LOCUS       NM_198467               6406 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens round spermatid basic protein 1 like (RSBN1L), mRNA.
ACCESSION   NM_198467 XM_168443
VERSION     NM_198467.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6406)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   2  (bases 1 to 6406)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC059402.1, AK127713.1, DA097202.1 and AC004955.3.
            
            On Nov 22, 2018 this sequence version replaced NM_198467.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.209178.1,
                                           SRR1660803.143517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162328, SAMN03568911
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334955.13/ ENSP00000334040.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1291              BC059402.1         17-1307
            1292-2350           AK127713.1         520-1578
            2351-2932           BC059402.1         2355-2936
            2933-3066           AK127713.1         2159-2292
            3067-3075           BC059402.1         3070-3078
            3076-3187           DA097202.1         314-425
            3188-6406           AC004955.3         88676-91894
FEATURES             Location/Qualifiers
     source          1..6406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..6406
                     /gene="RSBN1L"
                     /note="round spermatid basic protein 1 like"
                     /db_xref="GeneID:222194"
                     /db_xref="HGNC:HGNC:24765"
     exon            1..597
                     /gene="RSBN1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..2552
                     /gene="RSBN1L"
                     /note="round spermatid basic protein 1-like protein"
                     /codon_start=1
                     /product="lysine-specific demethylase RSBN1L"
                     /protein_id="NP_940869.2"
                     /db_xref="CCDS:CCDS43607.1"
                     /db_xref="GeneID:222194"
                     /db_xref="HGNC:HGNC:24765"
                     /translation="MAEPPSPVHCVAAAAPTATVSEKEPFGKLQLSSRDPPGSLSAKK
                     VRTEEKKAPRRVNGEGGSGGNSRQLQPPAAPSPQSYGSPASWSFAPLSAAPSPSSSRS
                     SFSFSAGTAVPSSASASLSQPVPRKLLVPPTLLHAQPHHLLLPAAAAAASANAKSRRP
                     KEKREKERRRHGLGGAREAGGASREENGEVKPLPRDKIKDKIKERDKEKEREKKKHKV
                     MNEIKKENGEVKILLKSGKEKPKTNIEDLQIKKVKKKKKKKHKENEKRKRPKMYSKSI
                     QTICSGLLTDVEDQAAKGILNDNIKDYVGKNLDTKNYDSKIPENSEFPFVSLKEPRVQ
                     NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN
                     ENSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVK
                     RTYSHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQ
                     SRKDSDDGPIMWVRPGEQMIPVADMPKSPFKRKRTTNEIKNLQYLPRTSEPREMLFED
                     RTRAHADHIGQGFERQTTAAVGVLKAVHCGEWPDQPRITKDVICFHAEDFLEVVQRMQ
                     LDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVC
                     SLAWHIRLKLYHSEEDTSQNTATHETGTSSDSTSSVLGPHTDNMICAVSKASLDSVFS
                     DKLHSKYELQQIKHEPIASVRIKEEPVNVNIPEKTTALNNMDGKNVKAKLDHVQFAEF
                     KIDMDSKFENSNKDLKEELCPGNLSLVDTRQHSSAHSNQDKKDDDILC"
     exon            598..714
                     /gene="RSBN1L"
                     /inference="alignment:Splign:2.1.0"
     exon            715..1355
                     /gene="RSBN1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1493
                     /gene="RSBN1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1636
                     /gene="RSBN1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1804
                     /gene="RSBN1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1913
                     /gene="RSBN1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..6406
                     /gene="RSBN1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2598..2603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSBN1L"
                     /note="hexamer: AATAAA"
     polyA_site      2625
                     /gene="RSBN1L"
                     /note="major polyA site"
     regulatory      3016..3021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSBN1L"
                     /note="hexamer: AATAAA"
     polyA_site      3045
                     /gene="RSBN1L"
     regulatory      6381..6386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSBN1L"
                     /note="hexamer: AATAAA"
     polyA_site      6406
                     /gene="RSBN1L"
                     /note="major polyA site"
ORIGIN      
        1 aggagcgcaa aatggcggaa ccgccgagcc ccgtgcactg tgtcgctgcc gcggccccca
       61 ccgccaccgt ctcggagaaa gaaccgtttg gcaagctgca actctcctcc cgggaccctc
      121 cgggttctct gtccgccaag aaggtccgga ctgaggagaa gaaggcaccg cggagagtga
      181 acggagaagg gggcagcggc gggaacagca ggcagctgca gccgccggca gcaccttcgc
      241 ctcagagcta tggcagcccc gcgtcttgga gctttgcccc tctgtctgct gctccctccc
      301 cgtcctcttc tcggagcagt ttctctttct ccgctggcac ggccgttccc tcctcagcct
      361 ccgcttcctt gtctcagccg gtgccgcgca aactgctggt ccctcctacg ctgctgcacg
      421 ctcagcctca ccatctcctc ctgcccgccg ccgccgccgc tgcctcggct aacgccaagt
      481 cgcgcagacc taaggagaag cgggagaagg agaggaggag gcacggtctc ggtggggccc
      541 gagaggccgg cggggcctcc cgggaggaga acggggaggt gaagccgctg ccccgagata
      601 aaatcaaaga caaaattaaa gagagagaca aagaaaaaga aagagaaaaa aagaaacata
      661 aagtaatgaa tgagatcaag aaagagaatg gagaagtaaa gattttgctg aaaagtggga
      721 aggagaaacc aaaaacaaat atagaagact tacaaattaa aaaggtaaag aagaaaaaga
      781 aaaagaaaca caaagagaat gaaaaacgga agcgtccgaa aatgtatagc aaatctattc
      841 agaccatctg ctcaggattg ctaactgatg ttgaagatca agcagccaaa ggcatcctaa
      901 atgataacat aaaagattac gttgggaaga atttggatac caagaactat gattccaaaa
      961 ttccagagaa cagtgagttt ccatttgtct cattaaagga gccacgagtt cagaataacc
     1021 tcaaaaggtt ggacactttg gaatttaaac aactcattca tatagagcac cagcctaatg
     1081 gaggtgcatc ggttatccat gcctacagta acgaactctc ccacctgtct cctatggaga
     1141 tggagaggtt tgcagaagag tttgtgggtc tagtgttcag tgaaaatgaa aactctgcag
     1201 ctttctacgt gatgggtatt gttcatgggg cagctactta tttacctgac tttttagact
     1261 atttttcatt taattttccc aattcaccag tgaaaatgga gatattggga aagaaagata
     1321 tagagacaac gactatgtcc aattttcatg ctcaggtaaa aagaacgtat tctcatggta
     1381 cttacagagc tggcccaatg agacaaataa gcttggtggg agcagttgat gaagaagtag
     1441 gagattattt ccctgagttc cttgacatgt tggaagagtc accattttta aaatgtacac
     1501 tgccatgggg gacgctatct agtctaaaat tacagagtcg aaaagatagt gatgatggtc
     1561 ccatcatgtg ggttcgtcca ggagaacaaa tgatccctgt ggctgatatg ccaaagtcac
     1621 ctttcaaaag gaaaagaact accaatgaaa taaaaaatct tcagtaccta cctcgaacaa
     1681 gtgagccccg tgagatgctc tttgaagaca ggacaagagc tcatgcagat catataggac
     1741 aaggttttga acgacagact acagctgctg ttggagtgct gaaggctgtg cactgtggag
     1801 agtggcctga tcaaccccgt ataaccaaag atgtaatttg ttttcatgct gaagatttct
     1861 tagaagtagt tcaacgaatg cagttagatt tacatgaacc tccactgtcc cagtgtgtcc
     1921 aatgggttga tgatgcaaaa ctgaatcaac tgaggaggga aggcattcgc tatgccagga
     1981 ttcagctata tgataatgac atttatttta ttccaaggaa tgttgttcat cagttcaaga
     2041 cagtttcagc tgtatgcagt ttagcatggc atattcggct caaattatat cactcagagg
     2101 aggacacttc tcagaataca gctactcatg aaacaggcac atcatcagat tccacatcat
     2161 ctgttcttgg acctcacact gacaacatga tttgtgctgt aagcaaagcc tccttggatt
     2221 ctgttttttc agataaactt cattctaaat atgaattaca gcagattaaa catgaaccta
     2281 ttgcatctgt aagaatcaag gaagaacctg tgaatgttaa tattcctgaa aagactacag
     2341 cactgaataa tatggatggc aagaatgtta aagcaaaatt ggatcatgtt caatttgcag
     2401 aatttaagat tgacatggat tctaaatttg aaaatagcaa caaagattta aaggaagaat
     2461 tgtgccctgg aaatctaagt ctagttgata caaggcaaca cagttcagca cattcaaatc
     2521 aagataaaaa agacgatgac attttgtgct aaatttgcat ataccatcta aaatcctttt
     2581 ttaaaaaaat ttaatgtaat aaagattcat gaattctgaa agcaagccaa ggacttgctc
     2641 ctatgtctgt tacaaaacat agtttatgta gctttgtaac attcctcagt gcctgtccat
     2701 aactgtgaag tattaagcac ttagggccag atgcactgta aacattgcag gtttaaacat
     2761 aaaggagtct ttaaaaaaaa atcatttacg ttggaatttt aggttttaga atagagctga
     2821 cattaacata tatatatata tataaatata tatatatatt ttgtaatatg agccagaatt
     2881 ctttttcaac aatttaaagc ttttccatag agcttattta tatccttttt tttcatttta
     2941 aatgtgtcag cactgtagtg taaatagctt ttaaatatct ttttagtgtg atttatactg
     3001 aaatgtgagc cacttaataa aggttcatat gttcatatta ataaatatgt tttctgttga
     3061 gtctgtaaag acaaactgac aattcattta agtcatttga taatgattct ctgctggtat
     3121 atctatttag tgtggtattg tagtgcaaat gtacgtaatt caaatctagt aaatatttaa
     3181 gttcctcaca ctgtgcaggc tttttttttt ttttcttttt ttcttttttt tgatacggag
     3241 tttcattctg tcaccaggct ggagttcagt ggtgcgatct cggctcactg caacctctgc
     3301 ctctcgggtt caagtgatta ttctcctgcc tcagcctcct gagtagctgg gactacaggc
     3361 acgcaccaca acacccagct aatttttgta tttttagtag agatggggtt tcatcatgtt
     3421 ggccaggatg gtcttgatct cttgaccttg tgatccgccc accttggcct cccaaagtgc
     3481 tgggattgca ggggtgagcc acagcgccca gcctatgcag gcatttttaa caaccaagac
     3541 tcagttaaga aagtgtgcat ctgcgtgtgt gtgaatgtgt atatatatgt atatatatat
     3601 catattttgc ataattttct taaattgctg aataagatca atatgtgaaa ttccttagcc
     3661 cttctcccca aaatacattg aaaaaagttt tatattaaac tattaagaaa gcagtttagg
     3721 taatagaaac agttttagaa agttgggaga aacaaggtat gttaatgata acaaaggctt
     3781 ctaactaata gttacgtggc cagattacat agcctaccat agattttttt tattgtgtat
     3841 gggatgataa gaagtttaga gaattttctt actagtaagt acctttacta agtaatagct
     3901 aagtataaaa tctttagtta cagaaagctt gtgagcaatt aaaatccttt tacatttttc
     3961 ttgcagaatg ggagaaaaat atggcaaata caaaactgta aaataagggc aatgacaatg
     4021 actcaactgc catatagaga tataattaac aaaatacttt gtggtacctc ttatctctca
     4081 ggatctcctc cctaccctag caaggcaaac aacttggagt acttcctttt cgaaagaagt
     4141 tctagaaatt aaattgaggt aggagacgga ttgacagtgc ctaactaaag atgagtaaaa
     4201 cagacctctt taatgataga ctcactattt gacactgctt ctactattgt aattaaaaat
     4261 cagaagtctt tgatgtatgc gttgctgtaa gaaactctgc tcattgcaaa tctattttgt
     4321 ttgtttttgg tattattctg ggcacatact ttggttgatg actttcaatt ggggttcttt
     4381 gtgctgcctt ttgggttact gttggtattt ccatttctgg cttaatttat ggtaaccatc
     4441 aaaactgctt atatttctgg ttagggcgaa gccatttagg aagaagcatt tcaccagaac
     4501 aagtaaaagt taattgcagc aatgatgtca gttttggccc ctagtttaat aaaaggatag
     4561 gcaaatatca taggaaatct tcatggtttg taggaaatca gtgtttgcaa cgtaggaagt
     4621 ttcatgggat agggaaggta taaatcaaga tagtaagggt tttgttttat atgtcattgt
     4681 cttaccatgc tccccaccta tttaatcttc tgttttaagc taaatttatg gatttgcacc
     4741 tacctttttg agtggcagaa gttcttaaca aaccagtatt gagaaataag aagggatgta
     4801 gttaaaatgg ttttctgttt ctctttaaag ttgaagaatg atatatttaa caagagttgt
     4861 gttttatttc cagttttcca gtagcatata tgtagatgca ttgaggtcat actgtgagaa
     4921 aatgtcttta gggtatccct ccaaaatagg agccttaaac tttttaactt aaaggaaggc
     4981 atatctaaaa accatagtgg ttgcttttag gtatagtttc ctatataacc tatagtcaga
     5041 cttatctata atatgaaaat ttaattgttt taaaaatgca tacatcggcc gggtgcagtg
     5101 gctcacgcct gtaatcccag cacttaggga ggccgaggcg ggcggatcac gaggtcagaa
     5161 gtttgagacc agtctggcca acatggtgaa accccgtctc tactaaaaat acaaaaaaat
     5221 tagttgggcg tggtggcgtg cgcctgtaat cccagctact tgggaggctg aggcagggga
     5281 attgcttgaa cccgggagga gaaggttgca gtgagccgag atcgccccac tgccctccag
     5341 cctgggcgac agtctcaaaa aaaaaaaaaa aaaaaagcat acatctctga aggtaaagta
     5401 taaatcagtg ggctcaagat ttgcaggtac agccttgtta atgccttcaa taatgcttac
     5461 gttccttgtc ttatgggtta taattttcac atcctcttca gatacaatct gagaacttgt
     5521 tgactacctt tgttacatgc aaaaattttc tattttaata ttgcattata ttaatggttt
     5581 catagtacat tccagttctt tatctgaata caagcgtttt gcttttattt ccagtttctt
     5641 ggaccagaac aataaaatac ataagacatc gtttctatat ggtcatatac tatatagaat
     5701 aaagaattgt tatgtaaatt attaaatgag tatacagacc tttacataaa aactaaggta
     5761 cctcagtgga atctgctaca gtgcttcccc ctccctaccc ctccattttg tttataacct
     5821 tttagctatc taaataatac gtattccata ctcaggatag ctggttagct agcaaaagaa
     5881 ttaacatttg tgatatttac ttgcaaactt tactgaagcc atattcatta tcttccttgt
     5941 caccaaggct gttgacctta aataaacatt aagttgattt tgcacaacac tgtatttgtg
     6001 tgtgtgcatg tgcctgtttt tgtgtgtgta tgtttgtggg aaataattat gtttgtttcc
     6061 gcatatattc atttttaatg cattctgtaa cttttctcga gtggtggtca ttgagggtag
     6121 ggaagatttt attttttaag ttgtcgttaa ggtatttcat tagtgttcct gagtgtaaaa
     6181 cagttttttc ccaaatactt atggcagata agagcatttt tgtaaataat aaactagcac
     6241 cgtttgggta aatttgcatt attttttgga caggttcatt gtcatgtaaa acaaatatct
     6301 caaaattcat tttacattta gcaaaggtgc aacatttgtt tttggagttt gagagatatt
     6361 ttccttgtct tccatcattc aataaatact aaaattgata accaca
//
