LOCUS       NM_014433               1188 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens radial spoke head 14 homolog (RSPH14), mRNA.
ACCESSION   NM_014433
VERSION     NM_014433.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1188)
  AUTHORS   Ma,K., Peng,J., Rong,H., Jiang,Y., Zhang,H., Zhu,J., Xiao,B.,
            Tang,P., He,J. and Yu,Z.
  TITLE     RSPH14 regulates the proliferation, cell cycle progression, and
            apoptosis of non-small cell lung cancer cells
  JOURNAL   FEBS Open Bio 11 (10), 2715-2726 (2021)
   PUBMED   34351079
REFERENCE   2  (bases 1 to 1188)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1188)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1188)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1188)
  AUTHORS   Estrada,K., Styrkarsdottir,U., Evangelou,E., Hsu,Y.H., Duncan,E.L.,
            Ntzani,E.E., Oei,L., Albagha,O.M., Amin,N., Kemp,J.P., Koller,D.L.,
            Li,G., Liu,C.T., Minster,R.L., Moayyeri,A., Vandenput,L.,
            Willner,D., Xiao,S.M., Yerges-Armstrong,L.M., Zheng,H.F.,
            Alonso,N., Eriksson,J., Kammerer,C.M., Kaptoge,S.K., Leo,P.J.,
            Thorleifsson,G., Wilson,S.G., Wilson,J.F., Aalto,V., Alen,M.,
            Aragaki,A.K., Aspelund,T., Center,J.R., Dailiana,Z., Duggan,D.J.,
            Garcia,M., Garcia-Giralt,N., Giroux,S., Hallmans,G., Hocking,L.J.,
            Husted,L.B., Jameson,K.A., Khusainova,R., Kim,G.S., Kooperberg,C.,
            Koromila,T., Kruk,M., Laaksonen,M., Lacroix,A.Z., Lee,S.H.,
            Leung,P.C., Lewis,J.R., Masi,L., Mencej-Bedrac,S., Nguyen,T.V.,
            Nogues,X., Patel,M.S., Prezelj,J., Rose,L.M., Scollen,S.,
            Siggeirsdottir,K., Smith,A.V., Svensson,O., Trompet,S., Trummer,O.,
            van Schoor,N.M., Woo,J., Zhu,K., Balcells,S., Brandi,M.L.,
            Buckley,B.M., Cheng,S., Christiansen,C., Cooper,C., Dedoussis,G.,
            Ford,I., Frost,M., Goltzman,D., Gonzalez-Macias,J., Kahonen,M.,
            Karlsson,M., Khusnutdinova,E., Koh,J.M., Kollia,P., Langdahl,B.L.,
            Leslie,W.D., Lips,P., Ljunggren,O., Lorenc,R.S., Marc,J.,
            Mellstrom,D., Obermayer-Pietsch,B., Olmos,J.M.,
            Pettersson-Kymmer,U., Reid,D.M., Riancho,J.A., Ridker,P.M.,
            Rousseau,F., Slagboom,P.E., Tang,N.L., Urreizti,R., Van Hul,W.,
            Viikari,J., Zarrabeitia,M.T., Aulchenko,Y.S.,
            Castano-Betancourt,M., Grundberg,E., Herrera,L., Ingvarsson,T.,
            Johannsdottir,H., Kwan,T., Li,R., Luben,R., Medina-Gomez,C.,
            Palsson,S.T., Reppe,S., Rotter,J.I., Sigurdsson,G., van Meurs,J.B.,
            Verlaan,D., Williams,F.M., Wood,A.R., Zhou,Y., Gautvik,K.M.,
            Pastinen,T., Raychaudhuri,S., Cauley,J.A., Chasman,D.I.,
            Clark,G.R., Cummings,S.R., Danoy,P., Dennison,E.M., Eastell,R.,
            Eisman,J.A., Gudnason,V., Hofman,A., Jackson,R.D., Jones,G.,
            Jukema,J.W., Khaw,K.T., Lehtimaki,T., Liu,Y., Lorentzon,M.,
            McCloskey,E., Mitchell,B.D., Nandakumar,K., Nicholson,G.C.,
            Oostra,B.A., Peacock,M., Pols,H.A., Prince,R.L., Raitakari,O.,
            Reid,I.R., Robbins,J., Sambrook,P.N., Sham,P.C., Shuldiner,A.R.,
            Tylavsky,F.A., van Duijn,C.M., Wareham,N.J., Cupples,L.A.,
            Econs,M.J., Evans,D.M., Harris,T.B., Kung,A.W., Psaty,B.M.,
            Reeve,J., Spector,T.D., Streeten,E.A., Zillikens,M.C.,
            Thorsteinsdottir,U., Ohlsson,C., Karasik,D., Richards,J.B.,
            Brown,M.A., Stefansson,K., Uitterlinden,A.G., Ralston,S.H.,
            Ioannidis,J.P., Kiel,D.P. and Rivadeneira,F.
  TITLE     Genome-wide meta-analysis identifies 56 bone mineral density loci
            and reveals 14 loci associated with risk of fracture
  JOURNAL   Nat Genet 44 (5), 491-501 (2012)
   PUBMED   22504420
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1188)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   7  (bases 1 to 1188)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   8  (bases 1 to 1188)
  AUTHORS   Zhou,J., Fogelgren,B., Wang,Z., Roe,B.A. and Biegel,J.A.
  TITLE     Isolation of genes from the rhabdoid tumor deletion region in
            chromosome band 22q11.2
  JOURNAL   Gene 241 (1), 133-141 (2000)
   PUBMED   10607907
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC000029.17 and AC245054.3.
            
            On May 17, 2019 this sequence version replaced NM_014433.2.
            
            Summary: This gene encodes a protein with no known function but
            with slight similarity to a yeast vacuolar protein. The gene is
            located in a region deleted in pediatric rhabdoid tumors of the
            brain, kidney and soft tissues, but mutations in this gene have not
            been associated with the disease. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF133587.1, BC008986.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158188 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216036.9/ ENSP00000216036.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC000029.17        121623-121664       c
            43-293              AC000029.17        119896-120146       c
            294-396             AC000029.17        118514-118616       c
            397-515             AC000029.17        113700-113818       c
            516-747             AC245054.3         50132-50363
            748-884             AC245054.3         52320-52456
            885-1188            AC245054.3         54547-54850
FEATURES             Location/Qualifiers
     source          1..1188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.22-q11.23"
     gene            1..1188
                     /gene="RSPH14"
                     /gene_synonym="RTDR1"
                     /note="radial spoke head 14 homolog"
                     /db_xref="GeneID:27156"
                     /db_xref="HGNC:HGNC:13437"
                     /db_xref="MIM:605663"
     exon            1..42
                     /gene="RSPH14"
                     /gene_synonym="RTDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            43..293
                     /gene="RSPH14"
                     /gene_synonym="RTDR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1141
                     /gene="RSPH14"
                     /gene_synonym="RTDR1"
                     /note="rhabdoid tumor deletion region protein 1; rhabdoid
                     tumor deletion region gene 1"
                     /codon_start=1
                     /product="radial spoke head 14 homolog"
                     /protein_id="NP_055248.1"
                     /db_xref="CCDS:CCDS13803.1"
                     /db_xref="GeneID:27156"
                     /db_xref="HGNC:HGNC:13437"
                     /db_xref="MIM:605663"
                     /translation="MAHSQNSLELPININATQITTAYGHRALPKLKEELQSEDLQTRQ
                     KALMALCDLMHDPECIYKAMNIGCMENLKALLKDSNSMVRIKTTEVLHITASHSVGRY
                     AFLEHDIVLALSFLLNDPSPVCRGNLYKAYMQLVQVPRGAQEIISKGLISSLVWKLQV
                     EVEEEEFQEFILDTLVLCLQEDATEALGSNVVLVLKQKLLSANQNIRSKAARALLNVS
                     ISREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGALMFATVITEGKYAALEAQAIGL
                     LLELLHSPMTIARLNATKALTMLAEAPEGRKALQTHVPTFRAMEVETYEKPQVAEALQ
                     RAARIAISVIEFKP"
     exon            294..396
                     /gene="RSPH14"
                     /gene_synonym="RTDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            397..515
                     /gene="RSPH14"
                     /gene_synonym="RTDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..747
                     /gene="RSPH14"
                     /gene_synonym="RTDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..884
                     /gene="RSPH14"
                     /gene_synonym="RTDR1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1188
                     /gene="RSPH14"
                     /gene_synonym="RTDR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1166..1171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSPH14"
                     /gene_synonym="RTDR1"
                     /note="hexamer: AATAAA"
     polyA_site      1188
                     /gene="RSPH14"
                     /gene_synonym="RTDR1"
                     /note="major polyA site"
ORIGIN      
        1 agtggcgcgg gctactggaa gcagaaaggg ctgcggaggc agtgagtggt ttctgcagag
       61 cttcatttgg aaaggcctct gtagttgggg aaagatggcc cattcccaga actccttgga
      121 gcttcccatt aacatcaatg ccacccagat taccactgcc tatggccatc gggccctgcc
      181 caagctgaag gaggagctgc agtcagagga cctccagacg aggcagaaag ccctcatggc
      241 cttgtgtgac ctcatgcatg accccgagtg tatctacaag gccatgaaca taggctgtat
      301 ggagaacctg aaagctttgc tgaaggatag caacagtatg gtgcgcataa agaccaccga
      361 ggtgctccac atcacggcaa gccatagcgt gggcagatac gcctttctag agcacgacat
      421 cgtccttgcc ctgtccttcc tgctgaatga ccccagccca gtctgccggg ggaacctgta
      481 caaggcatac atgcagctgg tccaggtgcc tagaggggcc caagagatca tcagcaaagg
      541 tctgatttcc tcactggtat ggaagctgca ggtggaggtg gaggaggagg agttccagga
      601 gttcatcctg gacacactgg tcctctgcct gcaggaggat gccaccgagg ccctgggcag
      661 caatgtggtg cttgtcctga agcagaagct cctcagcgcc aaccagaaca tccgcagcaa
      721 ggccgcccgt gcgctcctta atgtcagcat atctcgagag ggcaagaaac aggtgtgtca
      781 ttttgacgtc atccccatcc tggtccatct gctgaaagac ccagtggagc atgtgaagtc
      841 taacgctgcc ggtgccctga tgttcgccac agtgatcact gaagggaagt atgcggccct
      901 ggaggcacaa gccatcggcc tgctcctgga gctgctgcac tcccccatga ccatagcgcg
      961 cctgaatgcc accaaggccc ttaccatgct ggcagaggcc cccgagggcc gcaaggccct
     1021 gcagacgcac gtgcccactt tccgtgccat ggaggtggag acttacgaaa agcctcaagt
     1081 ggccgaagcc ttacagcggg cagcccggat cgccatcagt gtcatcgagt tcaaaccctg
     1141 agcccttcat tcacctctgt gagtgaataa atgtgctaag tctcttta
//
