LOCUS       NM_178570               2224 bp    mRNA    linear   PRI 20-NOV-2022
DEFINITION  Homo sapiens reticulon 4 receptor like 2 (RTN4RL2), mRNA.
ACCESSION   NM_178570
VERSION     NM_178570.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2224)
  AUTHORS   Quaglia F, Krishn SR, Sossey-Alaoui K, Rana PS, Pluskota E, Park
            PH, Shields CD, Lin S, McCue P, Kossenkov AV, Wang Y, Goodrich DW,
            Ku SY, Beltran H, Kelly WK, Corey E, Klose M, Bandtlow C, Liu Q,
            Altieri DC, Plow EF and Languino LR.
  TITLE     The NOGO receptor NgR2, a novel alphaVbeta3 integrin effector,
            induces neuroendocrine differentiation in prostate cancer
  JOURNAL   Sci Rep 12 (1), 18879 (2022)
   PUBMED   36344556
  REMARK    GeneRIF: The NOGO receptor NgR2, a novel alphaVbeta3 integrin
            effector, induces neuroendocrine differentiation in prostate
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2224)
  AUTHORS   Saha N, Kolev M and Nikolov DB.
  TITLE     Structural features of the Nogo receptor signaling complexes at the
            neuron/myelin interface
  JOURNAL   Neurosci Res 87, 1-7 (2014)
   PUBMED   24956133
  REMARK    GeneRIF: Authors highlight the structural and biochemical aspects
            of the interaction of Nogo receptors (R1 and R2) with myelin
            inhibitors such as MAG, Nogo A and OMgp.[Review]
            Review article
REFERENCE   3  (bases 1 to 2224)
  AUTHORS   McDonald CL, Steinbach K, Kern F, Schweigreiter R, Martin R,
            Bandtlow CE and Reindl M.
  TITLE     Nogo receptor is involved in the adhesion of dendritic cells to
            myelin
  JOURNAL   J Neuroinflammation 8, 113 (2011)
   PUBMED   21906273
  REMARK    GeneRIF: These results indicate that a lack of NgR1/2 expression
            promotes the adhesion of DCs to myelin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2224)
  AUTHORS   Thomas R, Favell K, Morante-Redolat J, Pool M, Kent C, Wright M,
            Daignault K, Ferraro GB, Montcalm S, Durocher Y, Fournier A,
            Perez-Tur J and Barker PA.
  TITLE     LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based
            growth inhibition
  JOURNAL   J Neurosci 30 (19), 6607-6612 (2010)
   PUBMED   20463223
REFERENCE   5  (bases 1 to 2224)
  AUTHORS   Lee H, Raiker SJ, Venkatesh K, Geary R, Robak LA, Zhang Y, Yeh HH,
            Shrager P and Giger RJ.
  TITLE     Synaptic function for the Nogo-66 receptor NgR1: regulation of
            dendritic spine morphology and activity-dependent synaptic strength
  JOURNAL   J Neurosci 28 (11), 2753-2765 (2008)
   PUBMED   18337405
  REMARK    GeneRIF: Nogo-66 receptor homolog 1 signaling regulates
            activity-dependent synaptic strength and neuronal plasticity.
REFERENCE   6  (bases 1 to 2224)
  AUTHORS   Walmsley AR, Mir AK and Frentzel S.
  TITLE     Ectodomain shedding of human Nogo-66 receptor homologue-1 by zinc
            metalloproteinases
  JOURNAL   Biochem Biophys Res Commun 327 (1), 112-116 (2005)
   PUBMED   15629437
  REMARK    GeneRIF: The release of N-terminal fragment-NgRH1 was blocked by a
            hydroxamate-based zinc metalloproteinase inhibitor and tissue
            inhibitor of metalloproteinases-2 and -3
REFERENCE   7  (bases 1 to 2224)
  AUTHORS   Lauren J, Airaksinen MS, Saarma M and Timmusk T.
  TITLE     Two novel mammalian Nogo receptor homologs differentially expressed
            in the central and peripheral nervous systems
  JOURNAL   Mol Cell Neurosci 24 (3), 581-594 (2003)
   PUBMED   14664809
  REMARK    GeneRIF: predominantly expressed in the neurons of the embryonic
            and adult nervous systems
REFERENCE   8  (bases 1 to 2224)
  AUTHORS   Barton WA, Liu BP, Tzvetkova D, Jeffrey PD, Fournier AE, Sah D,
            Cate R, Strittmatter SM and Nikolov DB.
  TITLE     Structure and axon outgrowth inhibitor binding of the Nogo-66
            receptor and related proteins
  JOURNAL   EMBO J 22 (13), 3291-3302 (2003)
   PUBMED   12839991
REFERENCE   9  (bases 1 to 2224)
  AUTHORS   Pignot V, Hein AE, Barske C, Wiessner C, Walmsley AR, Kaupmann K,
            Mayeur H, Sommer B, Mir AK and Frentzel S.
  TITLE     Characterization of two novel proteins, NgRH1 and NgRH2,
            structurally and biochemically homologous to the Nogo-66 receptor
  JOURNAL   J Neurochem 85 (3), 717-728 (2003)
   PUBMED   12694398
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002893.3, BU845536.1, BC113673.1, AF532858.1, BE410139.1 and
            HY323308.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178570.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113673.1, AF532858.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335099.8/ ENSP00000335397.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AP002893.3         31025-31033
            10-319              BU845536.1         1-310
            320-338             BC113673.1         4-22
            339-1601            AF532858.1         1-1263
            1602-1739           BE410139.1         269-406
            1740-2224           HY323308.1         8-492               c
FEATURES             Location/Qualifiers
     source          1..2224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..2224
                     /gene="RTN4RL2"
                     /gene_synonym="NgR2; NGRH1"
                     /note="reticulon 4 receptor like 2"
                     /db_xref="GeneID:349667"
                     /db_xref="HGNC:HGNC:23053"
                     /db_xref="MIM:610462"
     exon            1..369
                     /gene="RTN4RL2"
                     /gene_synonym="NgR2; NGRH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..1601
                     /gene="RTN4RL2"
                     /gene_synonym="NgR2; NGRH1"
                     /note="Nogo-66 receptor homolog 1; nogo receptor-like 3;
                     nogo-66 receptor-related protein 2"
                     /codon_start=1
                     /product="reticulon-4 receptor-like 2 precursor"
                     /protein_id="NP_848665.1"
                     /db_xref="CCDS:CCDS7957.1"
                     /db_xref="GeneID:349667"
                     /db_xref="HGNC:HGNC:23053"
                     /db_xref="MIM:610462"
                     /translation="MLPGLRRLLQAPASACLLLMLLALPLAAPSCPMLCTCYSSPPTV
                     SCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTF
                     RHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYL
                     YLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGV
                     HRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWF
                     QRARVSSSDVTCATPPERQGRDLRALREADFQACPPAAPTRPGSRARGNSSSNHLYGV
                     AEAGAPPADPSTLYRDLPAEDSRGRQGGDAPTEDDYWGGYGGEDQRGEQMCPGAACQA
                     PPDSRGPALSAGLPSPLLCLLLLVPHHL"
     exon            370..851
                     /gene="RTN4RL2"
                     /gene_synonym="NgR2; NGRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..2224
                     /gene="RTN4RL2"
                     /gene_synonym="NgR2; NGRH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2203..2208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTN4RL2"
                     /gene_synonym="NgR2; NGRH1"
                     /note="hexamer: ATTAAA"
     polyA_site      2224
                     /gene="RTN4RL2"
                     /gene_synonym="NgR2; NGRH1"
                     /note="major polyA site"
ORIGIN      
        1 actctccctc ggctagcagc ctgggcacac ggacagacgg actgacggac tctcgagcgg
       61 acagcgcagc tagcggggcg cgggcgctgg gcgtcgacgg ccagccccag ccttccccgc
      121 cccgtcgcgc cccgccccgt cccgtcgggg ccgatggctc ctcccgaggc ccgcagcccg
      181 ggcggcgcag ggtagagcgc cgcggcccgg ccacgcagcc cggggactcc cgggccctcc
      241 cggagccccg cggggtcccc gccgtgcatc cggcgggctc agggagcgag tgggagcgcc
      301 ctccccccgc tgccccctcc cccgagcatc gagacaagat gctgcccggg ctcaggcgcc
      361 tgctgcaagc tcccgcctcg gcctgcctcc tgctgatgct cctggccctg cccctggcgg
      421 cccccagctg ccccatgctc tgcacctgct actcatcccc gcccaccgtg agctgccagg
      481 ccaacaactt ctcctctgtg ccgctgtccc tgccacccag cactcagcga ctcttcctgc
      541 agaacaacct catccgcacg ctgcggccag gcacctttgg gtccaacctg ctcaccctgt
      601 ggctcttctc caacaacctc tccaccatct acccgggcac tttccgccac ttgcaagccc
      661 tggaggagct ggacctcggt gacaaccggc acctgcgctc gctggagccc gacaccttcc
      721 agggcctgga gcggctgcag tcgctgcatt tgtaccgctg ccagctcagc agcctgcccg
      781 gcaacatctt ccgaggcctg gtcagcctgc agtacctcta cctccaggag aacagcctgc
      841 tccacctaca ggatgacttg ttcgcggacc tggccaacct gagccacctc ttcctccacg
      901 ggaaccgcct gcggctgctc acagagcacg tgtttcgcgg cctgggcagc ctggaccggc
      961 tgctgctgca cgggaaccgg ctgcagggcg tgcaccgcgc ggccttccgc ggcctcagcc
     1021 gcctcaccat cctctacctg ttcaacaaca gcctggcctc gctgcccggc gaggcgctcg
     1081 ccgacctgcc ctcgctcgag ttcctgcggc tcaacgctaa cccctgggcg tgcgactgcc
     1141 gcgcgcggcc gctctgggcc tggttccagc gcgcgcgcgt gtccagctcc gacgtgacct
     1201 gcgccacccc cccggagcgc cagggccgag acctgcgcgc gctccgcgag gccgacttcc
     1261 aggcgtgtcc gcccgcggca cccacgcggc cgggcagccg cgcccgcggc aacagctcct
     1321 ccaaccacct gtacggggtg gccgaggccg gggcgccccc agccgatccc tccaccctct
     1381 accgagatct gcctgccgaa gactcgcggg ggcgccaggg cggggacgcg cctactgagg
     1441 acgactactg ggggggctac gggggtgagg accagcgagg ggagcagatg tgccccggcg
     1501 ctgcctgcca ggcgcccccg gactcccgag gccctgcgct ctcggccggg ctccccagcc
     1561 ctctgctttg cctcctgctc ctggtgcccc accacctctg actgcggtgc tgagatcgaa
     1621 gaggccagtg tccgatcccc gcttcccgtc cacccggggc tgcggctccg gccccagtcg
     1681 ccccaccttc cctggccttg ctgcctccct ttcccctccc agctcctctc ctccccgggg
     1741 agcaggccgc ctctccttgc ctgccccctg ggctgtcctg acttgtggca gccccaagag
     1801 ggcgtgtgtg gtggctcagc cctgccctcc ccagttctgg ccattaactc ttccccatcc
     1861 caaggctggg gtggggcccc ccaggcagcc gctgacccgc actcctaagg gcccacagcg
     1921 gacaccagag gggcttttgt ctgcagagcg tcttccacca gcagagcctt tggaagctcc
     1981 cccagggagc cccacccagg accctttggg ggatgcctca gtcagggcca ggctgaccct
     2041 gacccctgct taccctagtc ccctcaacct cctgacactg gaggaatact tttctcctaa
     2101 gtctaccctg gacacttttt agggcacctg gagagaactt tcctctccac tgtggcccct
     2161 gcgtggtgaa gatcaaaaga agttgtttgg gaaaaaaaat ttattaaaaa attctattat
     2221 ttta
//
