LOCUS       NM_001265589            4917 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens reticulon 3 (RTN3), transcript variant 5, mRNA.
ACCESSION   NM_001265589
VERSION     NM_001265589.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4917)
  AUTHORS   Kumar,K., Chidambaram,R., Parashar,S. and Ferro-Novick,S.
  TITLE     RTN3L and CALCOCO1 function in parallel to maintain proteostasis in
            the endoplasmic reticulum
  JOURNAL   Autophagy 20 (9), 2067-2075 (2024)
   PUBMED   38818751
  REMARK    GeneRIF: RTN3L and CALCOCO1 function in parallel to maintain
            proteostasis in the endoplasmic reticulum.
REFERENCE   2  (bases 1 to 4917)
  AUTHORS   Du,R., Liu,J.S., Huang,H., Liu,Y.X., Jin,J.Y., Wang,C.Y., Dong,Y.,
            Fan,L.L. and Xiang,R.
  TITLE     RTN3 deficiency exacerbates cisplatin-induced acute kidney injury
            through the disruption of mitochondrial stability
  JOURNAL   Mitochondrion 75, 101851 (2024)
   PUBMED   38336146
  REMARK    GeneRIF: RTN3 deficiency exacerbates cisplatin-induced acute kidney
            injury through the disruption of mitochondrial stability.
REFERENCE   3  (bases 1 to 4917)
  AUTHORS   Kratzel,A. and Thiel,V.
  TITLE     RTN3 and RTN4: Architects of SARS-CoV-2 replication organelles
  JOURNAL   J Cell Biol 222 (7) (2023)
   PUBMED   37318453
  REMARK    GeneRIF: RTN3 and RTN4: Architects of SARS-CoV-2 replication
            organelles.
REFERENCE   4  (bases 1 to 4917)
  AUTHORS   Fan,L.L., Du,R., Liu,J.S., Jin,J.Y., Wang,C.Y., Dong,Y., He,W.X.,
            Yan,R.Q. and Xiang,R.
  TITLE     Loss of RTN3 phenocopies chronic kidney disease and results in
            activation of the IGF2-JAK2 pathway in proximal tubular epithelial
            cells
  JOURNAL   Exp Mol Med 54 (5), 653-661 (2022)
   PUBMED   35596061
  REMARK    GeneRIF: Loss of RTN3 phenocopies chronic kidney disease and
            results in activation of the IGF2-JAK2 pathway in proximal tubular
            epithelial cells.
REFERENCE   5  (bases 1 to 4917)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 4917)
  AUTHORS   Qi,B., Qi,Y., Watari,A., Yoshioka,N., Inoue,H., Minemoto,Y.,
            Yamashita,K., Sasagawa,T. and Yutsudo,M.
  TITLE     Pro-apoptotic ASY/Nogo-B protein associates with ASYIP
  JOURNAL   J Cell Physiol 196 (2), 312-318 (2003)
   PUBMED   12811824
  REMARK    GeneRIF: The ASYIP protein co-localizes with ASY in the endoplasmic
            reticulum. Characterization of the ASYIP gene helps to clarify
            ASY-induced apoptosis or Nogo-involved inhibition of neuronal
            regeneration in the central nervous system.
REFERENCE   7  (bases 1 to 4917)
  AUTHORS   Di Sano,F., Fazi,B., Citro,G., Lovat,P.E., Cesareni,G. and
            Piacentini,M.
  TITLE     Glucosylceramide synthase and its functional interaction with
            RTN-1C regulate chemotherapeutic-induced apoptosis in
            neuroepithelioma cells
  JOURNAL   Cancer Res 63 (14), 3860-3865 (2003)
   PUBMED   12873973
REFERENCE   8  (bases 1 to 4917)
  AUTHORS   Oertle,T., Klinger,M., Stuermer,C.A. and Schwab,M.E.
  TITLE     A reticular rhapsody: phylogenic evolution and nomenclature of the
            RTN/Nogo gene family
  JOURNAL   FASEB J 17 (10), 1238-1247 (2003)
   PUBMED   12832288
REFERENCE   9  (bases 1 to 4917)
  AUTHORS   Qu,X., Qi,Y. and Qi,B.
  TITLE     Generation of multiple mRNA transcripts from the novel human
            apoptosis-inducing gene hap by alternative polyadenylation
            utilization and the translational activation function of 3'
            untranslated region
  JOURNAL   Arch Biochem Biophys 400 (2), 233-244 (2002)
   PUBMED   12054434
REFERENCE   10 (bases 1 to 4917)
  AUTHORS   Moreira,E.F., Jaworski,C.J. and Rodriguez,I.R.
  TITLE     Cloning of a novel member of the reticulon gene family (RTN3): gene
            structure and chromosomal localization to 11q13
  JOURNAL   Genomics 58 (1), 73-81 (1999)
   PUBMED   10331947
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY750848.1.
            
            On May 17, 2019 this sequence version replaced NM_001265589.1.
            
            Summary: This gene belongs to the reticulon family of highly
            conserved genes that are preferentially expressed in neuroendocrine
            tissues. This family of proteins interact with, and modulate the
            activity of beta-amyloid converting enzyme 1 (BACE1), and the
            production of amyloid-beta. An increase in the expression of any
            reticulon protein substantially reduces the production of
            amyloid-beta, suggesting that reticulon proteins are negative
            modulators of BACE1 in cells. Alternatively spliced transcript
            variants encoding different isoforms have been found for this gene,
            and pseudogenes of this gene are located on chromosomes 4 and 12.
            [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (5) includes two consecutive
            alternate exons in the coding region, but maintains the reading
            frame, compared to variant 1. The encoded isoform (e) is longer
            than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.126909.1,
                                           SRR1660807.108835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377819.10/ ENSP00000367050.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4917              AY750848.1         18-4934
FEATURES             Location/Qualifiers
     source          1..4917
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..4917
                     /gene="RTN3"
                     /gene_synonym="ASYIP; HAP; NSPL2; NSPLII; RTN3-A1"
                     /note="reticulon 3"
                     /db_xref="GeneID:10313"
                     /db_xref="HGNC:HGNC:10469"
                     /db_xref="MIM:604249"
     exon            1..279
                     /gene="RTN3"
                     /gene_synonym="ASYIP; HAP; NSPL2; NSPLII; RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..3236
                     /gene="RTN3"
                     /gene_synonym="ASYIP; HAP; NSPL2; NSPLII; RTN3-A1"
                     /note="isoform e is encoded by transcript variant 5; ASY
                     interacting protein; homolog of ASY protein;
                     neuroendocrine-specific protein-like 2; NSP-like protein
                     II; NSP-like protein 2; neuroendocrine-specific
                     protein-like II"
                     /codon_start=1
                     /product="reticulon-3 isoform e"
                     /protein_id="NP_001252518.1"
                     /db_xref="CCDS:CCDS58141.1"
                     /db_xref="GeneID:10313"
                     /db_xref="HGNC:HGNC:10469"
                     /db_xref="MIM:604249"
                     /translation="MAEPSAATQSHSISSSSFGAEPSAPGGGGSPGACPALGTKSCSS
                     SCADSFVSSSSSQPVSLFSTSQEGLSSLCSDEPSSEIMTSSFLSSSEIHNTGLTILHG
                     EKSHVLGSQPILAKEGKDHLDLLDMKKMEKPQGTSNNVSDSSVSLAAGVHCDRPSIPA
                     SFPEHPAFLSKKIGQVEEQIDKETKNPNGVSSREAKTALDADDRFTLLTAQKPPTEYS
                     KVEGIYTYSLSPSKVSGDDVIEKDSPESPFEVIIDKAAFDKEFKDSYKESTDDFGSWS
                     VHTDKESSEDISETNDKLFPLRNKEAGRYPMSALLSRQFSHTNAALEEVSRCVNDMHN
                     FTNEILTWDLVPQVKQQTDKSSDCITKTTGLDMSEYNSEIPVVNLKTSTHQKTPVCSI
                     DGSTPITKSTGDWAEASLQQENAITGKPVPDSLNSTKEFSIKGVQGNMQKQDDTLAEL
                     PGSPPEKCDSLGSGVATVKVVLPDDHLKDEMDWQSSALGEITEADSSGESDDTVIEDI
                     TADTSFENNKIQAEKPVSIPSAVVKTGEREIKEIPSCEREEKTSKNFEELVSDSELHQ
                     DQPDILGRSPASEAACSKVPDTNVSLEDVSEVAPEKPITTENPKLPSTVSPNVFNETE
                     FSLNVTTSAYLESLHGKNVKHIDDSSPEDLIAAFTETRDKGIVDSERNAFKAISEKMT
                     DFKTTPPVEVLHENESGGSEIKDIGSKYSEQSKETNGSEPLGVFPTQGTPVASLDLEQ
                     EQLTIKALKELGERQVEKSTSAQRDAELPSEEVLKQTFTFAPESWPQRSYDILERNVK
                     NGSDLGISQKPITIRETTRVDAVSSLSKTELVKKHVLARLLTDFSVHDLIFWRDVKKT
                     GFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKA
                     YLDVDITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGA
                     VFNGITLLILAELLIFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKK
                     AE"
     exon            280..336
                     /gene="RTN3"
                     /gene_synonym="ASYIP; HAP; NSPL2; NSPLII; RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            337..2667
                     /gene="RTN3"
                     /gene_synonym="ASYIP; HAP; NSPL2; NSPLII; RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2875
                     /gene="RTN3"
                     /gene_synonym="ASYIP; HAP; NSPL2; NSPLII; RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..3014
                     /gene="RTN3"
                     /gene_synonym="ASYIP; HAP; NSPL2; NSPLII; RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3084
                     /gene="RTN3"
                     /gene_synonym="ASYIP; HAP; NSPL2; NSPLII; RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3131
                     /gene="RTN3"
                     /gene_synonym="ASYIP; HAP; NSPL2; NSPLII; RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3190
                     /gene="RTN3"
                     /gene_synonym="ASYIP; HAP; NSPL2; NSPLII; RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..4917
                     /gene="RTN3"
                     /gene_synonym="ASYIP; HAP; NSPL2; NSPLII; RTN3-A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4084..4089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTN3"
                     /gene_synonym="ASYIP; HAP; NSPL2; NSPLII; RTN3-A1"
                     /note="hexamer: AATAAA"
     polyA_site      4085
                     /gene="RTN3"
                     /gene_synonym="ASYIP; HAP; NSPL2; NSPLII; RTN3-A1"
                     /note="major polyA site"
     polyA_site      4138
                     /gene="RTN3"
                     /gene_synonym="ASYIP; HAP; NSPL2; NSPLII; RTN3-A1"
     polyA_site      4768
                     /gene="RTN3"
                     /gene_synonym="ASYIP; HAP; NSPL2; NSPLII; RTN3-A1"
ORIGIN      
        1 agtctgtcgg agtctgtcct cggagcaggc ggagtaaagg gacttgagcg agccagttgc
       61 cggattattc tatttcccct ccctctctcc cgccccgtat ctcttttcac ccttctccca
      121 ccctcgctcg cgtagccatg gcggagccgt cggcggccac tcagtcccat tccatctcct
      181 cgtcgtcctt cggagccgag ccgtccgcgc ccggcggcgg cgggagccca ggagcctgcc
      241 ccgccctggg gacgaagagc tgcagctcct cctgtgcgga ttcctttgtt tcttcctctt
      301 cctctcagcc tgtatctcta ttttcgacct cacaagaggg attgagctct ctttgctctg
      361 atgagccatc ttcagaaatt atgacttctt cctttctttc atcttctgaa atacataaca
      421 ctggccttac aatactacat ggagaaaaaa gccatgtgtt agggagccag cctattttag
      481 ccaaagaagg aaaagaccac ttggatcttc tagatatgaa aaagatggaa aagcctcagg
      541 ggaccagcaa caacgtatca gactcttcag tttctcttgc agcaggagtt cattgtgacc
      601 gtccttctat tccagccagt ttcccagagc atcctgcttt tctctcaaag aaaattggtc
      661 aagtggaaga gcaaatagat aaagagacca agaacccaaa tggggtatca agtagggagg
      721 ctaaaactgc attggatgct gatgacagat tcactttgct gacagcccag aaaccaccta
      781 ctgagtactc taaggtagaa ggcatttata catattcttt gtctccatcc aaagtttcag
      841 gagatgatgt tattgaaaag gattcccctg aatcaccatt tgaagtaatt attgacaaag
      901 cagcatttga caaagaattt aaagactcat ataaggagag cacagatgat tttggtagct
      961 ggtctgtgca cactgataaa gaatcatccg aagacatttc agagactaat gacaagcttt
     1021 ttccactgag aaataaagag gcaggacgtt acccaatgtc tgcattgctc agtaggcagt
     1081 tttcacacac aaatgcagca ctggaagagg tgtccagatg cgtgaatgat atgcataact
     1141 ttactaacga aatactgact tgggatctgg ttccccaagt gaaacaacag accgataaat
     1201 cttctgactg catcacaaaa actacaggac ttgacatgag tgaatataat tcagaaattc
     1261 cagttgtaaa tcttaaaact agcactcatc agaaaactcc tgtatgttct attgatggga
     1321 gcactcccat cactaaatca acaggtgatt gggcagaagc atctctccag caagaaaatg
     1381 ctattactgg aaaacctgta cctgactctt tgaattccac aaaagaattc agtatcaaag
     1441 gtgtgcaagg caatatgcag aaacaggatg acacacttgc agaattacct ggatctccac
     1501 ctgagaaatg tgactctttg ggttctggag tggccacagt gaaagtggtt ttacctgatg
     1561 accacctgaa agatgaaatg gactggcaga gctctgcatt gggagaaatc acagaagctg
     1621 atagttctgg tgagtctgat gacacagtaa tagaggacat cacagcagat acatcatttg
     1681 aaaataacaa aattcaggct gaaaaacctg tttccattcc aagtgctgtt gtaaaaacag
     1741 gtgaaagaga aatcaaagag attcccagtt gtgagagaga agaaaaaaca tctaaaaact
     1801 ttgaagaatt ggtcagtgac tctgagctgc atcaagatca gcctgatatt cttggaagga
     1861 gtccagctag tgaggcagca tgttcaaaag tacccgatac gaatgtctcc ttagaagatg
     1921 tgagtgaagt tgctcctgaa aagcctatta ctactgagaa ccccaaactt ccttcaacag
     1981 tgtctccaaa tgtttttaat gagacagaat tctcattaaa tgtgacaaca tctgcctatt
     2041 tggagtcatt acatgggaaa aatgttaaac atatagatga ttcctcccca gaggacctga
     2101 tagcagcctt tacagaaacc agagataaag gaatagtaga tagtgaaaga aatgctttta
     2161 aagcaatatc agagaagatg acagacttta aaacaactcc tcctgtagaa gtcttacatg
     2221 aaaatgagtc cggtggttct gaaattaaag acattggaag caaatacagt gaacaaagca
     2281 aagaaacaaa tggaagtgag cctctaggtg ttttccctac ccaaggtact ccagtagcat
     2341 ctcttgactt agaacaagaa cagctcacaa ttaaggctct taaagaatta ggtgaaagac
     2401 aggttgagaa gtcaacttct gcacagcgtg acgcagaatt gccttctgaa gaagtactga
     2461 agcaaacttt cacatttgct ccagaatctt ggccacagag atcatatgac atcctagaac
     2521 gtaatgtcaa gaatggatct gatcttggga tttcccagaa gcccatcact atcagagaaa
     2581 ctactagggt agatgctgtt tccagcctta gcaagactga attggtaaaa aagcatgtcc
     2641 tagcaagact tctgacagac ttctcagtgc acgatctgat tttctggaga gatgtgaaga
     2701 agactgggtt tgtctttggc accacgctga tcatgctgct ttccctggca gctttcagtg
     2761 tcatcagtgt ggtttcttac ctcatcctgg ctcttctctc tgtcaccatc agcttcagga
     2821 tctacaagtc cgtcatccaa gctgtacaga agtcagaaga aggccatcca ttcaaagcct
     2881 acctggacgt agacattact ctgtcctcag aagctttcca taattacatg aatgctgcca
     2941 tggtgcacat caacagggcc ctgaaactca ttattcgtct ctttctggta gaagatctgg
     3001 ttgactcctt gaagctggct gtcttcatgt ggctgatgac ctatgttggt gctgttttta
     3061 acggaatcac ccttctaatt cttgctgaac tgctcatttt cagtgtcccg attgtctatg
     3121 agaagtacaa gacccagatt gatcactatg ttggcatcgc ccgagatcag accaagtcaa
     3181 ttgttgaaaa gatccaagca aaactccctg gaatcgccaa aaaaaaggca gaataagtac
     3241 atggaaacca gaaatgcaac agttactaaa acaccattta atagttataa cgtcgttact
     3301 tgtactatga aggaaaatac tcagtgtcag cttgagcctg cattccaagc ttttttttta
     3361 atttggtgtt ttctcccatc ctttcccttt aaccctcagt atcaagcaca aaaattgatg
     3421 gactgataaa agaactatct tagaactcag aagaagaaag aatcaaattc ataggataag
     3481 tcaatacctt aatggtggta gagcctttac ctgtagcttg aaaggggaaa gattggaggt
     3541 aagagagaaa atgaaagaac acctctgggt ccttctgtcc agttttcagc actagtctta
     3601 ctcagctatc cattatagtt ttgcccttaa gaagtcatga ttaacttatg aaaaaattat
     3661 ttggggacag gagtgtgata ccttccttgg tttttttttg cagccctcaa atcctatctt
     3721 cctgccccac aatgtgagca gctacccctg atactccttt tctttaatga tttaactatc
     3781 aacttgataa ataacttata ggtgatagtg ataattcctg attccaagaa tgccatctga
     3841 taaaaaagaa tagaaatgga aagtgggact gagagggagt cagcaggcat gctgcggtgg
     3901 cggtcactcc ctctgccact atccccaggg aaggaaaggc tccgccattt gggaaagtgg
     3961 tttctacgtc actggacacc ggttctgagc attagtttga gaactcgttc ccgaatgtgc
     4021 tttcctccct ctcccctgcc cacctcaagt ttaataaata aggttgtact tttcttacta
     4081 taaaataaat gtctgtaact gctgtgcact gctgtaaact tgttagagaa aaaaataacc
     4141 tgcatgtggg ctcctcagtt attgagtttt tgtgatccta tctcagtctg ggggggaaca
     4201 ttctcaagag gtgaaataca gaaagccttt ttttcttgat cttttcccga gattcaaatc
     4261 tccgattccc atttgggggc aagttttttt cttcaccttc aatatgagaa ttcagcgaac
     4321 ttgaaagaaa aatcatctgt gagttccttc aggttctcac tcatagtcat gatccttcag
     4381 agggaatatg cactggcgag tttaaagtaa gggctatgat atttgatggt cccaaagtac
     4441 ggcagctgca aaaagtagtg gaaggaaatt gtctacgtgt cttggaaaaa ttagttagga
     4501 atttggatgg gtaaaaggta cccttgcctt actccatctt attttcttag ccccctttga
     4561 gtgttttaac tggtttcatg tcctagtagg aagtgcattc tccatcctca tcctctgccc
     4621 tcccaggaag tcagtgattg tctttttggg cttcccctcc aaaggacctt ctgcagtgga
     4681 agtgccacat ccagttcttt tcttttgttg ctgctgtgtt tagataattg aagagatctt
     4741 tgtgccacac aggatttttt ttttttttta agaaaaacct atagatgaaa aattactaat
     4801 gaaactgtgt gtacgtgtct gtgcgtgcaa cataaaaata cagtagcacc taaggagctt
     4861 gaatcttggt tcctgtaaaa tttcaaattg atgtggtatt aataaaaaaa aaaaaaa
//
