LOCUS       NM_001283009            4615 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens regulator of telomere elongation helicase 1 (RTEL1),
            transcript variant 3, mRNA.
ACCESSION   NM_001283009 XM_005260207
VERSION     NM_001283009.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4615)
  AUTHORS   Tanshee,R.R., Mahmud,Z., Nabi,A.H.M.N. and Sayem,M.
  TITLE     A comprehensive in silico investigation into the pathogenic SNPs in
            the RTEL1 gene and their biological consequences
  JOURNAL   PLoS One 19 (9), e0309713 (2024)
   PUBMED   39240887
  REMARK    GeneRIF: A comprehensive in silico investigation into the
            pathogenic SNPs in the RTEL1 gene and their biological
            consequences.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4615)
  AUTHORS   Cortone,G., Graewert,M.A., Kanade,M., Longo,A., Hegde,R.,
            Gonzalez-Magana,A., Chaves-Arquero,B., Blanco,F.J.,
            Napolitano,L.M.R. and Onesti,S.
  TITLE     Structural and biochemical characterization of the C-terminal
            region of the human RTEL1 helicase
  JOURNAL   Protein Sci 33 (9), e5093 (2024)
   PUBMED   39180489
  REMARK    GeneRIF: Structural and biochemical characterization of the
            C-terminal region of the human RTEL1 helicase.
REFERENCE   3  (bases 1 to 4615)
  AUTHORS   Maksiutenko,E.M., Merkureva,V., Barbitoff,Y.A., Tsay,V.V.,
            Aseev,M.V., Glotov,A.S. and Glotov,O.S.
  TITLE     Exome sequencing in extreme altitude mountaineers identifies
            pathogenic variants in RTEL1 and COL6A1 previously associated with
            respiratory failure
  JOURNAL   Physiol Rep 12 (8), e16015 (2024)
   PUBMED   38653581
  REMARK    GeneRIF: Exome sequencing in extreme altitude mountaineers
            identifies pathogenic variants in RTEL1 and COL6A1 previously
            associated with respiratory failure.
REFERENCE   4  (bases 1 to 4615)
  AUTHORS   Wang,G., Ren,X., Li,J., Cui,R., Zhao,X., Sui,F., Liu,J., Chen,P.,
            Yang,Q., Ji,M., Hou,P., Gao,K. and Qu,Y.
  TITLE     High expression of RTEL1 predicates worse progression in gliomas
            and promotes tumorigenesis through JNK/ELK1 cascade
  JOURNAL   BMC Cancer 24 (1), 385 (2024)
   PUBMED   38532312
  REMARK    GeneRIF: High expression of RTEL1 predicates worse progression in
            gliomas and promotes tumorigenesis through JNK/ELK1 cascade.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4615)
  AUTHORS   Wrensch,M., Jenkins,R.B., Chang,J.S., Yeh,R.F., Xiao,Y.,
            Decker,P.A., Ballman,K.V., Berger,M., Buckner,J.C., Chang,S.,
            Giannini,C., Halder,C., Kollmeyer,T.M., Kosel,M.L., LaChance,D.H.,
            McCoy,L., O'Neill,B.P., Patoka,J., Pico,A.R., Prados,M.,
            Quesenberry,C., Rice,T., Rynearson,A.L., Smirnov,I., Tihan,T.,
            Wiemels,J., Yang,P. and Wiencke,J.K.
  TITLE     Variants in the CDKN2B and RTEL1 regions are associated with
            high-grade glioma susceptibility
  JOURNAL   Nat Genet 41 (8), 905-908 (2009)
   PUBMED   19578366
  REMARK    GeneRIF: On 9p21, rs1412829 near CDKN2B had discovery P = 3.4 x
            10(-8), replication P = 0.0038 and combined P = 1.85 x 10(-10). On
            20q13.3, rs6010620 intronic to RTEL1 had discovery P = 1.5 x
            10(-7), replication P = 0.00035 and combined P = 3.40 x 10(-9).
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   6  (bases 1 to 4615)
  AUTHORS   Barber,L.J., Youds,J.L., Ward,J.D., McIlwraith,M.J., O'Neil,N.J.,
            Petalcorin,M.I., Martin,J.S., Collis,S.J., Cantor,S.B., Auclair,M.,
            Tissenbaum,H., West,S.C., Rose,A.M. and Boulton,S.J.
  TITLE     RTEL1 maintains genomic stability by suppressing homologous
            recombination
  JOURNAL   Cell 135 (2), 261-271 (2008)
   PUBMED   18957201
  REMARK    GeneRIF: Study finds that rtel-1 mutant worms and RTEL1-depleted
            human cells share characteristic phenotypes with yeast srs2
            mutants: lethality upon deletion of the sgs1/BLM homolog,
            hyperrecombination, and DNA damage sensitivity.[RTEL1]
REFERENCE   7  (bases 1 to 4615)
  AUTHORS   Ding,H., Schertzer,M., Wu,X., Gertsenstein,M., Selig,S.,
            Kammori,M., Pourvali,R., Poon,S., Vulto,I., Chavez,E., Tam,P.P.,
            Nagy,A. and Lansdorp,P.M.
  TITLE     Regulation of murine telomere length by Rtel: an essential gene
            encoding a helicase-like protein
  JOURNAL   Cell 117 (7), 873-886 (2004)
   PUBMED   15210109
REFERENCE   8  (bases 1 to 4615)
  AUTHORS   Bai,C., Connolly,B., Metzker,M.L., Hilliard,C.A., Liu,X.,
            Sandig,V., Soderman,A., Galloway,S.M., Liu,Q., Austin,C.P. and
            Caskey,C.T.
  TITLE     Overexpression of M68/DcR3 in human gastrointestinal tract tumors
            independent of gene amplification and its location in a four-gene
            cluster
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1230-1235 (2000)
   PUBMED   10655513
REFERENCE   9  (bases 1 to 4615)
  AUTHORS   Savage,S.A. and Niewisch,M.R.
  TITLE     Dyskeratosis Congenita and Related Telomere Biology Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301779
REFERENCE   10 (bases 1 to 4615)
  AUTHORS   Garcia,C.K. and Talbert,J.L.
  TITLE     Pulmonary Fibrosis Predisposition Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301408
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF217795.1, JX119186.1 and
            AW005229.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 3, 2019 this sequence version replaced NM_001283009.1.
            
            Summary: This gene encodes a DNA helicase which functions in the
            stability, protection and elongation of telomeres and interacts
            with proteins in the shelterin complex known to protect telomeres
            during DNA replication. Mutations in this gene have been associated
            with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome.
            Read-through transcription of this gene into the neighboring
            downstream gene, which encodes tumor necrosis factor receptor
            superfamily, member 6b, generates a non-coding transcript.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest protein (isoform 3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: JX119186.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360203.11/ ENSP00000353332.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-325               AF217795.1         503-827
            326-2598            JX119186.1         1-2273
            2599-3451           AF217795.1         3101-3953
            3452-4599           JX119186.1         3127-4274
            4600-4615           AW005229.1         24-39               c
FEATURES             Location/Qualifiers
     source          1..4615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..4615
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /note="regulator of telomere elongation helicase 1"
                     /db_xref="GeneID:51750"
                     /db_xref="HGNC:HGNC:15888"
                     /db_xref="MIM:608833"
     exon            1..155
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            156..427
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..4228
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /EC_number="3.6.4.12"
                     /note="isoform 3 is encoded by transcript variant 3;
                     regulator of telomere length"
                     /codon_start=1
                     /product="regulator of telomere elongation helicase 1
                     isoform 3"
                     /protein_id="NP_001269938.1"
                     /db_xref="CCDS:CCDS63331.1"
                     /db_xref="GeneID:51750"
                     /db_xref="HGNC:HGNC:15888"
                     /db_xref="MIM:608833"
                     /translation="MPKIVLNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPT
                     GTGKTLCLLCTTLAWREHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIAC
                     YTDIPKIIYASRTHSQLTQVINELRNTSYRPKVCVLGSREQLCIHPEVKKQESNHLQI
                     HLCRKKVASRSCHFYNNVEEKSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQQ
                     ADIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEESASFDLTPHDLASGL
                     DVIDQVLEEQTKAAQQGEPHPEFSADSPSPGLNMELEDIAKLKMILLRLEGAIDAVEL
                     PGDDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQIIQHLAGRAGVFTNTAGLQKL
                     ADIIQIVFSVDPSEGSPGSPAGLGALQSYKVHIHPDAGHRRTAQRSDAWSTTAARKRG
                     KVLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLENPHIIDK
                     HQIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVM
                     EKSLEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGSTGATFLAVCR
                     GKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEW
                     YRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRFAFADARAQLPSWVRPHVRVYDNFGH
                     VIRDVAQFFRVAERTMPAPAPRATAPSVRGEDAVSEAKSPGPFFSTRKAKSLDLHVPS
                     LKQRSSGSPAAGDPESSLCVEYEQEPVPARQRPRGLLAALEHSEQRAGSPGEEQAHSC
                     STLSLLSEKRPAEEPRGGRKKIRLVSHPEEPVAGAQTDRAKLFMVAVKQELSQANFAT
                     FTQALQDYKGSDDFAALAACLGPLFAEDPKKHNLLQGFYQFVRPHHKQQFEEVCIQLT
                     GRGCGYRPEHSIPRRQRAQPVLDPTGRTAPDPKLTVSTAAAQQLDPQEHLNQGRPHLS
                     PRPPPTGDPGSQPQWGSGVPRAGKQGQHAVSAYLADARRALGSAGCSQLLAALTAYKQ
                     DDDLDKVLAVLAALTTAKPEDFPLLHRFSMFVRPHHKQRFSQTCTDLTGRPYPGMEPP
                     GPQEERLAVPPVLTHRAPQPGPSRSEKTGKTQSKISSFLRQRPAGTVGAGGEDAGPSQ
                     SSGPPHGPAASEWGEPHGRDIAGQQATGAPGGPLSAGCVCQGCGAEDVVPFQCPACDF
                     QRCQACWQRHLQASRMCPACHTASRKQSVMQVFWPEPQ"
     exon            428..626
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            627..720
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            721..802
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            803..863
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            864..939
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1024
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1090
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1244
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1283
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1362
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1460
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1516
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1591
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1673
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1806
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1920
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..1961
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2047
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2125
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2203
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2350
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2466
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2590
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2738
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2881
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..2977
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3176
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3317
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            3318..3434
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3668
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            3669..3824
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..4147
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     exon            4148..4615
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4593..4598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /note="hexamer: AATAAA"
     polyA_site      4615
                     /gene="RTEL1"
                     /gene_synonym="C20orf41; DKCA4; DKCB5; NHL; PFBMFT3; RTEL"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgcag tgggctcagc gccgactgcg cgcctctgcc cgcgaaaact ctgagctggc
       61 tgacagctgg ggacgggtgg cggccctcga ctggagtcgg ttgagttcct gagggacccc
      121 ggttctggaa ggttcgccgc ggagacaagt gagcagtctg tgccataggg attctcgaag
      181 agaacagcgt tgtgtcccag tgcacatgct cgcatcgctt accaggagtg cccgagaccc
      241 taagatgttc ggagtggttt tttcgcacag acccgaatag cctgcccctc agccacgctc
      301 tgtgcccttc tgagaacagg ctgatatgcc caagatagtc ctgaatggtg tgaccgtaga
      361 cttccctttc cagccctaca aatgccaaca ggagtacatg accaaggtcc tggaatgtct
      421 gcagcagaag gtgaatggca tcctggagag ccctacgggt acagggaaga cgctgtgcct
      481 gctgtgcacc acgctggcct ggcgagaaca cctccgagac ggcatctctg cccgcaagat
      541 tgccgagagg gcgcaaggag agcttttccc ggatcgggcc ttgtcatcct ggggcaacgc
      601 tgctgctgct gctggagacc ccatagcttg ctacacggac atcccaaaga ttatttacgc
      661 ctccaggacc cactcgcaac tcacacaggt catcaacgag cttcggaaca cctcctaccg
      721 gcctaaggtg tgtgtgctgg gctcccggga gcagctgtgc atccatcctg aggtgaagaa
      781 acaagagagt aaccatctac agatccactt gtgccgtaag aaggtggcaa gtcgctcctg
      841 tcatttctac aacaacgtag aagaaaaaag cctggagcag gagctggcca gccccatcct
      901 ggacattgag gacttggtca agagcggaag caagcacagg gtgtgccctt actacctgtc
      961 ccggaacctg aagcagcaag ccgacatcat attcatgccg tacaattact tgttggatgc
     1021 caagagccgc agagcacaca acattgacct gaaggggaca gtcgtgatct ttgacgaagc
     1081 tcacaacgtg gagaagatgt gtgaagaatc ggcatccttt gacctgactc cccatgacct
     1141 ggcttcagga ctggacgtca tagaccaggt gctggaggag cagaccaagg cagcgcagca
     1201 gggtgagccc cacccggagt tcagcgcgga ctcccccagc ccagggctga acatggagct
     1261 ggaagacatt gcaaagctga agatgatcct gctgcgcctg gagggggcca tcgatgctgt
     1321 tgagctgcct ggagacgaca gcggtgtcac caagccaggg agctacatct ttgagctgtt
     1381 tgctgaagcc cagatcacgt ttcagaccaa gggctgcatc ctggactcgc tggaccagat
     1441 catccagcac ctggcaggac gtgctggagt gttcaccaac acggccggac tgcagaagct
     1501 ggcggacatt atccagattg tgttcagtgt ggacccctcc gagggcagcc ctggttcccc
     1561 agcagggctg ggggccttac agtcctataa ggtgcacatc catcctgatg ctggtcaccg
     1621 gaggacggct cagcggtctg atgcctggag caccactgca gccagaaagc gagggaaggt
     1681 gctgagctac tggtgcttca gtcccggcca cagcatgcac gagctggtcc gccagggcgt
     1741 ccgctccctc atccttacca gcggcacgct ggccccggtg tcctcctttg ctctggagat
     1801 gcagatccct ttcccagtct gcctggagaa cccacacatc atcgacaagc accagatctg
     1861 ggtgggggtc gtccccagag gccccgatgg agcccagttg agctccgcgt ttgacagacg
     1921 gttttccgag gagtgcttat cctccctggg gaaggctctg ggcaacatcg cccgcgtggt
     1981 gccctatggg ctcctgatct tcttcccttc ctatcctgtc atggagaaga gcctggagtt
     2041 ctggcgggcc cgcgacttgg ccaggaagat ggaggcgctg aagccgctgt ttgtggagcc
     2101 caggagcaaa ggcagcttct ccgagaccat cagtgcttac tatgcaaggg ttgccgcccc
     2161 tgggtccacc ggcgccacct tcctggcggt ctgccggggc aaggccagcg aggggctgga
     2221 cttctcagac acgaatggcc gtggtgtgat tgtcacgggc ctcccgtacc ccccacgcat
     2281 ggacccccgg gttgtcctca agatgcagtt cctggatgag atgaagggcc agggtggggc
     2341 tgggggccag ttcctctctg ggcaggagtg gtaccggcag caggcgtcca gggctgtgaa
     2401 ccaggccatc gggcgagtga tccggcaccg ccaggactac ggagctgtct tcctctgtga
     2461 ccacaggttc gcctttgccg acgcaagagc ccaactgccc tcctgggtgc gtccccacgt
     2521 cagggtgtat gacaactttg gccatgtcat ccgagacgtg gcccagttct tccgtgttgc
     2581 cgagcgaact atgccagcgc cggccccccg ggctacagca cccagtgtgc gtggagaaga
     2641 tgctgtcagc gaggccaagt cgcctggccc cttcttctcc accaggaaag ctaagagtct
     2701 ggacctgcat gtccccagcc tgaagcagag gtcctcaggg tcaccagctg ccggggaccc
     2761 cgagagtagc ctgtgtgtgg agtatgagca ggagccagtt cctgcccggc agaggcccag
     2821 ggggctgctg gccgccctgg agcacagcga acagcgggcg gggagccctg gcgaggagca
     2881 ggcccacagc tgctccaccc tgtccctcct gtctgagaag aggccggcag aagaaccgcg
     2941 aggagggagg aagaagatcc ggctggtcag ccacccggag gagcccgtgg ctggtgcaca
     3001 gacggacagg gccaagctct tcatggtggc cgtgaagcag gagttgagcc aagccaactt
     3061 tgccaccttc acccaggccc tgcaggacta caagggttcc gatgacttcg ccgccctggc
     3121 cgcctgtctc ggccccctct ttgctgagga ccccaagaag cacaacctgc tccaaggctt
     3181 ctaccagttt gtgcggcccc accataagca gcagtttgag gaggtctgta tccagctgac
     3241 aggacgaggc tgtggctatc ggcctgagca cagcattccc cgaaggcagc gggcacagcc
     3301 ggtcctggac cccactggaa gaacggcgcc ggatcccaag ctgaccgtgt ccacggctgc
     3361 agcccagcag ctggaccccc aagagcacct gaaccagggc aggccccacc tgtcgcccag
     3421 gccaccccca acaggagacc ctggcagcca accacagtgg gggtctggag tgcccagagc
     3481 agggaagcag ggccagcacg ccgtgagcgc ctacctggct gatgcccgca gggccctggg
     3541 gtccgcgggc tgtagccaac tcttggcagc gctgacagcc tataagcaag acgacgacct
     3601 cgacaaggtg ctggctgtgt tggccgccct gaccactgca aagccagagg acttccccct
     3661 gctgcacagg ttcagcatgt ttgtgcgtcc acaccacaag cagcgcttct cacagacgtg
     3721 cacagacctg accggccggc cctacccggg catggagcca ccgggacccc aggaggagag
     3781 gcttgccgtg cctcctgtgc ttacccacag ggctccccaa ccaggcccct cacggtccga
     3841 gaagaccggg aagacccaga gcaagatctc gtccttcctt agacagaggc cagcagggac
     3901 tgtgggggcg ggcggtgagg atgcaggtcc cagccagtcc tcaggacctc cccacgggcc
     3961 tgcagcatct gagtggggtg agcctcatgg gagagacatc gctgggcagc aggccacggg
     4021 agctccgggc gggcccctct cagcaggctg tgtgtgccag ggctgtgggg cagaggacgt
     4081 ggtgcccttc cagtgccctg cctgtgactt ccagcgctgc caagcctgct ggcaacggca
     4141 ccttcaggcc tctaggatgt gcccagcctg ccacaccgcc tccaggaagc agagcgtcat
     4201 gcaggtcttc tggccagagc cccagtgagt gcccacggag gcccccagca cacccaacgt
     4261 ggcttgatca cctgcctgtc cagctctggt gggccaagaa cccacccaac agaataggcc
     4321 agcccatgcc agccggcttg gcccgctgca ggcctcaggc aggcggggcc catggttggt
     4381 ccctgcggtg ggaccggatc tgggcctgcc tctgagaagc cctgagctac cttggggtct
     4441 ggggtgggtt tctgggaaag tgcttcccca gaacttccct ggctcctggc ctgtgagtgg
     4501 tgccacaggg gcaccccagc tgagcccctc accgggaagg aggagacccc cgtgggcacg
     4561 tgtccacttt taatcagggg acagggctct ctaataaagc tgctggcagt gccca
//
