LOCUS       NM_023004               1944 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens reticulon 4 receptor (RTN4R), mRNA.
ACCESSION   NM_023004
VERSION     NM_023004.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1944)
  AUTHORS   Wang,J., Miao,Y., Wicklein,R., Sun,Z., Wang,J., Jude,K.M.,
            Fernandes,R.A., Merrill,S.A., Wernig,M., Garcia,K.C. and
            Sudhof,T.C.
  TITLE     RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal
            development
  JOURNAL   Cell 184 (24), 5869-5885 (2021)
   PUBMED   34758294
  REMARK    GeneRIF: RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates
            neuronal development.
            Erratum:[Cell. 2022 Jan 6;185(1):218. doi:
            10.1016/j.cell.2021.12.017.. PMID: 34995515]
REFERENCE   2  (bases 1 to 1944)
  AUTHORS   Hong,J.H., Kang,S., Sa,J.K., Park,G., Oh,Y.T., Kim,T.H., Yin,J.,
            Kim,S.S., D'Angelo,F., Koo,H., You,Y., Park,S., Kwon,H.J.,
            Kim,C.I., Ryu,H., Lin,W., Park,E.J., Kim,Y.J., Park,M.J., Kim,H.,
            Kim,M.S., Chung,S., Park,C.K., Park,S.H., Kang,Y.H., Kim,J.H.,
            Saya,H., Nakano,I., Gwak,H.S., Yoo,H., Lee,J., Hur,E.M., Shi,B.,
            Nam,D.H., Iavarone,A., Lee,S.H. and Park,J.B.
  TITLE     Modulation of Nogo receptor 1 expression orchestrates
            myelin-associated infiltration of glioblastoma
  JOURNAL   Brain 144 (2), 636-654 (2021)
   PUBMED   33479772
  REMARK    GeneRIF: Modulation of Nogo receptor 1 expression orchestrates
            myelin-associated infiltration of glioblastoma.
REFERENCE   3  (bases 1 to 1944)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1944)
  AUTHORS   Sato,S., Maekawa,R., Tamura,I., Shirafuta,Y., Shinagawa,M.,
            Asada,H., Taketani,T., Tamura,H. and Sugino,N.
  TITLE     SATB2 and NGR1: potential upstream regulatory factors in uterine
            leiomyomas
  JOURNAL   J Assist Reprod Genet 36 (11), 2385-2397 (2019)
   PUBMED   31728810
  REMARK    GeneRIF: SATB2 and NRG1 overexpression induced many of the
            signaling pathways.
REFERENCE   5  (bases 1 to 1944)
  AUTHORS   Kang,Y.H., Han,S.R., Jeon,H., Lee,S., Lee,J., Yoo,S.M., Park,J.B.,
            Park,M.J., Kim,J.T., Lee,H.G., Lee,M.S. and Lee,S.H.
  TITLE     Nogo receptor-vimentin interaction: a novel mechanism for the
            invasive activity of glioblastoma multiforme
  JOURNAL   Exp Mol Med 51 (10), 1-15 (2019)
   PUBMED   31649250
  REMARK    GeneRIF: the treatment of glioblastoma multiforme cells with TGFb1
            suppressed NgR maturation. We showed that NgR and vimentin
            interact, which could be a possible mechanism for the suppression
            of NgR maturation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1944)
  AUTHORS   GrandPre,T., Li,S. and Strittmatter,S.M.
  TITLE     Nogo-66 receptor antagonist peptide promotes axonal regeneration
  JOURNAL   Nature 417 (6888), 547-551 (2002)
   PUBMED   12037567
REFERENCE   7  (bases 1 to 1944)
  AUTHORS   Ng,C.E. and Tang,B.L.
  TITLE     Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron
            regeneration
  JOURNAL   J Neurosci Res 67 (5), 559-565 (2002)
   PUBMED   11891768
  REMARK    Review article
REFERENCE   8  (bases 1 to 1944)
  AUTHORS   Fournier,A.E., GrandPre,T. and Strittmatter,S.M.
  TITLE     Identification of a receptor mediating Nogo-66 inhibition of axonal
            regeneration
  JOURNAL   Nature 409 (6818), 341-346 (2001)
   PUBMED   11201742
REFERENCE   9  (bases 1 to 1944)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 1944)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007663.29, BM762412.1 and
            AL834449.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_023004.5.
            
            Summary: This gene encodes the receptor for reticulon 4,
            oligodendrocyte myelin glycoprotein and myelin-associated
            glycoprotein. This receptor mediates axonal growth inhibition and
            may play a role in regulating axonal regeneration and plasticity in
            the adult central nervous system. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL834449.1, ERR279866.1216.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000043402.8/ ENSP00000043402.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC007663.29        114609-114633       c
            26-82               BM762412.1         1-57
            83-1944             AL834449.1         1-1862
FEATURES             Location/Qualifiers
     source          1..1944
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..1944
                     /gene="RTN4R"
                     /gene_synonym="NGR; NOGOR"
                     /note="reticulon 4 receptor"
                     /db_xref="GeneID:65078"
                     /db_xref="HGNC:HGNC:18601"
                     /db_xref="MIM:605566"
     exon            1..248
                     /gene="RTN4R"
                     /gene_synonym="NGR; NOGOR"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1648
                     /gene="RTN4R"
                     /gene_synonym="NGR; NOGOR"
                     /note="nogo receptor; Nogo-66 receptor; UNQ330/PRO526"
                     /codon_start=1
                     /product="reticulon-4 receptor precursor"
                     /protein_id="NP_075380.1"
                     /db_xref="CCDS:CCDS13777.1"
                     /db_xref="GeneID:65078"
                     /db_xref="HGNC:HGNC:18601"
                     /db_xref="MIM:605566"
                     /translation="MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCP
                     QQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFT
                     GLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLY
                     LQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVH
                     PHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQ
                     KFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPK
                     CCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSAE
                     PPLTAVRPEGSEPPGFPTSGPRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGAL
                     PSLTCSLTPLGLALVLWTVLGPC"
     exon            249..1944
                     /gene="RTN4R"
                     /gene_synonym="NGR; NOGOR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1924..1929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTN4R"
                     /gene_synonym="NGR; NOGOR"
                     /note="hexamer: AATAAA"
     polyA_site      1944
                     /gene="RTN4R"
                     /gene_synonym="NGR; NOGOR"
                     /note="major polyA site"
ORIGIN      
        1 cccccgcgcc gccgccgccc tcgccctgtg cgccctgcgc gccctgcgca cccgcggccc
       61 gagcccagcc agagccgggc ggagcggagc gcgccgagcc tcgtcccgcg gccgggccgg
      121 ggccgggccg tagcggcggc gcctggatgc ggacccggcc gcggggagac gggcgcccgc
      181 cccgaaacga ctttcagtcc ccgacgcgcc ccgcccaacc cctacgatga agagggcgtc
      241 cgctggaggg agccggctgc tggcatgggt gctgtggctg caggcctggc aggtggcagc
      301 cccatgccca ggtgcctgcg tatgctacaa tgagcccaag gtgacgacaa gctgccccca
      361 gcagggcctg caggctgtgc ccgtgggcat ccctgctgcc agccagcgca tcttcctgca
      421 cggcaaccgc atctcgcatg tgccagctgc cagcttccgt gcctgccgca acctcaccat
      481 cctgtggctg cactcgaatg tgctggcccg aattgatgcg gctgccttca ctggcctggc
      541 cctcctggag cagctggacc tcagcgataa tgcacagctc cggtctgtgg accctgccac
      601 attccacggc ctgggccgcc tacacacgct gcacctggac cgctgcggcc tgcaggagct
      661 gggcccgggg ctgttccgcg gcctggctgc cctgcagtac ctctacctgc aggacaacgc
      721 gctgcaggca ctgcctgatg acaccttccg cgacctgggc aacctcacac acctcttcct
      781 gcacggcaac cgcatctcca gcgtgcccga gcgcgccttc cgtgggctgc acagcctcga
      841 ccgtctccta ctgcaccaga accgcgtggc ccatgtgcac ccgcatgcct tccgtgacct
      901 tggccgcctc atgacactct atctgtttgc caacaatcta tcagcgctgc ccactgaggc
      961 cctggccccc ctgcgtgccc tgcagtacct gaggctcaac gacaacccct gggtgtgtga
     1021 ctgccgggca cgcccactct gggcctggct gcagaagttc cgcggctcct cctccgaggt
     1081 gccctgcagc ctcccgcaac gcctggctgg ccgtgacctc aaacgcctag ctgccaatga
     1141 cctgcagggc tgcgctgtgg ccaccggccc ttaccatccc atctggaccg gcagggccac
     1201 cgatgaggag ccgctggggc ttcccaagtg ctgccagcca gatgccgctg acaaggcctc
     1261 agtactggag cctggaagac cagcttcggc aggcaatgcg ctgaagggac gcgtgccgcc
     1321 cggtgacagc ccgccgggca acggctctgg cccacggcac atcaatgact caccctttgg
     1381 gactctgcct ggctctgctg agcccccgct cactgcagtg cggcccgagg gctccgagcc
     1441 accagggttc cccacctcgg gccctcgccg gaggccaggc tgttcacgca agaaccgcac
     1501 ccgcagccac tgccgtctgg gccaggcagg cagcgggggt ggcgggactg gtgactcaga
     1561 aggctcaggt gccctaccca gcctcacctg cagcctcacc cccctgggcc tggcgctggt
     1621 gctgtggaca gtgcttgggc cctgctgacc cccagcggac acaagagcgt gctcagcagc
     1681 caggtgtgtg tacatacggg gtctctctcc acgccgccaa gccagccggg cggccgaccc
     1741 gtggggcagg ccaggccagg tcctccctga tggacgcctg ccgcccgcca cccccatctc
     1801 caccccatca tgtttacagg gttcggcggc agcgtttgtt ccagaacgcc gcctcccacc
     1861 cagatcgcgg tatatagaga tatgcatttt attttacttg tgtaaaaata tcggacgacg
     1921 tggaataaag agctcttttc ttaa
//
