LOCUS       NM_001078171            1192 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens retrotransposon Gag like 8C (RTL8C), mRNA.
ACCESSION   NM_001078171
VERSION     NM_001078171.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1192)
  AUTHORS   Mohan,H.M., Trzeciakiewicz,H., Pithadia,A., Crowley,E.V.,
            Pacitto,R., Safren,N., Trotter,B., Zhang,C., Zhou,X., Zhang,Y.,
            Basrur,V., Paulson,H.L. and Sharkey,L.M.
  TITLE     RTL8 promotes nuclear localization of UBQLN2 to subnuclear
            compartments associated with protein quality control
  JOURNAL   Cell Mol Life Sci 79 (3), 176 (2022)
   PUBMED   35247097
  REMARK    GeneRIF: RTL8 promotes nuclear localization of UBQLN2 to subnuclear
            compartments associated with protein quality control.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1192)
  AUTHORS   Mohammadi,Z., Azad,M., Foroughi,F., Khojastehpour,S., Gheibi,N.,
            Samiee-Rad,F., Maali,A. and Ahmadi,M.H.
  TITLE     Evaluation of expression level and methylation profile of CXX1 gene
            in breast cancer tissue blocks
  JOURNAL   J Cancer Res Ther 17 (6), 1328-1334 (2021)
   PUBMED   34916361
  REMARK    GeneRIF: Evaluation of expression level and methylation profile of
            CXX1 gene in breast cancer tissue blocks.
REFERENCE   3  (bases 1 to 1192)
  AUTHORS   Franz,M., Morchen,B., Degenhart,C., Gulden,D., Shkura,O.,
            Wolters,D., Koch,U., Klebl,B., Stoll,R., Helfrich,I. and
            Scherkenbeck,J.
  TITLE     Sequence-Selective Covalent CaaX-Box Receptors Prevent
            Farnesylation of Oncogenic Ras Proteins and Impact MAPK/PI3 K
            Signaling
  JOURNAL   ChemMedChem 16 (16), 2504-2514 (2021)
   PUBMED   33899342
  REMARK    GeneRIF: Sequence-Selective Covalent CaaX-Box Receptors Prevent
            Farnesylation of Oncogenic Ras Proteins and Impact MAPK/PI3 K
            Signaling.
REFERENCE   4  (bases 1 to 1192)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1192)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1192)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   7  (bases 1 to 1192)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   8  (bases 1 to 1192)
  AUTHORS   Brandt,J., Schrauth,S., Veith,A.M., Froschauer,A., Haneke,T.,
            Schultheis,C., Gessler,M., Leimeister,C. and Volff,J.N.
  TITLE     Transposable elements as a source of genetic innovation: expression
            and evolution of a family of retrotransposon-derived neogenes in
            mammals
  JOURNAL   Gene 345 (1), 101-111 (2005)
   PUBMED   15716091
REFERENCE   9  (bases 1 to 1192)
  AUTHORS   Brandt,J., Veith,A.M. and Volff,J.N.
  TITLE     A family of neofunctionalized Ty3/gypsy retrotransposon genes in
            mammalian genomes
  JOURNAL   Cytogenet Genome Res 110 (1-4), 307-317 (2005)
   PUBMED   16093683
REFERENCE   10 (bases 1 to 1192)
  AUTHORS   Frattini,A., Faranda,S., Zucchi,I. and Vezzoni,P.
  TITLE     A low-copy repeat in Xq26 represents a novel putatively prenylated
            protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and
            DXS9916)
  JOURNAL   Genomics 46 (1), 167-169 (1997)
   PUBMED   9403077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX784259.1, BC002385.2 and CD367165.1.
            
            On May 17, 2019 this sequence version replaced NM_001078171.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR5189652.194787.1, SRR5189655.66695.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257013.9/ ENSP00000257013.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                CX784259.1         53-70
            19-1188             BC002385.2         1-1170
            1189-1192           CD367165.1         11-14               c
FEATURES             Location/Qualifiers
     source          1..1192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..1192
                     /gene="RTL8C"
                     /gene_synonym="CXX1; FAM127A; Mar8; MAR8C; Mart8; MART8C;
                     SIRH5"
                     /note="retrotransposon Gag like 8C"
                     /db_xref="GeneID:8933"
                     /db_xref="HGNC:HGNC:2569"
                     /db_xref="MIM:300213"
     exon            1..1192
                     /gene="RTL8C"
                     /gene_synonym="CXX1; FAM127A; Mar8; MAR8C; Mart8; MART8C;
                     SIRH5"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..371
                     /gene="RTL8C"
                     /gene_synonym="CXX1; FAM127A; Mar8; MAR8C; Mart8; MART8C;
                     SIRH5"
                     /note="CAAX box 1; mammalian retrotransposon derived
                     protein 8C; protein FAM127A; Sushi-Ichi retrotransposon
                     homolog 5; mammalian retrotransposon-derived 8C; family
                     with sequence similarity 127 member A; retrotransposon
                     Gag-like protein 8B"
                     /codon_start=1
                     /product="retrotransposon Gag-like protein 8C"
                     /protein_id="NP_001071639.1"
                     /db_xref="CCDS:CCDS43997.1"
                     /db_xref="GeneID:8933"
                     /db_xref="HGNC:HGNC:2569"
                     /db_xref="MIM:300213"
                     /translation="MDGRVQLIKALLALPIRPATRRWRNPIPFPETFDGDTDRLPEFI
                     VQTGSYMFVDENTFSSDALKVTFLITRLTGPALQWVIPYIKKESPLLNDYRGFLAEMK
                     RVFGWEEDEDF"
     regulatory      1164..1169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTL8C"
                     /gene_synonym="CXX1; FAM127A; Mar8; MAR8C; Mart8; MART8C;
                     SIRH5"
                     /note="hexamer: AATAAA"
     polyA_site      1192
                     /gene="RTL8C"
                     /gene_synonym="CXX1; FAM127A; Mar8; MAR8C; Mart8; MART8C;
                     SIRH5"
                     /note="major polyA site"
ORIGIN      
        1 attgacgtcc agcgaagcga ggagcagcga tggacggtcg ggtgcagctg ataaaggccc
       61 tcctggcctt gccgatccgg cctgcgacgc gtcgctggag gaacccgatt ccctttcccg
      121 agacgtttga cggcgatacc gaccgactcc cggagttcat cgtgcagacg ggctcctaca
      181 tgttcgtgga cgagaacacg ttctccagcg acgccctgaa ggtgacgttc ctcatcaccc
      241 gcctcacagg gcccgccctg cagtgggtga tcccctacat caagaaggag agccccctcc
      301 tcaatgatta ccggggcttt ctggccgaga tgaagcgagt ctttggatgg gaggaggacg
      361 aggacttcta ggccgggaga ccctcgggcc tgggggcggg tgctctgggg agggtccgct
      421 gtgttactgg ccgccgccag ggtcgccacc ggcgccctcc ctccgcgcct ccctccccct
      481 cgagccgccg cgatgtcccc tgcgctcctg ttccctcccg cgtagtgctt gcctttgttc
      541 caggaatagc gctccaggct cctgctgccg cccctgggcc tcactctgga gcgagccgcc
      601 gccctctcct tccagccagc cagcccctcc catgtacatt tggacgctgt cctgcgctcc
      661 agctgcaagc tgggctcctg ttacacactg gacagaccac ccactgccgc cgctgccaag
      721 ccctctcctc cccaccagac tgccagacga ctacatcatt ctgcccacag acctgcgctg
      781 ccacagccat cgccatccat cgcatcccac cgacagactg ctgctcctag tgatctggac
      841 tcacctcgga ggtatctggg ctggccacag tccctggaca gtgatccaga cagctggccg
      901 ccccccaagg gatctgtcac cttcagcgag acctatttcc tccccacccc cagaaacctc
      961 ttgtgttctt gcctaggccc aggtgttcct ggcagccaaa tcgagtctct cattttctct
     1021 tgtggaccag ttagttttgc ccataacgca gtattctgag tttgcaactg tctctctgat
     1081 gtgtgccttt tgttcaacac agtaacccct gcattctgct ctgctctaat acactacctg
     1141 gagaaagtct tttccttatt ttcaataaat gtcagacatt attgaaaaga aa
//
