LOCUS       NM_020532               4697 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens reticulon 4 (RTN4), transcript variant 1, mRNA.
ACCESSION   NM_020532
VERSION     NM_020532.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4697)
  AUTHORS   Nheu,D. and Petratos,S.
  TITLE     How does Nogo-A signalling influence mitochondrial function during
            multiple sclerosis pathogenesis?
  JOURNAL   Neurosci Biobehav Rev 163, 105767 (2024)
   PUBMED   38885889
  REMARK    GeneRIF: How does Nogo-A signalling influence mitochondrial
            function during multiple sclerosis pathogenesis?
            Review article
REFERENCE   2  (bases 1 to 4697)
  AUTHORS   Kratzel,A. and Thiel,V.
  TITLE     RTN3 and RTN4: Architects of SARS-CoV-2 replication organelles
  JOURNAL   J Cell Biol 222 (7) (2023)
   PUBMED   37318453
  REMARK    GeneRIF: RTN3 and RTN4: Architects of SARS-CoV-2 replication
            organelles.
REFERENCE   3  (bases 1 to 4697)
  AUTHORS   Ou,X., Peng,S., Han,X., Zhou,S., Fan,L. and Gao,X.
  TITLE     Association of RTN4 indel polymorphisms with the risk of
            tumorigenesis in the Chinese Han population
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (2), 74-78 (2023)
   PUBMED   37224043
  REMARK    GeneRIF: Association of RTN4 indel polymorphisms with the risk of
            tumorigenesis in the Chinese Han population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4697)
  AUTHORS   Kalafatakis,I., Papagianni,F., Theodorakis,K. and Karagogeos,D.
  TITLE     Nogo-A and LINGO-1: Two Important Targets for Remyelination and
            Regeneration
  JOURNAL   Int J Mol Sci 24 (5), 4479 (2023)
   PUBMED   36901909
  REMARK    GeneRIF: Nogo-A and LINGO-1: Two Important Targets for
            Remyelination and Regeneration.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4697)
  AUTHORS   Wang,Y., He,L., Huang,J., Li,J., Liu,L., Xu,Y., Peng,T., Yang,X.,
            Zhao,Y., Fu,C., Huang,S., Tang,H. and Xu,K.
  TITLE     Association of Nogo-A Gene Polymorphisms with Cerebral Palsy in
            Southern China: A Case-Control Study
  JOURNAL   Dev Neurosci 45 (1), 8-18 (2023)
   PUBMED   36323241
  REMARK    GeneRIF: Association of Nogo-A Gene Polymorphisms with Cerebral
            Palsy in Southern China: A Case-Control Study.
REFERENCE   6  (bases 1 to 4697)
  AUTHORS   Tagami,S., Eguchi,Y., Kinoshita,M., Takeda,M. and Tsujimoto,Y.
  TITLE     A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on
            endoplasmic reticulum and reduces their anti-apoptotic activity
  JOURNAL   Oncogene 19 (50), 5736-5746 (2000)
   PUBMED   11126360
REFERENCE   7  (bases 1 to 4697)
  AUTHORS   GrandPre,T., Nakamura,F., Vartanian,T. and Strittmatter,S.M.
  TITLE     Identification of the Nogo inhibitor of axon regeneration as a
            Reticulon protein
  JOURNAL   Nature 403 (6768), 439-444 (2000)
   PUBMED   10667797
REFERENCE   8  (bases 1 to 4697)
  AUTHORS   Chen,M.S., Huber,A.B., van der Haar,M.E., Frank,M., Schnell,L.,
            Spillmann,A.A., Christ,F. and Schwab,M.E.
  TITLE     Nogo-A is a myelin-associated neurite outgrowth inhibitor and an
            antigen for monoclonal antibody IN-1
  JOURNAL   Nature 403 (6768), 434-439 (2000)
   PUBMED   10667796
REFERENCE   9  (bases 1 to 4697)
  AUTHORS   Prinjha,R., Moore,S.E., Vinson,M., Blake,S., Morrow,R.,
            Christie,G., Michalovich,D., Simmons,D.L. and Walsh,F.S.
  TITLE     Inhibitor of neurite outgrowth in humans
  JOURNAL   Nature 403 (6768), 383-384 (2000)
   PUBMED   10667780
REFERENCE   10 (bases 1 to 4697)
  AUTHORS   Yang,J., Yu,L., Bi,A.D. and Zhao,S.Y.
  TITLE     Assignment of the human reticulon 4 gene (RTN4) to chromosome
            2p14-->2p13 by radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 101-102 (2000)
   PUBMED   10773680
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC016165.1, AY123250.1,
            AF125103.1 and AF132048.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020532.4.
            
            Summary: This gene belongs to the family of reticulon encoding
            genes. Reticulons are associated with the endoplasmic reticulum,
            and are involved in neuroendocrine secretion or in membrane
            trafficking in neuroendocrine cells. The product of this gene is a
            potent neurite outgrowth inhibitor which may also help block the
            regeneration of the central nervous system in higher vertebrates.
            Alternatively spliced transcript variants derived both from
            differential splicing and differential promoter usage and encoding
            different isoforms have been identified. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1), also known as Nogo-A and
            RTN-XL, represents the longest transcript, and encodes the longest
            isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC152555.1, AY102279.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337526.11/ ENSP00000337838.6
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-764               BC016165.1         97-860
            765-3979            AY123250.1         129-3343
            3980-4424           AF125103.1         1064-1508
            4425-4697           AF132048.1         1407-1679
FEATURES             Location/Qualifiers
     source          1..4697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.1"
     gene            1..4697
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /note="reticulon 4"
                     /db_xref="GeneID:57142"
                     /db_xref="HGNC:HGNC:14085"
                     /db_xref="MIM:604475"
     exon            1..707
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..3730
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /note="isoform A is encoded by transcript variant 1;
                     neuroendocrine-specific protein C homolog; neurite
                     outgrowth inhibitor; foocen; reticulon 5; My043 protein;
                     neurite growth inhibitor 220; Human NogoA"
                     /codon_start=1
                     /product="reticulon-4 isoform A"
                     /protein_id="NP_065393.1"
                     /db_xref="CCDS:CCDS42684.1"
                     /db_xref="GeneID:57142"
                     /db_xref="HGNC:HGNC:14085"
                     /db_xref="MIM:604475"
                     /translation="MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEED
                     EDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAP
                     ERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWT
                     PPAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVIRSSAENMDLKEQPGNTIS
                     AGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPTEGTLQENVSEASKEV
                     SEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVKNKDEEEKL
                     VSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYADFKPFER
                     VWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESSNDDTSFPST
                     PEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVTEK
                     NTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEV
                     TGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAV
                     PSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPEN
                     INAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSP
                     DSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKP
                     YLESFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRET
                     ETFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTE
                     LPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKV
                     LVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLS
                     LTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELV
                     QKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALI
                     SLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE"
     exon            708..764
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     exon            765..3164
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3372
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3373..3511
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3581
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3582..3628
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3687
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     exon            3688..4697
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4676..4681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /note="hexamer: AATAAA"
     polyA_site      4697
                     /gene="RTN4"
                     /gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
                     NSP; NSP-CL; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C"
                     /note="major polyA site"
ORIGIN      
        1 attgttccgg gagccgtcac cacagtaggt ccctcggctc agtcggccca gcccctctca
       61 gtcctcccca acccccacaa ccgcccgcgg ctctgagacg cggccccggc ggcggcggca
      121 gcagctgcag catcatctcc accctccagc catggaagac ctggaccagt ctcctctggt
      181 ctcgtcctcg gacagcccac cccggccgca gcccgcgttc aagtaccagt tcgtgaggga
      241 gcccgaggac gaggaggaag aagaggagga ggaagaggag gacgaggacg aagacctgga
      301 ggagctggag gtgctggaga ggaagcccgc cgccgggctg tccgcggccc cagtgcccac
      361 cgcccctgcc gccggcgcgc ccctgatgga cttcggaaat gacttcgtgc cgccggcgcc
      421 ccggggaccc ctgccggccg ctccccccgt cgccccggag cggcagccgt cttgggaccc
      481 gagcccggtg tcgtcgaccg tgcccgcgcc atccccgctg tctgctgccg cagtctcgcc
      541 ctccaagctc cctgaggacg acgagcctcc ggcccggcct ccccctcctc ccccggccag
      601 cgtgagcccc caggcagagc ccgtgtggac cccgccagcc ccggctcccg ccgcgccccc
      661 ctccaccccg gccgcgccca agcgcagggg ctcctcgggc tcagtggatg agaccctttt
      721 tgctcttcct gctgcatctg agcctgtgat acgctcctct gcagaaaata tggacttgaa
      781 ggagcagcca ggtaacacta tttcggctgg tcaagaggat ttcccatctg tcctgcttga
      841 aactgctgct tctcttcctt ctctgtctcc tctctcagcc gcttctttca aagaacatga
      901 ataccttggt aatttgtcaa cagtattacc cactgaagga acacttcaag aaaatgtcag
      961 tgaagcttct aaagaggtct cagagaaggc aaaaactcta ctcatagata gagatttaac
     1021 agagttttca gaattagaat actcagaaat gggatcatcg ttcagtgtct ctccaaaagc
     1081 agaatctgcc gtaatagtag caaatcctag ggaagaaata atcgtgaaaa ataaagatga
     1141 agaagagaag ttagttagta ataacatcct tcataatcaa caagagttac ctacagctct
     1201 tactaaattg gttaaagagg atgaagttgt gtcttcagaa aaagcaaaag acagttttaa
     1261 tgaaaagaga gttgcagtgg aagctcctat gagggaggaa tatgcagact tcaaaccatt
     1321 tgagcgagta tgggaagtga aagatagtaa ggaagatagt gatatgttgg ctgctggagg
     1381 taaaatcgag agcaacttgg aaagtaaagt ggataaaaaa tgttttgcag atagccttga
     1441 gcaaactaat cacgaaaaag atagtgagag tagtaatgat gatacttctt tccccagtac
     1501 gccagaaggt ataaaggatc gttcaggagc atatatcaca tgtgctccct ttaacccagc
     1561 agcaactgag agcattgcaa caaacatttt tcctttgtta ggagatccta cttcagaaaa
     1621 taagaccgat gaaaaaaaaa tagaagaaaa gaaggcccaa atagtaacag agaagaatac
     1681 tagcaccaaa acatcaaacc cttttcttgt agcagcacag gattctgaga cagattatgt
     1741 cacaacagat aatttaacaa aggtgactga ggaagtcgtg gcaaacatgc ctgaaggcct
     1801 gactccagat ttagtacagg aagcatgtga aagtgaattg aatgaagtta ctggtacaaa
     1861 gattgcttat gaaacaaaaa tggacttggt tcaaacatca gaagttatgc aagagtcact
     1921 ctatcctgca gcacagcttt gcccatcatt tgaagagtca gaagctactc cttcaccagt
     1981 tttgcctgac attgttatgg aagcaccatt gaattctgca gttcctagtg ctggtgcttc
     2041 cgtgatacag cccagctcat caccattaga agcttcttca gttaattatg aaagcataaa
     2101 acatgagcct gaaaaccccc caccatatga agaggccatg agtgtatcac taaaaaaagt
     2161 atcaggaata aaggaagaaa ttaaagagcc tgaaaatatt aatgcagctc ttcaagaaac
     2221 agaagctcct tatatatcta ttgcatgtga tttaattaaa gaaacaaagc tttctgctga
     2281 accagctccg gatttctctg attattcaga aatggcaaaa gttgaacagc cagtgcctga
     2341 tcattctgag ctagttgaag attcctcacc tgattctgaa ccagttgact tatttagtga
     2401 tgattcaata cctgacgttc cacaaaaaca agatgaaact gtgatgcttg tgaaagaaag
     2461 tctcactgag acttcatttg agtcaatgat agaatatgaa aataaggaaa aactcagtgc
     2521 tttgccacct gagggaggaa agccatattt ggaatctttt aagctcagtt tagataacac
     2581 aaaagatacc ctgttacctg atgaagtttc aacattgagc aaaaaggaga aaattccttt
     2641 gcagatggag gagctcagta ctgcagttta ttcaaatgat gacttattta tttctaagga
     2701 agcacagata agagaaactg aaacgttttc agattcatct ccaattgaaa ttatagatga
     2761 gttccctaca ttgatcagtt ctaaaactga ttcattttct aaattagcca gggaatatac
     2821 tgacctagaa gtatcccaca aaagtgaaat tgctaatgcc ccggatggag ctgggtcatt
     2881 gccttgcaca gaattgcccc atgacctttc tttgaagaac atacaaccca aagttgaaga
     2941 gaaaatcagt ttctcagatg acttttctaa aaatgggtct gctacatcaa aggtgctctt
     3001 attgcctcca gatgtttctg ctttggccac tcaagcagag atagagagca tagttaaacc
     3061 caaagttctt gtgaaagaag ctgagaaaaa acttccttcc gatacagaaa aagaggacag
     3121 atcaccatct gctatatttt cagcagagct gagtaaaact tcagttgttg acctcctgta
     3181 ctggagagac attaagaaga ctggagtggt gtttggtgcc agcctattcc tgctgctttc
     3241 attgacagta ttcagcattg tgagcgtaac agcctacatt gccttggccc tgctctctgt
     3301 gaccatcagc tttaggatat acaagggtgt gatccaagct atccagaaat cagatgaagg
     3361 ccacccattc agggcatatc tggaatctga agttgctata tctgaggagt tggttcagaa
     3421 gtacagtaat tctgctcttg gtcatgtgaa ctgcacgata aaggaactca ggcgcctctt
     3481 cttagttgat gatttagttg attctctgaa gtttgcagtg ttgatgtggg tatttaccta
     3541 tgttggtgcc ttgtttaatg gtctgacact actgattttg gctctcattt cactcttcag
     3601 tgttcctgtt atttatgaac ggcatcaggc acagatagat cattatctag gacttgcaaa
     3661 taagaatgtt aaagatgcta tggctaaaat ccaagcaaaa atccctggat tgaagcgcaa
     3721 agctgaatga aaacgcccaa aataattagt aggagttcat ctttaaaggg gatattcatt
     3781 tgattatacg ggggagggtc agggaagaac gaaccttgac gttgcagtgc agtttcacag
     3841 atcgttgtta gatctttatt tttagccatg cactgttgtg aggaaaaatt acctgtcttg
     3901 actgccatgt gttcatcatc ttaagtattg taagctgcta tgtatggatt taaaccgtaa
     3961 tcatatcttt ttcctatcta tctgaggcac tggtggaata aaaaacctgt atattttact
     4021 ttgttgcaga tagtcttgcc gcatcttggc aagttgcaga gatggtggag ctagaaaaaa
     4081 aaaaaaaaaa gcccttttca gtttgtgcac tgtgtatggt ccgtgtagat tgatgcagat
     4141 tttctgaaat gaaatgtttg tttagacgag atcataccgg taaagcagga atgacaaagc
     4201 ttgcttttct ggtatgttct aggtgtattg tgacttttac tgttatatta attgccaata
     4261 taagtaaata tagattatat atgtatagtg tttcacaaag cttagacctt taccttccag
     4321 ccaccccaca gtgcttgata tttcagagtc agtcattggt tatacatgtg tagttccaaa
     4381 gcacataagc tagaagaaga aatatttcta ggagcactac catctgtttt caacatgaaa
     4441 tgccacacac atagaactcc aacatcaatt tcattgcaca gactgactgt agttaatttt
     4501 gtcacagaat ctatggactg aatctaatgc ttccaaaaat gttgtttgtt tgcaaatatc
     4561 aaacattgtt atgcaagaaa ttattaatta caaaatgaag atttatacca ttgtggttta
     4621 agctgtactg aactaaatct gtggaatgca ttgtgaactg taaaagcaaa gtatcaataa
     4681 agcttataga cttaaaa
//
