LOCUS       NM_001078172            1204 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens retrotransposon Gag like 8A (RTL8A), transcript
            variant 1, mRNA.
ACCESSION   NM_001078172 XM_001127698
VERSION     NM_001078172.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1204)
  AUTHORS   Mohan,H.M., Trzeciakiewicz,H., Pithadia,A., Crowley,E.V.,
            Pacitto,R., Safren,N., Trotter,B., Zhang,C., Zhou,X., Zhang,Y.,
            Basrur,V., Paulson,H.L. and Sharkey,L.M.
  TITLE     RTL8 promotes nuclear localization of UBQLN2 to subnuclear
            compartments associated with protein quality control
  JOURNAL   Cell Mol Life Sci 79 (3), 176 (2022)
   PUBMED   35247097
  REMARK    GeneRIF: RTL8 promotes nuclear localization of UBQLN2 to subnuclear
            compartments associated with protein quality control.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1204)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1204)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1204)
  AUTHORS   Brandt,J., Schrauth,S., Veith,A.M., Froschauer,A., Haneke,T.,
            Schultheis,C., Gessler,M., Leimeister,C. and Volff,J.N.
  TITLE     Transposable elements as a source of genetic innovation: expression
            and evolution of a family of retrotransposon-derived neogenes in
            mammals
  JOURNAL   Gene 345 (1), 101-111 (2005)
   PUBMED   15716091
REFERENCE   5  (bases 1 to 1204)
  AUTHORS   Brandt,J., Veith,A.M. and Volff,J.N.
  TITLE     A family of neofunctionalized Ty3/gypsy retrotransposon genes in
            mammalian genomes
  JOURNAL   Cytogenet Genome Res 110 (1-4), 307-317 (2005)
   PUBMED   16093683
REFERENCE   6  (bases 1 to 1204)
  AUTHORS   Frattini,A., Faranda,S., Zucchi,I. and Vezzoni,P.
  TITLE     A low-copy repeat in Xq26 represents a novel putatively prenylated
            protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and
            DXS9916)
  JOURNAL   Genomics 46 (1), 167-169 (1997)
   PUBMED   9403077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136169.6.
            
            On Jun 16, 2020 this sequence version replaced NM_001078172.1.
            
            Transcript Variant: This variant (1) is intronless and encodes the
            longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC000393.2, AL117556.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370775.3/ ENSP00000375267.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1204              AL136169.6         49277-50480         c
FEATURES             Location/Qualifiers
     source          1..1204
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..1204
                     /gene="RTL8A"
                     /gene_synonym="CXX1b; FAM127B; MAR8A; SIRH6"
                     /note="retrotransposon Gag like 8A"
                     /db_xref="GeneID:26071"
                     /db_xref="HGNC:HGNC:24514"
     exon            1..1204
                     /gene="RTL8A"
                     /gene_synonym="CXX1b; FAM127B; MAR8A; SIRH6"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..369
                     /gene="RTL8A"
                     /gene_synonym="CXX1b; FAM127B; MAR8A; SIRH6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mammalian retrotransposon derived protein 8A; protein
                     FAM127B; Sushi-Ichi retrotransposon homolog 6; family with
                     sequence similarity 127 member B; mammalian
                     retrotransposon-derived 8A; retrotransposon Gag-like
                     protein 8A"
                     /codon_start=1
                     /product="retrotransposon Gag-like protein 8A isoform 1"
                     /protein_id="NP_001071640.1"
                     /db_xref="CCDS:CCDS43998.1"
                     /db_xref="GeneID:26071"
                     /db_xref="HGNC:HGNC:24514"
                     /translation="MDGRVQLMKALLAGPLRPAARRWRNPIPFPETFDGDTDRLPEFI
                     VQTSSYMFVDENTFSNDALKVTFLITRLTGPALQWVIPYIRKESPLLNDYRGFLAEMK
                     RVFGWEEDEDF"
     regulatory      1176..1181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTL8A"
                     /gene_synonym="CXX1b; FAM127B; MAR8A; SIRH6"
                     /note="hexamer: AATAAA"
     polyA_site      1204
                     /gene="RTL8A"
                     /gene_synonym="CXX1b; FAM127B; MAR8A; SIRH6"
                     /note="major polyA site"
ORIGIN      
        1 gaaactccgc ggagcgcgcg cggcacgatg gacggtcggg tgcagctgat gaaggccctc
       61 ctggccgggc ccctccggcc cgcggcgcgt cgctggagga acccgattcc ctttcccgag
      121 acgtttgacg gagataccga ccgactcccg gagttcatcg tgcagacgag ctcctacatg
      181 ttcgtggacg agaacacgtt ctccaacgac gccctgaagg tgacgttcct catcacccgc
      241 ctcacggggc cagccctgca gtgggtgatc ccctacatca ggaaggagag ccccctgctc
      301 aatgattacc ggggcttcct ggccgagatg aagcgggtct ttggatggga ggaggacgag
      361 gacttctagg ccgggagacc cttgggcctg ggggcgggtg ctctgggaag agttcgctgt
      421 gccagtggcc accgctaggg tctccacagg cgccctccct ccgcgcctcc ctccccctcg
      481 agccgccgcg atgtcccctg cgctcctgtc ccctcccgcg tagtgcttgc ctttgttcca
      541 ggaatagcgc tccaggctcc tgctgcagct cctgggccgc actctagagc gcgctgcctc
      601 cgccctcttt tgccagccca gcccctccat gcacatttgg acgctgtcct gcacttcagg
      661 tgcaagctgg gctcctgtta catactggac agaccaccca cagccgctgc tgccaaccca
      721 cctccactcc tccagactgc cagccaacta catcattctg cccacagacc tacgctacca
      781 ctgccatcgc catccaccgc atctcaccaa cagactgtgg ctcctagtga tgtggactca
      841 cctcggaggt atccgagctg gacacagccc ctggacagtg atccagacag ctggccgtcc
      901 cccaaggagc ctgtcacctt cagcgagacc catttcctcc ccatccccag agacctcttg
      961 tgttcctgcc acatagctgc cagggcttaa gtgtgcctgg caaccaaatc gaatctctca
     1021 ttttctcctg tggaccagtt agttttgcct agaatcctgt tttcttctga atttgcagct
     1081 gtctctctga tgggtgcctt ttgttcaaca cagtaagccc tgctcccttc cctgctctaa
     1141 tacactacct gtacaaaggt tttttcctta tttttaataa atgtcagaca ctattaaata
     1201 gaaa
//
