LOCUS       NM_153708               2214 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens receptor transporter protein 1 (RTP1), mRNA.
ACCESSION   NM_153708
VERSION     NM_153708.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2214)
  AUTHORS   Fukutani,Y., Tamaki,R., Inoue,R., Koshizawa,T., Sakashita,S.,
            Ikegami,K., Ohsawa,I., Matsunami,H. and Yohda,M.
  TITLE     The N-terminal region of RTP1S plays important roles in dimer
            formation and odorant receptor-trafficking
  JOURNAL   J Biol Chem 294 (40), 14661-14673 (2019)
   PUBMED   31395660
  REMARK    GeneRIF: using recombinant proteins and split luciferase assays in
            mammalian cells, we provided evidence for the dimer formation of
            RTP1S. Furthermore, we determined that the 2nd Cys residue is
            required for the efficient dimerization of RTP1S. Altogether, these
            findings provide insights into the mechanism for plasma membrane
            transport of odorant receptors (ORs) by RTP1S.
REFERENCE   2  (bases 1 to 2214)
  AUTHORS   Yu,T., Su,X., Pan,Y. and Zhuang,H.
  TITLE     Receptor-transporting protein (RTP) family members play divergent
            roles in the functional expression of odorant receptors
  JOURNAL   PLoS One 12 (6), e0179067 (2017)
   PUBMED   28586385
  REMARK    GeneRIF: further cell-surface and permeabilized immunocytochemical
            studies revealed that odorant receptors (ORs) and the co-expressed
            RTP1S proteins were retained in the Golgi when co-transfected with
            RTP2, indicating that RTP1S and RTP2 could play different roles in
            the OR trafficking process.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2214)
  AUTHORS   Lin,Z., Liu,Z., Li,X., Li,F., Hu,Y., Chen,B., Wang,Z. and Liu,Y.
  TITLE     Whole-exome sequencing identifies a novel de novo mutation in
            DYNC1H1 in epileptic encephalopathies
  JOURNAL   Sci Rep 7 (1), 258 (2017)
   PUBMED   28325891
  REMARK    GeneRIF: Taken together, these results demonstrate DYNC1H1 as a
            strong candidate and RTP1 as a potential candidate on the onset of
            epileptic encephalopathies.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2214)
  AUTHORS   Wu,L., Pan,Y., Chen,G.Q., Matsunami,H. and Zhuang,H.
  TITLE     Receptor-transporting protein 1 short (RTP1S) mediates
            translocation and activation of odorant receptors by acting through
            multiple steps
  JOURNAL   J Biol Chem 287 (26), 22287-22294 (2012)
   PUBMED   22570474
  REMARK    GeneRIF: Receptor-transporting protein 1 short (RTP1S) mediates
            translocation and activation of odorant receptors by acting through
            multiple steps
REFERENCE   5  (bases 1 to 2214)
  AUTHORS   Zhuang,H. and Matsunami,H.
  TITLE     Synergism of accessory factors in functional expression of
            mammalian odorant receptors
  JOURNAL   J Biol Chem 282 (20), 15284-15293 (2007)
   PUBMED   17387175
REFERENCE   6  (bases 1 to 2214)
  AUTHORS   Behrens,M., Bartelt,J., Reichling,C., Winnig,M., Kuhn,C. and
            Meyerhof,W.
  TITLE     Members of RTP and REEP gene families influence functional bitter
            taste receptor expression
  JOURNAL   J Biol Chem 281 (29), 20650-20659 (2006)
   PUBMED   16720576
  REMARK    GeneRIF: RTP and REEP gene expression in human circumvallate
            papillae and testis, both of which are sites of taste receptor gene
            expression.
REFERENCE   7  (bases 1 to 2214)
  AUTHORS   Clark,A.J., Metherell,L.A., Cheetham,M.E. and Huebner,A.
  TITLE     Inherited ACTH insensitivity illuminates the mechanisms of ACTH
            action
  JOURNAL   Trends Endocrinol Metab 16 (10), 451-457 (2005)
   PUBMED   16271481
  REMARK    Review article
REFERENCE   8  (bases 1 to 2214)
  AUTHORS   Saito,H., Kubota,M., Roberts,R.W., Chi,Q. and Matsunami,H.
  TITLE     RTP family members induce functional expression of mammalian
            odorant receptors
  JOURNAL   Cell 119 (5), 679-691 (2004)
   PUBMED   15550249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC065202.1 and BC034744.1.
            
            On May 17, 2019 this sequence version replaced NM_153708.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065202.1, SRR7410570.229180.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312295.5/ ENSP00000311712.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1080              BC065202.1         1-1080
            1081-1216           BC034744.1         1047-1182
            1217-1221           BC065202.1         1217-1221
            1222-2214           BC034744.1         1183-2175
FEATURES             Location/Qualifiers
     source          1..2214
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3"
     gene            1..2214
                     /gene="RTP1"
                     /gene_synonym="Z3CXXC1"
                     /note="receptor transporter protein 1"
                     /db_xref="GeneID:132112"
                     /db_xref="HGNC:HGNC:28580"
                     /db_xref="MIM:609137"
     exon            1..302
                     /gene="RTP1"
                     /gene_synonym="Z3CXXC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..822
                     /gene="RTP1"
                     /gene_synonym="Z3CXXC1"
                     /note="zinc finger, 3CxxC-type 1; 3CxxC-type zinc finger
                     protein 1; receptor (chemosensory) transporter protein 1"
                     /codon_start=1
                     /product="receptor-transporting protein 1"
                     /protein_id="NP_714919.2"
                     /db_xref="CCDS:CCDS3287.2"
                     /db_xref="GeneID:132112"
                     /db_xref="HGNC:HGNC:28580"
                     /db_xref="MIM:609137"
                     /translation="MRIFRPWRLRCPALHLPSLSVFSLRWKLPSLTTDETMCKSVTTD
                     EWKKVFYEKMEEAKPADSWDLIIDPNLKHNVLSPGWKQYLELHASGRFHCSWCWHTWQ
                     SPYVVILFHMFLDRAQRAGSVRMRVFKQLCYECGTARLDESSMLEENIEGLVDNLITS
                     LREQCYGERGGQYRIHVASRQDNRRHRGEFCEACQEGIVHWKPSEKLLEEEATTYTFS
                     RAPSPTKSQDQTGSGWNFCSIPWCLFWATVLLLIIYLQFSFRSSV"
     exon            303..2214
                     /gene="RTP1"
                     /gene_synonym="Z3CXXC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2193..2198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTP1"
                     /gene_synonym="Z3CXXC1"
                     /note="hexamer: AATAAA"
     polyA_site      2214
                     /gene="RTP1"
                     /gene_synonym="Z3CXXC1"
                     /note="major polyA site"
ORIGIN      
        1 gctgggtcct gcttcctcct ggtcttgtcg atgaggattt ttagaccgtg gagactgcgc
       61 tgccctgccc tgcacctacc ctcactctcc gtgttctcac taaggtggaa attgccttcc
      121 ctcactactg acgagaccat gtgtaaaagc gtgaccacag atgagtggaa gaaagtcttc
      181 tatgagaaga tggaggaggc aaagccggct gacagctggg acctcatcat agaccccaac
      241 ctcaagcaca atgtgctgag ccctggttgg aagcagtacc tggaattgca tgcttcaggc
      301 aggttccact gctcctggtg ctggcacacc tggcagtcgc cctacgtggt catcctcttc
      361 cacatgttcc tggaccgcgc ccagcgggcg ggctcggtgc gcatgcgcgt cttcaagcag
      421 ctgtgctatg agtgcggcac ggcgcggctg gacgagtcca gcatgctgga ggagaacatc
      481 gagggcctgg tggacaacct catcaccagc ctgcgcgagc agtgctacgg cgagcgtggc
      541 ggccagtacc gcatccacgt ggccagccgc caggacaacc ggcggcaccg cggagagttc
      601 tgcgaggcct gccaggaggg catcgtgcac tggaagccca gcgagaagct gctggaggag
      661 gaggcgacca cctacacctt ctcccgggcg cccagcccca ccaagtcgca ggaccagacg
      721 ggctcaggct ggaacttctg ctctatcccc tggtgcttgt tttgggccac ggtcctgctg
      781 ctgatcatct acctgcagtt ctctttccgt agctccgtat aagattccgt ggttgggccc
      841 agagcctgtc gagggtgcca gttagctgat gcgagggtag aggagagacg tgggttgaga
      901 atagtgtaaa cttctagcgc tggtgatgtc actgactcag tggggatctt ggacaaatta
      961 tacagttttt ccatctataa aactcagggt ttgggcaaga tcattggttt atcatagtga
     1021 aacccaggac cccaaagttc tgcgtaggtg cctcagggac ttttggattt ggaaagtagg
     1081 ctaagctagt gggtgtctcc aactcctgat ctaaacaccc atcctccaac tcctacctcc
     1141 tcctcttgct tcgatcagaa cagctttact ttagataggg ttccatttaa gatttttgta
     1201 ccaaaaaaaa aaaaaaaaaa agtttaacta cttttaaaaa gtttgaaaat tagaggactg
     1261 ggtgatctca aaagggcttt ccacagtaat gagctcgacc ttgctcttat tagtccctca
     1321 cccctgcccc tcatgatctc ccactttctc tagctgcagc cttaaattag cttctttgcc
     1381 caccctgtga gcctcatccg tgattctgcc ttcacacacg cagcagaggt ttcccttgaa
     1441 gtgcaagagg tgggagatca ggctgttcct ttgctgccag gtacacaggg tctctttttt
     1501 ttgtttctca gattccagct tctttccact cagggcagat tctggggtct gcctgcctga
     1561 aagatggtgg ttggggtggg gtctcataga gttaggcttc tcacccactg cgtattaact
     1621 ggcagagaat ttaggggagg ttcagaagac agagttttag aagcaaagca caaaatctct
     1681 gggaggcatt ataatggagg gtcttcagag ttcggggacc aagtctagca gattctcagc
     1741 agtgctgatg gccagaattc aggagcaggg gcctggcctc ctgggttctt tgctgaaatt
     1801 atagttgaat ggctttctca cattggccaa gcatgaggcc tcttgccaaa gatcagctgt
     1861 ccccctaaag ccacagggat ggggtatctt cagcaagaga gagggcgtta aagatgtaaa
     1921 atgctttgtc catggggaag tgcacagata tgtgggagaa ccttacaagg ctctaaaatg
     1981 agatgtgata tggcttgaaa tgggaggaga cactttctga cagtgggggg tctggaatgg
     2041 aattggtggg gacaggcagc aagctgcact tttgaggggc ctcatttacc ccacctctgt
     2101 taaaaacttg actactctcc tctttaatag aaagtcacca tcatctgtag tgatggagga
     2161 agggggtcac ttatataaag atgggacact ttaataaaga caggatatct tcca
//
