LOCUS       NM_015138               5030 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens RTF1 homolog, Paf1/RNA polymerase II complex component
            (RTF1), mRNA.
ACCESSION   NM_015138
VERSION     NM_015138.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5030)
  AUTHORS   Zumer,K., Maier,K.C., Farnung,L., Jaeger,M.G., Rus,P., Winter,G.
            and Cramer,P.
  TITLE     Two distinct mechanisms of RNA polymerase II elongation stimulation
            in vivo
  JOURNAL   Mol Cell 81 (15), 3096-3109 (2021)
   PUBMED   34146481
  REMARK    GeneRIF: Two distinct mechanisms of RNA polymerase II elongation
            stimulation in vivo.
REFERENCE   2  (bases 1 to 5030)
  AUTHORS   Vos,S.M., Farnung,L., Linden,A., Urlaub,H. and Cramer,P.
  TITLE     Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex
            reveals RTF1 allosteric activation
  JOURNAL   Nat Struct Mol Biol 27 (7), 668-677 (2020)
   PUBMED   32541898
  REMARK    GeneRIF: Structure of complete Pol II-DSIF-PAF-SPT6 transcription
            complex reveals RTF1 allosteric activation.
REFERENCE   3  (bases 1 to 5030)
  AUTHORS   Cao,Q.F., Yamamoto,J., Isobe,T., Tateno,S., Murase,Y., Chen,Y.,
            Handa,H. and Yamaguchi,Y.
  TITLE     Characterization of the Human Transcription Elongation Factor Rtf1:
            Evidence for Nonoverlapping Functions of Rtf1 and the Paf1 Complex
  JOURNAL   Mol Cell Biol 35 (20), 3459-3470 (2015)
   PUBMED   26217014
  REMARK    GeneRIF: Human Rtf1 as a transcription elongation factor.
            Erratum:[Mol Cell Biol. 2015 Dec;35(23):4093. doi:
            10.1128/MCB.00914-15.. PMID: 26518638]
REFERENCE   4  (bases 1 to 5030)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   5  (bases 1 to 5030)
  AUTHORS   Wier,A.D., Mayekar,M.K., Heroux,A., Arndt,K.M. and VanDemark,A.P.
  TITLE     Structural basis for Spt5-mediated recruitment of the Paf1 complex
            to chromatin
  JOURNAL   Proc Natl Acad Sci U S A 110 (43), 17290-17295 (2013)
   PUBMED   24101474
  REMARK    GeneRIF: Data indicate that the Plus3 domain of the Rtf1 subunit
            mediates Paf1C recruitment to genes by binding a repeating domain
            within the phosphorylated elongation factor Spt5.
REFERENCE   6  (bases 1 to 5030)
  AUTHORS   de Jong,R.N., Truffault,V., Diercks,T., Ab,E., Daniels,M.A.,
            Kaptein,R. and Folkers,G.E.
  TITLE     Structure and DNA binding of the human Rtf1 Plus3 domain
  JOURNAL   Structure 16 (1), 149-159 (2008)
   PUBMED   18184592
REFERENCE   7  (bases 1 to 5030)
  AUTHORS   Warner,M.H., Roinick,K.L. and Arndt,K.M.
  TITLE     Rtf1 is a multifunctional component of the Paf1 complex that
            regulates gene expression by directing cotranscriptional histone
            modification
  JOURNAL   Mol Cell Biol 27 (17), 6103-6115 (2007)
   PUBMED   17576814
REFERENCE   8  (bases 1 to 5030)
  AUTHORS   Zhu,B., Mandal,S.S., Pham,A.D., Zheng,Y., Erdjument-Bromage,H.,
            Batra,S.K., Tempst,P. and Reinberg,D.
  TITLE     The human PAF complex coordinates transcription with events
            downstream of RNA synthesis
  JOURNAL   Genes Dev 19 (14), 1668-1673 (2005)
   PUBMED   16024656
REFERENCE   9  (bases 1 to 5030)
  AUTHORS   Yart,A., Gstaiger,M., Wirbelauer,C., Pecnik,M., Anastasiou,D.,
            Hess,D. and Krek,W.
  TITLE     The HRPT2 tumor suppressor gene product parafibromin associates
            with human PAF1 and RNA polymerase II
  JOURNAL   Mol Cell Biol 25 (12), 5052-5060 (2005)
   PUBMED   15923622
REFERENCE   10 (bases 1 to 5030)
  AUTHORS   Rozenblatt-Rosen,O., Hughes,C.M., Nannepaga,S.J., Shanmugam,K.S.,
            Copeland,T.D., Guszczynski,T., Resau,J.H. and Meyerson,M.
  TITLE     The parafibromin tumor suppressor protein is part of a human Paf1
            complex
  JOURNAL   Mol Cell Biol 25 (2), 612-620 (2005)
   PUBMED   15632063
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087721.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 21, 2021 this sequence version replaced NM_015138.4.
            
            Summary: This locus may represent a gene involved in regulation of
            transcription elongation and chromatin remodeling, based on studies
            of similar proteins in other organisms. The encoded protein may
            bind single-stranded DNA. [provided by RefSeq, Sep 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87440.2, BC015052.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389629.9/ ENSP00000374280.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AC087721.4         104166-104384
            220-330             AC087721.4         125392-125502
            331-478             AC087721.4         139972-140119
            479-683             AC087721.4         144743-144947
            684-798             AC087721.4         151842-151956
            799-910             AC087721.4         153212-153323
            911-1046            AC087721.4         157328-157463
            1047-1224           AC087721.4         158243-158420
            1225-1307           AC087721.4         161691-161773
            1308-1395           AC087721.4         162596-162683
            1396-1503           AC087721.4         162783-162890
            1504-1581           AC087721.4         163517-163594
            1582-1703           AC087721.4         164236-164357
            1704-1761           AC087721.4         164529-164586
            1762-1839           AC087721.4         165619-165696
            1840-1935           AC087721.4         166174-166269
            1936-2047           AC087721.4         167285-167396
            2048-5030           AC087721.4         167652-170634
FEATURES             Location/Qualifiers
     source          1..5030
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..5030
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /note="RTF1 homolog, Paf1/RNA polymerase II complex
                     component"
                     /db_xref="GeneID:23168"
                     /db_xref="HGNC:HGNC:28996"
                     /db_xref="MIM:611633"
     exon            1..219
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..2154
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /note="ortholog of mouse gene trap locus 7; Rtf1, Paf1/RNA
                     polymerase II complex component, homolog"
                     /codon_start=1
                     /product="RNA polymerase-associated protein RTF1 homolog"
                     /protein_id="NP_055953.3"
                     /db_xref="CCDS:CCDS32200.2"
                     /db_xref="GeneID:23168"
                     /db_xref="HGNC:HGNC:28996"
                     /db_xref="MIM:611633"
                     /translation="MRGRLCVGRAAAAAAAVAVPLAGGQEGSPGGGRRGSRGTTMVKK
                     RKGRVVIDSDTEDSGSDENLDQELLSLAKRKRSDSEEKEPPVSQPAASSDSETSDSDD
                     EWTFGSNKNKKKGKARKIEKKGTMKKQANKTASSGSSDKDSSAESSAPEEGEVSDSDS
                     NSSSSSSDSDSSSEDEEFHDGYGEDLMGDEEDRARLEQMTEKEREQELFNRIEKREVL
                     KRRFEIKKKLKTAKKKEKKEKKKKQEEEQEKKKLTQIQESQVTSHNKERRSKRDEKLD
                     KKSQAMEELKAEREKRKNRTAELLAKKQPLKTSEVYSDDEEEEEDDKSSEKSDRSSRT
                     SSSDEEEEKEEIPPKSQPVSLPEELNRVRLSRHKLERWCHMPFFAKTVTGCFVRIGIG
                     NHNSKPVYRVAEITGVVETAKVYQLGGTRTNKGLQLRHGNDQRVFRLEFVSNQEFTES
                     EFMKWKEAMFSAGMQLPTLDEINKKELSIKEALNYKFNDQDIEEIVKEKERFRKAPPN
                     YAMKKTQLLKEKAMAEDLGDQDKAKQIQDQLNELEERAEALDRQRTKNISAISYINQR
                     NREWNIVESEKALVAESHNMKNQQMDPFTRRQCKPTIVSNSRDPAVQAAILAQLNAKY
                     GSGVLPDAPKEMSKGQGKDKDLNSKSASDLSEDLFKVHDFDVKIDLQVPSSESKALAI
                     TSKAPPAKDGAPRRSLNLEDYKKRRGLI"
     exon            220..330
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            331..478
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            479..683
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            684..798
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            799..910
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1046
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1224
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1307
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1395
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1503
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1581
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1703
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1761
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1839
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1935
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2047
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..5030
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4425..4430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /note="hexamer: AATAAA"
     polyA_site      4448
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /note="major polyA site"
     regulatory      5001..5006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
                     /note="hexamer: AATAAA"
     polyA_site      5030
                     /gene="RTF1"
                     /gene_synonym="GTL7; KIAA0252"
ORIGIN      
        1 ggggggcgga gcggagcgcg catgcgcggt cgcctttgtg tgggtcgagc agcggcggcg
       61 gcggcggcag tggcggtccc actggcaggc gggcaagagg ggagtccggg cggcggccgg
      121 cgtgggagcc gggggaccac catggtaaag aagcggaaag gccgcgtcgt gatcgactcg
      181 gacacagagg acagcggcag cgacgagaac ctggatcagg agctcttgtc cctggcaaag
      241 cgaaagcgca gtgactctga ggagaaggag ccgcctgtga gtcagcctgc agcctcgtca
      301 gactcggaga cgtctgacag tgacgatgag tggacatttg ggagcaataa aaataagaag
      361 aaaggaaaag ccagaaaaat agagaagaaa ggaaccatga agaaacaggc caacaaaact
      421 gcctcctcag gcagttcaga caaagacagt tcagctgaga gctcagcccc tgaggaaggt
      481 gaagtgtcag actctgacag caacagctcc tcttccagtt cagattcaga ctcttcctca
      541 gaagatgaag agttccatga tggctatgga gaagacctca tgggagatga ggaagacagg
      601 gcccgtctgg aacagatgac agagaaagag agagagcaag aactgttcaa tcgcatagag
      661 aagagggagg tgttgaaaag aagatttgaa atcaagaaaa aactaaaaac agccaaaaag
      721 aaagaaaaga aagaaaagaa gaaaaagcaa gaagaggagc aagaaaagaa aaaactgaca
      781 cagattcaag aatctcaggt aacatcccac aacaaggaac ggcgttccaa gcgggatgag
      841 aaactagaca agaaatctca agccatggag gagctaaaag cagagcgaga aaaacgaaag
      901 aacagaacag ctgagctcct tgccaaaaaa cagccattaa aaaccagtga ggtctactct
      961 gatgatgaag aggaggaaga ggatgacaaa tccagtgaaa agtcagaccg ctcatcacga
     1021 acatcatcgt ctgatgaaga agaggagaaa gaagagatcc ctcccaaatc ccaaccagtt
     1081 tccttacctg aagaattgaa tcgggttcga ttatcacggc ataagctaga acgctggtgt
     1141 cacatgccct tctttgctaa aactgtcaca ggatgttttg tgcggattgg catcggaaac
     1201 cacaacagca aaccagttta ccgggtcgct gagattacgg gtgttgtgga aactgccaaa
     1261 gtttaccaac taggtggcac cagaacaaac aaagggctgc aactacggca tggcaatgac
     1321 caacgcgtgt tccgtttaga gtttgtctca aaccaagaat tcaccgaaag tgagtttatg
     1381 aagtggaaag aagcgatgtt ctctgctggc atgcagttgc ccactctaga tgaaatcaat
     1441 aaaaaggaat tatctattaa agaagctctt aattataaat tcaatgatca ggacattgaa
     1501 gagattgtaa aagagaaaga aaggttcaga aaagctccac ccaactacgc tatgaagaag
     1561 actcagctac tgaaggaaaa ggccatggct gaggacctgg gggatcagga caaggccaaa
     1621 caaatccaag atcaactgaa tgagctggag gaacgggcag aggccctgga ccgccagcgg
     1681 accaagaaca tatccgctat cagttacatc aaccagcgga accgggagtg gaacattgta
     1741 gagtctgaga aggcccttgt ggctgaaagt cacaacatga aaaaccaaca gatggatccc
     1801 tttactcggc ggcagtgcaa gcctaccatc gtttctaatt ccagagaccc agctgttcaa
     1861 gctgccatct tggcccagct gaatgcaaaa tacggttctg gagtgttacc agatgctcca
     1921 aaggaaatga gcaagggtca aggcaaagat aaagatttga attctaagtc agccagtgac
     1981 ctctcagaag atctgttcaa agtacacgat tttgatgtga agattgactt acaagttccc
     2041 agctcagagt caaaggcttt agccatcacc tccaaggctc cgccagccaa ggatggggct
     2101 ccaaggagat ctctgaactt ggaagactac aaaaaacgac gagggcttat ttgagcacac
     2161 ccagcctgct gcttctgacc ctgcatgccc catcgcagcg tcccaccttt cctcctttcc
     2221 tttgatttag cctctttggg ctggagcagc tgttgaactg ggaagagact ctaaactgcc
     2281 agtcatctgt aatataaacc atttgctgta tagacctcct ttgtctgcac accatctccc
     2341 accagcctcc cctcccccag ggccccaccc agtgtgggcc tgggctctct tgggctttat
     2401 ccatgtcttt agatttgtgt ttgccttttg tttttttaac cgcgcagttc attggccact
     2461 ctgcacgcat tcagtattac catggagctg ggaatcttgc tggagcccct ggggcaatag
     2521 cagcagcacc aggcggtctc ctctacagac tgccttggcc cacccattga acattcggca
     2581 cgtgaccttg tggggggagc ggggattggg cacctgcgat cctctttcct ctcttcatct
     2641 ttctcttctg cccttctttt tggaagaagg ggtttcaaaa ccagtttagt ttccaaaaag
     2701 tgtacatttg tggggggggg gggtctaatt tgagagcgag agtgtgtatg tgtgtgtgtg
     2761 taagtgtgtg gattttttta tcattttttt aaaatgcagt actctttgta tcagtctgtc
     2821 atgggtctat agctgtttca gatttttttc agctgtactt gagcatctga aactgcaaga
     2881 aagaaactca ttaaatgtga ttcttcttac taaacaggcc tgactgctgt agctgtgtaa
     2941 cttccccatt cccacctact cttcccatcc tttcccaact ttggagaaaa ctccccagtt
     3001 tagccccctg acctgcaggc tgtgtcctgg caggtgtggg agggaagccc atggccaggt
     3061 accagggagg gcagtgaatg tcttgctctt cccatgggta cagcccacag cttcttggct
     3121 gaacgtagaa cttctttttc tcacccagta taccagcctc ttcctggtga ttctgttttg
     3181 ctgctttggc aagaactaca ttttgttttt aagagaaatt tctgaatatg aatgtggaga
     3241 gcaaacacaa aaagatttag gttacgccgg gtgcagtagc tcacgcctgt aatcccagca
     3301 ctttgggagg cctaggcggg tggatcacct gaggtcagga gttcaagacc aatctgacta
     3361 acacggtgaa accccatctc tactaaaact acaaaactta gccgggcatg gtggtgcgtg
     3421 cctgtaatcc cagctactcg gggggctgag acaggagaat cccttgaacc tgggaggcgg
     3481 aggttgtggt gagccaagat cgtgccactg cactccagtc tgggtgacag agtgagactc
     3541 cgcctcaaaa agatttaggt tgcaaatgtt tcaagcatgt gcagttttgt gtgtgtgtat
     3601 acatatatat ggtcagcata tatattgtgc agctagggcg aagccagcag aggtgtgtgt
     3661 atgtctttat gaaatgtttg aaaagagata aactgactgc ttgataatca ctctcaggtg
     3721 taaagctcca agtgtaaata aaagtggcat ttaacaaatc tttcagaaca aagtacagct
     3781 gactatatat accaagagct aagctaaagg aacagctgag agctccgatc tccacgagag
     3841 actaatctaa aagctctgct ttgtacttcc tcaccctgct ttcgtacaag gaagggggac
     3901 gatgggaaat catggacttg taagttgtat ttaaacataa aaatgaactt ggtaacttct
     3961 gggtttagta gagcctcagt gtcgctttaa cttagtttac ttttttttta tttttaaagc
     4021 agcaatggat ggttttaaag gagtattatg attgtaaaat tgctaaatat gactgtaaca
     4081 cagctttgtg gtagctgtga cacagttcac ttgggcaaag gagtggtgat ggactcgtta
     4141 aaatcatata tacttgaata gtccattgac cgaaactctt tatagactat tgtgtaaatg
     4201 tggaatcaca gactgttaac attgcctgga cttcagcaga gtcctggagc tgctgggacc
     4261 tctcctatca tgatgaactt ggactttttt ttttgatttc tggttttaaa aaacataaaa
     4321 ttatagaatc cagataattc gctggagtca ttctgatcca ccatgtagat ctgtatttag
     4381 tatcatttgg atttggagaa gtgttgatta cattatggct gtgtaataaa atttttatta
     4441 aaactgcatc acactgtagc cactttgcca ccacctcccc acatgtagcc gctgaaaccc
     4501 ccacgagatg ccaatgcaca cagcagggag aaaagccaac caaagaagac cgaagggtat
     4561 ctttccaccc gagtagcctc tgtagtgatt gggaccaaga ctaaggactt gtctccaatc
     4621 tcagctgagg cagtgcctct gaaccaagat cttggtcagg cattaagaca ctggctttgt
     4681 cctaccaact aggatttctt ggtggttcac actatttctt gtgctgggga attccctcat
     4741 tgggcccctc ctccctccac agtgtggttt cagtgttgaa gggtgcagca cccaaggttg
     4801 tttttatgca ttttttcagt tccttccaag aagcaaaaag gccagtgtcc atctgcctag
     4861 ttcataatgt ttataggtct gtttgtctgt cttgcttctg gcaggtgtag ggaaagtcta
     4921 ctgcctgcca ctcccttcaa aaagaatgtt tttgcttttg tgaagtcctg acttgccact
     4981 caaactgtac caatattgta aataaatgtt atgccatttt aacaaaggga
//
