LOCUS       NP_006502                617 aa            linear   PRI 13-FEB-2025
DEFINITION  regulatory solute carrier protein family 1 member 1 [Homo sapiens].
ACCESSION   NP_006502
VERSION     NP_006502.1
DBSOURCE    REFSEQ: accession NM_006511.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 617)
  AUTHORS   Schafer,N., Rikkala,P.R., Veyhl-Wichmann,M., Keller,T.,
            Jurowich,C.F., Geiger,D. and Koepsell,H.
  TITLE     A Modified Tripeptide Motif of RS1 (RSC1A1) Down-Regulates
            Exocytotic Pathways of Human Na+-d-glucose Cotransporters SGLT1,
            SGLT2, and Glucose Sensor SGLT3 in the Presence of Glucose
  JOURNAL   Mol Pharmacol 95 (1), 82-96 (2019)
   PUBMED   30355744
  REMARK    GeneRIF: A domain of protein RS1 (RSC1A1) called RS1-Reg
            down-regulates the plasma membrane abundance of Na(+)-d-glucose
            cotransporter.
REFERENCE   2  (residues 1 to 617)
  AUTHORS   Sebastiani,A., Greve,F., Golz,C., Forster,C.Y., Koepsell,H. and
            Thal,S.C.
  TITLE     RS1 (Rsc1A1) deficiency limits cerebral SGLT1 expression and delays
            brain damage after experimental traumatic brain injury
  JOURNAL   J Neurochem 147 (2), 190-203 (2018)
   PUBMED   30022488
REFERENCE   3  (residues 1 to 617)
  AUTHORS   Koepsell,H.
  TITLE     The Na+-D-glucose cotransporters SGLT1 and SGLT2 are targets for
            the treatment of diabetes and cancer
  JOURNAL   Pharmacol Ther 170, 148-165 (2017)
   PUBMED   27773781
  REMARK    Review article
REFERENCE   4  (residues 1 to 617)
  AUTHORS   Chintalapati,C., Keller,T., Mueller,T.D., Gorboulev,V., Schafer,N.,
            Zilkowski,I., Veyhl-Wichmann,M., Geiger,D., Groll,J. and
            Koepsell,H.
  TITLE     Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of
            Glucose Transporter SGLT1 at Low Intracellular Glucose via
            Inhibition of Ornithine Decarboxylase
  JOURNAL   Mol Pharmacol 90 (5), 508-521 (2016)
   PUBMED   27555600
  REMARK    GeneRIF: Binding of RS1-Reg to ODC1 inhibits the enzymatic activity
            at low intracellular glucose, which is blunted at high
            intracellular glucose.
REFERENCE   5  (residues 1 to 617)
  AUTHORS   Veyhl-Wichmann,M., Friedrich,A., Vernaleken,A., Singh,S., Kipp,H.,
            Gorboulev,V., Keller,T., Chintalapati,C., Pipkorn,R.,
            Pastor-Anglada,M., Groll,J. and Koepsell,H.
  TITLE     Phosphorylation of RS1 (RSC1A1) Steers Inhibition of Different
            Exocytotic Pathways for Glucose Transporter SGLT1 and Nucleoside
            Transporter CNT1, and an RS1-Derived Peptide Inhibits Glucose
            Absorption
  JOURNAL   Mol Pharmacol 89 (1), 118-132 (2016)
   PUBMED   26464324
REFERENCE   6  (residues 1 to 617)
  AUTHORS   Veyhl,M., Keller,T., Gorboulev,V., Vernaleken,A. and Koepsell,H.
  TITLE     RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose
            cotransporter SGLT1
  JOURNAL   Am J Physiol Renal Physiol 291 (6), F1213-F1223 (2006)
   PUBMED   16788146
  REMARK    GeneRIF: hRS1 protein exhibits glucose-dependent, short-term
            inhibition of hSGLT1 and hOCT2 by inhibiting the release of
            vesicles from the trans-Golgi network
REFERENCE   7  (residues 1 to 617)
  AUTHORS   Veyhl,M., Wagner,C.A., Gorboulev,V., Schmitt,B.M., Lang,F. and
            Koepsell,H.
  TITLE     Downregulation of the Na(+)- D-glucose cotransporter SGLT1 by
            protein RS1 (RSC1A1) is dependent on dynamin and protein kinase C
  JOURNAL   J Membr Biol 196 (1), 71-81 (2003)
   PUBMED   14724758
  REMARK    GeneRIF: Taken together, these data indicate that RSC1A1 modulates
            dynamin-dependent trafficking of intracellular vesicles containing
            hSGLT1 in Xenopus oocytes, and modulates PKC-dependent short-term
            regulation of this transporter.
REFERENCE   8  (residues 1 to 617)
  AUTHORS   Valentin,M., Kuhlkamp,T., Wagner,K., Krohne,G., Arndt,P.,
            Baumgarten,K., Weber,W., Segal,A., Veyhl,M. and Koepsell,H.
  TITLE     The transport modifier RS1 is localized at the inner side of the
            plasma membrane and changes membrane capacitance
  JOURNAL   Biochim Biophys Acta 1468 (1-2), 367-380 (2000)
   PUBMED   11018680
REFERENCE   9  (residues 1 to 617)
  AUTHORS   Lambotte,S., Veyhl,M., Kohler,M., Morrison-Shetlar,A.I.,
            Kinne,R.K., Schmid,M. and Koepsell,H.
  TITLE     The human gene of a protein that modifies Na(+)-D-glucose
            co-transport
  JOURNAL   DNA Cell Biol 15 (9), 769-777 (1996)
   PUBMED   8836035
REFERENCE   10 (residues 1 to 617)
  AUTHORS   Koehler,M.R., Lambotte,S., Koepsell,H. and Schmid,M.
  TITLE     Assignment of the membrane-associated modulator of the Na(+)-sugar
            cotransport systems gene RSC1A1 to human chromosome 1p36.1 by in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 73 (4), 341-342 (1996)
   PUBMED   8751391
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314753.1, CR999543.1,
            CN345288.1, AI240658.1 and AL121992.24.
            
            Summary: The protein encoded by this intronless gene inhibits the
            expression of the solute carrier family 5 (sodium/glucose
            cotransporter), member 1 gene (SLC5A1) and downregulates exocytosis
            of the SLC5A1 protein. The encoded protein is sometimes found
            coating the trans-Golgi network and other times is localized to the
            nucleus, depending on the cell cycle stage. This protein also
            inhibits the expression of solute carrier family 22 (organic cation
            transporter), member 2 (SLC22A2). [provided by RefSeq, Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK314753.1, SRR7346977.2951095.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345034.2/ ENSP00000341963.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..617
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     Protein         1..617
                     /product="regulatory solute carrier protein family 1
                     member 1"
                     /note="transporter regulator RS1; regulatory solute
                     carrier protein, family 1, member 1"
                     /calculated_mol_wt=66659
     Region          1..106
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92681.1)"
     Region          155..181
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92681.1)"
     Region          217..237
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92681.1)"
     Region          410..412
                     /region_name="Involved in post-transcriptional
                     down-regulation of SLC5A1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92681.1)"
     CDS             1..617
                     /gene="RSC1A1"
                     /gene_synonym="RS1"
                     /coded_by="NM_006511.3:157..2010"
                     /db_xref="CCDS:CCDS161.1"
                     /db_xref="GeneID:6248"
                     /db_xref="HGNC:HGNC:10458"
                     /db_xref="MIM:601966"
ORIGIN      
        1 msslptsdgf nhparssgqs pdvgnpmsla rsvsasvcpi kpsdsdriep kavkalkasa
       61 efqlnsekke hlslqdlsdh assadhaptd qspampmqns seeitvagnl eksaerstqg
      121 lkfhlhtrqe aslsvtstrm hepqmflgek dwhpenqnls qvsdpqqhee pgneqyevaq
      181 qkashdqeyl cnigdlelpe erqqnqhkiv dleatmkgng lpqnvdppsa kksipssecs
      241 gcsnsetfme idtaqqslvt llnstgrqna nvknigaldl tldnplmeve tskcnpssei
      301 lndsistqdl qppetnveip gtnkeyghys spslcgscqp svesaeescp sitaalkelh
      361 ellvvsskpa sentseevic qsetiaegqt sikdlserwt qnehltqneq cpqvsfhqai
      421 svsveteklt gtssdtgrea venvnfrslg dglstdkegv pksresinkn rsvtvtsakt
      481 snqlhctlgv eispkllage edalnqtseq tkslssnfil vkdlgqgiqn svtdrpetre
      541 nvcpdasrpl leyepptshp ssspailppl ifpatdidri lragftlqea lgalhrvggn
      601 adlallvlla knivvpt
//
