa agtgaactta cttgagcctt tctcttctaa
     2701 atctaaacaa cctgatattg aaggtttgct ttatagcata tctttggaaa ggcaactcat
     2761 ttttatgatt agtgatactg gggtggattt aataggagag agaatccagg cagataagaa
     2821 taaaaaggaa aatgatcatc tccttctata gcatttgcag attcaagggg gagaggtaga
     2881 tgctgagatc aaaatgacag ttgttactta tttttccagg tgctgttagt ataaacattg
     2941 tttcctcttc acccctgcta actacctctt taaagtattt ctaccaaact gtgaacccaa
     3001 tctcagggaa aagaaattaa aaagtaatat aaattctgca tatattaaaa acaatattgt
     3061 aatatgttat aatttcagga ccagaatttt ctggtcttta cctacaaggg ttttcattat
     3121 caaaaaaaag aacatttgtt tttctacttt atgacttcaa agtaaataac tgcccttttc
     3181 agaatctcct tccacaaaac aagccaactc ttccccattc cctccatctt cctttccaag
     3241 tcataatgga aattgtaagg agttttaaaa atagggtttg gcttttgcaa atagaagata
     3301 ttgattaaag caaagtcaaa tatagagtaa aataagttta atttgttttc ttaagacagg
     3361 gtcttgctct gttgcacaag ctggagggca gtagtgcaat cacagctcac tgaatccctg
     3421 ttctcccggg cctcaagcaa tcttcccacc ttagcctccc aagtagctgg gactggcttt
     3481 tttttttttt ttttggccgg ggagggggtc tcattggttg ctcagcctgg tctcaaactc
     3541 ctgggcttaa gcagtcctcc caccttgact tccacagtgc cgagattaca ggcatgagcc
     3601 accacacctg gccaagttta atttgttcat ggctgagaac agttagctcg gaatacttac
     3661 attgtttttt gaataaggaa ttccttattc tgagtgagtc acgaatgaga gctgatagat
     3721 gctttcttga aaagggcaat acagtcatcc cttggtatcc atgggggatt ggttccagga
     3781 acccaacttg atatcagaat ccatgggtgc tcaagtccca ttatagagaa tgggttatat
     3841 ggtatttgca tataacctac atacatcctc ctgtgtactt taaatcatct gaagatgatt
     3901 acttatacct aataaaatac ctacacatca cttcatttgc atggattcaa catagtgctt
     3961 ggtgttcagt aaattcaagt tttgcttttt tggaactttg tggaattttt ctttttctga
     4021 atatttttga ttggcagttg gttgaagcca tggatgcaga acccatggat atggagggct
     4081 gactgtactt acttacatat ctatctatct ttgagtaaca aactctttgg gggaaaagag
     4141 ggaagtgtat tgagcaagag aaggcaaaaa acattacata atattttgat tctgttacgt
     4201 gtgtctatag attgtttcat tctaatcaag acctaagaag gtatgattct gtgactgatt
     4261 tagaattctg gggtggaaat atcctggaac catgtttttt aataaattct gtctcttgga
     4321 aagagttaac aacagcctgg gaaagagttg ttattccaaa agtcagcctg ttacttggtg
     4381 aagctgaagt ttaagagttc tggggaaaaa taaaatctag taattccagc cta
//
