LOCUS       NM_024627               6653 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens retrotransposon Gag like 10 (RTL10), mRNA.
ACCESSION   NM_024627
VERSION     NM_024627.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6653)
  AUTHORS   Busche,S., John,K., Wandrer,F., Vondran,F.W.R., Lehmann,U.,
            Wedemeyer,H., Essmann,F., Schulze-Osthoff,K. and Bantel,H.
  TITLE     BH3-only protein expression determines hepatocellular carcinoma
            response to sorafenib-based treatment
  JOURNAL   Cell Death Dis 12 (8), 736 (2021)
   PUBMED   34312366
  REMARK    GeneRIF: BH3-only protein expression determines hepatocellular
            carcinoma response to sorafenib-based treatment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6653)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6653)
  AUTHORS   Greaves,G., Milani,M., Butterworth,M., Carter,R.J., Byrne,D.P.,
            Eyers,P.A., Luo,X., Cohen,G.M. and Varadarajan,S.
  TITLE     BH3-only proteins are dispensable for apoptosis induced by
            pharmacological inhibition of both MCL-1 and BCL-XL
  JOURNAL   Cell Death Differ 26 (6), 1037-1047 (2019)
   PUBMED   30185825
  REMARK    GeneRIF: The BH3-only proteins were required for apoptosis induced
            as a result of BCL-XL inhibition, this requirement was overcome
            when both BCL-XL and MCL-1 were inhibited, implicating distinct
            mechanisms by which different anti-apoptotic BCL-2 family members
            may regulate apoptosis in cancer.
REFERENCE   4  (bases 1 to 6653)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6653)
  AUTHORS   Gao,W., Huang,W. and Liu,K.
  TITLE     [Effect and significance of BH3-only protein in targeted therapy of
            non-small cell lung cancer]
  JOURNAL   Zhongguo Fei Ai Za Zhi 17 (11), 819-823 (2014)
   PUBMED   25404273
  REMARK    GeneRIF: Studies indicate that BH3-only protein (C22orf29 protein)
            plays an important role in activation and communication in
            apoptosis pathways.
            Review article
REFERENCE   6  (bases 1 to 6653)
  AUTHORS   Plotz,M. and Eberle,J.
  TITLE     BH3-only proteins: possible proapoptotic triggers for melanoma
            therapy
  JOURNAL   Exp Dermatol 23 (6), 375-378 (2014)
   PUBMED   24673301
  REMARK    GeneRIF: Members of the subfamily of BH3-only proteins function as
            proapoptotic triggers, and mimetics of these proteins are already
            in clinical trials in other cancers.
REFERENCE   7  (bases 1 to 6653)
  AUTHORS   Zhang,X., Weng,C., Li,Y., Wang,X., Jiang,C., Li,X., Xu,Y., Chen,Q.,
            Pan,L. and Tang,H.
  TITLE     Human Bop is a novel BH3-only member of the Bcl-2 protein family
  JOURNAL   Protein Cell 3 (10), 790-801 (2012)
   PUBMED   23055042
  REMARK    GeneRIF: Bop may be a novel BH3-only factor that can engage with
            the regulatory network of Bcl-2 family members to process intrinsic
            apoptotic signaling
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC000076.2, DA182195.1, DA757523.1, BC011679.2 and AK026924.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024627.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX640969.1, SRR1660803.244936.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152474 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328554.9/ ENSP00000330596.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC000076.2         40839-40864         c
            27-193              DA182195.1         1-167
            194-626             DA757523.1         136-568
            627-2564            BC011679.2         108-2045
            2565-4994           AC000076.2         33795-36224         c
            4995-6653           AK026924.1         914-2572
FEATURES             Location/Qualifiers
     source          1..6653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..6653
                     /gene="RTL10"
                     /gene_synonym="BOP; C22orf29"
                     /note="retrotransposon Gag like 10"
                     /db_xref="GeneID:79680"
                     /db_xref="HGNC:HGNC:26112"
                     /db_xref="MIM:620751"
     exon            1..215
                     /gene="RTL10"
                     /gene_synonym="BOP; C22orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            216..312
                     /gene="RTL10"
                     /gene_synonym="BOP; C22orf29"
                     /inference="alignment:Splign:2.1.0"
     exon            313..6653
                     /gene="RTL10"
                     /gene_synonym="BOP; C22orf29"
                     /inference="alignment:Splign:2.1.0"
     CDS             538..1632
                     /gene="RTL10"
                     /gene_synonym="BOP; C22orf29"
                     /note="BH3-only protein; retrotransposon Gag-like protein
                     10"
                     /codon_start=1
                     /product="protein Bop"
                     /protein_id="NP_078903.3"
                     /db_xref="CCDS:CCDS13769.1"
                     /db_xref="GeneID:79680"
                     /db_xref="HGNC:HGNC:26112"
                     /db_xref="MIM:620751"
                     /translation="MPRGRCRQQGPRIPIWAAANYANAHPWQQMDKASPGVAYTPLVD
                     PWIERPCCGDTVCVRTTMEQKSTASGTCGGKPAERGPLAGHMPSSRPHRVDFCWVPGS
                     DPGTFDGSPWLLDRFLAQLGDYMSFHFEHYQDNISRVCEILRRLTGRAQAWAAPYLDG
                     DLPLPDDYELFCQDLKEVVQDPNSFAEYHAVVTCPLPLASSQLPVAPQLPVVRQYLAR
                     FLEGLALDMGTAPRSLPAAMATPAVSGSNSVSRSALFEQQLTKESTPGPKEPPVLPSS
                     TCSSKPGPVEPASSQPEEAAPTPVPRLSESANPPAQRPDPAHPGGPKPQKTEEEVLET
                     EGDQEVSLGTPQEVVEAPETPGEPPLSPGF"
     regulatory      6633..6638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTL10"
                     /gene_synonym="BOP; C22orf29"
                     /note="hexamer: AATAAA"
     polyA_site      6653
                     /gene="RTL10"
                     /gene_synonym="BOP; C22orf29"
                     /note="major polyA site"
ORIGIN      
        1 ctctggacgc tgcgcggcgc tcctaggagc aggcgttccc gactccggca agagggtcag
       61 tgtggaggcg ggagcccggg cggccggctt gaactccgtg cacgcgggcc tggagctgcg
      121 cccctgcgtc ttttcccgac ttctgatccg cagaggggca ctcggagccc cagcctgggt
      181 cgcagtgcct tcggtctgcg ggcctcagtt tctcggtggc gcctggactc tcgccctcag
      241 agggaggccc gtcccacggt ctgtggctac ggatcccagg accctcttcg cgggcgattc
      301 gcgtagcctc agattgcctc ggatgatggc ctgcgactga cagtctctca gctcttctca
      361 gctctcctga ggctgcagct gtcagctccc tgatcctcag cacttgcctg gaccagtgcg
      421 ggtctgccac gccctgttca gccatccctg tcctgttgtg tcgtgcaagc cacatctgtc
      481 cacaccccca ccacccacca gtgctggctc tcctctcttc tcccctgtgc tcccagcatg
      541 cctcgtggcc ggtgccgtca gcagggccct cgcattccca tctgggcagc cgccaattat
      601 gccaacgcac atccatggca gcagatggac aaggcgtctc ctggggtggc atacaccccc
      661 cttgtggatc cctggattga gcggccctgc tgtggggaca ccgtgtgtgt gcgaacgacc
      721 atggagcaga agagcacagc tagtggcact tgtggcggta aacctgcaga aaggggtccc
      781 ctagctgggc acatgcccag ctcccgaccc cacagggtgg acttctgctg ggtaccaggc
      841 tcagacccag gcacctttga tggctccccg tggctactgg accgcttctt ggcccagctg
      901 ggcgattaca tgtccttcca ctttgagcac tatcaggaca acatcagccg tgtctgcgag
      961 atcctcaggc gcctaacagg ccgagcccag gcctgggcag ccccctacct tgatggggac
     1021 ctgcccctgc ctgacgatta cgagctcttc tgccaggatc tcaaggaagt tgttcaagac
     1081 ccgaacagtt ttgctgagta ccatgctgtg gttacctgtc ccctgcccct ggcctccagc
     1141 cagctgccag tggcccctca gctgcctgtg gtgaggcaat acttagctag gttcttagag
     1201 ggcctggcac tcgacatggg tactgccccc aggtctttac cagccgccat ggccacccct
     1261 gctgtgtctg ggtccaactc tgtatctaga agtgctctgt tcgagcagca gctgaccaag
     1321 gagagcaccc ctgggcccaa ggagccccca gtcctgccca gttctacatg tagctccaag
     1381 cctggtcctg tggaaccagc ctcttcccag ccagaggagg cagcccccac acctgtccct
     1441 agactgtcgg agtcagctaa tcctcctgcc cagagaccag acccagctca tccaggaggt
     1501 ccaaaacccc agaaaacaga ggaggaggtt ttggagacag agggagacca ggaggtgtcc
     1561 ttaggtaccc cacaggaggt ggtggaggcc ccggagaccc caggagagcc accactttct
     1621 cctgggttct gaacacagcc caggtgggaa caatgctgcc cctcatgatg aagtggcctg
     1681 tgtggcttga gcgccccata gtccccagtc agagcagagt ggtgtcccca gatgacttca
     1741 gaccccatag ctgggcaaga tgcgcttgtt ttggactctg cgctgagcag aaccagctcc
     1801 cccaactcca gcagagcttg acctccgccc tgtgcccttt ccctgctgct ggctctctgc
     1861 tgcatccctg cccgtcttct gggagtgccg tctcacccag gcctgctccc acgagggggt
     1921 cgttttgtag atcaactctc agcagatagt tgcatcatct ttgtcacctc cacccccata
     1981 aaacaccccc cttggtgtct tccacactgg ctgggactga actgggtctg ccacgtctgc
     2041 cctgttggga cctcgttcct gtatggggtt tctgtgtctg tccccctagc cccaccctct
     2101 ctgctccctg tgacttctgt cccagctgga atgtgaggaa ggctgcctgg aggaagtggc
     2161 cactttgatt ctgggggatg agtgggatag catcttggca aagaatgatg tttcctgtgg
     2221 gattaccagc agttctgggc agctggaagg tttggatgca ggaaggtggg atgcaagccc
     2281 cttgccaggc tcagctgcag gcattcgccc tttgtgtgtt aacactgtag ctctaatcgt
     2341 gcctggtgtt ctgaagcagg ctcctcttcc ctgctgctgt gctgccatcc cctgctcact
     2401 ccgcactcgc atgcattgcg gattcagcac ttaagcccta gtgtgtaaat gacttggatc
     2461 tccctcctgg cagactgtga ccctcagcac aggggctctg tcttagtcag ctctgtggcc
     2521 tggtacacaa ttggtgctca ttaaacacgt gttggattac tggctgaggt ggtgcagtgg
     2581 ctgcctacca gcaagtcttt gtttcccatt ctgtcaggag cagaggcctg gccatgagca
     2641 ttccaggtca gcattgcagc tgtggtttct ggcaggggct ttgagggtcc aagggtctga
     2701 tcaaagaagc tgggtggggc tgagtagggg gtgggtggct ctgcaggtag agaactgact
     2761 tccgagagct gtaggtgaag tgaggaccag gcagcagtcc agagctgtga ggccccaggc
     2821 ccagaggaat ggaatgaaga aagacctgtt ccacacaagg aggggttttc tagtggaagc
     2881 tgagcttgga agctcctgga gccaagttta ccacaggata ggcaggtaca gccgcccagt
     2941 gtgtgcagtg tgtgcccact ctggtgcttg gacaagaagt tcaagtccct ttcaggttta
     3001 caattgtgaa aacaacaaaa caacaccttc ctggaaagta ggaagaaaaa gcagaaatgt
     3061 gaattggaaa tacagccaac tattttagga aaaactaatt agcaagcatc tgattaaact
     3121 tattcagaaa ctggccggga gcagtgtctc acacctgtaa tcccagcact ctgggaggcc
     3181 aaggtgggtg gatcacctga ggtcaggagt tcaagaccag cctgaccagc atggagaaat
     3241 ccatctctcc taaaaataca aaattagcca agtgtggtgg tgcatgcctg taatctcagc
     3301 tacttgggag gctgaggcag aagaattgct tgaacccagg aggcagaggg tgtggtgagc
     3361 cgagatcacg ccattgcact ccagcctgga caacaagagt gaaactccat cccaaaaaaa
     3421 aaaaaacaac aaaaaacaaa aaccttattt agaaaaatat aaattgttgg gattatttta
     3481 tggtaactat cactagaaaa ggctctgggt tcagatggtt ttatgtgtga gttatttcag
     3541 ggcacagata ccttgtaggt aaaacaactg gaaaccttgg aaataggtgg gaagctattt
     3601 ttagaaagca ggtatagccc tggtagcaaa gcaagtgagc tggcagaaga aacccatttt
     3661 cagtcttgat tctggtcaga tgtgagaagt ccctggatgt cctggcccag ccccatgctt
     3721 ctgtgccagg tcacagctgc cctccgtccg atgactcagg ccccatcccc ccttttgtgg
     3781 gttgggtcag actgctccct gatgcctacc tccagtgcac tgtggcctgg ctcacctgtg
     3841 ggtctggcag tagaacccag agttgctctc taggatggac agcctagtca cccagctgac
     3901 ctttaccctg tcccacaggc ttctggacag gccaccttcc ccatctccct ttagtggacc
     3961 tgaagtggat actccagcct gggattgctg ccttctcttt tgaaccctgt cctattgggg
     4021 ctttggggct tttgtgccct tgggacccag gcagctcctg ggggtgtgtg agttatggtc
     4081 tgccgtgtgt ctgagggcca gtcatgcagc atccacctag gcaggcttga gagtccttgg
     4141 gagagtccag gtgacctggt ttttaattaa aacgcgtcct gtttattgtg gttgggctct
     4201 gcccagaaag gaaggtaggg ccttgaagtg gtgatgtcca ggtttcctgc acaggtaggg
     4261 tggaggcaac gatggactct ggcatggcct tccagacagg cagtgcacac agctcctttc
     4321 agagtggctt tgttgccagc tgctgcagca cctgctttca gacagatgat gaccaagctg
     4381 ctttcctgct gggggaagga ggcattcccc ctgggttgtt tttctcttct ggcccccaca
     4441 cactggcaga cccgaaggca gggtgctcag gagctgcaga gcctggcagg gtttgctgga
     4501 catgctcagg gacgggccat ggtgctggct ctgctttcta atcatggtgt cagtccttca
     4561 cttcccttgg aaatacccag agattttatt tcctgaagat aggacatgat gggtgctgtg
     4621 agatggtatt taaagtacct gtctgcaagg aaaactttaa aataggaagt actaaggata
     4681 aggtcctatg ggatattgga atattttata aagccacaat agttaaagca cttagatgtg
     4741 gacagatgag cagagaatag aggactttga aacgggccaa ataaatatgg aaatttagta
     4801 caggctagag gtgtttccaa ttaacgagta aaatggatta ttcagtaaaa gcagttggcc
     4861 ctctggaaaa tagtaaagcc atgtatgtgc ctcactcttt atgccagtac atattccaga
     4921 ttaaagattt caatgttaca attatgaaag tactagagga aaatatgggt gaattttttt
     4981 tttttttttt ttttgcctat gattccagga ttttaaaagt tttagatgcc cagagttgtg
     5041 gaggtatgga gaagtggacc ttctcatact gttggtggga atacacaata atataatttg
     5101 accacgtaac aattctaggc acatgcatgc tgtgactact tgctaggtgc atgaaggctc
     5161 ttgccagggg tggtcatggt tcggtaccac tacatggggg tttagagcag ggactggagg
     5221 ttggccttgc ctcctcccct ccccgcatga gctgagggtc cttacctgac ctttttgagc
     5281 tgtgaccaga gtttttcctc atggggtggt tagaagggtt gaatgagaat gatgcccatg
     5341 cagtgccttg gctggggtct gggccctcta acacccacct catgggtgtc actgtttttt
     5401 gaacagcaga actggaaaag cccaaagatc cagcaataaa ggagcaaggc aaataaagct
     5461 gttaccctgc aggatcagtc agcatgagcc agattgtgct gcagtaacaa agatctccaa
     5521 cagcgcagcg gctacagttg gcactgctta tttcttgctt gcacctgtgg gccaccgtgg
     5581 ctggggcctg tcagacctgt gctgacgaca gcctacctgg acatatttct ccatgctcac
     5641 tgaggcaggg gaaaggccac agcaggccac aagtaatgtg tgtcacccca cttccatttc
     5701 tgtggccaaa ggaagccaca gagccacacc tgagttccat aggacggcag cagctgatca
     5761 tcctatgggc tggggtgctc agtatggaga agtacaagca gccacccagc gtggggctgg
     5821 ttggtgctgc tgaggatggg aggatgggag gggcctgcat ccatcccagg gcaacatacc
     5881 tgtttgtctg ctggggctgc ctgacaaagg accgcaggct aggggactta aacaacagac
     5941 atttcctcat gattctggag ctagaagcct gagatcaagg tgtgggcagg gttggtttct
     6001 cctgaggcct cgctccttgg cctgcagata gccatcttct tgccgtgtcc ctgtctgtgt
     6061 ctgtgtccta atctctcata agctcactag tctattggat cagggcccac cctcatgacc
     6121 tcatttaacc ctgaattacc tctttaaaga ccctgtcttc aaatgtaagt actaggggtt
     6181 aggacttgaa cataaaaata ttgaagggac atagttctgc ccacagcggt gcccgcgata
     6241 ggcttctctg gttttgtctt tgctgttcct ggcagcgcta tattgggcag gcttctgtgg
     6301 tctccacatg cctgtgtgca gagtccccca ggccctgggt tctggggccc atactgagga
     6361 gtggggatgg ccaagccttg gctgttgagt aggcagtgcc cagttgtgct gtatgggatg
     6421 ctgtttctca cttaagaaat ctttccctac ctggggggta caaaggcatt atcctgtatt
     6481 cccaggttgt aactttctgc ctttgacatt caaccttgag tccacctgta agtgtaactg
     6541 cggcagaagg gaggggtctg ctgtcatcct tgatagcctg tgatgagcag agcccctctg
     6601 ccgaccgcga tgcacatgta atatgagcaa gaaataaatt tttgatgtgc gaa
//
