LOCUS       NM_015659               5440 bp    mRNA    linear   PRI 19-MAR-2024
DEFINITION  Homo sapiens ribosomal L1 domain containing 1 (RSL1D1), mRNA.
ACCESSION   NM_015659 XM_085525
VERSION     NM_015659.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5440)
  AUTHORS   Jin,Y., Zhao,L., Wang,S., Zhang,X., Quan,J., Lin,Z. and Piao,J.
  TITLE     RSL1D1 knockdown induces ferroptosis and mediates ferrous iron
            accumulation in senescent cells by inhibiting FTH1 mRNA stability
  JOURNAL   Carcinogenesis 44 (2), 129-142 (2023)
   PUBMED   36913375
  REMARK    GeneRIF: RSL1D1 knockdown induces ferroptosis and mediates ferrous
            iron accumulation in senescent cells by inhibiting FTH1 mRNA
            stability.
REFERENCE   2  (bases 1 to 5440)
  AUTHORS   Wang,W., Miyamoto,Y., Chen,B., Shi,J., Diao,F., Zheng,W., Li,Q.,
            Yu,L., Li,L., Xu,Y., Wu,L., Mao,X., Fu,J., Li,B., Yan,Z., Shi,R.,
            Xue,X., Mu,J., Zhang,Z., Wu,T., Zhao,L., Wang,W., Zhou,Z., Dong,J.,
            Li,Q., Jin,L., He,L., Sun,X., Lin,G., Kuang,Y., Wang,L. and Sang,Q.
  TITLE     Karyopherin alpha deficiency contributes to human preimplantation
            embryo arrest
  JOURNAL   J Clin Invest 133 (2), e159951 (2023)
   PUBMED   36647821
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5440)
  AUTHORS   Ding,L., Zhao,C., Xu,Y., Zhang,Z., Nie,Y., Liao,K., Chen,Y., Tu,B.
            and Zhang,X.
  TITLE     Mutations in DNA binding domain of p53 impede RSL1D1-p53
            interaction to escape from degradation in human colorectal cancer
            cells
  JOURNAL   Exp Cell Res 417 (1), 113211 (2022)
   PUBMED   35597299
  REMARK    GeneRIF: Mutations in DNA binding domain of p53 impede RSL1D1-p53
            interaction to escape from degradation in human colorectal cancer
            cells.
REFERENCE   4  (bases 1 to 5440)
  AUTHORS   Liu,X., Chen,J., Long,X., Lan,J., Liu,X., Zhou,M., Zhang,S. and
            Zhou,J.
  TITLE     RSL1D1 promotes the progression of colorectal cancer through
            RAN-mediated autophagy suppression
  JOURNAL   Cell Death Dis 13 (1), 43 (2022)
   PUBMED   35013134
  REMARK    GeneRIF: RSL1D1 promotes the progression of colorectal cancer
            through RAN-mediated autophagy suppression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5440)
  AUTHORS   Ding,L., Zhang,Z., Zhao,C., Chen,L., Chen,Z., Zhang,J., Liu,Y.,
            Nie,Y., He,Y., Liao,K. and Zhang,X.
  TITLE     Ribosomal L1 domain-containing protein 1 coordinates with HDM2 to
            negatively regulate p53 in human colorectal Cancer cells
  JOURNAL   J Exp Clin Cancer Res 40 (1), 245 (2021)
   PUBMED   34362424
  REMARK    GeneRIF: Ribosomal L1 domain-containing protein 1 coordinates with
            HDM2 to negatively regulate p53 in human colorectal Cancer cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5440)
  AUTHORS   Petroziello,J., Yamane,A., Westendorf,L., Thompson,M., McDonagh,C.,
            Cerveny,C., Law,C.L., Wahl,A. and Carter,P.
  TITLE     Suppression subtractive hybridization and expression profiling
            identifies a unique set of genes overexpressed in non-small-cell
            lung cancer
  JOURNAL   Oncogene 23 (46), 7734-7745 (2004)
   PUBMED   15334068
REFERENCE   7  (bases 1 to 5440)
  AUTHORS   Cai,Y., Jin,J., Tomomori-Sato,C., Sato,S., Sorokina,I.,
            Parmely,T.J., Conaway,R.C. and Conaway,J.W.
  TITLE     Identification of new subunits of the multiprotein mammalian
            TRRAP/TIP60-containing histone acetyltransferase complex
  JOURNAL   J Biol Chem 278 (44), 42733-42736 (2003)
   PUBMED   12963728
REFERENCE   8  (bases 1 to 5440)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   9  (bases 1 to 5440)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   10 (bases 1 to 5440)
  AUTHORS   Huch,G., Hohn,H.P. and Denker,H.W.
  TITLE     Identification of differentially expressed genes in human
            trophoblast cells by differential-display RT-PCR
  JOURNAL   Placenta 19 (8), 557-567 (1998)
   PUBMED   9859858
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI856275.1, BC113699.1 and AC010654.8.
            
            On Nov 23, 2018 this sequence version replaced NM_015659.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.272823.1,
                                           SRR1803612.17981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000571133.6/ ENSP00000460871.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BI856275.1         44-47
            5-1582              BC113699.1         1-1578
            1583-5094           AC010654.8         108101-111612       c
            5095-5440           AC010654.8         107755-108100       c
FEATURES             Location/Qualifiers
     source          1..5440
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.13"
     gene            1..5440
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /note="ribosomal L1 domain containing 1"
                     /db_xref="GeneID:26156"
                     /db_xref="HGNC:HGNC:24534"
                     /db_xref="MIM:615874"
     exon            1..135
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1503
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /note="CATX-11; cellular senescence-inhibited gene
                     protein"
                     /codon_start=1
                     /product="ribosomal L1 domain-containing protein 1"
                     /protein_id="NP_056474.2"
                     /db_xref="CCDS:CCDS10551.1"
                     /db_xref="GeneID:26156"
                     /db_xref="HGNC:HGNC:24534"
                     /db_xref="MIM:615874"
                     /translation="MEDSASASLSSAAATGTSTSTPAAPTARKQLDKEQVRKAVDALL
                     THCKSRKNNYGLLLNENESLFLMVVLWKIPSKELRVRLTLPHSIRSDSEDICLFTKDE
                     PNSTPEKTEQFYRKLLNKHGIKTVSQIISLQTLKKEYKSYEAKLRLLSSFDFFLTDAR
                     IRRLLPSLIGRHFYQRKKVPVSVNLLSKNLSREINDCIGGTVLNISKSGSCSAIRIGH
                     VGMQIEHIIENIVAVTKGLSEKLPEKWESVKLLFVKTEKSAALPIFSSFVSNWDEATK
                     RSLLNKKKKEARRKRRERNFEKQKERKKKRQQARKTASVLSKDDVAPESGDTTVKKPE
                     SKKEQTPEHGKKKRGRGKAQVKATNESEDEIPQLVPIGKKTPANEKVEIQKHATGKKS
                     PAKSPNPSTPRGKKRKALPASETPKAAESETPGKSPEKKPKIKEEAVKEKSPSLGKKD
                     ARQTPKKPEAKFFTTPSKSVRKASHTPKKWPKKPKVPQST"
     exon            136..275
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /inference="alignment:Splign:2.1.0"
     exon            276..414
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /inference="alignment:Splign:2.1.0"
     exon            415..563
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /inference="alignment:Splign:2.1.0"
     exon            564..665
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /inference="alignment:Splign:2.1.0"
     exon            666..759
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /inference="alignment:Splign:2.1.0"
     exon            760..885
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1176
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..5440
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1917..1922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /note="hexamer: AATAAA"
     regulatory      1926..1931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /note="hexamer: AATAAA"
     polyA_site      1936
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /note="major polyA site"
     polyA_site      1951
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /note="major polyA site"
     regulatory      4966..4971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /note="hexamer: AATAAA"
     polyA_site      5006
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
     regulatory      5072..5077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /note="hexamer: CATAAA"
     polyA_site      5094
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
     regulatory      5417..5422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
                     /note="hexamer: ATTAAA"
     polyA_site      5440
                     /gene="RSL1D1"
                     /gene_synonym="CSIG; L12; PBK1; UTP30"
ORIGIN      
        1 acacgcgcct cttcacgagg tggaaacaag atggaggatt cggcctcggc ctcgctgtct
       61 tctgcagccg ctactggaac ctccacctcg actccagcgg ccccgacagc acggaagcag
      121 ctggataaag aacaggttag aaaggcagtg gacgctctct tgacgcattg caagtccagg
      181 aaaaacaatt atgggttgct tttgaatgag aatgaaagtt tatttttaat ggtggtatta
      241 tggaaaattc caagtaaaga actgagggtc agattgacct tgcctcatag tattcgatca
      301 gattcagaag atatctgttt atttacgaag gatgaaccca attcaactcc tgaaaagaca
      361 gaacagtttt atagaaagct tttaaacaag catggaatta aaaccgtttc tcagattatc
      421 tccctccaaa ctctaaagaa ggaatataaa tcctatgaag ccaagctccg ccttctgagc
      481 agttttgatt tcttccttac tgatgccaga attaggcggc tcttaccctc actcattggg
      541 agacatttct atcaaagaaa gaaagttcca gtatctgtaa accttctgtc caagaattta
      601 tcaagagaga tcaatgactg tataggtgga acagtcttaa acatttctaa aagtggttct
      661 tgcagtgcta tacgtattgg tcacgttgga atgcaaattg agcacatcat tgaaaacatt
      721 gttgctgtca ccaaaggact ttcagaaaaa ttgccagaga agtgggagag cgtgaaactc
      781 ctgtttgtga aaactgagaa atcggctgca cttcccatct tttcctcgtt tgtcagcaat
      841 tgggatgaag ccaccaaaag atctttgctt aataagaaga aaaaagaggc aaggagaaaa
      901 cgaagagaaa gaaattttga aaaacaaaag gagaggaaga agaagaggca gcaggctagg
      961 aagactgcat cagttcttag taaagatgat gtggcacctg aaagtggtga tactacagtg
     1021 aagaaacctg aatcaaagaa ggaacagacc ccagagcatg ggaagaaaaa acgtggcaga
     1081 ggaaaagccc aagttaaagc aacaaatgaa tccgaagacg aaatcccaca gctggtacca
     1141 ataggaaaga agactccagc taatgaaaaa gtagagattc aaaaacatgc cacaggaaag
     1201 aagtctccag caaagagtcc taatcccagc acacctcgtg ggaagaaaag aaaggctttg
     1261 ccagcatctg agaccccaaa agctgcagag tctgagaccc cagggaaaag cccagagaag
     1321 aagccaaaaa tcaaagaaga ggcagtgaag gaaaaaagtc cttcgctggg gaaaaaagat
     1381 gcgagacaga ctccaaaaaa gccagaggcc aagtttttca ccactcctag taaatctgtg
     1441 agaaaagctt cccacacccc caaaaaatgg cccaaaaaac ccaaagtacc ccagtcgacc
     1501 taaagtcagt gattcaactg gaaggaaacc tcaatgctgc ctccagagct ttttggaaat
     1561 actcagatcc tggccgcctt tgtaaccttc tctaaacgtc aggcctggac ttaaaagatt
     1621 ttttaaaacc tccataagta gtccaggggc ggtggctcac gcctgtaatc ccagcacttt
     1681 gggaggccga ggcaggcgga tcacaaggtc aacgagatcg agaccatcct ggccaacatg
     1741 gtgaaaccct gtctgtacca aaaatacaaa aattaattgg gcatggtggt ggacacctgt
     1801 aatcccagct actagggagg ctgaggcagg agaattgctt gaacctggga ggcggaggtt
     1861 gcagtgagcc actgcactcc agcctgatga cagagcaaga ctcagtctca aaaataaata
     1921 aaaataataa aacctccata agtaatcctg acatatgttc ctgggtataa tctgtttcta
     1981 aattgtcctt ctgtgtattt gctaatgtaa tagagggaaa aatagagtgc ttctctgtgg
     2041 ttgttcagca ctttaggtag ccaaggtgag aggattgctt gaggccagga gtttgagact
     2101 agcctgggca acttggtaaa accccatctc tacaaaagaa aaaaaaaaat tagtgtggca
     2161 tggtggcatg catctgtgct cccagctcct cacgaggctg aggtggaagg atcaagtgag
     2221 cgcaagaggt tgaggctcca gtgagccacg atcaccccac tgtgctgtag cctgggtgac
     2281 agtgtgagat tctgtctcag aaaaaacaaa gtataacatt gctttgcttc tgagtatact
     2341 gttggctttc caaatcagtg ggtctgactt gaggtctgtg atgtgaccct tttcctcacc
     2401 tgctcaacca ttattcacat ggactccatc atattcattt gtagtcattc ccagagtggc
     2461 ccagtgaggg tctcgctgta tgagagtcgg ctacggaatt taggagaaac agaagtttct
     2521 tggctttcat gctgagcttg ttggtctaag cttatgagtc actggattag catccatatg
     2581 ggaagggaaa ttaacatgga gtcatttata cagggactaa attgaatcct acctaccgga
     2641 ggcaagaaca tgatttatct tccataagcc ttatcctctt cctccttatt cctcagtcca
     2701 tatggatttg cttatgtatg acaactccaa ggaatcttgg aagagtagat tgctaacgtt
     2761 tccacaattg tcaagtatat tctgaggcag taaacacctt tttaggtacg tggcctttca
     2821 ctggttgtga attggtatgc atccgtagta gtaagttcac agattcactg cagtgcagga
     2881 atgttcttgc atgccaaaga ctcaactgct ttcaaagata atgtgggtgc tagatgcagt
     2941 ggcttacatc tgtaaccctg ttagggtgac cagacccaac accaggtcgt gggggtgaca
     3001 aagtccagtg gagtcaaagg attgagaaaa agacagtttg agagagaagt aggaccagca
     3061 gaccatcggg atggtggagg ctgtgaaggc cgtgagctct gggagcccac actatttatt
     3121 ggtaatccaa caaagaaaca gatggtgaga atgtgaaggt cagaagggca ccttgcatta
     3181 agcacatgat ttacagctgt gatggtttag catttgctct gctacttgag atgatggaga
     3241 gcaggttctt ttaactcaag ttacagtcga tcctgggaga gcaaggagcc agcaagtcta
     3301 gacattccag agccacaggc cctggatttt atccaagcca cgagggattt tatgccctgg
     3361 gcttagatta tggtgcgtca gggcagcctt ccacccttta gcacagagct tggtgttcca
     3421 aagaccacaa ggggttttag acccttgacc ctggacatat tccaagactc ttttacatta
     3481 tgtcagaatg caagccctgc ctcagcttct cccaacactc agcttttcgc aacataatcc
     3541 cagcactttg gaacgctggg tggattgctt gaacccagga gttcgagacc atcctgggca
     3601 atatggcaaa accccatctt taccaaaaat aagctgggtg tggtggaaca tgcctgtggt
     3661 cccagcttct tgggaggctg aggtgggagg attgcttgaa cccgggaggt agaggctgca
     3721 atgggccatg atcacgatcc tgcactccag cctgggcaac agagagagac agtccctggc
     3781 ccactgcccc cttccctggc ccagtctcaa aaaaaatgag gctgggcgtg gtggctcaca
     3841 tctgtaatcc cagccaaggc tggcagatca cttgaggcca ggagttctga gaccagcctg
     3901 gcttacatgg tgaaacccca tctctactaa aaatacaaaa actagccagg catggtggga
     3961 ggcacctgta atcccagcta cttgggaggc tgaagcagga gaatcacttt aacccgggag
     4021 gtggaggttg cagtgagctg agatcacacc actgcactcc agcctgggcg gcagagcaaa
     4081 actgaaaaaa agagaaaaaa aaaaacatct agctctccct gaaattagag gagtctagcc
     4141 tgcttttgct gtttttttgg tagcgagagt agcgggcagt gggggagatg gtcttactct
     4201 gttccccagg ctggagtgca ctagtgtcat cacagctcca gcctcaattt cctgggctca
     4261 aggcgatctt cccacctcag cctcccaagt agctcagact acaggggcat gccatcacag
     4321 ctggccagtt tttacgtctt gcgtagagat gggttttccc tgtgttccct aggctgggct
     4381 cgaactcctg ggctcaagtc ctcctgcctc agcctcccaa aatgttcaga ttacaggcat
     4441 gaggcagcat gccaatcctg tttttgcatt ttagtaacac aaattgtaat gttaactttt
     4501 taaattatga aagcatctaa aatataaaat tatttgtaac cccactgtcc ttttgggctt
     4561 ctataaatga atatacatct aaaatgtggg ggtttagctt aattgattgt tttccataga
     4621 aactaggttt tatgggaaga tggttggata gacttgtttc acttaaaggt ctggtttgtg
     4681 taggacaaac ccacatatgt aatcgtgcca gtctgttctc tgcatgacat aattttccag
     4741 caatagctgt gtggtttttg taatcctatc atctagtcag ttcaagatct tgcaacactg
     4801 tgtgattctt tgctccgtag ttcagtcttg ttgaacatga cacaggtgtt tactttcctg
     4861 ttcttgcatc tagtttcatt ctaataatgt tctctgttga aaaagctggc ttcaatttat
     4921 tgagcaagat gctggtgtta tcatctaaca taaaacctat cttataataa agtgttgaca
     4981 catgtaatga gtactgtact gaaaaatggt ggtatgtata tggtttgtac tgattatgta
     5041 tcgcttttat accatcaaaa agttgaaaaa tcataaagtt gaatcatcct aaaatgggta
     5101 cattctgtac tatgtttcca aggcttcaga agtgttgcat acacattcct agccagctga
     5161 tagtgctagg agccaacagt agtctccccc gggggccaag aggagggcga aatctctact
     5221 atggtatatg atgttctcgt gggccaagta tgagggtgat atttcattgt tggcactggg
     5281 tttctggaat ccatcctctt caccagggag atttaatgaa ccaaatgaga tctgatggga
     5341 gaaatttgag tgtaacgttt ttgttctgaa ggaagtaatt gagttttagt tcatttgttt
     5401 tttaggaatc gtaataatta aaatttcatt ttaaatgcca
//
