LOCUS       NM_207521               4068 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens reticulon 4 (RTN4), transcript variant 5, mRNA.
ACCESSION   NM_207521
VERSION     NM_207521.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4068)
  AUTHORS   Nheu,D. and Petratos,S.
  TITLE     How does Nogo-A signalling influence mitochondrial function during
            multiple sclerosis pathogenesis?
  JOURNAL   Neurosci Biobehav Rev 163, 105767 (2024)
   PUBMED   38885889
  REMARK    GeneRIF: How does Nogo-A signalling influence mitochondrial
            function during multiple sclerosis pathogenesis?
            Review article
REFERENCE   2  (bases 1 to 4068)
  AUTHORS   Kratzel,A. and Thiel,V.
  TITLE     RTN3 and RTN4: Architects of SARS-CoV-2 replication organelles
  JOURNAL   J Cell Biol 222 (7) (2023)
   PUBMED   37318453
  REMARK    GeneRIF: RTN3 and RTN4: Architects of SARS-CoV-2 replication
            organelles.
REFERENCE   3  (bases 1 to 4068)
  AUTHORS   Ou,X., Peng,S., Han,X., Zhou,S., Fan,L. and Gao,X.
  TITLE     Association of RTN4 indel polymorphisms with the risk of
            tumorigenesis in the Chinese Han population
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (2), 74-78 (2023)
   PUBMED   37224043
  REMARK    GeneRIF: Association of RTN4 indel polymorphisms with the risk of
            tumorigenesis in the Chinese Han population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4068)
  AUTHORS   Kalafatakis,I., Papagianni,F., Theodorakis,K. and Karagogeos,D.
  TITLE     Nogo-A and LINGO-1: Two Important Targets for Remyelination and
            Regeneration
  JOURNAL   Int J Mol Sci 24 (5), 4479 (2023)
   PUBMED   36901909
  REMARK    GeneRIF: Nogo-A and LINGO-1: Two Important Targets for
            Remyelination and Regeneration.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4068)
  AUTHORS   Wang,Y., He,L., Huang,J., Li,J., Liu,L., Xu,Y., Peng,T., Yang,X.,
            Zhao,Y., Fu,C., Huang,S., Tang,H. and Xu,K.
  TITLE     Association of Nogo-A Gene Polymorphisms with Cerebral Palsy in
            Southern China: A Case-Control Study
  JOURNAL   Dev Neurosci 45 (1), 8-18 (2023)
   PUBMED   36323241
  REMARK    GeneRIF: Association of Nogo-A Gene Polymorphisms with Cerebral
            Palsy in Southern China: A Case-Control Study.
REFERENCE   6  (bases 1 to 4068)
  AUTHORS   Tagami,S., Eguchi,Y., Kinoshita,M., Takeda,M. and Tsujimoto,Y.
  TITLE     A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on
            endoplasmic reticulum and reduces their anti-apoptotic activity
  JOURNAL   Oncogene 19 (50), 5736-5746 (2000)
   PUBMED   11126360
REFERENCE   7  (bases 1 to 4068)
  AUTHORS   GrandPre,T., Nakamura,F., Vartanian,T. and Strittmatter,S.M.
  TITLE     Identification of the Nogo inhibitor of axon regeneration as a
            Reticulon protein
  JOURNAL   Nature 403 (6768), 439-444 (2000)
   PUBMED   10667797
REFERENCE   8  (bases 1 to 4068)
  AUTHORS   Chen,M.S., Huber,A.B., van der Haar,M.E., Frank,M., Schnell,L.,
            Spillmann,A.A., Christ,F. and Schwab,M.E.
  TITLE     Nogo-A is a myelin-associated neurite outgrowth inhibitor and an
            antigen for monoclonal antibody IN-1
  JOURNAL   Nature 403 (6768), 434-439 (2000)
   PUBMED   10667796
REFERENCE   9  (bases 1 to 4068)
  AUTHORS   Prinjha,R., Moore,S.E., Vinson,M., Blake,S., Morrow,R.,
            Christie,G., Michalovich,D., Simmons,D.L. and Walsh,F.S.
  TITLE     Inhibitor of neurite outgrowth in humans
  JOURNAL   Nature 403 (6768), 383-384 (2000)
   PUBMED   10667780
REFERENCE   10 (bases 1 to 4068)
  AUTHORS   Yang,J., Yu,L., Bi,A.D. and Zhao,S.Y.
  TITLE     Assignment of the human reticulon 4 gene (RTN4) to chromosome
            2p14-->2p13 by radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 101-102 (2000)
   PUBMED   10773680
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF333336.1, BC016165.1,
            AY123250.1, AF125103.1 and AF132048.1.
            
            On May 31, 2019 this sequence version replaced NM_207521.1.
            
            Summary: This gene belongs to the family of reticulon encoding
            genes. Reticulons are associated with the endoplasmic reticulum,
            and are involved in neuroendocrine secretion or in membrane
            trafficking in neuroendocrine cells. The product of this gene is a
            potent neurite outgrowth inhibitor which may also help block the
            regeneration of the central nervous system in higher vertebrates.
            Alternatively spliced transcript variants derived both from
            differential splicing and differential promoter usage and encoding
            different isoforms have been identified. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (5), also known as hRTN4-E,
            differs in the 5' UTR and the 5' coding region, compared to variant
            1. The resulting isoform (E) has a shorter N-terminus, compared to
            isoform A. This variant (5), along with variants 6, 7, 8, 9, 10,
            and 11, encodes isoform E.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY123248.1, AF333336.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AF333336.1         39-116
            79-135              BC016165.1         804-860
            136-3350            AY123250.1         129-3343
            3351-3795           AF125103.1         1064-1508
            3796-4068           AF132048.1         1407-1679
FEATURES             Location/Qualifiers
     source          1..4068
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.1"
     gene            1..4068
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /note="reticulon 4"
                     /db_xref="GeneID:57142"
                     /db_xref="HGNC:HGNC:14085"
                     /db_xref="MIM:604475"
     exon            1..78
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     exon            79..135
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     exon            136..2535
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..3101
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /note="isoform E is encoded by transcript variant 5;
                     neuroendocrine-specific protein C homolog; neurite
                     outgrowth inhibitor; foocen; reticulon 5; My043 protein;
                     neurite growth inhibitor 220; Human NogoA"
                     /codon_start=1
                     /product="reticulon-4 isoform E"
                     /protein_id="NP_997404.1"
                     /db_xref="CCDS:CCDS1852.1"
                     /db_xref="GeneID:57142"
                     /db_xref="HGNC:HGNC:14085"
                     /db_xref="MIM:604475"
                     /translation="MDLKEQPGNTISAGQEDFPSVLLETAASLPSLSPLSAASFKEHE
                     YLGNLSTVLPTEGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSP
                     KAESAVIVANPREEIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAK
                     DSFNEKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKC
                     FADSLEQTNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPL
                     LGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTE
                     EVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCP
                     SFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENP
                     PPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPD
                     FSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLT
                     ETSFESMIEYENKEKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEVSTLSKKEKIPL
                     QMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSKTDSFSKLARE
                     YTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATS
                     KVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKTS
                     VVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQ
                     AIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLK
                     FAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMA
                     KIQAKIPGLKRKAE"
     exon            2536..2743
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2882
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2952
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..2999
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3058
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..4068
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4047..4052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /note="hexamer: AATAAA"
     polyA_site      4068
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /note="major polyA site"
ORIGIN      
        1 cacattgacc caaccgcagt gaagggagag cgcctccagt ggtgtggtgc gtggagaaat
       61 gggaaggaga gagttctgat gagacccttt ttgctcttcc tgctgcatct gagcctgtga
      121 tacgctcctc tgcagaaaat atggacttga aggagcagcc aggtaacact atttcggctg
      181 gtcaagagga tttcccatct gtcctgcttg aaactgctgc ttctcttcct tctctgtctc
      241 ctctctcagc cgcttctttc aaagaacatg aataccttgg taatttgtca acagtattac
      301 ccactgaagg aacacttcaa gaaaatgtca gtgaagcttc taaagaggtc tcagagaagg
      361 caaaaactct actcatagat agagatttaa cagagttttc agaattagaa tactcagaaa
      421 tgggatcatc gttcagtgtc tctccaaaag cagaatctgc cgtaatagta gcaaatccta
      481 gggaagaaat aatcgtgaaa aataaagatg aagaagagaa gttagttagt aataacatcc
      541 ttcataatca acaagagtta cctacagctc ttactaaatt ggttaaagag gatgaagttg
      601 tgtcttcaga aaaagcaaaa gacagtttta atgaaaagag agttgcagtg gaagctccta
      661 tgagggagga atatgcagac ttcaaaccat ttgagcgagt atgggaagtg aaagatagta
      721 aggaagatag tgatatgttg gctgctggag gtaaaatcga gagcaacttg gaaagtaaag
      781 tggataaaaa atgttttgca gatagccttg agcaaactaa tcacgaaaaa gatagtgaga
      841 gtagtaatga tgatacttct ttccccagta cgccagaagg tataaaggat cgttcaggag
      901 catatatcac atgtgctccc tttaacccag cagcaactga gagcattgca acaaacattt
      961 ttcctttgtt aggagatcct acttcagaaa ataagaccga tgaaaaaaaa atagaagaaa
     1021 agaaggccca aatagtaaca gagaagaata ctagcaccaa aacatcaaac ccttttcttg
     1081 tagcagcaca ggattctgag acagattatg tcacaacaga taatttaaca aaggtgactg
     1141 aggaagtcgt ggcaaacatg cctgaaggcc tgactccaga tttagtacag gaagcatgtg
     1201 aaagtgaatt gaatgaagtt actggtacaa agattgctta tgaaacaaaa atggacttgg
     1261 ttcaaacatc agaagttatg caagagtcac tctatcctgc agcacagctt tgcccatcat
     1321 ttgaagagtc agaagctact ccttcaccag ttttgcctga cattgttatg gaagcaccat
     1381 tgaattctgc agttcctagt gctggtgctt ccgtgataca gcccagctca tcaccattag
     1441 aagcttcttc agttaattat gaaagcataa aacatgagcc tgaaaacccc ccaccatatg
     1501 aagaggccat gagtgtatca ctaaaaaaag tatcaggaat aaaggaagaa attaaagagc
     1561 ctgaaaatat taatgcagct cttcaagaaa cagaagctcc ttatatatct attgcatgtg
     1621 atttaattaa agaaacaaag ctttctgctg aaccagctcc ggatttctct gattattcag
     1681 aaatggcaaa agttgaacag ccagtgcctg atcattctga gctagttgaa gattcctcac
     1741 ctgattctga accagttgac ttatttagtg atgattcaat acctgacgtt ccacaaaaac
     1801 aagatgaaac tgtgatgctt gtgaaagaaa gtctcactga gacttcattt gagtcaatga
     1861 tagaatatga aaataaggaa aaactcagtg ctttgccacc tgagggagga aagccatatt
     1921 tggaatcttt taagctcagt ttagataaca caaaagatac cctgttacct gatgaagttt
     1981 caacattgag caaaaaggag aaaattcctt tgcagatgga ggagctcagt actgcagttt
     2041 attcaaatga tgacttattt atttctaagg aagcacagat aagagaaact gaaacgtttt
     2101 cagattcatc tccaattgaa attatagatg agttccctac attgatcagt tctaaaactg
     2161 attcattttc taaattagcc agggaatata ctgacctaga agtatcccac aaaagtgaaa
     2221 ttgctaatgc cccggatgga gctgggtcat tgccttgcac agaattgccc catgaccttt
     2281 ctttgaagaa catacaaccc aaagttgaag agaaaatcag tttctcagat gacttttcta
     2341 aaaatgggtc tgctacatca aaggtgctct tattgcctcc agatgtttct gctttggcca
     2401 ctcaagcaga gatagagagc atagttaaac ccaaagttct tgtgaaagaa gctgagaaaa
     2461 aacttccttc cgatacagaa aaagaggaca gatcaccatc tgctatattt tcagcagagc
     2521 tgagtaaaac ttcagttgtt gacctcctgt actggagaga cattaagaag actggagtgg
     2581 tgtttggtgc cagcctattc ctgctgcttt cattgacagt attcagcatt gtgagcgtaa
     2641 cagcctacat tgccttggcc ctgctctctg tgaccatcag ctttaggata tacaagggtg
     2701 tgatccaagc tatccagaaa tcagatgaag gccacccatt cagggcatat ctggaatctg
     2761 aagttgctat atctgaggag ttggttcaga agtacagtaa ttctgctctt ggtcatgtga
     2821 actgcacgat aaaggaactc aggcgcctct tcttagttga tgatttagtt gattctctga
     2881 agtttgcagt gttgatgtgg gtatttacct atgttggtgc cttgtttaat ggtctgacac
     2941 tactgatttt ggctctcatt tcactcttca gtgttcctgt tatttatgaa cggcatcagg
     3001 cacagataga tcattatcta ggacttgcaa ataagaatgt taaagatgct atggctaaaa
     3061 tccaagcaaa aatccctgga ttgaagcgca aagctgaatg aaaacgccca aaataattag
     3121 taggagttca tctttaaagg ggatattcat ttgattatac gggggagggt cagggaagaa
     3181 cgaaccttga cgttgcagtg cagtttcaca gatcgttgtt agatctttat ttttagccat
     3241 gcactgttgt gaggaaaaat tacctgtctt gactgccatg tgttcatcat cttaagtatt
     3301 gtaagctgct atgtatggat ttaaaccgta atcatatctt tttcctatct atctgaggca
     3361 ctggtggaat aaaaaacctg tatattttac tttgttgcag atagtcttgc cgcatcttgg
     3421 caagttgcag agatggtgga gctagaaaaa aaaaaaaaaa agcccttttc agtttgtgca
     3481 ctgtgtatgg tccgtgtaga ttgatgcaga ttttctgaaa tgaaatgttt gtttagacga
     3541 gatcataccg gtaaagcagg aatgacaaag cttgcttttc tggtatgttc taggtgtatt
     3601 gtgactttta ctgttatatt aattgccaat ataagtaaat atagattata tatgtatagt
     3661 gtttcacaaa gcttagacct ttaccttcca gccaccccac agtgcttgat atttcagagt
     3721 cagtcattgg ttatacatgt gtagttccaa agcacataag ctagaagaag aaatatttct
     3781 aggagcacta ccatctgttt tcaacatgaa atgccacaca catagaactc caacatcaat
     3841 ttcattgcac agactgactg tagttaattt tgtcacagaa tctatggact gaatctaatg
     3901 cttccaaaaa tgttgtttgt ttgcaaatat caaacattgt tatgcaagaa attattaatt
     3961 acaaaatgaa gatttatacc attgtggttt aagctgtact gaactaaatc tgtggaatgc
     4021 attgtgaact gtaaaagcaa agtatcaata aagcttatag acttaaaa
//
