LOCUS       NM_022147               1501 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens receptor transporter protein 4 (RTP4), mRNA.
ACCESSION   NM_022147
VERSION     NM_022147.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1501)
  AUTHORS   Yamamoto,Y., Shimada,S., Akiyama,Y., Tsukihara,S., Sugimoto,R.,
            Kabashima,A., Tokunaga,M., Kinugasa,Y., Kawakami,Y. and Tanaka,S.
  TITLE     RTP4 silencing provokes tumor-intrinsic resistance to immune
            checkpoint blockade in colorectal cancer
  JOURNAL   J Gastroenterol 58 (6), 540-553 (2023)
   PUBMED   36859628
  REMARK    GeneRIF: RTP4 silencing provokes tumor-intrinsic resistance to
            immune checkpoint blockade in colorectal cancer.
REFERENCE   2  (bases 1 to 1501)
  AUTHORS   Li,Y., Qi,J. and Yang,J.
  TITLE     RTP4 is a novel prognosis-related hub gene in cutaneous melanoma
  JOURNAL   Hereditas 158 (1), 22 (2021)
   PUBMED   34154655
  REMARK    GeneRIF: RTP4 is a novel prognosis-related hub gene in cutaneous
            melanoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1501)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1501)
  AUTHORS   He,X., Ashbrook,A.W., Du,Y., Wu,J., Hoffmann,H.H., Zhang,C.,
            Xia,L., Peng,Y.C., Tumas,K.C., Singh,B.K., Qi,C.F., Myers,T.G.,
            Long,C.A., Liu,C., Wang,R., Rice,C.M. and Su,X.Z.
  TITLE     RTP4 inhibits IFN-I response and enhances experimental cerebral
            malaria and neuropathology
  JOURNAL   Proc Natl Acad Sci U S A 117 (32), 19465-19474 (2020)
   PUBMED   32709745
  REMARK    GeneRIF: RTP4 inhibits IFN-I response and enhances experimental
            cerebral malaria and neuropathology.
REFERENCE   5  (bases 1 to 1501)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1501)
  AUTHORS   Schoggins,J.W., Wilson,S.J., Panis,M., Murphy,M.Y., Jones,C.T.,
            Bieniasz,P. and Rice,C.M.
  TITLE     A diverse range of gene products are effectors of the type I
            interferon antiviral response
  JOURNAL   Nature 472 (7344), 481-485 (2011)
   PUBMED   21478870
  REMARK    Erratum:[Nature. 2015 Sep 3;525(7567):144. doi:
            10.1038/nature14554.. PMID: 26153858]
REFERENCE   7  (bases 1 to 1501)
  AUTHORS   Behrens,M., Bartelt,J., Reichling,C., Winnig,M., Kuhn,C. and
            Meyerhof,W.
  TITLE     Members of RTP and REEP gene families influence functional bitter
            taste receptor expression
  JOURNAL   J Biol Chem 281 (29), 20650-20659 (2006)
   PUBMED   16720576
REFERENCE   8  (bases 1 to 1501)
  AUTHORS   Clark,A.J., Metherell,L.A., Cheetham,M.E. and Huebner,A.
  TITLE     Inherited ACTH insensitivity illuminates the mechanisms of ACTH
            action
  JOURNAL   Trends Endocrinol Metab 16 (10), 451-457 (2005)
   PUBMED   16271481
  REMARK    Review article
REFERENCE   9  (bases 1 to 1501)
  AUTHORS   Saito,H., Kubota,M., Roberts,R.W., Chi,Q. and Matsunami,H.
  TITLE     RTP family members induce functional expression of mammalian
            odorant receptors
  JOURNAL   Cell 119 (5), 679-691 (2004)
   PUBMED   15550249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC013161.1, CA413859.1 and AC068299.21.
            
            On Nov 23, 2018 this sequence version replaced NM_022147.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP199993.1, SRR1660805.202527.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259030.3/ ENSP00000259030.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               BC013161.1         6-375
            371-1009            CA413859.1         14-652              c
            1010-1501           AC068299.21        58245-58736         c
FEATURES             Location/Qualifiers
     source          1..1501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3"
     gene            1..1501
                     /gene="RTP4"
                     /gene_synonym="IFRG28; Z3CXXC4"
                     /note="receptor transporter protein 4"
                     /db_xref="GeneID:64108"
                     /db_xref="HGNC:HGNC:23992"
                     /db_xref="MIM:609350"
     exon            1..212
                     /gene="RTP4"
                     /gene_synonym="IFRG28; Z3CXXC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..798
                     /gene="RTP4"
                     /gene_synonym="IFRG28; Z3CXXC4"
                     /note="28kD interferon responsive protein; 28 kDa
                     interferon-responsive protein; zinc finger, 3CxxC-type 4;
                     3CxxC-type zinc finger protein 4; receptor (chemosensory)
                     transporter protein 4"
                     /codon_start=1
                     /product="receptor-transporting protein 4"
                     /protein_id="NP_071430.2"
                     /db_xref="CCDS:CCDS33910.1"
                     /db_xref="GeneID:64108"
                     /db_xref="HGNC:HGNC:23992"
                     /db_xref="MIM:609350"
                     /translation="MVVDFWTWEQTFQELIQEAKPRATWTLKLDGNLQLDCLAQGWKQ
                     YQQRAFGWFRCSSCQRSWASAQVQILCHTYWEHWTSQGQVRMRLFGQRCQKCSWSQYE
                     MPEFSSDSTMRILSNLVQHILKKYYGNGTRKSPEMPVILEVSLEGSHDTANCEACTLG
                     ICGQGLKSCMTKPSKSLLPHLKTGNSSPGIGAVYLANQAKNQSAEAKEAKGSGYEKLG
                     PSRDPDPLNICVFILLLVFIVVKCFTSE"
     exon            213..1501
                     /gene="RTP4"
                     /gene_synonym="IFRG28; Z3CXXC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      984..989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTP4"
                     /gene_synonym="IFRG28; Z3CXXC4"
                     /note="hexamer: AATAAA"
     polyA_site      1009
                     /gene="RTP4"
                     /gene_synonym="IFRG28; Z3CXXC4"
                     /note="major polyA site"
     regulatory      1477..1482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTP4"
                     /gene_synonym="IFRG28; Z3CXXC4"
                     /note="hexamer: CATAAA"
     polyA_site      1501
                     /gene="RTP4"
                     /gene_synonym="IFRG28; Z3CXXC4"
ORIGIN      
        1 ctcttcctga gaaacgagca aacctgaaag ctactctctc agcttcagag ggaaaaaatg
       61 gttgtagatt tctggacttg ggagcagaca tttcaagaac taatccaaga ggcaaaaccc
      121 cgggccacat ggacgctgaa gttggatggc aaccttcagc tagactgcct ggctcaaggg
      181 tggaagcaat accaacagag agcatttggc tggttccggt gttcctcctg ccagcgaagt
      241 tgggcttccg cccaagtgca gattctgtgc cacacgtact gggagcactg gacatcccag
      301 ggtcaggtgc gtatgaggct ctttggccaa aggtgccaga agtgctcctg gtcccaatat
      361 gagatgcctg agttctcctc ggatagcacc atgaggattc tgagcaacct ggtgcagcat
      421 atactgaaga aatactatgg aaatggcacg aggaagtctc cagaaatgcc agtaatcctg
      481 gaagtgtccc tggaaggatc ccatgacaca gccaattgtg aggcatgcac tttgggcatc
      541 tgtggacagg gcttaaaaag ctgcatgaca aagccgtcca aatccctact cccccaccta
      601 aagactggga attcctcacc tggaattggt gctgtgtacc tcgcaaacca agccaagaac
      661 cagtcagctg aggcaaaaga ggctaagggg agtgggtatg agaaattagg gcccagtcga
      721 gacccagatc cactgaacat ctgtgtcttt attttgctgc ttgtatttat tgtagtcaaa
      781 tgctttacat cagaatgatg aaaataggct tgccactttc tcttatttta attccatggt
      841 agtcaatgaa ctggctgcca ctttaatata actgaaaatt cattttgaga ccaagcagga
      901 tcaagtttgt agaataaaca ctggtttcct agccatcctc tgaaaacagt atgaaacatg
      961 accaagtaca taatggattt agtaataaat attgtcgaat tgctaaaaag tcttcaatca
     1021 ttcattcact aagtcactca gtgatatcaa tatacttagc tcagaaagtg tgggaggctg
     1081 aataatggtg tctcccaaca tatgcatgac ttaatcccca gaacctgtaa acatgttact
     1141 ttacatggta gaatggactt tgcggatgta attaaggacc ttgaaatggt tagattattt
     1201 catattgtcc gggtggataa gaaccaggat tttgtaacag ggaggcaaca agctcaaaat
     1261 cagaaaaaag agatttgtca atggaacaag aggttgaagt gctttgaagt tggaggaaga
     1321 ggtcacaggc aaaaaagtac aggcagcctt tagaaaccca aaaggacaaa ggaacagatt
     1381 ctcccctgga gtctgcagaa ggaaccagcc ctgcctgcac atggctttag cccagtgaca
     1441 ctgattttgg acatctgacc ttcagaactg cttgctcata aacttgtctt gttttaatgc
     1501 a
//
