LOCUS       NM_014306               2019 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RNA 2',3'-cyclic phosphate and 5'-OH ligase (RTCB),
            mRNA.
ACCESSION   NM_014306
VERSION     NM_014306.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2019)
  AUTHORS   Gerber,J.L., Morales Guzman,S.I., Worf,L., Hubbe,P., Kopp,J. and
            Peschek,J.
  TITLE     Structural and mechanistic insights into activation of the human
            RNA ligase RTCB by Archease
  JOURNAL   Nat Commun 15 (1), 2378 (2024)
   PUBMED   38493148
  REMARK    GeneRIF: Structural and mechanistic insights into activation of the
            human RNA ligase RTCB by Archease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2019)
  AUTHORS   Cao,L., Hui,X., Xu,T., Mao,H., Lin,X., Huang,K., Zhao,L. and Jin,M.
  TITLE     The RNA-Splicing Ligase RTCB Promotes Influenza A Virus Replication
            by Suppressing Innate Immunity via Interaction with RNA Helicase
            DDX1
  JOURNAL   J Immunol 211 (6), 1020-1031 (2023)
   PUBMED   37556111
  REMARK    GeneRIF: The RNA-Splicing Ligase RTCB Promotes Influenza A Virus
            Replication by Suppressing Innate Immunity via Interaction with RNA
            Helicase DDX1.
REFERENCE   3  (bases 1 to 2019)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2019)
  AUTHORS   Kroupova,A., Ackle,F., Asanovic,I., Weitzer,S., Boneberg,F.M.,
            Faini,M., Leitner,A., Chui,A., Aebersold,R., Martinez,J. and
            Jinek,M.
  TITLE     Molecular architecture of the human tRNA ligase complex
  JOURNAL   Elife 10, e71656 (2021)
   PUBMED   34854379
  REMARK    GeneRIF: Molecular architecture of the human tRNA ligase complex.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2019)
  AUTHORS   Hubel,P., Urban,C., Bergant,V., Schneider,W.M., Knauer,B.,
            Stukalov,A., Scaturro,P., Mann,A., Brunotte,L., Hoffmann,H.H.,
            Schoggins,J.W., Schwemmle,M., Mann,M., Rice,C.M. and Pichlmair,A.
  TITLE     A protein-interaction network of interferon-stimulated genes
            extends the innate immune system landscape
  JOURNAL   Nat Immunol 20 (4), 493-502 (2019)
   PUBMED   30833792
REFERENCE   6  (bases 1 to 2019)
  AUTHORS   de Hoog,C.L., Foster,L.J. and Mann,M.
  TITLE     RNA and RNA binding proteins participate in early stages of cell
            spreading through spreading initiation centers
  JOURNAL   Cell 117 (5), 649-662 (2004)
   PUBMED   15163412
REFERENCE   7  (bases 1 to 2019)
  AUTHORS   Collins,J.E., Goward,M.E., Cole,C.G., Smink,L.J., Huckle,E.J.,
            Knowles,S., Bye,J.M., Beare,D.M. and Dunham,I.
  TITLE     Reevaluating human gene annotation: a second-generation analysis of
            chromosome 22
  JOURNAL   Genome Res 13 (1), 27-36 (2003)
   PUBMED   12529303
REFERENCE   8  (bases 1 to 2019)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   9  (bases 1 to 2019)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   10 (bases 1 to 2019)
  AUTHORS   Garcia-Huidobro,M.
  TITLE     [Pregnancies after conization of the cervix uteri]
  JOURNAL   Rev Chil Obstet Ginecol 36 (3), 175-177 (1971)
   PUBMED   5163412
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC396330.1 and AL050255.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014306.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016707.1, SRR1803616.239874.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216038.6/ ENSP00000216038.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DC396330.1         41-56
            17-2019             AL050255.1         1-2003
FEATURES             Location/Qualifiers
     source          1..2019
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..2019
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /note="RNA 2',3'-cyclic phosphate and 5'-OH ligase"
                     /db_xref="GeneID:51493"
                     /db_xref="HGNC:HGNC:26935"
                     /db_xref="MIM:613901"
     exon            1..184
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1609
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /EC_number="6.5.1.8"
                     /note="tRNA-splicing ligase RtcB homolog; ankyrin repeat
                     domain 54; focal adhesion-associated protein;
                     3'-phosphate/5'-hydroxy nucleic acid ligase"
                     /codon_start=1
                     /product="RNA-splicing ligase RtcB homolog"
                     /protein_id="NP_055121.1"
                     /db_xref="CCDS:CCDS13905.1"
                     /db_xref="GeneID:51493"
                     /db_xref="HGNC:HGNC:26935"
                     /db_xref="MIM:613901"
                     /translation="MSRSYNDELQFLEKINKNCWRIKKGFVPNMQVEGVFYVNDALEK
                     LMFEELRNACRGGGVGGFLPAMKQIGNVAALPGIVHRSIGLPDVHSGYGFAIGNMAAF
                     DMNDPEAVVSPGGVGFDINCGVRLLRTNLDESDVQPVKEQLAQAMFDHIPVGVGSKGV
                     IPMNAKDLEEALEMGVDWSLREGYAWAEDKEHCEEYGRMLQADPNKVSARAKKRGLPQ
                     LGTLGAGNHYAEIQVVDEIFNEYAAKKMGIDHKGQVCVMIHSGSRGLGHQVATDALVA
                     MEKAMKRDKIIVNDRQLACARIASPEGQDYLKGMAAAGNYAWVNRSSMTFLTRQAFAK
                     VFNTTPDDLDLHVIYDVSHNIAKVEQHVVDGKERTLLVHRKGSTRAFPPHHPLIAVDY
                     QLTGQPVLIGGTMGTCSYVLTGTEQGMTETFGTTCHGAGRALSRAKSRRNLDFQDVLD
                     KLADMGIAIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKAIKLRPIAVIKG"
     exon            185..263
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            264..331
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            332..431
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            432..588
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            589..745
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            746..905
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1081
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1270
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1381
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1501
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..2019
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1986..1991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /note="hexamer: AAGAAA"
     polyA_site      2019
                     /gene="RTCB"
                     /gene_synonym="C22orf28; DJ149A16.6; FAAP; HSPC117"
                     /note="major polyA site"
ORIGIN      
        1 gttcttggaa ggcggtgctc tgagaagccg gactacgcgg cagcggctct tcaaagcgga
       61 gccgggagtt tttgctacag ttttcgccac catgagtcgc agctataatg atgagctgca
      121 gttcttggag aagatcaata aaaactgctg gaggatcaag aagggcttcg tgcccaacat
      181 gcaggttgaa ggtgttttct atgtgaatga tgctctggag aaattgatgt ttgaggaatt
      241 aaggaatgcc tgtcgaggtg gtggtgttgg tggcttcctg ccagccatga aacagattgg
      301 caatgtggca gccctgcctg gaattgttca tcgatctatt gggcttcctg atgtccattc
      361 aggatatggg tttgctattg ggaacatggc agcctttgat atgaatgacc ctgaagcagt
      421 agtatcccca ggtggtgtcg ggtttgacat caactgtggt gtccgcttgc taagaaccaa
      481 tttagatgaa agtgatgtcc agcctgtgaa ggagcaactt gcccaagcta tgtttgacca
      541 cattcctgtt ggggtggggt caaaaggtgt catcccaatg aatgccaaag acttggagga
      601 ggccttggag atgggggtgg actggtcctt aagagaaggg tatgcctggg ctgaagacaa
      661 ggagcactgc gaggagtacg gaaggatgct gcaggctgac cccaataaag tttctgcaag
      721 ggcgaagaaa agaggccttc ctcagttggg gaccctggga gcaggcaacc attatgcaga
      781 aatccaggtt gtggatgaga ttttcaatga gtatgctgct aaaaaaatgg gcatcgacca
      841 taagggacag gtgtgtgtga tgatccacag tggaagcaga ggcttgggcc accaagtagc
      901 cacagatgcg ctggtagcta tggagaaggc catgaagaga gacaagatta tagtcaatga
      961 tcggcagttg gcttgtgctc gaatcgcttc cccagagggt caagactatc tgaagggaat
     1021 ggcagctgct gggaactatg cctgggtcaa ccgctcttcc atgaccttct taacccgtca
     1081 ggctttcgcc aaggtcttca acacaacccc tgatgacttg gacctacatg tgatctatga
     1141 tgtttctcac aacattgcca aagtggagca gcatgtggtg gacggaaagg aacggacact
     1201 gttagtacac aggaagggat ccacccgcgc tttccctcct caccatcccc tcattgctgt
     1261 tgattaccaa ctcactggac agccagtgct cattggtggc accatgggaa cctgtagtta
     1321 tgttcttact ggcactgaac agggcatgac tgagaccttt ggaacaacct gtcatggagc
     1381 gggccgtgca ttgtcccgag caaaatctcg acgtaattta gatttccagg atgtcttaga
     1441 caaattggca gatatgggaa ttgcgatccg tgttgcctca cccaaactgg ttatggaaga
     1501 ggctcctgag tcctataaga atgtgacaga tgtggtaaat acctgccatg atgctggaat
     1561 cagcaagaaa gccattaaac tgagaccaat tgctgtgatc aaaggataga accttggaca
     1621 gcagggctgc ctgacaccac caaccctctc tgaagtggaa gtggactgac atgctcttct
     1681 gacatcagac tcaaggcggg acaagttgca aagtgtgcag ctgtaactgc tcacgccaaa
     1741 atggctgatg gggaggctgc tgctttcagg ggcccgtgct tgtaaaataa ccttccagga
     1801 agaggcacat tgcccacctt tggaaaggga ggaatatgcc ttctccttgg ttgttccaca
     1861 gagttttagg aaaatctgtt agggatgggt agatgtcaaa ctgccttacg cagtcatact
     1921 gatctttagc catcagattg atcttcttca caccaagctc tgtttacatt ccgagaggtg
     1981 tcatgaagaa agttctgttc aataaggttt tggaatgtt
//
