LOCUS       NM_001270441            1023 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens retbindin (RTBDN), transcript variant 4, mRNA.
ACCESSION   NM_001270441
VERSION     NM_001270441.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1023)
  AUTHORS   Kelley,R.A., Al-Ubaidi,M.R. and Naash,M.I.
  TITLE     Retbindin Is Capable of Protecting Photoreceptors from
            Flavin-Sensitized Light-Mediated Cell Death In Vitro
  JOURNAL   Adv Exp Med Biol 1074, 485-490 (2018)
   PUBMED   29721980
  REMARK    GeneRIF: Retbindin is capable of flavin binding. This
            characteristic can protect photoreceptors from flavin-sensitized
            light damage. Human retbindin in the culture media of a
            riboflavin-sensitized transgenic mouse cone cell line protected it
            from a 1-hour light-box exposure at 12,000 lux.
REFERENCE   2  (bases 1 to 1023)
  AUTHORS   Kelley,R.A., Al-Ubaidi,M.R. and Naash,M.I.
  TITLE     Retbindin is an extracellular riboflavin-binding protein found at
            the photoreceptor/retinal pigment epithelium interface
  JOURNAL   J Biol Chem 290 (8), 5041-5052 (2015)
   PUBMED   25542898
  REMARK    GeneRIF: retbindin is an excellent candidate for binding retinal
            flavins and possibly participating in their transport from the
            extracellular space to the photoreceptors.
REFERENCE   3  (bases 1 to 1023)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1023)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   5  (bases 1 to 1023)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020934.9.
            
            On May 14, 2019 this sequence version replaced NM_001270441.1.
            
            Summary: This gene was first identified in a study of human eye
            tissues. The protein encoded by this gene is preferentially
            expressed in the retina and may play a role in binding retinoids
            and other carotenoids as it shares homology with riboflavin binding
            proteins. Alternative splicing results in multiple transcript
            variants and protein isoforms. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1, 4, 6 and 7 encode the same isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.651402.1,
                                           SRR7410570.651400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000674343.2/
                                                ENSP00000501410.1
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC020934.9         69413-69503         c
            92-278              AC020934.9         64735-64921         c
            279-363             AC020934.9         63793-63877         c
            364-474             AC020934.9         63581-63691         c
            475-571             AC020934.9         61699-61795         c
            572-1023            AC020934.9         60406-60857         c
FEATURES             Location/Qualifiers
     source          1..1023
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..1023
                     /gene="RTBDN"
                     /note="retbindin"
                     /db_xref="GeneID:83546"
                     /db_xref="HGNC:HGNC:30310"
                     /db_xref="MIM:609553"
     exon            1..91
                     /gene="RTBDN"
                     /inference="alignment:Splign:2.1.0"
     exon            92..278
                     /gene="RTBDN"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..799
                     /gene="RTBDN"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 4"
                     /codon_start=1
                     /product="retbindin isoform 1 precursor"
                     /protein_id="NP_001257370.2"
                     /db_xref="CCDS:CCDS45994.1"
                     /db_xref="GeneID:83546"
                     /db_xref="HGNC:HGNC:30310"
                     /db_xref="MIM:609553"
                     /translation="MDCRVHMRPIGLTWVLQLTLAWILLEACGGSRPLQARSQQHHGL
                     AADLGKGKLHLAGPCCPSEMDTTETSGPGNHPERCGVPSPECESFLEHLQRALRSRFR
                     LRLLGVRQAQPLCEELCQAWFANCEDDITCGPTWLPLSEKRGCEPSCLTYGQTFADGT
                     DLCRSALGHALPVAAPGARHCFNISISAVPRPRPGRRGREAPSRRSRSPRTSILDAAG
                     SGSGSGSGSGP"
     exon            279..363
                     /gene="RTBDN"
                     /inference="alignment:Splign:2.1.0"
     exon            364..474
                     /gene="RTBDN"
                     /inference="alignment:Splign:2.1.0"
     exon            475..571
                     /gene="RTBDN"
                     /inference="alignment:Splign:2.1.0"
     exon            572..1023
                     /gene="RTBDN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1002..1007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RTBDN"
                     /note="hexamer: AATAAA"
     polyA_site      1023
                     /gene="RTBDN"
                     /note="major polyA site"
ORIGIN      
        1 gttgtagtgg aggaggtgga atgaagagtg agaaagctgt ctaggtgcct gtccaattag
       61 ggcagtagga agaatcctga tggccaggca gctcttatct caggtggaca tggactgcag
      121 ggtccacatg cgacccatcg gcctgacgtg ggtgctgcaa ctgaccttgg catggatcct
      181 gctagaagcc tgtggaggga gccgcccact ccaagccagg tcccagcaac accatgggct
      241 ggcagctgat ctgggcaaag gcaagctgca cctggcagga ccttgttgtc cctcagagat
      301 ggacacaaca gagacatcgg gccctggaaa ccatccagaa cgctgtggag tgccgagccc
      361 tgaatgcgaa tccttcctgg aacacctcca acgtgccctt cgcagtcgct tccgcctgcg
      421 gctattgggg gtacgccagg cacagccgct ctgcgaggag ctctgccagg cctggttcgc
      481 caactgcgaa gatgatatca cctgcggccc gacttggctc ccactctcag aaaaaagggg
      541 ctgtgagccc agctgcctta cctatggaca gaccttcgca gacgggacgg acctttgtcg
      601 ctcggctctg ggccacgccc taccggtggc tgctcctgga gcccgtcact gcttcaacat
      661 ctccatctcc gcggtacctc gtcccagacc aggacgacgg ggccgggaag ctccctcccg
      721 gcgttcccgc agccctcgca cctccatcct ggacgctgcg ggcagcggga gtggcagtgg
      781 aagcggcagc ggcccctagc ggacgcgtgg ccctgagttg ggggagcgac ccttccccca
      841 gccccgcccc tcaggacacc cagaacccca cccctcgtcc tctcggcctt ctgtaatagt
      901 tttgagatgt ctgtccctcc tccctggagc tccagagacc cacccctctc caggttatcc
      961 cagaaatgac ccaactctct cacttttccc tctccccttt gaataaagtc gccagctaga
     1021 gca
//
