LOCUS       NM_016407               2176 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens replication termination factor 2 (RTF2), transcript
            variant 2, mRNA.
ACCESSION   NM_016407
VERSION     NM_016407.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2176)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2176)
  AUTHORS   Chia,B.S., Li,B., Cui,A., Eisenhaure,T., Raychowdhury,R., Lieb,D.
            and Hacohen,N.
  TITLE     Loss of the Nuclear Protein RTF2 Enhances Influenza Virus
            Replication
  JOURNAL   J Virol 94 (22), e00319-20 (2020)
   PUBMED   32878895
  REMARK    GeneRIF: Loss of the Nuclear Protein RTF2 Enhances Influenza Virus
            Replication.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2176)
  AUTHORS   Kottemann,M.C., Conti,B.A., Lach,F.P. and Smogorzewska,A.
  TITLE     Removal of RTF2 from Stalled Replisomes Promotes Maintenance of
            Genome Integrity
  JOURNAL   Mol Cell 69 (1), 24-35 (2018)
   PUBMED   29290612
  REMARK    GeneRIF: The results establish that RTF2 removal is a key
            determinant for the ability of cells to manage replication stress
            and maintain genome integrity.
REFERENCE   4  (bases 1 to 2176)
  AUTHORS   Cai,D.C., Fonteijn,H., Guadalupe,T., Zwiers,M., Wittfeld,K.,
            Teumer,A., Hoogman,M., Arias-Vasquez,A., Yang,Y., Buitelaar,J.,
            Fernandez,G., Brunner,H.G., van Bokhoven,H., Franke,B.,
            Hegenscheid,K., Homuth,G., Fisher,S.E., Grabe,H.J., Francks,C. and
            Hagoort,P.
  TITLE     A genome-wide search for quantitative trait loci affecting the
            cortical surface area and thickness of Heschl's gyrus
  JOURNAL   Genes Brain Behav 13 (7), 675-685 (2014)
   PUBMED   25130324
REFERENCE   5  (bases 1 to 2176)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   6  (bases 1 to 2176)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC397043.1, BC003359.1, BG468509.1, AA814039.1 and AL109806.22.
            
            On Feb 27, 2020 this sequence version replaced NM_016407.4.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1, resulting in
            an isoform (b) that is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003359.1, AF161518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357348.10/ ENSP00000349906.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DC397043.1         43-73
            32-581              BC003359.1         1-550
            582-634             BG468509.1         586-638
            635-1609            BC003359.1         604-1578
            1610-1613           AA814039.1         52-55               c
            1614-2176           AL109806.22        55300-55862
FEATURES             Location/Qualifiers
     source          1..2176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.31"
     gene            1..2176
                     /gene="RTF2"
                     /gene_synonym="C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3"
                     /note="replication termination factor 2"
                     /db_xref="GeneID:51507"
                     /db_xref="HGNC:HGNC:15890"
     exon            1..140
                     /gene="RTF2"
                     /gene_synonym="C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..992
                     /gene="RTF2"
                     /gene_synonym="C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3"
                     /note="isoform b is encoded by transcript variant 2;
                     UPF0549 protein C20orf43; replication termination factor 2
                     domain-containing protein 1; protein RTF2 homolog;
                     replication termination factor 2 domain containing 1"
                     /codon_start=1
                     /product="replication termination factor 2 isoform b"
                     /protein_id="NP_057491.2"
                     /db_xref="CCDS:CCDS13453.1"
                     /db_xref="GeneID:51507"
                     /db_xref="HGNC:HGNC:15890"
                     /translation="MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEIL
                     RRPIVACELGRLYNKDAVIEFLLDKSAEKALGKAASHIKSIKNVTELKLSDNPAWEGD
                     KGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTC
                     GAAFQEDDVIMLNGTKEDVDVLKTRMEERRLRAKLEKKTKKPKAAESVSKPDVSEEAP
                     GPSKVKTGKPEEASLDSREKKTNLAPKSTAMNESSSGKAGKPPCGATKRSIADSEESE
                     AYKSLFTTHSSAKRSKEESAHWVTHTSYCF"
     exon            141..235
                     /gene="RTF2"
                     /gene_synonym="C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3"
                     /inference="alignment:Splign:2.1.0"
     exon            236..329
                     /gene="RTF2"
                     /gene_synonym="C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3"
                     /inference="alignment:Splign:2.1.0"
     exon            330..469
                     /gene="RTF2"
                     /gene_synonym="C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3"
                     /inference="alignment:Splign:2.1.0"
     exon            470..548
                     /gene="RTF2"
                     /gene_synonym="C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3"
                     /inference="alignment:Splign:2.1.0"
     exon            549..662
                     /gene="RTF2"
                     /gene_synonym="C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3"
                     /inference="alignment:Splign:2.1.0"
     exon            663..717
                     /gene="RTF2"
                     /gene_synonym="C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3"
                     /inference="alignment:Splign:2.1.0"
     exon            718..813
                     /gene="RTF2"
                     /gene_synonym="C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3"
                     /inference="alignment:Splign:2.1.0"
     exon            814..2176
                     /gene="RTF2"
                     /gene_synonym="C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1588..1593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTF2"
                     /gene_synonym="C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3"
                     /note="hexamer: AATAAA"
     polyA_site      1609
                     /gene="RTF2"
                     /gene_synonym="C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3"
                     /note="major polyA site"
     regulatory      2159..2164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTF2"
                     /gene_synonym="C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3"
                     /note="hexamer: AATAAA"
     polyA_site      2176
                     /gene="RTF2"
                     /gene_synonym="C20orf43; CDAO5; HSPC164; RTFDC1; SHUJUN-3"
ORIGIN      
        1 gcggatttcg ccggaaatcc cggaagtgac agctttgggg gtttgctgct ggctctgact
       61 cccgtcctgc gatgggttgc gacgggggaa caatccccaa gaggcatgaa ctggtgaagg
      121 ggccgaagaa ggttgagaag gtcgacaaag atgctgaatt agtggcccaa tggaactatt
      181 gtactctaag tcaggaaata ttaagacgac caatagttgc ctgtgaactt ggcagacttt
      241 ataacaaaga tgccgtcatt gaatttctct tggacaaatc tgcagaaaag gctcttggga
      301 aggcagcatc tcacattaaa agcattaaga atgtgacaga gctgaagctt tctgataatc
      361 ctgcctggga aggggataaa ggaaacacta aaggtgacaa gcacgatgac ctccagcggg
      421 cgcgtttcat ctgccccgtt gtgggcctgg agatgaacgg ccgacacagg ttctgcttcc
      481 ttcggtgctg cggctgtgtg ttttctgagc gagccttgaa agagataaaa gcggaagttt
      541 gccacacgtg tggggctgcc ttccaggagg atgatgtcat catgctcaat ggcaccaagg
      601 aggatgtgga cgtgctgaag acaaggatgg aggagagaag gctgagagcg aagctggaaa
      661 agaaaacaaa gaaacccaag gcagcagagt ctgtttcaaa accagatgtc agtgaagaag
      721 ccccagggcc atcaaaagtt aagacaggga agcctgaaga agccagcctt gattctagag
      781 agaagaaaac caacttggct cccaaaagca cagcaatgaa tgagagctct tctggaaaag
      841 ctgggaagcc tccgtgtgga gccacaaaga ggtccatcgc tgacagtgaa gaatcggagg
      901 cctacaagtc cctctttacc actcacagct ccgccaagcg ctccaaggag gagtctgccc
      961 actgggtcac ccacacgtcc tactgcttct gaagcccgca ctgccaccgc tcctgcccca
     1021 gaaggttgtt tagtttccac gtaggcaggt cgctttgtgc ctctgagtgc gctgctgtgt
     1081 gttctctcta tagttctgtg tcataaagct gtcctggcca gccttcaagc tggtgtggcc
     1141 actcttgatg tgaggcgtgt cggttccagg ggggacatgg gaggggctgc acagtggccc
     1201 gaggtcatgc ttgcttccac ctgcaggtgc atttggtcct ttccatggcc aggaagccct
     1261 gtgggctgca ctttttatgc ttgcagtaac aagagactcc agagtcctca ccggtgcaga
     1321 gttggcacat attaattaac taaaattcta atgatcttgc taccagcaat aaatcaagta
     1381 ggccaagtga aactgggctt taaaaaggat ggatttcaaa tacactgtgc ccactagaag
     1441 cttcgaaggg cctcgtccct ctgctacagc cctgggagga gccaggatcc ttgttggtct
     1501 agctaaatac tgttagggga gtgtgcccca tctcatcatt tcgaagatag cagagtcata
     1561 gttgggcacc cagtgattgg gttcaaaaat aaagctggtc tgcctcttct ctcctctgtg
     1621 tttttatctt ttctaccttc tgctcatgct tgggtaagaa cattgcagcc gttgcattgg
     1681 tgattacagg agtcattcca tgaagtcaga agaacccacc cttctctcct ccagcagatg
     1741 gtaaagggag aatcgtaccc aaaaagaggt gcattttatc tgcctataag ttgtgttgac
     1801 gtcaatagct agtgaaactt ctcatgagac tcctaatgaa gaaccaagag ccacaggcct
     1861 ctgcgtggct ttctgcacac ggtggtatga ctgagatagt gactggttct ctatacagac
     1921 cccggggccc tgggtttcct tcagaagcag aaggagctgt gggaggtgaa tggtgggagg
     1981 tgaacaggca ggttctgtgg gagacacaga cacgtgggca gaactccagg gagaggccag
     2041 caagggagaa ccatgtgtgg ccctgctttt tctcaaaccc tgtgtggttc ccggcttcac
     2101 agttgatggg aaggtttggc cccaaggata ttttgacatt gtgagtatag agcattttaa
     2161 taaaaattaa gtgatg
//
