LOCUS       NM_001078173            2030 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens retrotransposon Gag like 8B (RTL8B), mRNA.
ACCESSION   NM_001078173 XM_931980 XM_944128
VERSION     NM_001078173.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2030)
  AUTHORS   Mohan,H.M., Trzeciakiewicz,H., Pithadia,A., Crowley,E.V.,
            Pacitto,R., Safren,N., Trotter,B., Zhang,C., Zhou,X., Zhang,Y.,
            Basrur,V., Paulson,H.L. and Sharkey,L.M.
  TITLE     RTL8 promotes nuclear localization of UBQLN2 to subnuclear
            compartments associated with protein quality control
  JOURNAL   Cell Mol Life Sci 79 (3), 176 (2022)
   PUBMED   35247097
  REMARK    GeneRIF: RTL8 promotes nuclear localization of UBQLN2 to subnuclear
            compartments associated with protein quality control.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2030)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2030)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2030)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2030)
  AUTHORS   Brandt,J., Schrauth,S., Veith,A.M., Froschauer,A., Haneke,T.,
            Schultheis,C., Gessler,M., Leimeister,C. and Volff,J.N.
  TITLE     Transposable elements as a source of genetic innovation: expression
            and evolution of a family of retrotransposon-derived neogenes in
            mammals
  JOURNAL   Gene 345 (1), 101-111 (2005)
   PUBMED   15716091
REFERENCE   6  (bases 1 to 2030)
  AUTHORS   Brandt,J., Veith,A.M. and Volff,J.N.
  TITLE     A family of neofunctionalized Ty3/gypsy retrotransposon genes in
            mammalian genomes
  JOURNAL   Cytogenet Genome Res 110 (1-4), 307-317 (2005)
   PUBMED   16093683
REFERENCE   7  (bases 1 to 2030)
  AUTHORS   Frattini,A., Faranda,S., Zucchi,I. and Vezzoni,P.
  TITLE     A low-copy repeat in Xq26 represents a novel putatively prenylated
            protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and
            DXS9916)
  JOURNAL   Genomics 46 (1), 167-169 (1997)
   PUBMED   9403077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136169.6, DB490903.2, BC113720.1 and BC048268.1.
            
            On May 17, 2019 this sequence version replaced NM_001078173.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660803.153953.1, SRR1803617.37046.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391440.3/ ENSP00000375268.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL136169.6         20882-20887         c
            7-51                DB490903.2         1-45
            52-451              BC113720.1         1-400
            452-669             AL136169.6         20219-20436         c
            670-2030            BC048268.1         307-1667
FEATURES             Location/Qualifiers
     source          1..2030
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..2030
                     /gene="RTL8B"
                     /gene_synonym="CXX1c; FAM127C; MAR8B; SIRH4"
                     /note="retrotransposon Gag like 8B"
                     /db_xref="GeneID:441518"
                     /db_xref="HGNC:HGNC:33156"
     exon            1..2030
                     /gene="RTL8B"
                     /gene_synonym="CXX1c; FAM127C; MAR8B; SIRH4"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..425
                     /gene="RTL8B"
                     /gene_synonym="CXX1c; FAM127C; MAR8B; SIRH4"
                     /note="mammalian retrotransposon derived protein 8B;
                     protein FAM127C; Sushi-Ichi retrotransposon homolog 1;
                     mammalian retrotransposon-derived 2; family with sequence
                     similarity 127 member C"
                     /codon_start=1
                     /product="retrotransposon Gag-like protein 8B"
                     /protein_id="NP_001071641.1"
                     /db_xref="CCDS:CCDS43996.1"
                     /db_xref="GeneID:441518"
                     /db_xref="HGNC:HGNC:33156"
                     /translation="MEGRVQLMKALLARPLRPAARRWRNPIPFPETFDGDTDRLPEFI
                     VQTSSYMFVDENTFSNDALKVTFLITRLTGPALQWVIPYIKKESPLLSDYRGFLAEMK
                     RVFGWEEDEDF"
     regulatory      1231..1236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTL8B"
                     /gene_synonym="CXX1c; FAM127C; MAR8B; SIRH4"
                     /note="hexamer: AATAAA"
     regulatory      1259..1264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTL8B"
                     /gene_synonym="CXX1c; FAM127C; MAR8B; SIRH4"
                     /note="hexamer: AATAGA"
     polyA_site      1260
                     /gene="RTL8B"
                     /gene_synonym="CXX1c; FAM127C; MAR8B; SIRH4"
                     /note="major polyA site"
     polyA_site      1282
                     /gene="RTL8B"
                     /gene_synonym="CXX1c; FAM127C; MAR8B; SIRH4"
     regulatory      2006..2011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTL8B"
                     /gene_synonym="CXX1c; FAM127C; MAR8B; SIRH4"
                     /note="hexamer: ATTAAA"
     polyA_site      2030
                     /gene="RTL8B"
                     /gene_synonym="CXX1c; FAM127C; MAR8B; SIRH4"
ORIGIN      
        1 atgcacttcc cgctacgcct cggtgcagcc cccggcgaag cccagcgcag ctcagctaaa
       61 ctcagcggag ccagcgcggc gcgatggaag gtcgagtgca gctgatgaag gccctcctgg
      121 ctcggcccct ccggcccgcg gcgcgtcgct ggaggaaccc gattcccttt cccgagacgt
      181 ttgatggcga taccgaccgg ctcccggagt tcatcgtgca gacgagctcc tacatgttcg
      241 tggacgagaa cacgttctcc aacgacgccc tgaaggtgac gttcctcatc acccgcctca
      301 cggggcccgc cctgcagtgg gtgatcccct acatcaagaa ggagagcccc ctcctcagtg
      361 attaccgggg cttcctggct gagatgaagc gggtctttgg atgggaggag gacgaggact
      421 tctaggccgg gagaccctcg ggcctgggga ccggtgctct gggaagggtc cgctgtgtta
      481 ctggccgccg ccagggtcgc caccggcgcc ctccctccgc gcctccctcc ccctcgagcc
      541 gccacgatgt cccctgcgct cctgtcccct cccgcgtagt gcttgccttt gttccaggaa
      601 tagcgctcca ggctcctgct gccgcccctg ggcctcactc tggagcgggc tgcctccgcc
      661 ctctcgtgcc agctcagccc ctcccatgca catttggacg ctgtcctgcg ctccagttgc
      721 acaaagctga gctcctgtta cacactgaca gaccactgac agccgccgct gccaaccccc
      781 ctcctcctca ccagacttcc agacgactac atcatgctgc ccacagacct gcgctgccac
      841 tgccatcgcc atccatcgca ttccaccgac agactgctgc ttctagtgat ctgtactcac
      901 ctcggaggta tctgggctgg acacagcccc tggacaatga tccagacagc tggctgcccc
      961 tcaagggacc tgttaccttc agcgagaccc atttcctccc caatcccaga gactttttgt
     1021 gctcctgcca catggctgcc agggctcagt tgtgcctggc agccaaatcg agtctctcat
     1081 tttctcttgt ggaccagtta gttttgccca gaatccattt ctcttctgaa tttgcagcat
     1141 tttctcaggt gctttttgat caacaaaata acttgtatct tctgcttaac tcctttatac
     1201 tacctggaga aaagtatttt ccatattttc aataaatgtc agacactatt gagaaagaaa
     1261 tagagtctga atgaatatgg cacctttccc tccctggtcc tgtaaatgtg gtccatatct
     1321 tgttcagaag cgatatcccc tgccattcag tgactgatgt tgactcctgc attataaaac
     1381 atctaagata gagtcctgtg gtaacctggg ggatagtgtc cccactggtg atccttctgt
     1441 cccagatgtt gaatcctcta aaccagttag gattatccca agcctcttag taaatgaatc
     1501 gttacctcat tttggtcaac actatgtgag aagtcagcca gcaggctctt ggaaaatgta
     1561 tcctcatttc cagaaagtgg tttgaaaaca caattcccaa attgttacaa accataaatc
     1621 ccacacagat tattggtgaa cagctgtaaa attttactca acccatgatt cagggaacca
     1681 acagaattat ataggtgctt ttcaaaagca tttataaatt cttgattatg taggtagtgg
     1741 ggggaaatgc agaaatgaga tcattaattt agatacaaac ctggttgatg accagggggt
     1801 tttattttgc agaagaattg ggtatttggt atcattttat tcaattacat gtgatcctgg
     1861 tacatttcat aagcttgggt aaaaaaattt tttgttattt tccatgcaca ataagggaaa
     1921 tgttttaatt ggctttgtgc ctcctgcttt acaacagttc tggcctcaag ttaccaggta
     1981 gcctgaactt tgattttatt ttaccattaa attgctttaa taccattgta
//
