LOCUS       NM_178568               3614 bp    mRNA    linear   PRI 28-OCT-2024
DEFINITION  Homo sapiens reticulon 4 receptor like 1 (RTN4RL1), mRNA.
ACCESSION   NM_178568
VERSION     NM_178568.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3614)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3614)
  AUTHORS   He,J.Y., Han,P., Zhang,Y., Liu,Y.D., Song,S.J., Feng,G.K., An,Y.,
            Zhou,A.J., Wang,H.B., Yuan,L., Lin,Z.R., Xia,T.L., Li,M.Z.,
            Liu,Y.M., Huang,X.M., Zhang,H. and Zhong,Q.
  TITLE     Overexpression of Nogo receptor 3 (NgR3) correlates with poor
            prognosis and contributes to the migration of epithelial cells of
            nasopharyngeal carcinoma patients
  JOURNAL   J Mol Med (Berl) 96 (3-4), 265-279 (2018)
   PUBMED   29327067
  REMARK    GeneRIF: RTN4RL1 plays an important role in promoting the EMT of
            nasopharyngeal carcinoma (NPC) by regulating the phosphorylation of
            Src and FAK, thus activating their downstream pathways and
            eventually altering E-cadherin levels, F-actin polymerization, and
            cell polarity. Additionally, a high level of RTN4RL1 correlates
            with a poor prognosis of NPC.
REFERENCE   3  (bases 1 to 3614)
  AUTHORS   Tang,M., Yang,Y.F., Xie,L., Chen,J.L., Zhang,W.Z., Wang,J.,
            Zhao,T.L., Yang,J.F. and Tan,Z.P.
  TITLE     Duplication of 10q22.3-q23.3 encompassing BMPR1A and NGR3
            associated with congenital heart disease, microcephaly, and mild
            intellectual disability
  JOURNAL   Am J Med Genet A 167A (12), 3174-3179 (2015)
   PUBMED   26383923
  REMARK    GeneRIF: Duplication of 10q22.3-q23.3 encompassing NGR3 gene is
            associated with congenital heart disease, microcephaly, and mild
            intellectual disability
REFERENCE   4  (bases 1 to 3614)
  AUTHORS   Zhang,L., Kuang,X. and Zhang,J.
  TITLE     Nogo receptor 3, a paralog of Nogo-66 receptor 1 (NgR1), may
            function as a NgR1 co-receptor for Nogo-66
  JOURNAL   J Genet Genomics 38 (11), 515-523 (2011)
   PUBMED   22133682
  REMARK    GeneRIF: Nogo receptor 3, a paralog of NgR1,functions as a NgR1
            co-receptor for Nogo-66.
REFERENCE   5  (bases 1 to 3614)
  AUTHORS   Thomas,R., Favell,K., Morante-Redolat,J., Pool,M., Kent,C.,
            Wright,M., Daignault,K., Ferraro,G.B., Montcalm,S., Durocher,Y.,
            Fournier,A., Perez-Tur,J. and Barker,P.A.
  TITLE     LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based
            growth inhibition
  JOURNAL   J Neurosci 30 (19), 6607-6612 (2010)
   PUBMED   20463223
REFERENCE   6  (bases 1 to 3614)
  AUTHORS   Lauren,J., Airaksinen,M.S., Saarma,M. and Timmusk,T.
  TITLE     Two novel mammalian Nogo receptor homologs differentially expressed
            in the central and peripheral nervous systems
  JOURNAL   Mol Cell Neurosci 24 (3), 581-594 (2003)
   PUBMED   14664809
  REMARK    GeneRIF: predominantly expressed in the neurons of the embryonic
            and adult nervous systems
REFERENCE   7  (bases 1 to 3614)
  AUTHORS   Barton,W.A., Liu,B.P., Tzvetkova,D., Jeffrey,P.D., Fournier,A.E.,
            Sah,D., Cate,R., Strittmatter,S.M. and Nikolov,D.B.
  TITLE     Structure and axon outgrowth inhibitor binding of the Nogo-66
            receptor and related proteins
  JOURNAL   EMBO J 22 (13), 3291-3302 (2003)
   PUBMED   12839991
REFERENCE   8  (bases 1 to 3614)
  AUTHORS   Pignot,V., Hein,A.E., Barske,C., Wiessner,C., Walmsley,A.R.,
            Kaupmann,K., Mayeur,H., Sommer,B., Mir,A.K. and Frentzel,S.
  TITLE     Characterization of two novel proteins, NgRH1 and NgRH2,
            structurally and biochemically homologous to the Nogo-66 receptor
  JOURNAL   J Neurochem 85 (3), 717-728 (2003)
   PUBMED   12694398
REFERENCE   9  (bases 1 to 3614)
  AUTHORS   Wang,K.C., Koprivica,V., Kim,J.A., Sivasankaran,R., Guo,Y.,
            Neve,R.L. and He,Z.
  TITLE     Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that
            inhibits neurite outgrowth
  JOURNAL   Nature 417 (6892), 941-944 (2002)
   PUBMED   12068310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099684.7 and AC130689.8.
            
            On Nov 23, 2018 this sequence version replaced NM_178568.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138522.549692.1, AL535679.3
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331238.7/ ENSP00000330631.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               AC099684.7         159777-160258       c
            483-3614            AC130689.8         14183-17314
FEATURES             Location/Qualifiers
     source          1..3614
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..3614
                     /gene="RTN4RL1"
                     /gene_synonym="NgR3; NGRH2"
                     /note="reticulon 4 receptor like 1"
                     /db_xref="GeneID:146760"
                     /db_xref="HGNC:HGNC:21329"
                     /db_xref="MIM:610461"
     exon            1..482
                     /gene="RTN4RL1"
                     /gene_synonym="NgR3; NGRH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             470..1795
                     /gene="RTN4RL1"
                     /gene_synonym="NgR3; NGRH2"
                     /note="Nogo-66 receptor homolog 2; Nogo-66
                     receptor-related protein 3; nogo receptor-like 2"
                     /codon_start=1
                     /product="reticulon-4 receptor-like 1 precursor"
                     /protein_id="NP_848663.1"
                     /db_xref="CCDS:CCDS45569.1"
                     /db_xref="GeneID:146760"
                     /db_xref="HGNC:HGNC:21329"
                     /db_xref="MIM:610461"
                     /translation="MLRKGCCVELLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHN
                     FAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHL
                     EELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNH
                     IEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFH
                     DLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCRARSLWEWLQRFRGS
                     SSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPASPHQIKSHTLTTTDRAARKEHHSPHG
                     PTRSKGHPHGPRPGHRKPGKNCTNPRNRNQISKAGAGKQAPELPDYAPDYQHKFSFDI
                     MPTARPKRKGKCARRTPIRAPSGVQQASSASSLGASLLAWTLGLAVTLR"
     exon            483..3614
                     /gene="RTN4RL1"
                     /gene_synonym="NgR3; NGRH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3593..3598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTN4RL1"
                     /gene_synonym="NgR3; NGRH2"
                     /note="hexamer: AATAAA"
     polyA_site      3614
                     /gene="RTN4RL1"
                     /gene_synonym="NgR3; NGRH2"
                     /note="major polyA site"
ORIGIN      
        1 gatcgctcgg tcctgcaaac gcgcgccggg cgctttcccc ggagctcggc ggtgcgtgcg
       61 agcgcccttt tgctgcagcc gcggcggcgg tggtccgagg gggcggagag gagggggctg
      121 cggccggccg gccagggggc ggcgtccccc ctcaaaaccg cctgcgaagt gctccgggtg
      181 gcagaagcag gccgccggct ccgcggagca agccgctcgc cccggggctg agcaagcgcg
      241 cggggctgcc gggcagcacc acggttgctt gcgggcgccg gtgccctcgg cgcggggctg
      301 gagctcacca tgcccctgcg gggccgggcc accgggcacg agcggatccc cggcttgccc
      361 ccgcctcgac gcgctcggat tagctgcagc tggcgcccag ggatttgaat ctggaccccg
      421 ggagggagtg cgcctaggcc gacctcggag cggcggcccc gtggccaaca tgcttcgcaa
      481 agggtgctgt gtggagttgc tgctgctgtt ggtagctgcg gagctgcccc tgggtggtgg
      541 ctgcccacgg gactgtgtgt gctacccggc gcccatgacg gtcagctgcc aggcgcacaa
      601 ctttgcagcc atcccggagg gcatccccgt ggacagcgag cgcgtcttcc tgcagaacaa
      661 ccgcatcggc ctcctccagc ccggccactt cagccccgcc atggtcaccc tgtggatcta
      721 ctcgaacaac atcacctaca tccaccccag caccttcgag ggcttcgtgc acctggagga
      781 gctggacctc ggcgacaacc ggcagctgcg gacgctggca cccgagacct tccagggcct
      841 ggtgaagctt cacgccctct acctctacaa gtgtgggctc agcgccttgc cggccggcgt
      901 ctttggcggc ctgcacagcc tgcagtacct ctacctgcag gacaaccaca tcgagtacct
      961 ccaggacgac atcttcgtgg acctggtcaa cctcagccac ctgtttctcc acggcaacaa
     1021 gctgtggagt ctgggcccgg gcaccttccg gggcctggtg aacctggacc gtcttttgct
     1081 gcacgagaac cagctgcagt gggtccacca caaggcgttc cacgacctcc gcaggctgac
     1141 caccctcttc ctcttcaaca acagcctctc ggagctgcag ggtgagtgcc tggccccgct
     1201 gggggccctg gagttcctcc gcctcaacgg caacccctgg gactgtggtt gtcgcgcgcg
     1261 ctccctgtgg gaatggctgc agaggttccg gggctccagc tccgctgtcc cctgtgtgtc
     1321 ccctgggctg cggcacggcc aggacctgaa gctgctgagg gccgaggact tccggaactg
     1381 cacgggacca gcgtccccgc accagatcaa gtcacacacg ctcaccacca ccgacagggc
     1441 cgcccgcaag gaacaccact caccccacgg ccccaccagg agcaagggcc acccgcacgg
     1501 cccccggccc ggccacagga agccggggaa gaactgcacc aaccccagga accgcaatca
     1561 gatctctaag gcgggcgccg ggaaacaggc ccccgagctg ccagactatg ccccagacta
     1621 ccagcacaag ttcagttttg acatcatgcc tacggcccgg cccaagagga agggcaagtg
     1681 tgcccgcagg acccccatcc gtgcccccag cggggtgcag caggcctcct cggccagttc
     1741 cctgggggcc tccctcctgg cctggacact ggggctggcg gtcactctcc gctgaggacc
     1801 cagggcgtca gcacccagca ctgccacatg tccaccaagg aacagaattt attttcttct
     1861 ttttttaaca agtggaagat ctgctgggtt tcaggaaaag gctggtagag ccttcggctg
     1921 ctgtctggac gtctggaccc tgccatgtgg attataaacc caaagtgtac agccctaggc
     1981 gggagggggt ggcgcttctc agccggctgt cccagccagc cccgcagagc gcccacggac
     2041 agtgtccact ctggcaaggt gggaaaaggc actccaagtg catcctccac tggcaacagt
     2101 gggacaattg cccccgacgg cggcaccggg gctctgtgga atcccgatcg ttccgagagg
     2161 tctggagggc cccgtggttc ctggagaaag caggacgcag agaagaacaa atgaggctca
     2221 cccacgaggc tgggtggcca gcagtctggg cacacacgag caggtggcat cttggctctt
     2281 gcctgaggcc agtcaccctg ccctgaattc tatcctactc caccttcagc ccctccctcg
     2341 ggggtagcgc ctctcattcc tgatgtctca ggcaaccctg gcagacccag gtccaactgc
     2401 tggggtccaa gaaccaatta ccaaaggaaa gatcatcaga ggctgaaatc tagaacttca
     2461 tcccgggcaa tgaggttctc acagaaggtg cagttttata actaactacg tccacttata
     2521 tatattcaca ctctacatat atatatatat atatatatat atatatatat atatatatac
     2581 acaaatgcac agtccccctc ccactccgtt acctaactgt acgtcttttc atgtttataa
     2641 actatacaga aaactgtatt tgctgaacta aggattgtat tggtgatttc tagcaaaaac
     2701 aaagtgatag aatttttgtc tagaatccca aactggcaac gatagtctcc aagggacctg
     2761 gccttgccaa gggcctgggg caaggtgtcg gcgggacggt gaggaagggg gaggcagcaa
     2821 gagtcacttt gggggaccaa tattcttaga tatttagagc atcaccttgt ttttatatgc
     2881 aacacaagcc tgtctgccac cctggagcgc cctgtcaccc ctgctgtcgt agctgttggc
     2941 ttcagggtga gaagtgagaa gcagcttatt gtatatgagg gagccaggcc ccgagggtga
     3001 gcgagatgga gaaggggaag gaaggggctt tgggatctgg aaaccagcag gccaggcagc
     3061 atccacagtg ttagtccaaa gggtcggacc gtgtcgtcag cctagcgttt ggtcagtgac
     3121 ggcctggacg ggccaaggag actccgggct tgagcccagg cctcccgcac ggctcagctg
     3181 ctgaattttt ccttgaggct gtttggtgtg tgacccagca agggccctgt gtgggacagc
     3241 aggagggagg cgtcgggggc cttagcagaa ggggaacaat gagggcattt catgaaccat
     3301 ctcaggcact tctgcatcac ggaagacctg gccctcccag ccgtcctggg gatgctcagg
     3361 gtgcaggcag aggctcggga ggccggactc aggggtcaga agcagggact ggggcaggcg
     3421 agcccggaca gggaagaggg gctccgatca aagccggccg tgctgctggc cgggggccca
     3481 ggtgggtaca agctcctttg tgctttgcac aaacctgaat cccccaccag agaggatgtg
     3541 tgtgaggagc cagaaacgct gaatccaatt aagagagaaa aataataata acaataaatg
     3601 atcttggaca agaa
//
