LOCUS       NM_016578              11242 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens remodeling and spacing factor 1 (RSF1), mRNA.
ACCESSION   NM_016578
VERSION     NM_016578.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11242)
  AUTHORS   Gelemanovic,A., Catipovic Ardalic,T., Pribisalic,A., Hayward,C.,
            Kolcic,I. and Polasek,O.
  TITLE     Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants
            to Predict Common Human Infectious Diseases Risk
  JOURNAL   Int J Mol Sci 24 (8), 7006 (2023)
   PUBMED   37108169
  REMARK    GeneRIF: Genome-Wide Meta-Analysis Identifies Multiple Novel Rare
            Variants to Predict Common Human Infectious Diseases Risk.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11242)
  AUTHORS   Zhou,P., Cheng,B., Sun,Y., Wu,D. and Chen,Y.
  TITLE     [Circular RNA circRSF1 binds to HuR to promote radiation-induced
            inflammatory phenotype in hepatic stellate cells]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (1), 46-51 (2023)
   PUBMED   36856209
  REMARK    GeneRIF: [Circular RNA circRSF1 binds to HuR to promote
            radiation-induced inflammatory phenotype in hepatic stellate
            cells].
REFERENCE   3  (bases 1 to 11242)
  AUTHORS   Tian,J., Cheng,L., Kong,E., Gu,W., Jiang,Y., Hao,Q., Kong,B. and
            Sun,L.
  TITLE     linc00958/miR-185-5p/RSF-1 modulates cisplatin resistance and
            angiogenesis through AKT1/GSK3beta/VEGFA pathway in cervical cancer
  JOURNAL   Reprod Biol Endocrinol 20 (1), 132 (2022)
   PUBMED   36056431
  REMARK    GeneRIF: linc00958/miR-185-5p/RSF-1 modulates cisplatin resistance
            and angiogenesis through AKT1/GSK3beta/VEGFA pathway in cervical
            cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11242)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 11242)
  AUTHORS   Hao,J., Wei,H., Qi,Y. and Liu,H.
  TITLE     miR-129-5p Plays an Anticancer Role in Colon Cancer by Targeting
            RSF1
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 196-201 (2022)
   PUBMED   35818253
  REMARK    GeneRIF: miR-129-5p Plays an Anticancer Role in Colon Cancer by
            Targeting RSF1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11242)
  AUTHORS   Loyola,A., Huang,J.Y., LeRoy,G., Hu,S., Wang,Y.H., Donnelly,R.J.,
            Lane,W.S., Lee,S.C. and Reinberg,D.
  TITLE     Functional analysis of the subunits of the chromatin assembly
            factor RSF
  JOURNAL   Mol Cell Biol 23 (19), 6759-6768 (2003)
   PUBMED   12972596
REFERENCE   7  (bases 1 to 11242)
  AUTHORS   Shamay,M., Barak,O. and Shaul,Y.
  TITLE     HBXAP, a novel PHD-finger protein, possesses transcription
            repression activity
  JOURNAL   Genomics 79 (4), 523-529 (2002)
   PUBMED   11944984
REFERENCE   8  (bases 1 to 11242)
  AUTHORS   Shamay,M., Barak,O., Doitsh,G., Ben-Dor,I. and Shaul,Y.
  TITLE     Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to
            coactivate transcription
  JOURNAL   J Biol Chem 277 (12), 9982-9988 (2002)
   PUBMED   11788598
REFERENCE   9  (bases 1 to 11242)
  AUTHORS   Loyola,A., LeRoy,G., Wang,Y.H. and Reinberg,D.
  TITLE     Reconstitution of recombinant chromatin establishes a requirement
            for histone-tail modifications during chromatin assembly and
            transcription
  JOURNAL   Genes Dev 15 (21), 2837-2851 (2001)
   PUBMED   11691835
REFERENCE   10 (bases 1 to 11242)
  AUTHORS   LeRoy,G., Orphanides,G., Lane,W.S. and Reinberg,D.
  TITLE     Requirement of RSF and FACT for transcription of chromatin
            templates in vitro
  JOURNAL   Science 282 (5395), 1900-1904 (1998)
   PUBMED   9836642
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000580.6, AP002343.2 and AP000609.5.
            
            On Nov 18, 2020 this sequence version replaced NM_016578.3.
            
            Summary: This gene encodes a nuclear protein that interacts with
            hepatitis B virus X protein (HBX) and facilitates transcription of
            hepatitis B virus genes by the HBX transcription activator,
            suggesting a role for this interaction in the virus life cycle.
            This protein also interacts with SNF2H protein to form the RSF
            chromatin-remodeling complex, where the SNF2H subunit functions as
            the nucleosome-dependent ATPase, and this protein as the histone
            chaperone. [provided by RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF380176.1, SRR14038194.3328770.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308488.11/ ENSP00000311513.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AP000580.6         17646-17840         c
            196-287             AP002343.2         31934-32025         c
            288-380             AP002343.2         14372-14464         c
            381-586             AP002343.2         8067-8272           c
            587-741             AP000609.5         121564-121718       c
            742-2516            AP000609.5         96740-98514         c
            2517-2723           AP000609.5         94506-94712         c
            2724-2828           AP000609.5         89526-89630         c
            2829-2908           AP000609.5         87178-87257         c
            2909-2963           AP000609.5         81124-81178         c
            2964-3073           AP000609.5         79729-79838         c
            3074-3141           AP000609.5         74105-74172         c
            3142-3349           AP000609.5         72811-73018         c
            3350-3570           AP000609.5         71055-71275         c
            3571-3759           AP000609.5         68061-68249         c
            3760-11242          AP000609.5         56028-63510         c
FEATURES             Location/Qualifiers
     source          1..11242
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1"
     gene            1..11242
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /note="remodeling and spacing factor 1"
                     /db_xref="GeneID:51773"
                     /db_xref="HGNC:HGNC:18118"
                     /db_xref="MIM:608522"
     exon            1..195
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..4334
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /note="hepatitis B virus x-associated protein; HBV
                     pX-associated protein 8; p325 subunit of RSF
                     chromatin-remodeling complex"
                     /codon_start=1
                     /product="remodeling and spacing factor 1"
                     /protein_id="NP_057662.3"
                     /db_xref="CCDS:CCDS8253.1"
                     /db_xref="GeneID:51773"
                     /db_xref="HGNC:HGNC:18118"
                     /db_xref="MIM:608522"
                     /translation="MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPF
                     PELERVLQAPPPDVGNGEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTW
                     AWEMEKKGYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDG
                     LMYWYQLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSS
                     QQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTV
                     KKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPK
                     DTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLS
                     DDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDER
                     VAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAP
                     LRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKG
                     EEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPE
                     AAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDN
                     LDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRIS
                     SRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADK
                     KRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKY
                     SSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDS
                     GYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLV
                     YVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAI
                     DEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKR
                     RRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSR
                     RLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRR
                     RRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDE
                     LAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQ
                     PARDSQPRVLPSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGK
                     AIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLVDYVC
                     NSEQL"
     exon            196..287
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            288..380
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            381..586
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            587..741
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            742..2516
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2723
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2828
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2908
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..2963
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3073
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3141
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3349
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3570
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3571..3759
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3760..11242
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9633..9638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /note="hexamer: ATTAAA"
     polyA_site      9656
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
     regulatory      11223..11228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /note="hexamer: AATAAA"
     polyA_site      11242
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /note="major polyA site"
ORIGIN      
        1 agttcaaaat ggcgacggcg gcggcagcgg cggcggtgat ggctcctccg ggctgcccgg
       61 gttcgtgccc caacttcgcc gtagtctgct ccttcttgga gcgctacggg ccgctgctag
      121 acctgcctga gttgccgttc cctgagctgg agcgggtgct gcaggcgccg ccgccggacg
      181 tcggcaacgg agaagtacca aaagaattgg tggagctcca tttgaagctg atgaggaaaa
      241 ttggcaaatc tgttactgca gacagatggg aaaaatattt gatcaagata tgccaagagt
      301 ttaacagtac ctgggcatgg gagatggaga agaagggcta tcttgaaatg agtgttgaat
      361 gcaaactagc actcttaaag tacctctgtg agtgtcagtt tgatgacaat ctcaaattca
      421 agaatattat taatgaggag gatgccgata ctatgcgtct ccagccaatt ggtcgagaca
      481 aagatggcct catgtactgg taccaattgg atcaagatca caatgtcaga atgtacatag
      541 aagaacaaga tgatcaagat ggctcttcat ggaaatgcat tgtcagaaat cgaaacgagt
      601 tggctgagac tcttgcactc ctgaaagcac aaattgatcc tgtactattg aaaaactcta
      661 gccaacaaga caactcttct cgggaaagtc ccagcttaga ggatgaggag actaaaaaag
      721 aggaagaaac acctaaacaa gaggaacaga aagaaagtga aaagatgaaa agtgaggagc
      781 agcctatgga tttagaaaac cgttctacag ccaatgttct agaagagact actgtgaaaa
      841 aagaaaaaga agatgaaaag gaacttgtga aactgccagt catagtgaag ctagaaaaac
      901 ctttgccaga aaatgaagaa aaaaagatta tcaaagaaga aagtgattcc ttcaaggaaa
      961 atgtcaaacc cattaaagtt gaggtgaagg aatgtagagc agatcctaaa gataccaaaa
     1021 gtagcatgga gaagccagtg gcacaggagc ctgaaaggat cgaatttggt ggcaatatta
     1081 aatcttctca cgaaattact gagaaatcta ctgaagaaac tgagaaactt aaaaatgacc
     1141 agcaggccaa gataccacta aaaaaacgag aaattaaact gagtgatgat tttgacagtc
     1201 cagtcaaggg acctttgtgt aaatcagtta ctccaacaaa agagtttttg aaagatgaaa
     1261 taaaacaaga ggaagagact tgtaaaagga tctctacaat cactgctttg ggtcatgaag
     1321 ggaaacagct ggtaaatgga gaagttagtg atgaaagggt agctccaaat tttaagacag
     1381 aaccaataga gacaaagttt tatgagacaa aggaagagag ctatagcccc tctaaggaca
     1441 gaaatatcat cacggaggga aatggaacag agtccttaaa ttctgtcata acaagtatga
     1501 aaacaggtga gcttgagaaa gaaacagccc ctttgaggaa agatgcagat agttcaatat
     1561 cagtcttaga gatccatagt caaaaagcac aaatagagga acccgatcct ccagaaatgg
     1621 aaacttctct tgattcttct gagatggcaa aagatctctc ttcaaaaact gctttatctt
     1681 ccaccgagtc gtgtaccatg aaaggtgaag agaagtctcc caaaactaag aaggataagc
     1741 gcccaccaat cctagaatgt cttgaaaagt tagagaagtc caaaaagact tttcttgata
     1801 aggacgcaca aagattgagt ccaataccag aagaagttcc aaagagtact ctagagtcag
     1861 aaaagcctgg ctctcctgag gcagctgaaa cttctccacc atctaatatc attgaccact
     1921 gtgagaaact agcctcagaa aaagaagtgg tagaatgcca gagtacaagt actgttggtg
     1981 gccagtctgt gaaaaaagta gacctagaaa ccctaaaaga ggattctgag ttcacaaagg
     2041 tagaaatgga taatctggac aatgcccaga cctctggcat agaggagcct tctgagacaa
     2101 agggttctat gcaaaaaagc aaattcaaat ataagttggt tcctgaagaa gaaaccactg
     2161 cctcagaaaa tacagagata acctctgaaa ggcagaaaga gggcatcaaa ttaacaatca
     2221 ggatatcaag tcggaaaaag aagcccgatt ctccccccaa agttctagaa ccagaaaaca
     2281 agcaagagaa gacagaaaag gaagaggaga aaacaaatgt gggtcgtact ttaagaagat
     2341 ctccaagaat atctagaccc actgcaaaag tggctgagat cagagatcag aaagctgata
     2401 aaaaaagagg ggaaggagaa gatgaggtgg aagaagagtc aacagctttg caaaaaactg
     2461 acaaaaagga aattttgaaa aaatcagaga aagatacaaa ttctaaagta agcaaggtaa
     2521 aacccaaagg caaagttcga tggactggtt ctcggacacg tggcagatgg aaatattcca
     2581 gcaatgatga aagtgaaggg tctggcagtg aaaaatcatc tgcagcttca gaagaggagg
     2641 aagaaaagga aagtgaagaa gccatcctag cagatgatga tgaaccatgc aaaaaatgtg
     2701 gccttccaaa ccatcctgag ctaattcttc tgtgtgactc ttgcgatagt ggataccata
     2761 ctgcctgcct tcgccctcct ctgatgatca tcccagatgg agaatggttc tgcccacctt
     2821 gccaacataa actgctctgt gaaaaattag aggaacagtt gcaggatttg gatgttgcct
     2881 taaagaagaa agagcgtgcc gaacgaagaa aagaacgctt ggtgtatgtt ggtatcagta
     2941 ttgaaaacat cattcctcca caagagccag acttttctga agatcaagaa gaaaagaaaa
     3001 aagattcaaa aaaatccaaa gcaaacttgc ttgaaaggag gtcaacaaga acaaggaaat
     3061 gtataagcta cagatttgat gagtttgatg aagcaattga tgaagctatt gaagatgaca
     3121 tcaaagaagc cgatggagga ggagttggcc gaggaaaaga tatctccacc atcacaggtc
     3181 atcgtgggaa agacatctct actattttgg atgaagaaag aaaagaaaat aaacgacccc
     3241 agagggcagc tgctgctcga aggaagaaac gccggcgatt aaatgatctg gacagtgata
     3301 gcaacctgga tgaagaagag agcgaggatg aattcaagat cagtgatgga tctcaagatg
     3361 agtttgttgt gtctgatgaa aacccagatg aaagtgaaga agatccgcca tctaatgatg
     3421 acagtgacac tgacttttgt agccgtagac tgaggcgaca cccctctcgg ccaatgaggc
     3481 agagcaggcg tttgcgaaga aagaccccaa agaaaaaata ttccgatgat gatgaagagg
     3541 aggaatctga ggagaatagt agagactctg aaagtgactt cagtgatgat tttagtgatg
     3601 attttgtaga aactcggcga aggcggtcaa ggagaaatca gaaaagacaa attaactaca
     3661 aagaagactc agaaagtgac ggttcccaga agagtttgcg acgtggtaaa gaaataaggc
     3721 gagtacacaa gcgaagactt tccagctcag agagtgaaga gagctatttg tccaagaact
     3781 ctgaagatga tgagctagct aaagaatcaa agcggtcagt tcgaaagcgg ggccgaagca
     3841 cagacgagta ttcagaagca gatgaggagg aggaggaaga ggaaggcaaa ccatcccgca
     3901 aacggctaca ccggattgag acggatgagg aggagagttg tgacaatgct catggagatg
     3961 caaatcagcc tgcccgtgac agccagccta gggtcctgcc ctcagaacaa gagagcacca
     4021 agaagcccta ccggatagaa agtgatgagg aagaggactt tgaaaatgta ggcaaagtgg
     4081 ggagcccatt ggactatagc ttagtggact taccttcaac caatggacag agccctggca
     4141 aagccattga gaacttgatt ggcaagccta ctgagaagtc tcagaccccc aaggacaaca
     4201 gcacagccag tgcaagccta gcctccaatg ggacaagtgg tgggcaggag gcaggagcac
     4261 cagaagagga ggaagatgag cttttgagag tgactgacct tgttgattat gtctgtaaca
     4321 gtgaacagtt ataagacttt ttttccattt ttgtgctaat ttattccacg gtagctctca
     4381 caccagcggg ccagttatta aaagctgttt aatttttcct agaaaactcc actacagaat
     4441 gacttttaga agaaaaattt caacaaatcc tgaagtcttt ctgtgaagtg accagttctg
     4501 aactttgaag ataaataatt gctgtaaatt ccttttgatt ttctttttcc aggttcatgg
     4561 tccttggtaa tttcattcat ggaaaaaaat cttattataa taacaacaaa gatttgtata
     4621 tttttgactt tatatttcct gagctctcct gactttgtga aaaagggtgg atgaaaatgc
     4681 attccgaatc tgtgagggcc caaaacagaa tttaggggtg ggtgaaagca cttgtgcttt
     4741 agctttttca tattaaatat atattatatt taaacattca tggcatagat gatgatttac
     4801 agacaattta aaagttcaag tctgtactgt tacagtttga gaattgtaga taacatcata
     4861 cataagtcat ttagtaacag cctttgtgaa atgaacttgt ttactattgg agataaccac
     4921 acttaataaa gaagagacag tgaaagtacc atcataatta acctaaattt ttgttatagc
     4981 agagtttctt gtttaaaaaa aaataaaatc atctgaaaag catttgtaca gtaaaatgta
     5041 taatgaagct ttgccaacca gactgtgcta gcaacaaatt tttttaaata agctttatgc
     5101 agtggtaata aggtggcctc aaatatattg tgtctgatgg agagttatta gtgaaatgaa
     5161 tgtggtcttt cttaaggcct gggtggactg taaactttgc caatagtata actcttgtct
     5221 tctggccact tgatgtttaa atatctgaaa tatcattttg aaaaaaatac atctatatat
     5281 aacatacatg aagagatgct aagctgacag tgatatttta gcacatttga agactgggaa
     5341 gagattttca ggtgaatttt aactggtcta ttcttgccct tagtatctac ttcaaattga
     5401 agtctacaaa caaagcagtt cctttgggag gtttttagtt tgagttttag cgtgtgtgtg
     5461 tgtttgtgtg tgtgcgtgtg cgtgtgtgtg tgtgttggaa tttcctatct gcctggatat
     5521 attagcagag tttgaatgta gttttggcct ttggccatta gacttctatt aaaattcatt
     5581 aatagtcata caaccaacat agagttgaat gagaactgcc gatgtaatta ataggcatga
     5641 catccatttc aaacatctca acactttaaa gaaaagccct ttgtttcaag aaaaaagggt
     5701 ttgtaactaa ctaaatacct aacatgtaat tgacactaaa atatgaactt tgtcttattt
     5761 agtttctgtt atagctgtaa aatttcaggc agagccataa cattgtacag agtgtagcac
     5821 ttgtgattaa acctagcctg ttaaatcctg aaaccttcaa ccattacttc tgtgaatact
     5881 ttagccctgg gatttgggtt tttctgttcc ggtgttgtgt ctgttgccgg caatggacac
     5941 accatatctg ctgctggccc aaggaacgtc attaattttt ctttccaaat taagtattat
     6001 gtgctagtca gtgtatagta aagcacttct cttttttatt actaaaaagc tggcattaga
     6061 tttgcattat aaatacctct ctaggaactt tatactcctt ttccttcttc aacaggtatt
     6121 gcccttaaat cttatctttt ggccttgaaa gtttatagct attgtttttc agttgttcgt
     6181 tgttttgttt tgtttcactt tagttctgta gtacctgccc attaatattt ttgctttgat
     6241 tctagcaatg tgtatgtatc tgtataaaaa ataaaataat gaaagcaacc taaaaatagg
     6301 atgcaccaat agcatgtggt tccaagtaag ttgtgatttt tattttgaga cagtgttcca
     6361 ctggaaggga gggaagggct tacattcaca gacagtaaag cagggctgtg taaggagcta
     6421 catttactta acagtctcct ttccagctag gtttgtttta tttatttgca agtcagctaa
     6481 gaattaacct tttaaaccat ctaaaacagg caagcaatat aaagatttct actagtgcaa
     6541 ggtaagtggt ttgaatatac aagtgccctt tcctgccacc cagtctcact accgttttag
     6601 tcctgcagct gggtaaagcc actattgtgt ggaaactctc ccatgtgccc tgtctctacc
     6661 tctggacaca ccagctcctt cttccaccta ttctattcct cagttaagcc aagtgatcag
     6721 aagtagtatt aaatgggtag ataattttaa caggatgcct aatgtgaaat aaggagttat
     6781 ttttactctt ctactataga aagcctaagg taattcttac catctcaaag actgagtatt
     6841 ccatttaggt ttggagacca cttgtgctgt gctgcctgat atttaccaaa cttgaataag
     6901 tgttcgtcaa cttgatagtg aatgtacccc ttctcacctt atattttgat taaatcaatt
     6961 aactataggt catctaccaa gaatgtaatc caagcggttg ataaaacatt attaggcaga
     7021 tagattattg attattaaat tttgagcagt gcaaaaacgg ttttgctgct tggagttcag
     7081 attcagtccc tcaaagagtt tatgatcact gaaatacact ctgaaggtat tctgaagaag
     7141 ttaaaaaatt ttagaaaacg aaatgttctg tatacaaaga caatacagtc actacgaact
     7201 gcagaaagta taggaaagca gtaattgatg tagagtttag acagtcttgg atctttttta
     7261 gagcactaac catggattta gactcaaaat agctgctaca taatagagcc ctttaataat
     7321 ttaaaccccc cttgttgaaa tacaagttgg actcccagtg tcaaactcta gactgtagct
     7381 aatgtattaa agggagatgt agattaatat tcagtatatt tagtttgcaa tttctgaaaa
     7441 ggtttgaaaa ctagtcagct tttcacacag cagaagcttt gaactgaaat atgtgtgaaa
     7501 aggacgcaga ctgaaaacgt tttggttttg tacatcagtg ctgatgaaat tagtgtaaaa
     7561 cattttccat cattggcaca ttactgcaaa atgatggcag agatattttc aagaatgtac
     7621 atcaagttat atttccttga catccttttt tcaattggtc aaggttacag attcagagga
     7681 taaagggtag tttcatttag aataaattca tgtctactgg caatctatat ataaaagtga
     7741 cctgcccaag aaccaaaaac tttaaatgct aatgaagctt ttgaaaaata atttttaaac
     7801 aaattaattt taaaagggtg ttacacgtac ccagttttta ctttttagtt gatgaaaccc
     7861 atcctataat atacatttga gcaaagtaca catattaaga aaaacatgga catttacttg
     7921 tttaatagtc aaaatgatga ggaaatgtta gctgttttta agtgggactg gtggggtgtc
     7981 ctttgtcaca aggaatgctt ttttagcttg tttgtgggca taagagatgt taaccctttg
     8041 ctgattctac cacacaactg taaagaacct aatgaatcta caagtttaat attcagaaaa
     8101 agctaggaac tccgctcttt accagtacag tggaacaggc ccgttattca aggtgatgcc
     8161 tcacagctat agaacaacta ttcaaagacc cagagttaaa tggtacatgt gtatatgtgt
     8221 gtgtgtgtgt gcacacgcac acacttcaga taagtatcag aaaaaataaa aatgaatcca
     8281 tcattaactt gaaagaaata agatggctgc attgcaacag atacaaatat tatgaacatc
     8341 atttaattac agaaaatcta gacaacagtt tctcctgatg tttgacattc tcaaaatata
     8401 ttcctcattc tcgaagaagc agagaatgcc aaggctgcat atctgctgta atctacctag
     8461 ccctcttctg cttaatatga tccattattg aatcttctca gattaaaatc cattcctata
     8521 tcatctacct ttcccaaagt gtgtgcctgt aaacctacct tggaagtggc aagttaactg
     8581 atttttttgt gtcattttta taccaatcct taaggtcaaa gccttttgct atcaatgtat
     8641 ttaaactgag ttgctatatg ttcactaatt tgttttcaaa atgttttgct ccaacttaaa
     8701 ttatctttta acatcttttg agtgccaaga attgctaagt aactgtaata tgttgaagag
     8761 agtaattgcc aagcaagcag tcataagcca aaatgtaatg agcttagtat ataaccactt
     8821 tagagtatac actcaccact ttttgtattc attcatgcaa accctcctgg aagtcgatta
     8881 gaagaggatc caatttgtgg accttttttc ctccttttgg acacctgagc acaatttttt
     8941 ttttcctttc atatttatac cactttggaa aattcagtaa acccaattct ggcacatcat
     9001 aatggtttca gttagtgaag atgtttattt taataacttt aaaatatgac tatcctatac
     9061 ataagttata taagagggca taacaataga tgagtagaaa tttataaaat ttcttggata
     9121 ttttgaatga gaaaaaaaca tttttaaagg aattttgttt tttccttttt tggccaaacc
     9181 ggtacaagtt agaaagtgtg ctaaggactg aatacttgcc tcgtgctttt tgccactgga
     9241 tgatgtaagt taagaatgga attgttaatc ctaagtatat attttcttga ctttcatcag
     9301 tttctaaaga aatctaattt aagtgttttg cggttttgtt tgatctgtat ttattgagtt
     9361 ctggtcatag accagcagct tgcacgtcat gctcatgaac agccagaaca tagttattgg
     9421 ggaacttcat ggctcaaaac cttctgaatc atttaactta ttttgtatgt tgcaaaaaaa
     9481 aaaaaaaagt ttattttgct tgagagtcac ctttttttaa aaaaaataac tgtacagctt
     9541 ttaagggatg ggaggtggga aaatacccta aaataggatg tagatttttt acaattgtgt
     9601 ttatgctaga tcatctacag gtgcattatg taattaaacc taaaattgtt taaaaatttg
     9661 tgccatgtct ttttcattct cctgcccttt agcagaattg gtgcatgtca actgctatgt
     9721 ggacaagcct tgaaattaga gtaacaagcc ctgtctccaa agctttaagg tcactgcatg
     9781 aaaattgcac acacacacac acacacacac acatctagct tatattagta aatggatttt
     9841 caggatcaga acagctacag tagcccagat ttggctgtta acagcatatt cttacagcac
     9901 atgatttttg tgatgcctaa ctagggtatt ctcaatgtta gtctggtgtt ctattctctt
     9961 tcaaagtagc ttcttgagat ggtatctgtt gtagcttgcc caaacctgcc atgaggttgt
    10021 gtgtacactt tgaaagggta tgtcctatgc taagatggtg gtagagcagg gcttgatttt
    10081 aatctattca tataaaagaa ggaaaaaact agaattggtc tatttggtta ttcagtggac
    10141 ttaattccac aggaatagtt gtctgctgaa gcgtggcagc aagagaagtc aaattcaagt
    10201 ttcagttcct tccttattca ctaagtattt tgaaatcttg tagaacttct gattctagca
    10261 cagtctttta catggcacat tttaccatgg tatattcaca gcttcgttta aatgtcagta
    10321 ctttttccca tctgataatt ttgccattct aatttctcac ctttgtagta caagtgtatt
    10381 cttgaaaata attaaattca tctaagtgtg tcataatttc aatcaaagct atattcatgt
    10441 gttgccagcg tcagtttttt gctatcctca ttcagaaggg aagcctgcag atcatgagtt
    10501 tccatatgaa gaatacaaat tccacataaa aatttataaa tggtatcttt agaattttga
    10561 tttaaagtaa tagctggaat tcagggactg atcagaatgc ctcttgaatt ttccaacatg
    10621 cttatatgaa atgctttatt ttcctatgcg ttaaaaaaaa tattcctgga ataggttctc
    10681 agaatgtttt atttggtttc taggagatga gatttaaagc agaagctcca agattggcat
    10741 aaaactaact cttgaggtaa tcaggaccat gctgttagtc aaatagaagc tggagtgctc
    10801 tctgtcacat aatgtactgc atgtgtgtgg gggtgggggg gcagggaaga tcagaaaact
    10861 ggaaatgtaa ttctgataac acgcaaagta aattgtgcat taaaagtatg ggaattcttg
    10921 gtagcttaaa gcttcagggg ttaacttcag tgtatgaaca cctagtgtgt tagaattgca
    10981 gtgcatagtt gtttaaatac aatattcctt gtaagtgaca accaaaatat gttgtggctg
    11041 gtgccagtat ttttgttaat gaaatgttca gtgtctcact acagtctgat cagaactctt
    11101 ggtgttataa gccaggccta aagccatttt atagctattg gcctaattgt gtaacttttt
    11161 ctttcaaaat gttttattat aatacttctg tcatttcttt cacttaatat gtcaattgtc
    11221 ataataaaaa tttaaatttg aa
//
