LOCUS       NM_020317               1425 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens arginine and serine rich protein 1 (RSRP1), transcript
            variant 2, mRNA.
ACCESSION   NM_020317
VERSION     NM_020317.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1425)
  AUTHORS   Li,Y., Wang,X., Qi,S., Gao,L., Huang,G., Ren,Z., Li,K., Peng,Y.,
            Yi,G., Guo,J., Yang,R., Wang,H., Zhang,X. and Liu,Y.
  TITLE     Spliceosome-regulated RSRP1-dependent NF-kappaB activation promotes
            the glioblastoma mesenchymal phenotype
  JOURNAL   Neuro Oncol 23 (10), 1693-1708 (2021)
   PUBMED   34042961
REFERENCE   2  (bases 1 to 1425)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1425)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1425)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1425)
  AUTHORS   Hong,C.Q., Zhang,F., You,Y.J., Qiu,W.L., Giuliano,A.E., Cui,X.J.,
            Zhang,G.J. and Cui,Y.K.
  TITLE     Elevated C1orf63 expression is correlated with CDK10 and predicts
            better outcome for advanced breast cancers: a retrospective study
  JOURNAL   BMC Cancer 15, 548 (2015)
   PUBMED   26209438
  REMARK    GeneRIF: Results show that C1orf63 expression was elevated in tumor
            tissues and correlated with better prognosis for breast cancers
            with advanced stage but the underlying mechanism is unknown.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1425)
  AUTHORS   Kullo,I.J., Ding,K., Shameer,K., McCarty,C.A., Jarvik,G.P.,
            Denny,J.C., Ritchie,M.D., Ye,Z., Crosslin,D.R., Chisholm,R.L.,
            Manolio,T.A. and Chute,C.G.
  TITLE     Complement receptor 1 gene variants are associated with erythrocyte
            sedimentation rate
  JOURNAL   Am J Hum Genet 89 (1), 131-138 (2011)
   PUBMED   21700265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA471865.1, BC001892.1, AK226012.1, AK292532.1 and BM875537.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020317.4.
            
            Transcript Variant: This variant (2) encodes the supported protein,
            which is also encoded by variant 14.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.83761.1,
                                           SRR3476690.845693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267767 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243189.12/ ENSP00000243189.7
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA471865.1         66-76
            12-927              BC001892.1         1-916
            928-968             AK226012.1         1521-1561
            969-1418            AK292532.1         2486-2935
            1419-1425           BM875537.1         519-525
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..1425
                     /gene="RSRP1"
                     /gene_synonym="C1orf63; NPD014"
                     /note="arginine and serine rich protein 1"
                     /db_xref="GeneID:57035"
                     /db_xref="HGNC:HGNC:25234"
                     /db_xref="MIM:620030"
     exon            1..146
                     /gene="RSRP1"
                     /gene_synonym="C1orf63; NPD014"
                     /inference="alignment:Splign:2.1.0"
     exon            147..732
                     /gene="RSRP1"
                     /gene_synonym="C1orf63; NPD014"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1085
                     /gene="RSRP1"
                     /gene_synonym="C1orf63; NPD014"
                     /note="UPF0471 protein C1orf63"
                     /codon_start=1
                     /product="arginine/serine-rich protein 1"
                     /protein_id="NP_064713.3"
                     /db_xref="CCDS:CCDS260.1"
                     /db_xref="GeneID:57035"
                     /db_xref="HGNC:HGNC:25234"
                     /db_xref="MIM:620030"
                     /translation="MSNYVNDMWPGSPQEKDSPSTSRSGGSSRLSSRSRSRSFSRSSR
                     SHSRVSSRFSSRSRRSKSRSRSRRRHQRKYRRYSRSYSRSRSRSRSRRYRERRYGFTR
                     RYYRSPSRYRSRSRSRSRSRGRSYCGRAYAIARGQRYYGFGRTVYPEEHSRWRDRSRT
                     RSRSRTPFRLSEKDRMELLEIAKTNAAKALGTTNIDLPASLRTVPSAKETSRGIGVSS
                     NGAKPELSEKVTEDGTRNPNEKPTQQRSIAFSSNNSVAKPIQKSAKAATEEASSRSPK
                     IDQKKSPYGLWIPI"
     exon            733..884
                     /gene="RSRP1"
                     /gene_synonym="C1orf63; NPD014"
                     /inference="alignment:Splign:2.1.0"
     exon            885..968
                     /gene="RSRP1"
                     /gene_synonym="C1orf63; NPD014"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1425
                     /gene="RSRP1"
                     /gene_synonym="C1orf63; NPD014"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1401..1406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSRP1"
                     /gene_synonym="C1orf63; NPD014"
                     /note="hexamer: AATAAA"
     polyA_site      1425
                     /gene="RSRP1"
                     /gene_synonym="C1orf63; NPD014"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgcatc cggacgtagg aggtggaggt tgtggaattc gccgttcgaa agcagggact
       61 aaaagcccca cttcgtctta cgttccgaaa ggaaggcgtc tgttgagcct ttctctcagt
      121 cgtgagggag gcgtcgacgg cgtgcggaag tcctgagttg aggcttgcgg gatcctttcc
      181 ggagaaagcg caggctaaag ccgcaggtga agatgtccaa ctacgtgaac gacatgtggc
      241 cgggctcgcc gcaggagaag gattcgccct cgacctcgcg gtcgggcggg tccagccggc
      301 tgtcgtcgcg gtctaggagc cgctcttttt ccagaagctc tcggtcccat tcccgcgtct
      361 cgagccggtt ttcgtccagg agtcggagga gcaagtccag gtcccgttcc cgaaggcgcc
      421 accagcggaa gtacaggcgc tactcgcggt catactcgcg gagccggtcg cgatcccgca
      481 gccgccgtta ccgagagagg cgctacgggt tcaccaggag atactaccgg tctccttcgc
      541 ggtaccggtc ccggtcccgt agcaggtcgc gctctcgggg aaggtcgtac tgcggaaggg
      601 cgtacgcgat cgcgcgggga cagcgctact acggctttgg tcgcacagtg tacccggagg
      661 agcacagcag atggagggac agatccagga cgaggtcgcg gagcagaacc ccctttcgct
      721 taagtgaaaa agatcgaatg gagctgttag aaatagcaaa aaccaatgca gcgaaagctc
      781 taggaacaac caacattgac ttgccagcta gtctcagaac tgttccttca gccaaagaaa
      841 caagccgtgg aataggtgta tcaagtaatg gtgcaaagcc tgaactgtcg gaaaaggtaa
      901 cagaagatgg aactcgaaat cccaatgaaa aacctaccca gcaaagaagc atagctttta
      961 gctctaataa ttctgtagca aagccaatac aaaaatcagc taaagctgcc acagaagagg
     1021 catcttcaag atcaccaaaa atagatcaga aaaaaagtcc atatggactg tggataccta
     1081 tctaaaagaa gaaaactgat ggctaagttt gcatgaaaac tgcactttat tgcaagttag
     1141 tgtttctagc attatcccat ccctttgagc cattcagggg tacttgtgca tttaaaaacc
     1201 aacacaaaaa gatgtaaata cttaacactc aaatattaac attttaggtt tctcttgcag
     1261 atatgagaga tagcacagat ggaccaaagg ttatgcacag gtgggagtct tttgtatata
     1321 gttgtaaata ttgtcttggt tatgtaaaaa tgaaattttt tagacacagt aattgaactg
     1381 tattcctgtt ttgtatattt aataaatttc ttgttttcat tctta
//
