LOCUS       NM_032287               5419 bp    mRNA    linear   PRI 06-NOV-2024
DEFINITION  Homo sapiens retrotransposon Gag like 6 (RTL6), mRNA.
ACCESSION   NM_032287
VERSION     NM_032287.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5419)
  AUTHORS   Brandt,J., Schrauth,S., Veith,A.M., Froschauer,A., Haneke,T.,
            Schultheis,C., Gessler,M., Leimeister,C. and Volff,J.N.
  TITLE     Transposable elements as a source of genetic innovation: expression
            and evolution of a family of retrotransposon-derived neogenes in
            mammals
  JOURNAL   Gene 345 (1), 101-111 (2005)
   PUBMED   15716091
REFERENCE   2  (bases 1 to 5419)
  AUTHORS   Brandt,J., Veith,A.M. and Volff,J.N.
  TITLE     A family of neofunctionalized Ty3/gypsy retrotransposon genes in
            mammalian genomes
  JOURNAL   Cytogenet Genome Res 110 (1-4), 307-317 (2005)
   PUBMED   16093683
REFERENCE   3  (bases 1 to 5419)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z75407.2, BC030232.1, AL136553.1 and BC018713.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032287.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.123001.1,
                                           SRR1803614.260014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341255.4/ ENSP00000340434.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               Z75407.2           4448-4555           c
            109-4486            BC030232.1         1-4378
            4487-5410           AL136553.1         1730-2653
            5411-5419           BC018713.1         2480-2488
FEATURES             Location/Qualifiers
     source          1..5419
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.31"
     gene            1..5419
                     /gene="RTL6"
                     /gene_synonym="dJ1033E15.2; LDOC1L; Mar6; Mart6; SIRH3"
                     /note="retrotransposon Gag like 6"
                     /db_xref="GeneID:84247"
                     /db_xref="HGNC:HGNC:13343"
                     /db_xref="MIM:621006"
     exon            1..190
                     /gene="RTL6"
                     /gene_synonym="dJ1033E15.2; LDOC1L; Mar6; Mart6; SIRH3"
                     /inference="alignment:Splign:2.1.0"
     exon            191..5419
                     /gene="RTL6"
                     /gene_synonym="dJ1033E15.2; LDOC1L; Mar6; Mart6; SIRH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             446..1165
                     /gene="RTL6"
                     /gene_synonym="dJ1033E15.2; LDOC1L; Mar6; Mart6; SIRH3"
                     /note="protein LDOC1L; mammalian retrotransposon-derived
                     protein 6; leucine zipper protein down-regulated in cancer
                     cells-like; leucine zipper down-regulated in cancer 1
                     like; Sushi-Ichi retrotransposon homolog 3; mammalian
                     retrotransposon-derived 6; LDOC1 like"
                     /codon_start=1
                     /product="retrotransposon Gag-like protein 6"
                     /protein_id="NP_115663.2"
                     /db_xref="CCDS:CCDS33662.1"
                     /db_xref="GeneID:84247"
                     /db_xref="HGNC:HGNC:13343"
                     /db_xref="MIM:621006"
                     /translation="MVQPQTSKAESPALAASPNAQMDDVIDTLTSLRLTNSALRREAS
                     TLRAEKANLTNMLESVMAELTLLRTRARIPGALQITPPISSITSNGTRPMTTPPTSLP
                     EPFSGDPGRLAGFLMQMDRFMIFQASRFPGEAERVAFLVSRLTGEAEKWAIPHMQPDS
                     PLRNNYQGFLAELRRTYKSPLRHARRAQIRKTSASNRAVRERQMLCRQLASAGTGPCP
                     VHPASNGTSPAPALPARARNL"
     regulatory      5392..5397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTL6"
                     /gene_synonym="dJ1033E15.2; LDOC1L; Mar6; Mart6; SIRH3"
                     /note="hexamer: ATTAAA"
     polyA_site      5419
                     /gene="RTL6"
                     /gene_synonym="dJ1033E15.2; LDOC1L; Mar6; Mart6; SIRH3"
                     /note="major polyA site"
ORIGIN      
        1 ctggcccggt ccctgcacct gccggaggcc gcccgccgcc atcgccagcg ccgtcgcttg
       61 gctgcgctga ccgggaagca gttctcggcg gtccgcgcgg tgattcatcg gcctggccgc
      121 gtcccccgcg cgggccatct tggtcacggc cggcggcgga cagagccgcg gaggaaccgc
      181 gagaccccag ggcccagagc aggtccagcc acccgtctgg ctccgtagtc cgcgaagtct
      241 gcagtaaagg agccgcgtgg gaccggggcc gaagtcccta gggcctggca ccgcgtgccc
      301 ctctctcggg ccctcggctt gggggtctcg cagcgccctg ccgtcgtgca ccccacactg
      361 cccccatttc tacaggggcc cacctggtca ccacaccctc ttggtccacc cgcggatctc
      421 agcgtgtggc tgacctctgg ccagcatggt gcagccgcag acgtccaaag ctgaaagccc
      481 agccttggca gcgtctccga atgcccagat ggatgacgtt attgacaccc tgacctccct
      541 gcgcctcacc aactcggcgc tgaggcggga ggcttccacc ctgcgggcgg agaaggccaa
      601 tctcaccaac atgctggaga gcgtgatggc agagctgacc ttgttacgca ccagggcgcg
      661 gatcccgggg gctctgcaga tcaccccgcc catctcctca attacttcaa acgggactcg
      721 acccatgacc acacctccaa cctctctgcc cgagcccttt tccggggacc caggccggtt
      781 ggcggggttc ctgatgcaga tggacagatt catgatcttc caggcctccc gcttcccggg
      841 tgaggccgag cgtgtggcct tccttgtgtc tcgactgact ggggaggcgg agaagtgggc
      901 tatcccccac atgcaacctg acagcccctt gcgcaacaac tatcaggggt tcctggcaga
      961 gttgcggaga acctacaagt ctccgctccg gcatgcgcgg cgcgcccaaa tcaggaagac
     1021 ttctgcctct aatagggctg tgcgagagag gcagatgctc tgccgccagc tggcctctgc
     1081 gggcacgggg ccttgcccag tgcatccagc ttccaacggg actagtccag cgccagccct
     1141 gcctgcccga gcacggaatc tttaagaatc cgccagcact tggtagcgtc tgcagccacc
     1201 caggtagcat acgctctttg ctgtgtagaa gaaatgccca tacgacagct ttgcccctgt
     1261 ttgaagacct cccttcttgc ctctccagac gtgttccccg aggagatctt ccttccgtcc
     1321 ttcctggcgc cctggttgcc caccttgccg tgcttcctct tacgtgctag ctttgtacct
     1381 atcgctcact gcatgctcgc ctccctcttg ctggcatccc ggcctgtttc aatgactacc
     1441 gctctgctac ttaggcacag ggactccgcc gcacgctgac ggaccacgag ggctgacccc
     1501 ttccagcctg acttggttca tggaggctcc tactctgccc tctccaagct cccctggcgg
     1561 ctccccacct ggttgcccag ttcctattga tgagctctgg acagaaagat gcccgtttgg
     1621 ccaggctggt ggcttgatgg gtgtacctgg agagggggtc tggcttcctg cccaagatgc
     1681 ctcccagccc tgccagggcc cggtgcagcg ggcagggcct catctgtgct gtagtggtcg
     1741 agtggttgct gcaaggagcg tagttctgcc atgtctgggg gccaggttcc actctgcaca
     1801 tgaatatgca gtctgggagg ccccactgct ctcactggga aggaccaatg ttgcacctct
     1861 gttaatgcct gacttcagct gctggtgttc tgatggagcc agaggcttgg ggaatctgga
     1921 acttgcctgc taaataaggt cgtggtggac tctcagccat tgggcaggtc tatcaggctg
     1981 caggttccta cacacccacg cctgagggtc atagcaggct aagggtggat accagcgact
     2041 ccctttgctg cccaggatct ccatgggcag tgccacagcg gctgatgctc agtcactcct
     2101 gcttctaccc cctgtcactg atggcgagcc ttgcccagct tgagacctgt tcccatctct
     2161 attcaggtgc catgtggcct tcactgcagc cctgcagcca cccacgcacc atctgtgggt
     2221 ctccaaaggc accttgtagc atgtactccc cgtgcctggg caatcagatg ggctgccttt
     2281 gtccaaggga aaacagactc ccttcgggaa acatccttaa gcacttaagg ccgggggggg
     2341 tgtctgcctc tggcaaccca gccagggtct tggtggcatt tgtaaaagca aagagctgtg
     2401 gactgccgtg gtcctagtgt ggtgacaatg cagcactggc atgcatgtcc tccttctgaa
     2461 ggacctcatc cttcctcaca gggggatgac caagaaatca ttttgtggct gagtttggcc
     2521 acgccctttg gactgtgctg ttccgccata tttcaatgcc aaatgaacca cattgacatg
     2581 acctggacca tagggcttcc tatcctgggc tcagctgccc ctgtctgaag ggtcttggct
     2641 tgattgcaga aggacaacct ccgcacccac ctaaagacat gtatatgtct tgggatccca
     2701 gagattgggt ccttgggcct ggcttcttaa gagttttgat gatgctggga aaagtgactg
     2761 cgattctgaa gaaccgctgc cttgcaaggt caaggacatt cagtggttgc tggggtccgc
     2821 agactactgc cacccactca ccatcaactc tgttagccca attgccctgc tgaacaactg
     2881 cctgaataca ggctttaggt tcccctggac tccagccaag gctgttcagg tgggaccatg
     2941 gtgctcttta agcgtgatcg gagggaagac acacagcagg gccaccattc catgaatggg
     3001 aggtgtacag atcactttct ctttgtgctc agttctgttc tgtctccagc agctatattg
     3061 gtaagactag tacctgccag ggagaggtgc ccccaagtga aggggtacag tggcacctgg
     3121 gaaaaggcac ctggaaggtt tccatgtggc ccagcccagc atggaagcag ggtgggaact
     3181 ctgctgtgtc gccagcgctc actctactcg agtggctttt tgaaagccct accatgtctg
     3241 tgtcaggcct gtgctgcttc acatcctaca gctgcctagg aaaggccggc cacgctccct
     3301 gtccacacac tccctgtcca cacactccct gtccacacac tccctgtcca caactgcagc
     3361 cgggccctct gcctatgggc acccaatcca agcagctgct ccacctttgt ttggcatggt
     3421 gatttgtgtt ttttctcttg gtgcttatgt gtgtgggctt gggacgagtg ctggtatgca
     3481 cttaggacct tcttgatagc tccctgcact ttggaacacg gagcagatga gagagggtcg
     3541 gggcttgccc tccaccttgg acttggaaga agcccacatt ggagaggtga ggaccccatg
     3601 gtggctctag tggaagatac gttagtctcc agctaaggag gatgaggcgc agccccagag
     3661 ggagacctca gtgatagggg atcaggctaa gaaagtgggg gaagggagat gctttgtaca
     3721 tattttgggg ttataatttc tctaaatttt aggagaacgg gtattgattg ataaaaggga
     3781 caggcagtag tgttcaacag tgcatgtgaa ggaaagttct gttttccatg gttttgacat
     3841 tctttggact gtattgtgac tgctgtctgg tccacatggt acccctttgg taagtaggct
     3901 tcagtgcata ccagggtatc actggagatg ggagttagtg aaggggtgac tccctggcct
     3961 agtatagtgt gaccctggga ctaacttaat gtcctaaagc attttggtga cttctaggga
     4021 atagcaaaga cctatttcat tgtccccagg taagtatgtg atgagcaatg aggaggagtg
     4081 gaaaacaaaa cccagaaagt gcggcaggac cagcctgacg cacacgctcc tgttgtcatg
     4141 gcagacagcc gccttgggtg ggcaccaccc tggcagttcc agcctgtagg ggagtgaagg
     4201 gacatggctg agctgggcat gtgctgaggt tgacttaggg aacaagccct gggattggac
     4261 aaaagggccc atgctgcagc cactgactgg gggcagagct ctgggtggaa gagggaagag
     4321 atcctaatgg aggcgcctcc atctgcaacc acagttgtaa ggctcatggc acctctgctt
     4381 ggaaagcact ggtttaggga cttagagagg taggcacaag gtgggtctcc tgggtaaggg
     4441 aagcaagagc agactgttgg gccaacagga gaagctcccc agagtagggg agaaggttgg
     4501 ggtgtagggc cttccacgtg gaacagacag cccctgtgtc tctgtctctt ggggacctga
     4561 gtttgggtgg ggtggcagtt ggcacagcgc agatgcggta gagatgggag gaaacccagc
     4621 tcctcacttc cgtgtgcctc atgcctttgc atacacaagc accaaaccta ctaggtcttc
     4681 tcattaccca tgtaaaccac atgttagata aatttttgca agtagaggaa agaaggaaat
     4741 aaaacatcac attttggtgt ctctcaggct ttccccccca actatggttt ctttgctttt
     4801 tgttttaaca tagttttgtt gctgtcttct gtaatgatac agttttgtgc agctgttttc
     4861 acttagcata tcgtgggcat ctccccttat gattactaaa tattttattt tggagtggct
     4921 gtgtactctc ccattgacta gatggaccat tgtgccagtt gccaatcact aatgctgtta
     4981 ctaacttttc agttataaat tgatgaatat ctttgtgcac aggctgtttc ccaatgtcaa
     5041 gttattaggg tagactccag gaggtgggat tcttcaacta aagaatatga aaacctttga
     5101 ggcttttact acatattgac aaaatggttt ccggaaatat ttgtatcccc ttacactgcc
     5161 accagcaagg ataaacatgt ccatcttgcc cgtattggga attatcatct ggctaaatat
     5221 ttgctaattt gataatgaaa aaatagcatc gtgtttcagt tggcatttca ctgacttcta
     5281 gcacggttga acatctttca tgtggagcga ttgtatttcc tcctttgtgg attgtcagtg
     5341 tcctttgctc tatcttctgg ggtcagataa atttgtatga gctcggtata tattaaagat
     5401 attaacctgg tgtgtgtca
//
