LOCUS       NM_021136               3239 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens reticulon 1 (RTN1), transcript variant 1, mRNA.
ACCESSION   NM_021136
VERSION     NM_021136.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3239)
  AUTHORS   Gao,Y., Wang,Y., Xu,L., Xie,X., Zhu,L. and Wang,F.
  TITLE     CircRTN1 acts as a miR-431-5p sponge to promote thyroid cancer
            progression by upregulating TGFA
  JOURNAL   Hormones (Athens) 21 (4), 611-623 (2022)
   PUBMED   35804263
  REMARK    GeneRIF: CircRTN1 acts as a miR-431-5p sponge to promote thyroid
            cancer progression by upregulating TGFA.
REFERENCE   2  (bases 1 to 3239)
  AUTHORS   Cichon,M.A., Pfisterer,K., Leitner,J., Wagner,L., Staud,C.,
            Steinberger,P. and Elbe-Burger,A.
  TITLE     Interoperability of RTN1A in dendrite dynamics and immune functions
            in human Langerhans cells
  JOURNAL   Elife 11, e80578 (2022)
   PUBMED   36223176
  REMARK    GeneRIF: Interoperability of RTN1A in dendrite dynamics and immune
            functions in human Langerhans cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3239)
  AUTHORS   Xie,Y., E,J., Cai,H., Zhong,F., Xiao,W., Gordon,R.E., Wang,L.,
            Zheng,Y.L., Zhang,A., Lee,K. and He,J.C.
  TITLE     Reticulon-1A mediates diabetic kidney disease progression through
            endoplasmic reticulum-mitochondrial contacts in tubular epithelial
            cells
  JOURNAL   Kidney Int 102 (2), 293-306 (2022)
   PUBMED   35469894
  REMARK    GeneRIF: Reticulon-1A mediates diabetic kidney disease progression
            through endoplasmic reticulum-mitochondrial contacts in tubular
            epithelial cells.
REFERENCE   4  (bases 1 to 3239)
  AUTHORS   Zhu,S., Zu,L. and Xu,S.
  TITLE     [The Expression of RTN1 in Lung Adenocarcinoma and Its Effect on
            Immune Microenvironment]
  JOURNAL   Zhongguo Fei Ai Za Zhi 25 (6), 385-395 (2022)
   PUBMED   35747917
  REMARK    GeneRIF: [The Expression of RTN1 in Lung Adenocarcinoma and Its
            Effect on Immune Microenvironment].
REFERENCE   5  (bases 1 to 3239)
  AUTHORS   Hens,J., Nuydens,R., Geerts,H., Senden,N.H., Van de Ven,W.J.,
            Roebroek,A.J., van de Velde,H.J., Ramaekers,F.C. and Broers,J.L.
  TITLE     Neuronal differentiation is accompanied by NSP-C expression
  JOURNAL   Cell Tissue Res 292 (2), 229-237 (1998)
   PUBMED   9560466
REFERENCE   6  (bases 1 to 3239)
  AUTHORS   Senden,N.H., Timmer,E.D., Boers,J.E., van de Velde,H.J.,
            Roebroek,A.J., Van de Ven,W.J., Broers,J.L. and Ramaekers,F.C.
  TITLE     Neuroendocrine-specific protein C (NSP-C): subcellular localization
            and differential expression in relation to NSP-A
  JOURNAL   Eur J Cell Biol 69 (3), 197-213 (1996)
   PUBMED   8900485
REFERENCE   7  (bases 1 to 3239)
  AUTHORS   van de Velde,H.J., Senden,N.H., Roskams,T.A., Broers,J.L.,
            Ramaekers,F.C., Roebroek,A.J. and Van de Ven,W.J.
  TITLE     NSP-encoded reticulons are neuroendocrine markers of a novel
            category in human lung cancer diagnosis
  JOURNAL   Cancer Res 54 (17), 4769-4776 (1994)
   PUBMED   8062278
REFERENCE   8  (bases 1 to 3239)
  AUTHORS   van de Velde,H.J., Roebroek,A.J., Senden,N.H., Ramaekers,F.C. and
            Van de Ven,W.J.
  TITLE     NSP-encoded reticulons, neuroendocrine proteins of a novel gene
            family associated with membranes of the endoplasmic reticulum
  JOURNAL   J Cell Sci 107 (Pt 9), 2403-2416 (1994)
   PUBMED   7844160
REFERENCE   9  (bases 1 to 3239)
  AUTHORS   Senden,N.H., van de Velde,H.J., Broers,J.L., Timmer,E.D.,
            Roebroek,A.J., van de Ven,W.J. and Ramaekers,F.C.
  TITLE     Cluster-10 lung-cancer antibodies recognize NSPs, novel
            neuro-endocrine proteins associated with membranes of the
            endoplasmic reticulum
  JOURNAL   Int J Cancer Suppl 8, 84-88 (1994)
   PUBMED   7515034
REFERENCE   10 (bases 1 to 3239)
  AUTHORS   Roebroek,A.J., van de Velde,H.J., Van Bokhoven,A., Broers,J.L.,
            Ramaekers,F.C. and Van de Ven,W.J.
  TITLE     Cloning and expression of alternative transcripts of a novel
            neuroendocrine-specific gene and identification of its 135-kDa
            translational product
  JOURNAL   J Biol Chem 268 (18), 13439-13447 (1993)
   PUBMED   7685762
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133299.4, AL139194.7 and
            AL121694.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_021136.2.
            
            Summary: This gene belongs to the family of reticulon encoding
            genes. Reticulons are associated with the endoplasmic reticulum,
            and are involved in neuroendocrine secretion or in membrane
            trafficking in neuroendocrine cells. This gene is considered to be
            a specific marker for neurological diseases and cancer, and is a
            potential molecular target for therapy. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (A, also known as NSP-A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.990833.1, BC068510.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267484.10/ ENSP00000267484.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               AL133299.4         70874-71260         c
            388-1161            AL139194.7         72422-73195         c
            1162-1911           AL139194.7         53633-54382         c
            1912-2119           AL121694.4         68357-68564
            2120-2258           AL121694.4         70343-70481
            2259-2328           AL121694.4         71928-71997
            2329-2375           AL121694.4         72591-72637
            2376-2434           AL121694.4         72726-72784
            2435-3239           AL121694.4         79062-79866
FEATURES             Location/Qualifiers
     source          1..3239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.1"
     gene            1..3239
                     /gene="RTN1"
                     /gene_synonym="NSP"
                     /note="reticulon 1"
                     /db_xref="GeneID:6252"
                     /db_xref="HGNC:HGNC:10467"
                     /db_xref="MIM:600865"
     exon            1..387
                     /gene="RTN1"
                     /gene_synonym="NSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..2477
                     /gene="RTN1"
                     /gene_synonym="NSP"
                     /note="isoform A is encoded by transcript variant 1;
                     neuroendocrine-specific protein"
                     /codon_start=1
                     /product="reticulon-1 isoform A"
                     /protein_id="NP_066959.1"
                     /db_xref="CCDS:CCDS9740.1"
                     /db_xref="GeneID:6252"
                     /db_xref="HGNC:HGNC:10467"
                     /db_xref="MIM:600865"
                     /translation="MAAPGDPQDELLPLAGPGSQWLRHRGEGENEAVTPKGATPAPQA
                     GEPSPGLGARAREAASREAGSGPARQSPVAMETASTGVAGVSSAMDHTFSTTSKDGEG
                     SCYTSLISDICYPPQEDSTYFTGILQKENGHVTISESPEELGTPGPSLPDVPGIESRG
                     LFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEEVKHQEQHHPELEDK
                     DLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQ
                     ITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPP
                     SSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGP
                     PTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQ
                     YSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEE
                     RAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAA
                     TKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVV
                     AYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFY
                     VNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYV
                     KHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE"
     exon            388..1161
                     /gene="RTN1"
                     /gene_synonym="NSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1911
                     /gene="RTN1"
                     /gene_synonym="NSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2119
                     /gene="RTN1"
                     /gene_synonym="NSP"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2258
                     /gene="RTN1"
                     /gene_synonym="NSP"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2328
                     /gene="RTN1"
                     /gene_synonym="NSP"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2375
                     /gene="RTN1"
                     /gene_synonym="NSP"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2434
                     /gene="RTN1"
                     /gene_synonym="NSP"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..3239
                     /gene="RTN1"
                     /gene_synonym="NSP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3220..3225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTN1"
                     /gene_synonym="NSP"
                     /note="hexamer: AATAAA"
     polyA_site      3239
                     /gene="RTN1"
                     /gene_synonym="NSP"
                     /note="major polyA site"
ORIGIN      
        1 gttgcagcag aggcggcggc gacgctgaga caccgcagct tccctgagcg ccgagtccct
       61 ccggggacag cagcagggag cgcccgcgca gccaccgagc ctctgcccag ccaagccgcc
      121 gtcgccgcgc cgggggaccg ccagccatgg ccgcgccggg ggatccgcag gacgagctgc
      181 tgccgctggc cggccccggg tcccagtggc tcaggcaccg gggggagggg gagaacgaag
      241 cggtgacgcc gaaaggggcc acgccggcgc cgcaggctgg ggagcccagc ccggggttgg
      301 gcgccagggc ccgggaagcg gcgtcgcggg aagccggctc gggccccgcc cggcagtcgc
      361 ccgttgccat ggaaactgca tccacaggtg tggcaggtgt ttccagtgcc atggaccaca
      421 ccttctcaac aacatcaaaa gatggggaag gatcgtgtta cacatctctc atttctgaca
      481 tctgctatcc acctcaggag gattctacat attttactgg aattcttcag aaggaaaatg
      541 gccacgtcac catttcagag agccctgagg agctgggtac acccggcccc tccttaccag
      601 atgtgcctgg gatagagtct cgtggcttat ttagttctga ttctggaata gagatgactc
      661 ctgcagagtc cacggaagtg aacaagatct tagcagaccc tctggaccag atgaaagcag
      721 aggcctataa atacattgac ataaccagac ccgaggaggt gaagcaccaa gaacaacatc
      781 accccgagct ggaagataaa gacttggact ttaagaataa agacactgac atctcaatta
      841 aacctgaagg agtccgtgaa cctgacaaac cagctcctgt ggagggaaaa atcatcaagg
      901 accatttatt ggaagaatcc acatttgctc catacataga tgatctctct gaagaacagc
      961 gcagggctcc tcagatcacc acccctgtca aaatcacact gacggaaata gaaccttctg
     1021 ttgaaaccac tacccaagag aagacccctg agaagcaaga tatatgtcta aagccaagtc
     1081 ctgacacagt ccccactgtc actgtctcgg agcctgaaga cgacagccca ggatctatca
     1141 cccctccatc ttctggaaca gaaccatctg ctgcagaatc ccaggggaaa ggcagcatct
     1201 ccgaggatga gctgatcacc gccatcaaag aagcaaaggg attatcgtat gaaaccgccg
     1261 agaacccacg gccggtgggc cagctggccg acaggcccga ggtcaaggcc aggtccggac
     1321 cgccaaccat ccccagcccc ctggaccacg aggccagcag cgcggagtcg ggggactcag
     1381 agatcgagct ggtgtccgag gaccccatgg ccgcggagga cgcgctgccc tcaggctatg
     1441 tgagctttgg ccacgtgggc ggcccgccgc cctcgcccgc ctcgccatcc atccagtaca
     1501 gcatcctgag ggaggagcgc gaggccgagc tggacagcga gctcatcatc gagtcgtgcg
     1561 acgcctcctc ggcctcggag gagagcccca agcgggagca ggactcaccc ccgatgaagc
     1621 ccagcgccct ggatgccatc cgggaggaga ctggcgtccg ggccgaggag cgtgcgccaa
     1681 gccggcgggg cctggccgag ccgggttcct tcctcgacta cccctcaact gagccccagc
     1741 ctggccccga gctgccccct ggagacggag ccctggagcc tgagacgccc atgttgccac
     1801 ggaagcctga agaagactcg agttccaacc aaagtcctgc ggccacaaag ggccctgggc
     1861 ctctaggtcc tggcgccccg cccccactgc tgtttctcaa taagcaaaaa gctattgacc
     1921 tgttgtattg gcgggacatc aagcagacgg gcatcgtgtt tgggagtttc ctgctgctgc
     1981 tcttctccct gacccagttc agcgtggtga gcgtcgtggc ctacctggcc ctggccgcac
     2041 tctcagccac catcagtttc cgcatctaca agtctgtttt acaagcagtg cagaaaaccg
     2101 acgaaggcca ccctttcaag gcctacttgg agcttgagat caccctttct caggagcaga
     2161 ttcagaagta cacggactgc ctgcagttct acgtgaacag cacacttaag gaactgagga
     2221 ggctcttcct tgtccaggac ctggtggatt ccttaaaatt tgcagtcctg atgtggctcc
     2281 tgacctacgt tggcgctctc ttcaatggcc tgaccctgct gctcatggct gtggtttcaa
     2341 tgtttactct acctgtagtg tatgttaagc accaggcaca gattgaccaa tatctgggac
     2401 ttgtgaggac tcacataaat gctgttgtgg caaagattca ggctaaaatc ccaggcgcta
     2461 agaggcatgc tgagtaaact gatttcccac cggggactgg acacaaacag gaatgtctgg
     2521 agtggtaaca gctctcttct tactcattac tgcaaattga ttgtctttcc cccctccctc
     2581 cagtaccata atcttagaga caaaccttaa aacagctgtt tttaggctgt tccttgtact
     2641 cttaggatat ttgagtcact tgtgtcaacc actaaagtat agagaaaagt gtattagatg
     2701 tggtttttaa ttttgtgttg ctaaaaaaag tgcatgatgg tgagagccca agttatcttt
     2761 ccctcttcgg tgttcttctt ctcttctctg caatgcttct gtagcttcta atgttccccg
     2821 tggctaggcc tttcctgccg agtgctctga tgcaatagtg gaaatcgctt atatgtcctt
     2881 gggttgctgg ttggattaat ctttaataac aatatataga attgtagact gatgttttag
     2941 catttttcca acacacacaa cgtaaaaata aaagcagtcg accgcactta tggtaatcag
     3001 ttttgtataa cttaaaataa ttaaataaat gaataaatcc aaaacaaaca tgcagtactt
     3061 ttgttgtatg ggattggtgg gctgatttac atgtatggtt actaaaaagt accagcatgt
     3121 taactttatt acaatttgta ttactttctc tgtagttcct aatggattca attacggact
     3181 ctggatattt gcacttatgt acttgatact gaatgcataa ataaatgtta ctaaatgta
//
