LOCUS       NM_152694               2649 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens retrotransposon Gag like 3 (RTL3), mRNA.
ACCESSION   NM_152694
VERSION     NM_152694.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2649)
  AUTHORS   Brandt,J., Schrauth,S., Veith,A.M., Froschauer,A., Haneke,T.,
            Schultheis,C., Gessler,M., Leimeister,C. and Volff,J.N.
  TITLE     Transposable elements as a source of genetic innovation: expression
            and evolution of a family of retrotransposon-derived neogenes in
            mammals
  JOURNAL   Gene 345 (1), 101-111 (2005)
   PUBMED   15716091
REFERENCE   2  (bases 1 to 2649)
  AUTHORS   Brandt,J., Veith,A.M. and Volff,J.N.
  TITLE     A family of neofunctionalized Ty3/gypsy retrotransposon genes in
            mammalian genomes
  JOURNAL   Cytogenet Genome Res 110 (1-4), 307-317 (2005)
   PUBMED   16093683
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK096184.1, AI091777.1 and
            AL662885.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_152694.2.
            
            Summary: This gene is a member of a family of gag-related
            retrotransposon genes. These genes appear to have lost the ability
            to retrotranspose; however, their open reading frames have remained
            intact, which may indicate that these genes have acquired new
            functions in the cell. [provided by RefSeq, Nov 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096184.1, DA656923.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321110.2/ ENSP00000316794.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2426              AK096184.1         1-2426
            2427-2435           AI091777.1         213-221             c
            2436-2648           AK096184.1         2436-2648
            2649-2649           AL662885.7         84933-84933         c
FEATURES             Location/Qualifiers
     source          1..2649
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..2649
                     /gene="RTL3"
                     /gene_synonym="Mar3; Mart3; SIRH9; ZCCHC5; ZHC5"
                     /note="retrotransposon Gag like 3"
                     /db_xref="GeneID:203430"
                     /db_xref="HGNC:HGNC:22997"
                     /db_xref="MIM:301130"
     exon            1..68
                     /gene="RTL3"
                     /gene_synonym="Mar3; Mart3; SIRH9; ZCCHC5; ZHC5"
                     /inference="alignment:Splign:2.1.0"
     exon            69..2649
                     /gene="RTL3"
                     /gene_synonym="Mar3; Mart3; SIRH9; ZCCHC5; ZHC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..1724
                     /gene="RTL3"
                     /gene_synonym="Mar3; Mart3; SIRH9; ZCCHC5; ZHC5"
                     /note="zinc finger CCHC domain-containing protein 5;
                     mammalian retrotransposon-derived 3; zinc finger, CCHC
                     domain containing 5; Sushi-Ichi retrotransposon homolog 9;
                     zinc finger CCHC-type containing 5"
                     /codon_start=1
                     /product="retrotransposon Gag-like protein 3"
                     /protein_id="NP_689907.1"
                     /db_xref="CCDS:CCDS14440.1"
                     /db_xref="GeneID:203430"
                     /db_xref="HGNC:HGNC:22997"
                     /db_xref="MIM:301130"
                     /translation="MVEDLAASYIVLKLENEIRQAQVQWLMEENAALQAQIPELQKSQ
                     AAKEYDLLRKSSEAKEPQKLPEHMNPPAAWEAQKTPEFKEPQKPPEPQDLLPWEPPAA
                     WELQEAPAAPESLAPPATRESQKPPMAHEIPTVLEGQGPANTQDATIAQEPKNSEPQD
                     PPNIEKPQEAPEYQETAAQLEFLELPPPQEPLEPSNAQEFLELSAAQESLEGLIVVET
                     SAASEFPQAPIGLEATDFPLQYTLTFSGDSQKLPEFLVQLYSYMRVRGHLYPTEAALV
                     SFVGNCFSGRAGWWFQLLLDIQSPLLEQCESFIPVLQDTFDNPENMKDANQCIHQLCQ
                     GEGHVATHFHLIAQELNWDESTLWIQFQEGLASSIQDELSHTSPATNLSDLITQCISL
                     EEKPDPNPLGKSSSAEGDGPESPPAENQPMQAAINCPHISEAEWVRWHKGRLCLYCGY
                     PGHFARDCPVKPHQALQAGNIQACQ"
     regulatory      2629..2634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTL3"
                     /gene_synonym="Mar3; Mart3; SIRH9; ZCCHC5; ZHC5"
                     /note="hexamer: AATAAA"
     polyA_site      2649
                     /gene="RTL3"
                     /gene_synonym="Mar3; Mart3; SIRH9; ZCCHC5; ZHC5"
                     /note="major polyA site"
ORIGIN      
        1 atttacacat ttccctcctc agcaatgggt acacagacag ccaagctcct ggactaagtc
       61 tctgaatgtg tatctgacac ttccccttac tgagctccgg aggctccttc ttgccgagct
      121 ccggaggctc ccagtgacct cttgataatc agccttggcg gggcccaaat accacccctt
      181 ggaaaactca ctgagcctga catctgcctg taagcagctt tcaggaagga tctcacaaac
      241 acccacccaa tctctcttgg tagcaaattg tcaaatcata cccatttcct caaaagatgg
      301 tggaggactt agcagcctcc tatattgttc tgaaattgga gaatgaaatt cggcaggctc
      361 aagtgcagtg gctgatggaa gaaaatgctg ctctccaggc ccagatccca gagcttcaga
      421 agtcccaagc agccaaggag tatgatctac tccgaaagtc ctcagaggcc aaggagcccc
      481 agaagctccc agagcacatg aatcccccag cagcctggga ggcccaaaag accccagagt
      541 tcaaggaacc ccagaagcca ccagagccac aggatcttct accctgggaa cccccagcag
      601 cctgggaact ccaggaggcc ccagcagccc cagagtccct ggcgcctcca gcaacccggg
      661 agtcccagaa acctccaatg gcccatgaga tcccaacagt cttggagggc caggggcctg
      721 caaacaccca ggatgccaca atagcccaag agcccaagaa ttcagaaccc caggatcccc
      781 caaatattga gaagccccag gaggcaccag aataccagga aactgcagca cagctagagt
      841 tccttgagct tccacctccc caggagcctc tggagccttc aaatgcccag gaattcctag
      901 aactctcagc agcccaggag tccctggagg gtctaatagt tgtggagaca tcagcagctt
      961 cagagtttcc acaggcccct attgggttag aggctacaga tttccccctg caatacactt
     1021 taaccttcag tggagattcc cagaagcttc ctgagttcct ggttcagctg tatagttaca
     1081 tgagagtcag agggcacctg tatcccactg aagcagccct ggtgagcttt gttggcaatt
     1141 gcttctcagg tagggcagga tggtggttcc agctcttact ggatatccaa agccccttac
     1201 tggagcaatg tgaaagtttc atacctgtgc tccaggatac ttttgataat ccagaaaaca
     1261 tgaaagatgc caaccagtgc atccatcaac tctgccaagg ggagggtcat gtagcaaccc
     1321 acttccacct cattgctcaa gagctgaact gggatgaaag cactctctgg atccaatttc
     1381 aagaaggtct tgccagttct atacaagatg aactgtctca cacaagccca gccaccaacc
     1441 tatctgatct catcactcag tgcatcagcc tggaagagaa gcctgatccc aatccattag
     1501 ggaaaagttc ctctgcagag ggagatggac ccgagagtcc accagctgaa aaccaaccta
     1561 tgcaggctgc aatcaactgc ccacacatca gtgaagctga atgggtccgt tggcacaaag
     1621 gccgcttatg cctctactgt ggttatcctg gtcattttgc cagagattgc cctgtcaagc
     1681 ctcatcaggc cctgcaggcg ggaaacatcc aggcctgcca gtaaggggga ccccacgtgg
     1741 gccaatctac aaatatgcgt ccccctctct tccaatatcc atgtctcata cactatggct
     1801 tactgttgaa atccaactgg gaagaagata attctttgag caagcaatgg tagattcagg
     1861 ctcctacaga aacagcattg atcatactgt ggttcttcga gagaagctgc ccatccgcag
     1921 taatatcttc cctctgatgc tggaaactgt cgacggccat ccacttatta atggacccat
     1981 aactaaggaa acatcacctg tccaagttca aattggaaac catgttgaag agctccagtt
     2041 tgacattatt catgcaccac gataccctct gattattgga atccattggc ttgagacaca
     2101 tgacccaaac atagaatgga gtacccgcac tgtgtccttt ctatcacgtt attgtcacta
     2161 caattgcttc aggcacaggt ggaatagaag aaatcgtgat gaaataattt ctgggtagat
     2221 cctgtgtcct agtgactgtt cctggcaacc tgtcttctgt tacctcagct gtcatcagca
     2281 tttgctgctc cctgaatctt ctactgaaca tcttgctatg tactaaggct acctgtacaa
     2341 cgactctgcc tcttagatga tagactgaac ctgatgactt tgagctgctt tttttttttt
     2401 cactaactct gcatgcctct atctcagaac tctgcatcct gcggaactgt tttaattaca
     2461 attatactaa caatacacat gagaatagat attagaaact aataatgaaa aagcatagct
     2521 gttaaactga cttgattttt ttcttatcaa tattttctat atcacaaaaa tggcaacatc
     2581 ttttacataa agaaaataag tttgtaagtg atatttctta aaagaatcaa taaatattag
     2641 caatttcta
//
