LOCUS       NM_001174103            3772 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens ribosomal protein S6 kinase related (RSKR), mRNA.
ACCESSION   NM_001174103 NM_001287207
VERSION     NM_001174103.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3772)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3772)
  AUTHORS   Arencibia,J.M., Pastor-Flores,D., Bauer,A.F., Schulze,J.O. and
            Biondi,R.M.
  TITLE     AGC protein kinases: from structural mechanism of regulation to
            allosteric drug development for the treatment of human diseases
  JOURNAL   Biochim Biophys Acta 1834 (7), 1302-1321 (2013)
   PUBMED   23524293
  REMARK    Review article
REFERENCE   3  (bases 1 to 3772)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    GeneRIF: Discovered as a novel human kinase, classified within the
            AGC group and a novel RSKR (RSK-related) family.
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005726.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001174103.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by partial transcript alignments, including human AK057735.1,
            BE968821.1, and rabbit DN889839.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.250637.1,
                                           SRR7410570.631270.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301037.11/ ENSP00000301037.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC005726.1         43627-43725
            100-348             AC005726.1         44124-44372
            349-432             AC005726.1         44467-44550
            433-501             AC005726.1         44666-44734
            502-571             AC005726.1         45125-45194
            572-676             AC005726.1         45446-45550
            677-717             AC005726.1         45728-45768
            718-745             AC005726.1         46017-46044
            746-835             AC005726.1         46156-46245
            836-924             AC005726.1         46331-46419
            925-1035            AC005726.1         46559-46669
            1036-3772           AC005726.1         47113-49849
FEATURES             Location/Qualifiers
     source          1..3772
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..3772
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /note="ribosomal protein S6 kinase related"
                     /db_xref="GeneID:124923"
                     /db_xref="HGNC:HGNC:26314"
     exon            1..99
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1257
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /EC_number="2.7.11.1"
                     /note="sugen kinase 494"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase-related protein"
                     /protein_id="NP_001167574.1"
                     /db_xref="GeneID:124923"
                     /db_xref="HGNC:HGNC:26314"
                     /translation="MGAVSCRQGQHTQQGEHTRVAVPHKQGGNIRGPWARGWKSLWTG
                     LGTIRSDLEELWELRGHHYLHQESLKPAPVLVEKPLPEWPVPQFINLFLPEFPIRPIR
                     GQQQLKILGLVAKGSFGTVLKVLDCTQKAVFAVKVVPKVKVLQRDTVRQCKEEVSIQR
                     QINHPFVHSLGDSWQGKRHLFIMCSYCSTDLYSLWSAVGCFPEASIRLFAAELVLVLC
                     YLHDLGIMHRDVKMENILLDERGHLKLTDFGLSRHVPQGAQAYTICGTLQYMAPEVLS
                     GGPYNHAADWWSLGVLLFSLATGKFPVAAERDHVAMLASVTHSDSEIPASLNQGLSLL
                     LHELLCQNPLHRLRYLHHFQVHPFFRGVAFDPELLQKQPVNFVTETQATQPSSAETMP
                     FDDFDCDLESFLLYPIPA"
     exon            100..348
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /inference="alignment:Splign:2.1.0"
     exon            349..432
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /inference="alignment:Splign:2.1.0"
     exon            433..501
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /inference="alignment:Splign:2.1.0"
     exon            502..571
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /inference="alignment:Splign:2.1.0"
     exon            572..676
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /inference="alignment:Splign:2.1.0"
     exon            677..717
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /inference="alignment:Splign:2.1.0"
     exon            718..745
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /inference="alignment:Splign:2.1.0"
     exon            746..835
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /inference="alignment:Splign:2.1.0"
     exon            836..924
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1035
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..3772
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3748..3753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /note="hexamer: AATAAA"
     polyA_site      3772
                     /gene="RSKR"
                     /gene_synonym="SGK494"
                     /note="major polyA site"
ORIGIN      
        1 agagagagga ggcagaggct gggaatggga gcagtaagct gtcggcaggg gcagcacacc
       61 cagcaggggg aacacacccg ggtggctgtc cctcacaagc agggtggcaa catccggggt
      121 ccctgggccc gaggctggaa gagcctctgg acaggtttgg gaaccatcag gtcagatctg
      181 gaagaactct gggaactacg ggggcaccac tatctgcacc aggaatccct aaagccagcc
      241 ccagtactgg tagagaagcc tctgccagag tggccagtgc ctcagttcat caacctcttt
      301 ctaccagagt ttcccattag gcccattagg gggcagcagc agctgaagat tttaggcctc
      361 gtggctaaag gctcctttgg aactgtcctc aaggtgctag attgcaccca gaaagctgta
      421 tttgcagtga aggtggtgcc caaggtaaag gtcctacaga gggataccgt gaggcagtgc
      481 aaagaggagg ttagcatcca gcgacagatc aaccatccct ttgtacacag cttgggggac
      541 agctggcagg gaaaacggca ccttttcatt atgtgtagct actgcagcac agatctgtac
      601 tccctttggt cggctgttgg ctgctttcct gaggcttcca tccgtctctt tgctgccgag
      661 ttggtgctgg tactgtgtta tctccatgac ttgggcatca tgcatcgaga tgtgaagatg
      721 gagaatattc ttctagatga acgaggccat ctgaaactga cagactttgg tctgtcccgc
      781 cacgtgcccc agggagctca agcctacact atctgtggca ctcttcagta catggcccca
      841 gaggtcctaa gtggaggacc ttacaaccat gctgctgatt ggtggtccct gggtgtcttg
      901 cttttctctc tggcgactgg aaagtttcca gtggctgcag agagagatca tgtggccatg
      961 ttggcaagtg tgacccacag tgactctgag atcccagctt ctcttaacca gggcctctca
     1021 ctcctgctcc atgagctctt atgccagaac cccctccatc gtctacgtta tctgcatcac
     1081 ttccaggtcc accctttctt tcggggtgtg gccttcgacc cagagctcct acagaagcag
     1141 ccagtgaact ttgtcacgga gacacaagct acccagccca gttcagcgga gaccatgccc
     1201 tttgacgact ttgactgtga tctggagtcc ttcttgctct accctatccc tgcttgagcc
     1261 tctctactgt aaattggggc ccggctggga gcctgaagat ctccatccct gcctactcag
     1321 tatgaccacc ttgataatcc agtttgtttt tattttgtag cctcttaccg ttctgctctc
     1381 ctaggcttta gaccagagtt ccaacctgga cattctgcta ctggcagcca cagctggccc
     1441 tattccttcc ctatcataca acctacctct caattcaaca tgtcagatca gggtggtgac
     1501 cttttccttt tctttacttc tccagtgctc tttaccctca ggctgtcagc cagagctgct
     1561 tctgcttgtt tctctgccat gtttcctttc ttgagcaata ataatacttc atgggctccc
     1621 agggtgctat tgatgtgttt aataggcttg tcagaagcaa tatgaatttt tttttttttt
     1681 ttgagacaga gtctcactct gttgcccagg ctggagtgca gtggtgcgtt ctcagctcac
     1741 tgcaacctcc gtctcctggg ttgaagtgat tttcatgcct cagcctcccg agtagctggg
     1801 attacaaatg cacaccatta tgcccagcta atttttgtat tttttagtag agacagggtt
     1861 caccatgttg gccaggctga tctcaaactc ctgacctcaa gtgatcggcc tgccttggcc
     1921 tcccaaagtg ctggaattac aggtaggtgt gagccactgc accagaccct tttttttttt
     1981 tttttttttt ttttttgaga tagggtctca ctctcgtcac ccaggttgga gtgcagtggc
     2041 acgatctcag ctcactgcaa ccttcacagg catgagcctc cacacccagc ctgtgaattt
     2101 ttcaaaagtc tcaaaagctg gcatttcaac ccctaaataa tgcagctaaa aaatatagtc
     2161 tgggagcttg aggccagtct gcaataaatc taatttttaa aaattgaaaa gtgaataaaa
     2221 taatctagtg aggaagaaaa tagaaactga aacatgggtg ggttaaatgt cttctctagg
     2281 tctataattg caacagttat ccaaaataaa acctctttga aaagcatagg atttttaaac
     2341 tgacaatttc tcctagtgag cccatgattc agtttctgat gggcaaacca agagattaag
     2401 aggcatgcat caaccttaag atttaaggtt atttgggagg ccaaggtggg cagatcagtt
     2461 gaggtcaaga gttcgagacc agcgtggcca acatggtgaa accttgtgtc tactaaaaaa
     2521 atacaaaaat tagctgggtg tggtgttgca cacctgtagt cccagctact cagaaggctg
     2581 aagcaggaga actgcttgaa ccctggaggc caaggttgca gtgagccaag attgtgccat
     2641 tgaactcctg ggtgacagag gtagactctg tctcaaaaaa aaaaaaaaaa aaaaaaaaaa
     2701 aagatttaag gttagagaca tatctcaata accttttcct ttagtaagga aaatcatctg
     2761 gaccttaaat ttgtatacag ttttggcctt tatgacttct tttcattttt cttaaactaa
     2821 tttctcacaa ttttcatttt tgtcctgaga cttgaaggga aagtaagttt taatctagac
     2881 catattattt agttacatct aatctctcta gacaaaagac agtctggaga gtactcttta
     2941 gttctattta ttaattttgt ctctagattg agccagattt ccccatgcat agctggcatt
     3001 ttattggcct ctgcagaatt gctttttctg gattggactt tggtaatcca tatgaaaatc
     3061 tctatgaaat ttaattgctc gccaggtgtg gtggctcaca cttgtaatcc cagcactttg
     3121 ggaggctgag gtgggcggat caccagaggt caggagttcg agaccagcct ggccaacatg
     3181 gtgaaacccc gtttctcccc aaaaaataca aaaattagct ggtcatgagg gcacacactg
     3241 tagtcccagc tactcaggag gctgaggggg aagaattgct tgaacccagg agatggaggt
     3301 tgcaatgagt gaagatcgtg ccactgcatc cagcctgagc aacagagtga gatcttgtct
     3361 caggaaaaaa ataaatttaa ttgctgtgga tactgtaaag ggtgtttatc gtaacagttc
     3421 ataatattct atttaagaat gcgtgggaga aattttctct ggacccagtt atgcttttcc
     3481 tgaattgctg tttggttttt accttaagga cactaaatat tcagctgatt gtatttttct
     3541 gtttgtactg atactagacc atttagagcc caatttgtgg tctaccttca gcaagtgttt
     3601 atgtattttg tatgctagtc atgttcttgg ttctgtcttc cttttctact tttattttcc
     3661 ttattctcat ttttctaagt tttaatcgtt ttatattact ataatatctg catcttgtaa
     3721 gcctttttgt aataaggttg ggatataaat aaataaggca atgtatcctt ta
//
