LOCUS       NM_016304               1889 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ribosomal L24 domain containing 1 (RSL24D1), mRNA.
ACCESSION   NM_016304
VERSION     NM_016304.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1889)
  AUTHORS   Durand,S., Bruelle,M., Bourdelais,F., Bennychen,B.,
            Blin-Gonthier,J., Isaac,C., Huyghe,A., Martel,S., Seyve,A.,
            Vanbelle,C., Adrait,A., Coute,Y., Meyronet,D., Catez,F., Diaz,J.J.,
            Lavial,F., Ricci,E.P., Ducray,F. and Gabut,M.
  TITLE     RSL24D1 sustains steady-state ribosome biogenesis and pluripotency
            translational programs in embryonic stem cells
  JOURNAL   Nat Commun 14 (1), 356 (2023)
   PUBMED   36690642
  REMARK    GeneRIF: RSL24D1 sustains steady-state ribosome biogenesis and
            pluripotency translational programs in embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1889)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1889)
  AUTHORS   Ramsuran,V., Kulkarni,H., He,W., Mlisana,K., Wright,E.J.,
            Werner,L., Castiblanco,J., Dhanda,R., Le,T., Dolan,M.J., Guan,W.,
            Weiss,R.A., Clark,R.A., Karim,S.S., Ahuja,S.K. and Ndung'u,T.
  TITLE     Duffy-null-associated low neutrophil counts influence HIV-1
            susceptibility in high-risk South African black women
  JOURNAL   Clin Infect Dis 52 (10), 1248-1256 (2011)
   PUBMED   21507922
REFERENCE   4  (bases 1 to 1889)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1889)
  AUTHORS   Kobayashi,S., Ito,A., Okuzaki,D., Onda,H., Yabuta,N., Nagamori,I.,
            Suzuki,K., Hashimoto,H. and Nojima,H.
  TITLE     Expression profiling of PBMC-based diagnostic gene markers isolated
            from vasculitis patients
  JOURNAL   DNA Res 15 (4), 253-265 (2008)
   PUBMED   18562305
REFERENCE   6  (bases 1 to 1889)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   7  (bases 1 to 1889)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   8  (bases 1 to 1889)
  AUTHORS   Saveanu,C., Namane,A., Gleizes,P.E., Lebreton,A., Rousselle,J.C.,
            Noaillac-Depeyre,J., Gas,N., Jacquier,A. and Fromont-Racine,M.
  TITLE     Sequential protein association with nascent 60S ribosomal particles
  JOURNAL   Mol Cell Biol 23 (13), 4449-4460 (2003)
   PUBMED   12808088
REFERENCE   9  (bases 1 to 1889)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   10 (bases 1 to 1889)
  AUTHORS   Saveanu,C., Bienvenu,D., Namane,A., Gleizes,P.E., Gas,N.,
            Jacquier,A. and Fromont-Racine,M.
  TITLE     Nog2p, a putative GTPase associated with pre-60S subunits and
            required for late 60S maturation steps
  JOURNAL   EMBO J 20 (22), 6475-6484 (2001)
   PUBMED   11707418
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011912.7.
            
            On Nov 26, 2018 this sequence version replaced NM_016304.2.
            
            Summary: This gene encodes a protein sharing a low level of
            sequence similarity with human ribosomal protein L24. Although this
            gene has been referred to as RPL24, L30, and 60S ribosomal protein
            L30 isolog in the sequence databases, it is distinct from the human
            genes officially named RPL24 (which itself has been referred to as
            ribosomal protein L30) and RPL30. The protein encoded by this gene
            localizes to the nucleolus and is thought to play a role in the
            biogenesis of the 60S ribosomal subunit. The precise function of
            this gene is currently unknown. This gene utilizes alternative
            polyadenylation signals and has multiple pseudogenes. [provided by
            RefSeq, Jul 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.258086.1,
                                           SRR5189658.179228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154529, SAMN03267772
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260443.9/ ENSP00000260443.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AC011912.7         121658-121789       c
            133-246             AC011912.7         117568-117681       c
            247-319             AC011912.7         115823-115895       c
            320-383             AC011912.7         110210-110273       c
            384-469             AC011912.7         108163-108248       c
            470-1889            AC011912.7         105654-107073       c
FEATURES             Location/Qualifiers
     source          1..1889
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..1889
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
                     /note="ribosomal L24 domain containing 1"
                     /db_xref="GeneID:51187"
                     /db_xref="HGNC:HGNC:18479"
                     /db_xref="MIM:613262"
     exon            1..132
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..543
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
                     /EC_number="3.6.5.3"
                     /note="homolog of yeast ribosomal like protein 24; 60S
                     ribosomal protein L30 isolog; my024 protein; ribosomal L24
                     domain-containing protein 1"
                     /codon_start=1
                     /product="probable ribosome biogenesis protein RLP24"
                     /protein_id="NP_057388.1"
                     /db_xref="CCDS:CCDS10152.1"
                     /db_xref="GeneID:51187"
                     /db_xref="HGNC:HGNC:18479"
                     /db_xref="MIM:613262"
                     /translation="MRIEKCYFCSGPIYPGHGMMFVRNDCKVFRFCKSKCHKNFKKKR
                     NPRKVRWTKAFRKAAGKELTVDNSFEFEKRRNEPIKYQRELWNKTIDAMKRVEEIKQK
                     RQAKFIMNRLKKNKELQKVQDIKEVKQNIHLIRAPLAGKGKQLEEKMVQQLQEDVDME
                     DAP"
     exon            133..246
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            247..319
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            320..383
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            384..469
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            470..1889
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1360..1365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
                     /note="hexamer: AATAAA"
     polyA_site      1381
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
                     /note="major polyA site"
     regulatory      1488..1493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
                     /note="hexamer: ATTAAA"
     regulatory      1498..1503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
                     /note="hexamer: AATAGA"
     polyA_site      1510
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
     polyA_site      1517
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
     regulatory      1870..1875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
                     /note="hexamer: AATAAA"
     polyA_site      1889
                     /gene="RSL24D1"
                     /gene_synonym="C15orf15; HRP-L30-iso; L30; RLP24; RPL24;
                     RPL24L; TVAS3"
ORIGIN      
        1 acttcctctc aagcttggcg tttgtttggt ggggttacac gcgggttcaa catgcgtatc
       61 gaaaagtgtt atttctgttc ggggcccatc tatcctggac acggcatgat gttcgtccgc
      121 aacgattgca aggtgttcag attttgcaaa tctaaatgtc ataaaaactt taaaaagaag
      181 cgcaatcctc gcaaagttag gtggaccaaa gcattccgga aagcagctgg taaagagctt
      241 acagtggata attcatttga atttgaaaaa cgtagaaatg aacctatcaa ataccagcga
      301 gagctatgga ataaaactat tgatgcgatg aagagagttg aagaaatcaa acagaagcgc
      361 caagctaaat ttataatgaa cagattgaag aaaaataaag agctacagaa agttcaggat
      421 atcaaagaag tcaagcaaaa catccatctt atccgagccc ctcttgcagg caaagggaaa
      481 cagttggaag agaaaatggt acagcagtta caagaggatg tggacatgga agatgctcct
      541 taaaaatctc tgtaaccatt tcttttatgt acatttgaaa atgccctttg gatacttgga
      601 actgctaaat tattttattt tttacataag gtcacttaaa tgaaaagcga ttaaaagaca
      661 tctttcctgc attgccatct acataatatc agatattacg gatgttagat tgcatctcag
      721 tgttaaatct ttactgatag atgtacttaa gtaaatcatg aaaattctac ttgtaactat
      781 agaagtgaat tgtggacgta aaatggttgt gctatttgga taatggcact aggcagcatt
      841 tgtatagtaa ctaatggcaa aaattcatgg ctagtgatgt ataaaataaa atattctttg
      901 cagtaaaata ttccctttgt taatgttata gaagggggga tacaaaaagg aactaacaat
      961 ttgtatggca gtgtcagata tttttatttt agtatttcct gttttggttt atttgcatct
     1021 tagaagagca taatgacatt gtttgatgaa gcctaattat gctggactgt tttgacctgg
     1081 tttaaccctt ctgataggta gttgtggatg ctggggatga gaactgaata atctttgcct
     1141 ggagtgacac tacactctag aatttccact ttggagaata ctcagttcca acttgtgatt
     1201 cctgatagaa cagactttac ttttctagcc cagcattgat ctagaagcag aggaatccca
     1261 gcgcctttta aaagttgtta tgtggttttc ttttaaaaag ctcctgtttt tggaaagtag
     1321 aatttatggg tacaacgtat gttcattatt tgtacataaa ataaaaccat ttaaaaagta
     1381 atgctgatat ttattcttta aaggcactaa acaaagatat gaaatattga tgacctggaa
     1441 gaagaaatct tcctccacac atcccattta agtaggagat acatttaatt aaagagaaat
     1501 agatacttaa tacttaatgt tttgtgtttt tacattgttt acagttttaa gtatgttaaa
     1561 tacattaagt aacgatcagt ttgcataatg gtttttttag ggtagagttt aaaatcagta
     1621 attcttagcc ttacataatt ataaagtaat ggctcatttt ttgtttcagt attagatagt
     1681 aaaactaagg ctgtagacca gtccctggac caagtgttag gagacctgag ttccaatgtg
     1741 gttttgcctg ggtattctta tttgtaaata atattattga ttgaagatta ggggaaatga
     1801 tacatgtgag gaaagacatt tgtaaaattt cttgggtttt tactacatac cgtattcatt
     1861 ttttaaagaa ataaacattt tgaaagtta
//
