LOCUS       NM_023012               3461 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens arginine and serine rich coiled-coil 2 (RSRC2),
            transcript variant 1, mRNA.
ACCESSION   NM_023012 NM_198263
VERSION     NM_023012.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3461)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3461)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3461)
  AUTHORS   Liu,T., Sun,H., Zhu,D., Dong,X., Liu,F., Liang,X., Chen,C.,
            Shao,B., Wang,M., Wang,Y. and Sun,B.
  TITLE     TRA2A Promoted Paclitaxel Resistance and Tumor Progression in
            Triple-Negative Breast Cancers via Regulating Alternative Splicing
  JOURNAL   Mol Cancer Ther 16 (7), 1377-1388 (2017)
   PUBMED   28416606
  REMARK    GeneRIF: our findings suggest that paclitaxel targets the
            TRA2A-RSRC2 splicing pathway, and deregulated TRA2A and RSRC2
            expression may confer paclitaxel resistance. In addition, our study
            demonstrates that expression of TRA2A in conjunction with RSRC2 may
            provide valuable molecular biomarker evidence for triple-negative
            breast cancer (TNBC)clinical treatment decisions and patient
            outcome
REFERENCE   4  (bases 1 to 3461)
  AUTHORS   Varjosalo,M., Keskitalo,S., Van Drogen,A., Nurkkala,H.,
            Vichalkovski,A., Aebersold,R. and Gstaiger,M.
  TITLE     The protein interaction landscape of the human CMGC kinase group
  JOURNAL   Cell Rep 3 (4), 1306-1320 (2013)
   PUBMED   23602568
REFERENCE   5  (bases 1 to 3461)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3461)
  AUTHORS   Kurehara,H., Ishiguro,H., Kimura,M., Mitsui,A., Ando,T., Sugito,N.,
            Mori,R., Takashima,N., Ogawa,R., Fujii,Y. and Kuwabara,Y.
  TITLE     A novel gene, RSRC2, inhibits cell proliferation and affects
            survival in esophageal cancer patients
  JOURNAL   Int J Oncol 30 (2), 421-428 (2007)
   PUBMED   17203224
  REMARK    GeneRIF: RSRC2 might play a role in cell proliferation and
            progression of esophageal cancer
REFERENCE   7  (bases 1 to 3461)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB212664.1 and AC127002.3.
            
            On Nov 23, 2018 this sequence version replaced NM_023012.5.
            
            Transcript Variant: This variant (1) is the shortest transcript but
            encodes a functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.242686.1,
                                           SRR1660809.61872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267760, SAMN03267763
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331738.12/ ENSP00000330188.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2189              AB212664.1         64-2252
            2190-3461           AC127002.3         84299-85570         c
FEATURES             Location/Qualifiers
     source          1..3461
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..3461
                     /gene="RSRC2"
                     /note="arginine and serine rich coiled-coil 2"
                     /db_xref="GeneID:65117"
                     /db_xref="HGNC:HGNC:30559"
                     /db_xref="MIM:619996"
     exon            1..89
                     /gene="RSRC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1388
                     /gene="RSRC2"
                     /note="arginine/serine-rich coiled-coil 2"
                     /codon_start=1
                     /product="arginine/serine-rich coiled-coil protein 2"
                     /protein_id="NP_075388.2"
                     /db_xref="CCDS:CCDS31920.1"
                     /db_xref="GeneID:65117"
                     /db_xref="HGNC:HGNC:30559"
                     /db_xref="MIM:619996"
                     /translation="MAASDTERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSR
                     SRSRERKRKSDNEGRKHRSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERL
                     NSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSR
                     ERKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLS
                     RTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEIAAAAATGGSV
                     LNVAALLASGTQVTPQIAMAAQMAALQAKALAETGIAVPSYYNPAAVNPMKFAEQEKK
                     RKMLWQGKKEGDKSQSAEIWEKLNFGNKDQNVKFRKLMGIKSEDEAGCSSVDEESYKT
                     LKQQEEVFRNLDAQYEMARSQTHTQRGMGLGFTSSMRGMDAV"
     exon            90..246
                     /gene="RSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            247..290
                     /gene="RSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            291..481
                     /gene="RSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..685
                     /gene="RSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            686..808
                     /gene="RSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..888
                     /gene="RSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1118
                     /gene="RSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1208
                     /gene="RSRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..3461
                     /gene="RSRC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1839..1844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSRC2"
                     /note="hexamer: AATAAA"
     polyA_site      1860
                     /gene="RSRC2"
                     /note="major polyA site"
     regulatory      2170..2175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSRC2"
                     /note="hexamer: AATAAA"
     polyA_site      2189
                     /gene="RSRC2"
     regulatory      3142..3147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSRC2"
                     /note="hexamer: AATAAA"
     polyA_site      3164
                     /gene="RSRC2"
     regulatory      3439..3444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSRC2"
                     /note="hexamer: AATAAA"
     polyA_site      3461
                     /gene="RSRC2"
ORIGIN      
        1 agtctgaggc gaagcttcgg agcggccggt actgttgaaa gcgacaagtg gaggcgccgc
       61 tctagcggcc gggactctga actatggcgg ctagtgatac agagcgagat ggactagccc
      121 cagaaaagac atcaccagat agagataaga aaaaagagca gtcagaagta tctgtttctc
      181 ctagagcttc aaaacatcat tattcaagat cacgatcaag gtcaagagaa agaaaacgaa
      241 agtcagataa tgaaggaaga aaacacagga gccggagcag aagcaaagag ggaagaagac
      301 atgaatccaa agataaatcc tctaagaaac ataagtctga ggaacataat gacaaagaac
      361 attcttctga taaaggaaga gagcgactaa attcatctga aaatggtgag gacaggcaca
      421 aacgcaaaga aagaaagtca tcaagaggca gaagtcactc aagatctagg tctcgtgaaa
      481 gacgccatcg tagtagaagc agggagcgga agaagtctcg atccaggagt agggagcgga
      541 agaaatcgag atccagaagc agagagagga agaaatcgag atccagaagc agggaaagaa
      601 aacggcggat caggtctcgt tcccgctcaa gatcaagaca caggcatagg actagaagca
      661 ggagtaggac aaggagtagg agtcgagata gaaagaagag aattgaaaag ccgagaagat
      721 ttagcagaag tttaagccgg actccaagtc cacctccctt cagaggcaga aacacagcaa
      781 tggatgcaca ggaagcttta gctagaaggt tggaaagggc aaagaaatta caagaacagc
      841 gagaaaagga aatggttgaa aaacaaaaac aacaagaaat agctgcagct gcagctactg
      901 gaggttctgt tctcaatgtt gctgccctgt tggcatcagg aacacaagta acacctcaga
      961 tagccatggc agctcagatg gcagccctgc aagctaaagc tttggcagag acaggaatag
     1021 ctgttcctag ctactataac ccagccgctg ttaatccaat gaaatttgct gaacaagaga
     1081 aaaaaaggaa aatgctttgg cagggcaaga aagaagggga caaatcccaa tctgctgaaa
     1141 tatgggaaaa attgaatttt ggaaacaagg accaaaatgt caaatttagg aaattgatgg
     1201 gtattaagag tgaagatgaa gctggatgta gctcagttga tgaagaaagt tacaagactc
     1261 tgaagcagca ggaagaagta tttcgaaatt tagatgctca gtatgaaatg gcaagatcac
     1321 aaacccacac acaaagagga atgggtttgg gtttcacatc ttcaatgcga ggaatggatg
     1381 cagtttgaaa atgatcacac ttgtaaagtt tgggacttat agacttcttg ttctgatgtc
     1441 acgtccttgt tcaccaaaca gctagcactc tagcttgcat gggtgttgca ttgactttaa
     1501 tttattgaaa aatacaaatt tttgtaaata tcagatcagt gatactggtg ttagtgttgt
     1561 aatcaggtta aacccacttc cattaaactt gacaggacta tagaaggata atatttttta
     1621 gttcatgaat tctacttttc aaatatataa aagctgcagg tggggataaa atctcataca
     1681 tggatttttt cgtgtccgct gtcttgtgta cttttgtact taaccttgta cagttatttt
     1741 catctcttga aacatgaaag aaatgttatg tagatgttct ttagaagatc tggccatttg
     1801 gtacataatc cagcacagat aagctgggtg gtaatgataa taaaaatggt tttctcaaaa
     1861 ctggtgttaa tttaagttac ctgggatgtt tctttgaatt tgttttatag tttctgtagc
     1921 atttggcaat tgctgttaga aaacactagc tagaaatccc ctccccacca ccctttttaa
     1981 ggccagttaa ctatactaca gtcaataccg tggtgagcaa aaatgtaaaa ggtggaagga
     2041 gaaaacttac taaaatagta tgttttccta ttataaggga cagacttggt attcagtatt
     2101 tgtcaaatat tacatgtgtt attcaggaga tagattaatg cattaaaggg atgtaagcac
     2161 ttttatttta ataaagtgcc ttataacaag ttctttgcat gctttttgct cattatccct
     2221 ttgaagtctt ctccagcata gactataaaa tattaaaata ttagaaattt tttttgtttg
     2281 tttttttgag acaggatctt gctctgttgc ctaaactggg tgcagtggca caatctcggc
     2341 tcactgccag agcctctgcc ccccaggttc aagcaattct cccacctcca cctcccatgt
     2401 aactgggatt acaggcgtac caccgcaccc agctaatttt tgtattttta gtagaggtgg
     2461 ggttttacca tgttggccag gctggtcctg aactcctgac ctcaggtgat ccaccctcct
     2521 cagcctccca aagtgccggg attataggcg tgagccactg cagccagcct agaaaatgtt
     2581 ttgttactag attgaacata aatctggagc caaggggtgg ggggggcctg caaaacttga
     2641 agttaattta cttcagttac agcaaagtaa taaggtttgg ctttcctttg aaaaatcctt
     2701 tggaaaacat cacagaatga gagcacatta caatcaggga agactacagg aataagattg
     2761 acagccttat tttaaaagct ggaattaagt cttgccaact tgctcattag gtattttttt
     2821 tatacatgaa aatgaagtaa tggggtgttt tctttttttt tgctttctgt cctaggctgg
     2881 agtgcagtgc attgcagcag gctcccccag gctcaagcag tcctcccacc tcagcctctt
     2941 gagtacctgg gaccacaggt gctcaccaac acacctagct tgtttttaat tttttataaa
     3001 gacaaggtct tgttacgttg cccaggttgg tcttgaattc ctggcctcaa gcaatcctcc
     3061 cacctcaggg ctcccaaagt gatggggtta caggtgtgat ccacttcacc tagccagatt
     3121 gtaagatttt taatgtactt taataaacct ttcattttcc cagagcacag aaattctatg
     3181 gcaaaatggc ttttcaccgt gtttcagtga caaatctaag ccttctaagg aaatgacact
     3241 atggatcctt catttcgtga tcatcaacat ttttcaatta agctctgcct ttttaaatca
     3301 atcttattaa aaatgttcat gaccttctaa ggcagtgtgg acgcaaaagc ttcctgtgtg
     3361 tctacagtta ttttaggagc tgaccataca tgatgagtga tacagcctgt actttgctca
     3421 tctagagcag cactgtccaa taaaatatgt gtgtatatgt a
//
