LOCUS       NM_006511               2321 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens regulator of solute carriers 1 (RSC1A1), mRNA.
ACCESSION   NM_006511
VERSION     NM_006511.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2321)
  AUTHORS   Schafer,N., Rikkala,P.R., Veyhl-Wichmann,M., Keller,T.,
            Jurowich,C.F., Geiger,D. and Koepsell,H.
  TITLE     A Modified Tripeptide Motif of RS1 (RSC1A1) Down-Regulates
            Exocytotic Pathways of Human Na+-d-glucose Cotransporters SGLT1,
            SGLT2, and Glucose Sensor SGLT3 in the Presence of Glucose
  JOURNAL   Mol Pharmacol 95 (1), 82-96 (2019)
   PUBMED   30355744
  REMARK    GeneRIF: A domain of protein RS1 (RSC1A1) called RS1-Reg
            down-regulates the plasma membrane abundance of Na(+)-d-glucose
            cotransporter.
REFERENCE   2  (bases 1 to 2321)
  AUTHORS   Sebastiani,A., Greve,F., Golz,C., Forster,C.Y., Koepsell,H. and
            Thal,S.C.
  TITLE     RS1 (Rsc1A1) deficiency limits cerebral SGLT1 expression and delays
            brain damage after experimental traumatic brain injury
  JOURNAL   J Neurochem 147 (2), 190-203 (2018)
   PUBMED   30022488
REFERENCE   3  (bases 1 to 2321)
  AUTHORS   Koepsell,H.
  TITLE     The Na+-D-glucose cotransporters SGLT1 and SGLT2 are targets for
            the treatment of diabetes and cancer
  JOURNAL   Pharmacol Ther 170, 148-165 (2017)
   PUBMED   27773781
  REMARK    Review article
REFERENCE   4  (bases 1 to 2321)
  AUTHORS   Chintalapati,C., Keller,T., Mueller,T.D., Gorboulev,V., Schafer,N.,
            Zilkowski,I., Veyhl-Wichmann,M., Geiger,D., Groll,J. and
            Koepsell,H.
  TITLE     Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of
            Glucose Transporter SGLT1 at Low Intracellular Glucose via
            Inhibition of Ornithine Decarboxylase
  JOURNAL   Mol Pharmacol 90 (5), 508-521 (2016)
   PUBMED   27555600
  REMARK    GeneRIF: Binding of RS1-Reg to ODC1 inhibits the enzymatic activity
            at low intracellular glucose, which is blunted at high
            intracellular glucose.
REFERENCE   5  (bases 1 to 2321)
  AUTHORS   Veyhl-Wichmann,M., Friedrich,A., Vernaleken,A., Singh,S., Kipp,H.,
            Gorboulev,V., Keller,T., Chintalapati,C., Pipkorn,R.,
            Pastor-Anglada,M., Groll,J. and Koepsell,H.
  TITLE     Phosphorylation of RS1 (RSC1A1) Steers Inhibition of Different
            Exocytotic Pathways for Glucose Transporter SGLT1 and Nucleoside
            Transporter CNT1, and an RS1-Derived Peptide Inhibits Glucose
            Absorption
  JOURNAL   Mol Pharmacol 89 (1), 118-132 (2016)
   PUBMED   26464324
REFERENCE   6  (bases 1 to 2321)
  AUTHORS   Veyhl,M., Keller,T., Gorboulev,V., Vernaleken,A. and Koepsell,H.
  TITLE     RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose
            cotransporter SGLT1
  JOURNAL   Am J Physiol Renal Physiol 291 (6), F1213-F1223 (2006)
   PUBMED   16788146
  REMARK    GeneRIF: hRS1 protein exhibits glucose-dependent, short-term
            inhibition of hSGLT1 and hOCT2 by inhibiting the release of
            vesicles from the trans-Golgi network
REFERENCE   7  (bases 1 to 2321)
  AUTHORS   Veyhl,M., Wagner,C.A., Gorboulev,V., Schmitt,B.M., Lang,F. and
            Koepsell,H.
  TITLE     Downregulation of the Na(+)- D-glucose cotransporter SGLT1 by
            protein RS1 (RSC1A1) is dependent on dynamin and protein kinase C
  JOURNAL   J Membr Biol 196 (1), 71-81 (2003)
   PUBMED   14724758
  REMARK    GeneRIF: Taken together, these data indicate that RSC1A1 modulates
            dynamin-dependent trafficking of intracellular vesicles containing
            hSGLT1 in Xenopus oocytes, and modulates PKC-dependent short-term
            regulation of this transporter.
REFERENCE   8  (bases 1 to 2321)
  AUTHORS   Valentin,M., Kuhlkamp,T., Wagner,K., Krohne,G., Arndt,P.,
            Baumgarten,K., Weber,W., Segal,A., Veyhl,M. and Koepsell,H.
  TITLE     The transport modifier RS1 is localized at the inner side of the
            plasma membrane and changes membrane capacitance
  JOURNAL   Biochim Biophys Acta 1468 (1-2), 367-380 (2000)
   PUBMED   11018680
REFERENCE   9  (bases 1 to 2321)
  AUTHORS   Lambotte,S., Veyhl,M., Kohler,M., Morrison-Shetlar,A.I.,
            Kinne,R.K., Schmid,M. and Koepsell,H.
  TITLE     The human gene of a protein that modifies Na(+)-D-glucose
            co-transport
  JOURNAL   DNA Cell Biol 15 (9), 769-777 (1996)
   PUBMED   8836035
REFERENCE   10 (bases 1 to 2321)
  AUTHORS   Koehler,M.R., Lambotte,S., Koepsell,H. and Schmid,M.
  TITLE     Assignment of the membrane-associated modulator of the Na(+)-sugar
            cotransport systems gene RSC1A1 to human chromosome 1p36.1 by in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 73 (4), 341-342 (1996)
   PUBMED   8751391
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314753.1, CR999543.1,
            CN345288.1, AI240658.1 and AL121992.24.
            
            On Aug 14, 2020 this sequence version replaced NM_006511.2.
            
            Summary: The protein encoded by this intronless gene inhibits the
            expression of the solute carrier family 5 (sodium/glucose
            cotransporter), member 1 gene (SLC5A1) and downregulates exocytosis
            of the SLC5A1 protein. The encoded protein is sometimes found
            coating the trans-Golgi network and other times is localized to the
            nucleus, depending on the cell cycle stage. This protein also
            inhibits the expression of solute carrier family 22 (organic cation
            transporter), member 2 (SLC22A2). [provided by RefSeq, Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK314753.1, SRR7346977.2951095.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345034.2/ ENSP00000341963.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               AK314753.1         1-339
            340-1152            CR999543.1         115-927
            1153-2010           AK314753.1         1153-2010
            2011-2299           CN345288.1         310-598
            2300-2318           AI240658.1         27-45               c
            2319-2321           AL121992.24        126207-126209
FEATURES             Location/Qualifiers
     source          1..2321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..2321
                     /gene="RSC1A1"
                     /gene_synonym="RS1"
                     /note="regulator of solute carriers 1"
                     /db_xref="GeneID:6248"
                     /db_xref="HGNC:HGNC:10458"
                     /db_xref="MIM:601966"
     exon            1..2321
                     /gene="RSC1A1"
                     /gene_synonym="RS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..2010
                     /gene="RSC1A1"
                     /gene_synonym="RS1"
                     /note="transporter regulator RS1; regulatory solute
                     carrier protein, family 1, member 1"
                     /codon_start=1
                     /product="regulatory solute carrier protein family 1
                     member 1"
                     /protein_id="NP_006502.1"
                     /db_xref="CCDS:CCDS161.1"
                     /db_xref="GeneID:6248"
                     /db_xref="HGNC:HGNC:10458"
                     /db_xref="MIM:601966"
                     /translation="MSSLPTSDGFNHPARSSGQSPDVGNPMSLARSVSASVCPIKPSD
                     SDRIEPKAVKALKASAEFQLNSEKKEHLSLQDLSDHASSADHAPTDQSPAMPMQNSSE
                     EITVAGNLEKSAERSTQGLKFHLHTRQEASLSVTSTRMHEPQMFLGEKDWHPENQNLS
                     QVSDPQQHEEPGNEQYEVAQQKASHDQEYLCNIGDLELPEERQQNQHKIVDLEATMKG
                     NGLPQNVDPPSAKKSIPSSECSGCSNSETFMEIDTAQQSLVTLLNSTGRQNANVKNIG
                     ALDLTLDNPLMEVETSKCNPSSEILNDSISTQDLQPPETNVEIPGTNKEYGHYSSPSL
                     CGSCQPSVESAEESCPSITAALKELHELLVVSSKPASENTSEEVICQSETIAEGQTSI
                     KDLSERWTQNEHLTQNEQCPQVSFHQAISVSVETEKLTGTSSDTGREAVENVNFRSLG
                     DGLSTDKEGVPKSRESINKNRSVTVTSAKTSNQLHCTLGVEISPKLLAGEEDALNQTS
                     EQTKSLSSNFILVKDLGQGIQNSVTDRPETRENVCPDASRPLLEYEPPTSHPSSSPAI
                     LPPLIFPATDIDRILRAGFTLQEALGALHRVGGNADLALLVLLAKNIVVPT"
     regulatory      2294..2299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSC1A1"
                     /gene_synonym="RS1"
                     /note="hexamer: AATAAA"
     polyA_site      2321
                     /gene="RSC1A1"
                     /gene_synonym="RS1"
                     /note="major polyA site"
ORIGIN      
        1 aagagaaacc cgagtttgag gaccttattt tattctacgc tgtttagatt tgtatcctct
       61 ggtaatttag tggcattagt cacctgctaa ttaatctttt tcctttcccc tgtgttccat
      121 atagagaaaa gtggtaaaga atctacctca ctgggaatgt catcattacc aacttcagat
      181 gggtttaacc atcccgcccg ttcttcagga cagagtcctg atgttggtaa tcctatgagt
      241 cttgctcgct ctgtctctgc ttcagtctgc cctatcaagc ccagtgactc agatcgcatt
      301 gaacctaaag ctgtgaaggc tttgaaggct tcagctgaat tccagctaaa ctctgaaaag
      361 aaagaacatc tttctttaca agatctttct gatcatgctt cctcagcaga ccatgctcca
      421 acagaccaga gtccagctat gcctatgcag aattcatccg aagaaataac tgttgcaggt
      481 aatctggaga aatctgctga aagaagcacc cagggcctca aatttcatct ccatacaaga
      541 caggaagcta gtttatctgt cacatctact aggatgcatg aaccacagat gtttctaggt
      601 gaaaaggatt ggcatccaga aaatcagaac ctgagtcaag tgagtgaccc tcagcagcac
      661 gaagaaccag ggaatgaaca gtatgaggtt gcacaacaaa aagcttcaca tgaccaagaa
      721 tatctttgta acatagggga ccttgagctt cctgaagaaa ggcaacagaa tcaacacaaa
      781 attgttgatt tggaagctac gatgaaagga aatgggctcc cacagaatgt ggatcctcca
      841 agtgcgaaga aaagtattcc atcttcagaa tgcagtggct gctcaaattc agaaacattt
      901 atggaaatcg atacagctca acagtcccta gttactttgc ttaattcaac aggcaggcag
      961 aatgccaatg tcaagaacat tggtgcattg gatctcactt tagataatcc cttgatggaa
     1021 gtagaaacat caaaatgtaa cccttcatct gaaattttga atgattccat ttccactcag
     1081 gatttacagc ccccagaaac taatgttgaa atacctggaa caaataaaga atatggccat
     1141 tactcctctc caagtctctg tggcagttgt cagccttctg tggagtcagc agaagaatct
     1201 tgcccgtcta taacggcagc cttgaaagaa cttcatgaac ttttggttgt tagcagtaaa
     1261 ccagcttcag aaaatacatc tgaagaagta atctgtcaat cagaaaccat agctgagggc
     1321 caaaccagta ttaaagacct ttctgaaaga tggacccaaa atgagcatct tacccagaat
     1381 gaacagtgtc cacaagtctc ctttcatcag gccatatctg tatcagtgga gacagaaaaa
     1441 ttaacaggta cttcatctga cactggaaga gaagctgtag aaaatgtaaa cttcaggagt
     1501 ctaggtgatg gcctgtcaac cgataaggaa ggtgtcccca aatctaggga atccataaat
     1561 aagaaccgtt ctgtcactgt aacctcagct aaaacatcca atcagttaca ctgcacctta
     1621 ggtgtagaaa tttcacccaa acttttagca ggtgaggagg atgcactcaa tcagacttct
     1681 gagcaaacta agtctttgtc atccaatttc atattggtta aagacttagg tcagggcata
     1741 cagaattcag taacagacag gcctgaaacc agagaaaatg tctgtcctga tgcttcgagg
     1801 ccattacttg aatatgaacc acctaccagc catccatcat caagtcctgc cattcttcca
     1861 ccattgattt ttcctgccac agatattgac cgcattctcc gtgctggctt tactttgcag
     1921 gaagctcttg gagctttgca tcgagttggt gggaatgcag accttgcact tcttgttttg
     1981 ctcgcaaaaa acatcgtagt tcctacatga ctgtgggaaa gtgggctaga ccgttctcca
     2041 ttccctttaa acaaaagaaa gctctctcta tatacacgca cacatacaca ctcaccacat
     2101 atacagtata tatagaaacc tgcaagcaga atgttgagcc agattttttt taaagatttt
     2161 tttcggccaa agtaatttat gatcttttgt ctgatgaatt tgtctatcct acttgttaaa
     2221 atttaggcct ttttaaatgt attggcagta tgtgcataca gaagcttttt attctcatta
     2281 agatgtatcc tggaataaaa tggatggttt tgtgtgtagc a
//
