LOCUS       NM_018364               6621 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens round spermatid basic protein 1 (RSBN1), transcript
            variant 1, mRNA.
ACCESSION   NM_018364
VERSION     NM_018364.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6621)
  AUTHORS   Brejc,K., Bian,Q., Uzawa,S., Wheeler,B.S., Anderson,E.C.,
            King,D.S., Kranzusch,P.J., Preston,C.G. and Meyer,B.J.
  TITLE     Dynamic Control of X Chromosome Conformation and Repression by a
            Histone H4K20 Demethylase
  JOURNAL   Cell 171 (1), 85-102 (2017)
   PUBMED   28867287
REFERENCE   2  (bases 1 to 6621)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 6621)
  AUTHORS   Eriksson,N., Tung,J.Y., Kiefer,A.K., Hinds,D.A., Francke,U.,
            Mountain,J.L. and Do,C.B.
  TITLE     Novel associations for hypothyroidism include known autoimmune risk
            loci
  JOURNAL   PLoS One 7 (4), e34442 (2012)
   PUBMED   22493691
REFERENCE   4  (bases 1 to 6621)
  AUTHORS   Prahalad,S., Hansen,S., Whiting,A., Guthery,S.L., Clifford,B.,
            McNally,B., Zeft,A.S., Bohnsack,J.F. and Jorde,L.B.
  TITLE     Variants in TNFAIP3, STAT4, and C12orf30 loci associated with
            multiple autoimmune diseases are also associated with juvenile
            idiopathic arthritis
  JOURNAL   Arthritis Rheum 60 (7), 2124-2130 (2009)
   PUBMED   19565500
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 6621)
  AUTHORS   Smyth,D.J., Cooper,J.D., Howson,J.M., Walker,N.M., Plagnol,V.,
            Stevens,H., Clayton,D.G. and Todd,J.A.
  TITLE     PTPN22 Trp620 explains the association of chromosome 1p13 with type
            1 diabetes and shows a statistical interaction with HLA class II
            genotypes
  JOURNAL   Diabetes 57 (6), 1730-1737 (2008)
   PUBMED   18305142
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 6621)
  AUTHORS   Takahashi,T., Tanaka,H., Iguchi,N., Kitamura,K., Chen,Y.,
            Maekawa,M., Nishimura,H., Ohta,H., Miyagawa,Y., Matsumiya,K.,
            Okuyama,A. and Nishimune,Y.
  TITLE     Rosbin: a novel homeobox-like protein gene expressed exclusively in
            round spermatids
  JOURNAL   Biol Reprod 70 (5), 1485-1492 (2004)
   PUBMED   14724137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL137856.24 and AL365321.16.
            
            On Jul 17, 2020 this sequence version replaced NM_018364.4.
            
            Transcript Variant: This variant (1) is the protein-coding
            transcript.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292552.1, AK002082.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261441.9/ ENSP00000261441.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-767               AL137856.24        18797-19563         c
            768-1441            AL137856.24        4450-5123           c
            1442-1579           AL365321.16        23650-23787         c
            1580-1722           AL365321.16        23189-23331         c
            1723-1890           AL365321.16        14201-14368         c
            1891-1999           AL365321.16        13078-13186         c
            2000-6621           AL365321.16        7811-12432          c
FEATURES             Location/Qualifiers
     source          1..6621
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..6621
                     /gene="RSBN1"
                     /gene_synonym="KDM9; ROSBIN"
                     /note="round spermatid basic protein 1"
                     /db_xref="GeneID:54665"
                     /db_xref="HGNC:HGNC:25642"
                     /db_xref="MIM:615858"
     exon            1..767
                     /gene="RSBN1"
                     /gene_synonym="KDM9; ROSBIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..2473
                     /gene="RSBN1"
                     /gene_synonym="KDM9; ROSBIN"
                     /codon_start=1
                     /product="lysine-specific demethylase 9"
                     /protein_id="NP_060834.2"
                     /db_xref="CCDS:CCDS862.1"
                     /db_xref="GeneID:54665"
                     /db_xref="HGNC:HGNC:25642"
                     /db_xref="MIM:615858"
                     /translation="MFISGRRTADKWRAEERLQCPAGSARAALARCADGGAVGPFKCV
                     FVGEMAAQVGAVRVVRAVAAQEEPDKEGKEKPHAGVSPRGVKRQRRSSSGGSQEKRGR
                     PSQEPPLAPPHRRRRSRQHPGPLPPTNAAPTVPGPVEPLLLPPPPPPSLAPAGPAVAA
                     PLPAPSTSALFTFSPLTVSAAGPKHKGHKERHKHHHHRGPDGDPSSCGTDLKHKDKQE
                     NGERTGGVPLIKAPKRETPDENGKTQRADDFVLKKIKKKKKKKHREDMRGRRLKMYNK
                     EVQTVCAGLTRISKEILTQGQINSTSGLNKESFRYLKDEQLCRLNLGMQEYRVPQGVQ
                     TPFMTHQEHSIRRNFLKTGTKFSNFIHEEHQSNGGALVLHAYMDELSFLSPMEMERFS
                     EEFLALTFSENEKNAAYYALAIVHGAAAYLPDFLDYFAFNFPNTPVKMEILGKKDIET
                     TTISNFHTQVNRTYCCGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKMTL
                     PWGTLSSLRLQCRSQSDDGPIMWVRPGEQMIPTADMPKSPFKRRRSMNEIKNLQYLPR
                     TSEPREVLFEDRTRAHADHVGQGFDWQSTAAVGVLKAVQFGEWSDQPRITKDVICFHA
                     EDFTDVVQRLQLDLHEPPVSQCVQWVDEAKLNQMRREGIRYARIQLCDNDIYFIPRNV
                     IHQFKTVSAVCSLAWHIRLKQYHPVVEATQNTESNSNMDCGLTGKRELEVDSQCVRIK
                     TESEEACTEIQLLTTASSSFPPASELNLQQDQKTQPIPVLKVESRLDSDQQHNLQEHS
                     TTSV"
     exon            768..1441
                     /gene="RSBN1"
                     /gene_synonym="KDM9; ROSBIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1579
                     /gene="RSBN1"
                     /gene_synonym="KDM9; ROSBIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1722
                     /gene="RSBN1"
                     /gene_synonym="KDM9; ROSBIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1890
                     /gene="RSBN1"
                     /gene_synonym="KDM9; ROSBIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1999
                     /gene="RSBN1"
                     /gene_synonym="KDM9; ROSBIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..6621
                     /gene="RSBN1"
                     /gene_synonym="KDM9; ROSBIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6595..6600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RSBN1"
                     /gene_synonym="KDM9; ROSBIN"
                     /note="hexamer: AATAAA"
     polyA_site      6621
                     /gene="RSBN1"
                     /gene_synonym="KDM9; ROSBIN"
                     /note="major polyA site"
ORIGIN      
        1 gctttacaat agaagctcgg ttggagaggc ctgcggagaa aagctgggaa cggccgcttc
       61 cggcatgttc atctctggac gaagaacggc cgacaagtgg agggcggagg agagactcca
      121 atgcccagcg ggcagtgcgc gggcggcgct tgcgcgatgc gcggacgggg gggcggtcgg
      181 gccatttaaa tgtgtgtttg tgggtgaaat ggctgcgcag gtcggagcgg tgcgcgtagt
      241 acgggcggtg gcggcgcagg aggagccgga caaagagggg aaggagaaac ctcatgctgg
      301 ggtctccccg cggggagtta aacggcagcg ccgatctagc agtggggggt ctcaggagaa
      361 gcgggggcgg ccgagccagg agccccctct cgctccccct caccggcggc gtcgcagccg
      421 ccaacatcct gggccgctgc cgccaacgaa tgcagcccca actgtcccag gccctgttga
      481 gcctcttctc ctgccgcctc cgccgccacc ttcgctggca cccgccgggc ccgctgtcgc
      541 tgcccctctc ccggccccaa gcacctcggc cctcttcacc ttctcgcctc tgacggtgag
      601 cgcggccggg cccaagcata agggccacaa ggagcggcac aagcaccatc accaccgcgg
      661 ccccgatggt gatcccagct cctgcggaac cgatctcaag cacaaggaca agcaggaaaa
      721 cggcgagagg actggagggg tgcctctgat caaagccccc aagagagaaa caccagatga
      781 aaatggtaaa acccagagag ccgatgattt tgtcttgaag aaaataaaga agaaaaagaa
      841 aaagaaacac cgagaagaca tgcgaggaag acgccttaaa atgtacaata aggaagtaca
      901 aaccgtctgt gctggcctga cccgcatcag taaagaaatt ctcacccaag gacaaataaa
      961 tagcacttca ggacttaata aggagtcctt caggtatctg aaagatgaac agctgtgccg
     1021 attaaatttg ggtatgcaag aatatcgggt accccaggga gtacaaacac cttttatgac
     1081 tcaccaggaa cattctattc gtagaaattt cttaaaaaca ggtactaaat ttagcaactt
     1141 tattcatgag gaacaccagt ccaatggtgg tgctcttgtc cttcatgctt acatggatga
     1201 actctcattt ttgtctccaa tggagatgga gagattttct gaggagtttc ttgctttgac
     1261 attcagtgaa aatgagaaaa atgctgctta ctatgcttta gcaatagtgc atggagcggc
     1321 tgcttatctc ccagacttct tggactactt tgcttttaat ttccccaaca ctccagtgaa
     1381 aatggaaatt ctgggcaaga aagatattga aacaaccacc atttcaaatt ttcacactca
     1441 ggtcaacagg acatactgct gtggcaccta ccgagcaggt cctatgcggc agataagtct
     1501 cgttggagca gtagatgaag aagttggtga ttatttccca gagttccttg atatgttaga
     1561 agaatcacca tttctgaaaa tgactttgcc ctggggtaca ctttctagcc tccgactcca
     1621 gtgtaggtcc cagagtgatg atgggcctat aatgtgggta aggccaggag aacagatgat
     1681 ccctacagca gatatgccaa agtcaccctt caaaagacga cgatcaatga atgaaataaa
     1741 aaatctccag tacctacctc ggaccagtga accccgcgaa gttctctttg aagataggac
     1801 tagagctcat gctgatcatg tcggtcaggg gtttgactgg cagagtacgg ctgctgttgg
     1861 agttttgaaa gctgtacaat ttggtgaatg gagtgaccaa cctcgcataa ccaaagatgt
     1921 gatttgtttt catgctgagg attttactga tgttgtacaa agacttcagt tagatcttca
     1981 tgaacctcca gtttcccagt gcgtacagtg ggtagatgaa gctaaactaa accaaatgag
     2041 gcgggaaggc attcgttatg ctagaattca gctttgcgac aatgatatct acttcatccc
     2101 tagaaatgtc attcatcagt tcaaaacagt ttcggcggtg tgcagcttag cctggcatat
     2161 aaggcttaaa cagtaccacc ctgttgtgga agccactcaa aacacagaaa gcaattctaa
     2221 catggactgt ggtttaactg gaaagcgaga attagaagtt gactcccaat gtgtgaggat
     2281 aaaaactgaa tctgaagaag catgcacaga gattcagctg ttaacaactg cttcatcatc
     2341 tttcccacct gcatcagaac ttaatctaca gcaagatcag aagactcagc ctattccagt
     2401 tttaaaagtg gaaagtagac tggactctga ccagcaacac aatctgcaag aacattcaac
     2461 cacttctgtg tgatatgtac atattcaaac acatttttta acttttttaa attttgatgt
     2521 gaagttatag ttttataact ggcttaagtt aagttttatt ggagaaatct tgcctataat
     2581 tctataaaga gaaatgacat tccacaaatg tcaagcatat cttttttaca cagattatgc
     2641 aaagttaaga gttgtatctt atcccgttag tacagtatgt aatagtgggt ctgctgctac
     2701 tttctgtttt aaggtgtgag gtaacaattc aatctcttct tcaaatcaaa atgagaattc
     2761 tctggaataa cagattcttg tttggtaaat tattcacttc ccttaatttt atcttgcctt
     2821 gtctcttgcc atatttgctg tttttatgga taaataagat ttatggttta gtacttgtgt
     2881 ctttatggca caggttcaat ttctacagtg aaaatggcat aggttgcagg aaagaatttc
     2941 tgcatctggt acatgggcaa gtaagttatt tagttctaac cacaaataac aagtagtttc
     3001 caaggaaatt tcagtggctc tctggtttct taacaaaaga gaaagcacag cactttctga
     3061 tccaaactgt cttttttttg tatctgttat ttaaagccca gtggatattt caattaaaaa
     3121 aaaaatctaa agatgaatag tccttggtca ttcattatcc atggctcatt aatctcttct
     3181 agaatatatg ctaactgttg aagatatttt gggtaaaaga gataatgttg acatgatact
     3241 ctattgttct gcttcctggc atcctcacat tttgtgggga taattttgct tcctaaactg
     3301 atcacaacta ttaaacttag agaataataa tagtctttct gatgaggctg ccatattttg
     3361 agcatcaatc ttatgataaa ctattcttgt cacttggcat caacctcttc atgataaata
     3421 tctactactg agacacttca attcacagtt ttaactggtg aatacctggg tttatttact
     3481 attactctgt gttgctattt tctaagaaag aatacagcac tagacttcat cctagagttt
     3541 caggtaggct aatgcttagt gcctgagtat ttaaattttc ttttcaaaca ggcacagttc
     3601 acattgctag tatggtccta actttctgtt attttagaat gttaacatga ttcacattat
     3661 actttctctt agttaataat acagtaggcc ttttgtttat taatggaaga gtactcccca
     3721 cacctaagac cagattctta tatctccctg gttacagtgc aatttggaga tttttttttt
     3781 ttcctggatg gtaagatttg aaatatttac attaacatag gcaaaaaaaa aaaaaaatac
     3841 aagatgctgc tttattatgt ctgtcaccat gaaaacttag ctgcatcttt tgaaatatca
     3901 aatatgaatt ttctctaaaa tattctgaaa taggttaaat cttatataaa tattactttg
     3961 tgcaatattg ttgtgtagtt aaatgcatat tagcaaagta tagaggtcac tgtgtaaacc
     4021 gatagaaaag taaccatcag caaatactgc agtgattagt tagaatctgt attattcctt
     4081 atatatatgt atatgtatgt attctctgtt acaaaggatg aagacaaata gggatacatt
     4141 tcaatgtaaa ccatttatga attggaagtg atgttggctt tagttatctt tgtaaataag
     4201 gtaattagaa tggtatgaaa ggtaatgtga ttattgcagg ggtgttttta aatcttgggt
     4261 ataaattcta gggtaaattc cagtttatcc agactagttt ttaacgggac ctgcctttga
     4321 gggtgttttt tgttattttg ttggggaggg gtttaatcac aaagtgtgtg ggtttgggtt
     4381 atttcttgtt tttatttttc tgtccagaag agctttacca ggctgtgcaa agtaaaattc
     4441 ttctcaggca acatttgctt ttaaaaataa tcatgaagag aaggctgtta aagcaaaaat
     4501 tttttttttt taattttttc ttgtcttcca agatccgatt tccccatctc ccacttgcca
     4561 tccagcagat gccatctgtc atccaagctg gtcattgcta ataaacaagg agactgtctc
     4621 ctgacagcca gcactgtgta ttatcactca ggaaccagcg gatctgcaaa gacctacaat
     4681 caaaagcaaa tccccatttt ccttttataa aacattctac cctcacctcc aatataaaca
     4741 cattaaaaga gtacaataaa aatgtttaaa atcatgtact aataaattca ttgtatgtta
     4801 gaattgcaat agaatgaaga gaaacattta gctagtaacg tgatctgaaa actgaatgtc
     4861 ctatgtgagt attagatttt aatagcatgc tttaaagact gatgagtata aaagcagaag
     4921 ttttgcgttt tttactgctt tcaaagctgt atcctagttt agtgatacaa atgattgcaa
     4981 tttttctaaa tcattaaatt atttggtttg gtggagtgag gcatggagca atctggcgtc
     5041 ttctgatttg ttaaagtagt gatggcagtg aagttgtaac tgaaatttaa gctgatcttc
     5101 ctttttggta tattatccgt tgtgccagct cttgagatta cttgcacaat gtggctataa
     5161 gttttaatat tttgtggagc agagggatgg tttttaaatg tgcttatgga aaggacccaa
     5221 taaatgaata ttcctaactt agtaaagtag aataatttca tggtattcat taaaaagcat
     5281 aaaagtcttc ctcttgcccc agaagtaatt ctctatacca agatatgcta ggagtaggat
     5341 gatgattcaa agtggtaacc caaattcata aagcaataat aataaaaacc tatatagtat
     5401 gttctctcct ccaaagtttt aactctaaaa attggttcct aggtttaatt gtacctttaa
     5461 tttgcttatt cagtacttag aatttgttta actggtactt ttattatttt ttagtgaaag
     5521 acttttgaaa agtgcccttt ccccttaaga gacagttgga ataccagttg actaatatta
     5581 caagctcttg tagggggaaa aaggagctta ttaaagttgt ttactaaact ttaggaaaag
     5641 atgtcttgca tcagtcttac taggcataaa agtcacactt aatgactgga aaaaacttgc
     5701 ttattgcctt tccctatata aatattaatt gtctagaatg aaagctaata taggaacaag
     5761 actcccaaat ccatgaaaac gcttagtgaa tatattctta atcattaata aattagccca
     5821 ttatattttc atctgtattt gccataaaaa atttatttgc atttatgcct ttaggataat
     5881 tttgtatctt tctaatctgt tttatcattg ctacaggttt ttaaaaaaga acctttcact
     5941 agctagcaca tgccagaggt tcacatctgt tttgtttttc aaacaggtcg tagctgtatt
     6001 tattggccat gcaagtagag gaaatgcaca gtacaaatgt ttttctttag cacgtaaggg
     6061 acctatcctt gtcttgaaag tttgttgctt taaaagcaag tatctctcca taaatattat
     6121 ggccttccat tttcttcata cattttttag gatccacttg tgcatgtagt tgagaccact
     6181 gtctcttaaa atatagcact tttcaattct ctctaaagaa atacttatgt actactatca
     6241 catgttgtaa attttcatgt aatagtgttt tctgtgagta aactccattt tgattggcag
     6301 ctaagacttt ttttcctgtg gcttttattt atctaagagg tctttgcata tagatgaaat
     6361 gtatatttgc ctggcggact atttgcgttg tgtggcctta gtttgtttat tgacattaac
     6421 gagtgtttta aaaaggtttt taatgaatag tcttaaatct aaatttgtgt gaataatcct
     6481 tttaacacag tgcttttttg tagctgtcta agtgtgttaa attgttaagc tatttctttg
     6541 taaaatagga caatggaatg catagttttt ttttttcctg taaagtattt ttttaataaa
     6601 aaaagtctga tttgtccttt a
//
