LOCUS       NM_012425               3730 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Ras suppressor protein 1 (RSU1), transcript variant 1,
            mRNA.
ACCESSION   NM_012425
VERSION     NM_012425.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3730)
  AUTHORS   Cheng,Y., Wang,F., Guo,C., Yuan,S., Li,J. and Zhang,Y.
  TITLE     CircRSU1 alleviates LPS-induced human pulmonary microvascular
            endothelial cell injury by targeting miR-1224-5p/ITGA5 axis
  JOURNAL   Gen Physiol Biophys 43 (1), 1-11 (2024)
   PUBMED   38312030
  REMARK    GeneRIF: CircRSU1 alleviates LPS-induced human pulmonary
            microvascular endothelial cell injury by targeting
            miR-1224-5p/ITGA5 axis.
REFERENCE   2  (bases 1 to 3730)
  AUTHORS   Nikou,S., Arbi,M., Dimitrakopoulos,F.D., Kalogeropoulou,A.,
            Geramoutsou,C., Zolota,V., Kalofonos,H.P., Taraviras,S., Lygerou,Z.
            and Bravou,V.
  TITLE     Ras suppressor-1 (RSU1) exerts a tumor suppressive role with
            prognostic significance in lung adenocarcinoma
  JOURNAL   Clin Exp Med 23 (3), 871-885 (2023)
   PUBMED   35729367
  REMARK    GeneRIF: Ras suppressor-1 (RSU1) exerts a tumor suppressive role
            with prognostic significance in lung adenocarcinoma.
REFERENCE   3  (bases 1 to 3730)
  AUTHORS   Christou,C., Christodoulou,M.I., Zaravinos,A. and Gkretsi,V.
  TITLE     Ras suppressor 1 long form (RSU1L) silencing promotes apoptosis in
            invasive breast cancer cells
  JOURNAL   Cell Signal 101, 110522 (2023)
   PUBMED   36375714
  REMARK    GeneRIF: Ras suppressor 1 long form (RSU1L) silencing promotes
            apoptosis in invasive breast cancer cells.
REFERENCE   4  (bases 1 to 3730)
  AUTHORS   Geramoutsou,C., Nikou,S., Karavias,D., Arbi,M., Tavlas,P.,
            Tzelepi,V., Lygerou,Z., Maroulis,I. and Bravou,V.
  TITLE     Focal adhesion proteins in hepatocellular carcinoma: RSU1 a novel
            tumour suppressor with prognostic significance
  JOURNAL   Pathol Res Pract 235, 153950 (2022)
   PUBMED   35642986
  REMARK    GeneRIF: Focal adhesion proteins in hepatocellular carcinoma: RSU1
            a novel tumour suppressor with prognostic significance.
REFERENCE   5  (bases 1 to 3730)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3730)
  AUTHORS   Masuelli,L. and Cutler,M.L.
  TITLE     Increased expression of the Ras suppressor Rsu-1 enhances Erk-2
            activation and inhibits Jun kinase activation
  JOURNAL   Mol Cell Biol 16 (10), 5466-5476 (1996)
   PUBMED   8816460
REFERENCE   7  (bases 1 to 3730)
  AUTHORS   Tsuda,T., Marinetti,M.R., Masuelli,L. and Cutler,M.L.
  TITLE     The Ras suppressor RSU-1 localizes to 10p13 and its expression in
            the U251 glioblastoma cell line correlates with a decrease in
            growth rate and tumorigenic potential
  JOURNAL   Oncogene 11 (2), 397-403 (1995)
   PUBMED   7624154
REFERENCE   8  (bases 1 to 3730)
  AUTHORS   Matoba,R., Okubo,K., Hori,N., Fukushima,A. and Matsubara,K.
  TITLE     The addition of 5'-coding information to a 3'-directed cDNA library
            improves analysis of gene expression
  JOURNAL   Gene 146 (2), 199-207 (1994)
   PUBMED   8076819
REFERENCE   9  (bases 1 to 3730)
  AUTHORS   Tsuda,T. and Cutler,M.L.
  TITLE     Human RSU1 is highly homologous to mouse Rsu-1 and localizes to
            human chromosome 10
  JOURNAL   Genomics 18 (2), 461-462 (1993)
   PUBMED   8288261
REFERENCE   10 (bases 1 to 3730)
  AUTHORS   Cutler,M.L., Bassin,R.H., Zanoni,L. and Talbot,N.
  TITLE     Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras
            transformation
  JOURNAL   Mol Cell Biol 12 (9), 3750-3756 (1992)
   PUBMED   1508180
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG400752.1, BC005993.1,
            BX647733.1, AK055596.1 and AC073367.11.
            
            On Nov 22, 2018 this sequence version replaced NM_012425.3.
            
            Summary: This gene encodes a protein that is involved in the Ras
            signal transduction pathway, growth inhibition, and nerve-growth
            factor induced differentiation processes, as determined in mouse
            and human cell line studies. In mouse, the encoded protein was
            initially isolated based on its ability to inhibit v-Ras
            transformation. Multiple alternatively spliced transcript variants
            for this gene have been reported; one of these variants was found
            only in glioma tumors. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.245998.1,
                                           SRR1803613.241393.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345264.10/ ENSP00000339521.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BG400752.1         32-55
            25-1472             BC005993.1         25-1472
            1473-1615           BX647733.1         1367-1509
            1616-2391           AK055596.1         157-932
            2392-3189           BX647733.1         2285-3082
            3190-3678           AK055596.1         1730-2218
            3679-3725           BX647733.1         3572-3618
            3726-3730           AC073367.11        145553-145557
FEATURES             Location/Qualifiers
     source          1..3730
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..3730
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /note="Ras suppressor protein 1"
                     /db_xref="GeneID:6251"
                     /db_xref="HGNC:HGNC:10464"
                     /db_xref="MIM:179555"
     exon            1..110
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            111..222
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..947
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rsu-1"
                     /codon_start=1
                     /product="ras suppressor protein 1 isoform 1"
                     /protein_id="NP_036557.1"
                     /db_xref="CCDS:CCDS7112.1"
                     /db_xref="GeneID:6251"
                     /db_xref="HGNC:HGNC:10464"
                     /db_xref="MIM:179555"
                     /translation="MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQ
                     LVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLP
                     RGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQ
                     ILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPW
                     VTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKN
                     R"
     exon            223..273
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..394
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..513
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..596
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..711
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..844
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..3730
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1409..1414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /note="hexamer: AATAAA"
     polyA_site      1428
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /note="major polyA site"
     regulatory      1452..1457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /note="hexamer: AATAAA"
     polyA_site      1482
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
     regulatory      1571..1576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1598
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
     regulatory      3702..3707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
                     /note="hexamer: ATTAAA"
     polyA_site      3730
                     /gene="RSU1"
                     /gene_synonym="RSP-1"
ORIGIN      
        1 agggcgtgtt cgctgttcag tgccggtgtt gcagggagtg agggcagctg gagtgcgttc
       61 tgccgaagct tgtggttgca cgcccatcgt cttaggggct accttccgtg accatgtcca
      121 agtctctgaa gaagttggtg gaggagagcc gggagaagaa ccagcccgag gtggacatga
      181 gtgaccgggg catctccaac atgctggatg tcaacggcct ctttacctta tcccatatca
      241 cacaactggt cctcagccat aacaagctaa caatggtgcc accgaacatc gcagaactga
      301 agaatttgga ggtgctcaac ttttttaata accaaatcga ggagctgccc acacagatca
      361 gtagccttca gaaactcaaa cacctgaacc ttggcatgaa caggctgaac actttgccac
      421 gaggcttcgg ctccctgcca gctcttgagg ttctggactt gacgtacaac aacttgagcg
      481 aaaattctct tcctggaaac ttcttctacc tgaccaccct gcgtgcactc tatctaagtg
      541 acaacgattt tgaaatcctg ccgccagata ttgggaagct cacaaagttg cagatactca
      601 gccttaggga taacgacctg atctcgctgc ctaaggaaat cggggagctt acccagctta
      661 aagagctcca cattcagggg aaccgcctca ccgttctgcc cccagaacta ggaaacttgg
      721 atttaactgg ccagaagcag gtattcaaag cagagaacaa tccctgggtg acccccattg
      781 cagaccagtt ccagcttggc gtgtcccatg tttttgagta tatccgttct gagacataca
      841 aatacctcta cggcagacac atgcaggcca acccagaacc accgaagaag aataatgaca
      901 aatcgaaaaa gatcagccgg aaacccctgg cagccaagaa cagataagga agggattggc
      961 atcggctggc cttccagcac cttctctctc caacacttca ttctctcttg ccctgtctct
     1021 caaataaacc caatgctgcg tgtgaggcct tttttatttt tcttttcact ctctttctaa
     1081 tgcttcccac cttacctttt agattctttt gctaggtggg agattgttat aaggtcttta
     1141 aaccatttcc atttgtttct ttaacattac caaaagcagg gaacaaagct cttattcaac
     1201 tgcgaattcc atagtgggct ctggcttttc ttgaatagat atcacaaggt tgcttattat
     1261 caaaagaata attaaaatca tgtaaccatt taaatgtcac tgttaacact tttcactctt
     1321 tctgttgatt cacctaactc attattttgc tttattaaaa gtcttccttc accaccgaga
     1381 tatgctaatt taacttacaa atgattttaa taaaatcttg agtttgtatc acatgttact
     1441 tattgactca gaataaaaga acagtctgat cttggggtat aacacatttt catttacttt
     1501 tctcccccaa aatcatctta tccaatttta ttggttatac atgataaact tttcatgaaa
     1561 gaaatgcaaa attaaatcac agttcgtttc ttctcacatt aatttgtcaa gttttttttt
     1621 tctttgaaga ctttctaaat taggaagcag aaaaacaaat ctctaggaga ttctgccaaa
     1681 ggattttgga aagtagcatt ccttcgccga agaaatggtg atttctgcca ggggctggta
     1741 gacaagaact gtgaaagaga gagagaaaaa acctcaactg tgtattttgt cacggcggaa
     1801 aatctgctcg catcgaagca ttcttctaag cgacttcgat gccaaggaag ttgtgtaaat
     1861 gtgcacgcgc tacaccacac ccagggtgga aaccacagtt gcagagtcat taaacaatca
     1921 attgtttgtt taacatctgt gataggcagc tttccttctt ttcaacagtg atacctacga
     1981 aaatcaaaat aaatgcaagc tgaggttttg tgctcactga aagggctgtc aaccccagaa
     2041 ggccgacaca aaaaaaatgg tatgtgaaga tgcaccgtct tttcaaatgg cctgggagag
     2101 tcaaatggcc tgggagaggg ggcctgccct tctctgctgt gtcctttcgg cttcccagtt
     2161 gagctcccaa gaccaggacc cactggggca tataaaatct ctgctgtatc ctttcggctt
     2221 cccagttgag ctcccaagac caggacccac tggggcatat aaaaaagtca aaaatcaaaa
     2281 tcaaacaaca agttctgagt tacttaggaa acagacttcg catttcaatc agagaggcca
     2341 cagagcaagg tctaaacttc tggcttctag acaaattcct gatagaacat ttaaatgtgg
     2401 gaagtggctt ccccaggtcc catcccctgt ttagggatag agttgatatc atttttatag
     2461 gtgccatgta tgcctctgcc tgaatttttt taattgactt ttgagctttt gagattgcac
     2521 gagggagaac aaggcctttg ctgttgtgga taggaaagac ttaacctaaa attaaaccag
     2581 caagaaagca ttagtaaaaa tctaacaata tgaagggctc ttatgagtca tttttttcaa
     2641 aagatgaaaa ctccagaaac gcacaggaac gaaatacctc ccagaaacat gaagcaatca
     2701 tcgaagactc actggtaata tttttaaaaa gtatacagat caaagcaaaa agaagccatg
     2761 tgtaacaaag agaaatgtgc aaatattttt taaggcagta ttaagtgcaa gaggagtaac
     2821 atgaaataaa cattctttca catggctact gggaatataa atttcgctcc agaaaggccg
     2881 tagcagtttg acgataggtg gcaaaacctt aagattgtgt actggggccc agaattttta
     2941 tttctaggaa tgtatcctga ggaaattatc cgagatcccc acaaactgca atgtttagga
     3001 attgtcctta tagcattgca tacacaagaa aaacagagaa aagcctgatc cctgtcagtg
     3061 gaaaaggggt tcaatgaatt acggtgtgtc tgcatgaggc ttttatgaca ttaaaaattg
     3121 ttgaacaacg gccaggcaca gtggctcatg cctgtaatcc taacactttg ggaggccaag
     3181 gtgggaagat tgcctgagct caggagtttg agaccagcct gggcaacacg gtgaaacccc
     3241 gtctctacta aaatacaaaa aattagccgg gcgtcgcagc atgcgcctgt agtcccagct
     3301 gctcaggagg ctgaggcagg agaattgatt gaacccggga ggcagaggtt gcactgagct
     3361 gagattaagc caccgcactc cagcctgggc gacagagcaa gattccgttc ccaagaaaaa
     3421 aaaattgttc aacaataagg gcaaagggag agaatcataa catctgatta aacagaaaaa
     3481 gcaagatttt taaaactaac tatataagga tggtcccagc tgtgtcaaaa ggaagcttgt
     3541 ttgtaatacg tgtgcataaa aattaaatag aggtgaacac aattatttta aggcagttaa
     3601 attatctctg tattgtgaac taagactttc tagaatttta cttattcatt ctgtacttaa
     3661 attttttcta atgaacacat atacttttgt aatcagaaaa tattaaatgc atgtattttt
     3721 caaaatcaaa
//
