LOCUS       NM_015169               1720 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ribosome biogenesis regulator 1 homolog (RRS1), mRNA.
ACCESSION   NM_015169
VERSION     NM_015169.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1720)
  AUTHORS   He,J., Liu,S., Luo,S., Fu,J., Liao,Z., Song,J., Guo,J. and Hua,Y.
  TITLE     The role of RRS1 in breast cancer cells metastasis and
            AEG-1/AKT/c-Myc signaling pathway
  JOURNAL   Neoplasma 71 (4), 347-358 (2024)
   PUBMED   39267538
  REMARK    GeneRIF: The role of RRS1 in breast cancer cells metastasis and
            AEG-1/AKT/c-Myc signaling pathway.
REFERENCE   2  (bases 1 to 1720)
  AUTHORS   Deng,L., Wang,J., Song,J., Wu,Q., Gong,Z., Song,J. and Hou,L.
  TITLE     Long noncoding RNA SNHG1 promotes breast cancer progression by
            regulating the miR-641/RRS1 axis
  JOURNAL   Sci Rep 14 (1), 3265 (2024)
   PUBMED   38331968
  REMARK    GeneRIF: Long noncoding RNA SNHG1 promotes breast cancer
            progression by regulating the miR-641/RRS1 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1720)
  AUTHORS   Zhang,X., Cong,P., Tian,L., Zheng,Y., Zhang,H., Liu,Q., Wu,T.,
            Zhang,Q., Wu,H., Huang,X. and Xiong,L.
  TITLE     Genomic gain/methylation modification/hsa-miR-132-3p increases RRS1
            overexpression in liver hepatocellular carcinoma
  JOURNAL   Cancer Sci 114 (11), 4329-4342 (2023)
   PUBMED   37705317
  REMARK    GeneRIF: Genomic gain/methylation modification/hsa-miR-132-3p
            increases RRS1 overexpression in liver hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 1720)
  AUTHORS   Cao,P., Yang,A., Li,P., Xia,X., Han,Y., Zhou,G., Wang,R., Yang,F.,
            Li,Y., Zhang,Y., Cui,Y., Ji,H., Lu,L., He,F. and Zhou,G.
  TITLE     Genomic gain of RRS1 promotes hepatocellular carcinoma through
            reducing the RPL11-MDM2-p53 signaling
  JOURNAL   Sci Adv 7 (35) (2021)
   PUBMED   34433556
  REMARK    GeneRIF: Genomic gain of RRS1 promotes hepatocellular carcinoma
            through reducing the RPL11-MDM2-p53 signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1720)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1720)
  AUTHORS   Gambe,A.E., Matsunaga,S., Takata,H., Ono-Maniwa,R., Baba,A.,
            Uchiyama,S. and Fukui,K.
  TITLE     A nucleolar protein RRS1 contributes to chromosome congression
  JOURNAL   FEBS Lett 583 (12), 1951-1956 (2009)
   PUBMED   19465021
  REMARK    GeneRIF: RNA interference experiments revealed that RRS1-depleted
            cells show abnormalities in chromosome alignment and spindle
            organization, which result in mitotic delay.
REFERENCE   7  (bases 1 to 1720)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   8  (bases 1 to 1720)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   9  (bases 1 to 1720)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   10 (bases 1 to 1720)
  AUTHORS   Tsuno,A., Miyoshi,K., Tsujii,R., Miyakawa,T. and Mizuta,K.
  TITLE     RRS1, a conserved essential gene, encodes a novel regulatory
            protein required for ribosome biogenesis in Saccharomyces
            cerevisiae
  JOURNAL   Mol Cell Biol 20 (6), 2066-2074 (2000)
   PUBMED   10688653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009879.8, D25218.1 and BC001811.2.
            
            On Nov 23, 2018 this sequence version replaced NM_015169.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC001811.2, SRR7346977.226327.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320270.4/ ENSP00000322396.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC009879.8         96844-96857         c
            15-1620             D25218.1           1-1606
            1621-1720           BC001811.2         1592-1691
FEATURES             Location/Qualifiers
     source          1..1720
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.1"
     gene            1..1720
                     /gene="RRS1"
                     /note="ribosome biogenesis regulator 1 homolog"
                     /db_xref="GeneID:23212"
                     /db_xref="HGNC:HGNC:17083"
                     /db_xref="MIM:618311"
     exon            1..1720
                     /gene="RRS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1216
                     /gene="RRS1"
                     /note="homolog of yeast ribosome biogenesis regulatory
                     protein RRS1; RRS1 ribosome biogenesis regulator homolog;
                     ribosome biogenesis regulatory protein RRS1 homolog"
                     /codon_start=1
                     /product="ribosome biogenesis regulatory protein homolog"
                     /protein_id="NP_055984.1"
                     /db_xref="CCDS:CCDS6189.1"
                     /db_xref="GeneID:23212"
                     /db_xref="HGNC:HGNC:17083"
                     /db_xref="MIM:618311"
                     /translation="MEGQSVEELLAKAEQDEAEKLQRITVHKELELQFDLGNLLASDR
                     NPPTGLRCAGPTPEAELQALARDNTQLLINQLWQLPTERVEEAIVARLPEPTTRLPRE
                     KPLPRPRPLTRWQQFARLKGIRPKKKTNLVWDEVSGQWRRRWGYQRARDDTKEWLIEV
                     PGNADPLEDQFAKRIQAKKERVAKNELNRLRNLARAHKMQLPSAAGLHPTGHQSKEEL
                     GRAMQVAKVSTASVGRFQERLPKEKVPRGSGKKRKFQPLFGDFAAEKKNQLELLRVMN
                     SKKPQLDVTRATNKQMREEDQEEAAKRRKMSQKGKRKGGRQGPGGKRKGGPPSQGGKR
                     KGGLGGKMNSGPPGLGGKRKGGQRPGGKRRK"
     regulatory      1689..1694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRS1"
                     /note="hexamer: AATAAA"
     polyA_site      1720
                     /gene="RRS1"
                     /note="major polyA site"
ORIGIN      
        1 cttttccgga ttgggcatcc cggcatctgc acgtggttat gctgccggag tttgggccgc
       61 cactgtagga aaagtaactt cagctgcagc cccaaagcga gtgagccgag ccggagccat
      121 ggagggccag agcgtggagg agctgctcgc aaaggcagag caggacgagg cagagaagtt
      181 gcaacgcatc acggtgcaca aggagctgga gctgcagttt gacctgggca acctgctggc
      241 gtcggaccgg aaccccccga ccgggctgcg gtgcgccgga cccacgccgg aggccgagct
      301 acaggccctg gcgcgggaca acacgcaact gctcatcaac cagctgtggc agctgcccac
      361 ggagcgcgtg gaagaggcga tagtggcgcg gctgccggag cccaccacac gcctgccgcg
      421 agagaagcct ctgccccgac cgcggccact tacacgctgg cagcagttcg cgcgcctcaa
      481 gggcatccgt cccaagaaga agaccaacct ggtgtgggac gaggtgagtg gccagtggcg
      541 gcggcgctgg ggctaccagc gcgcccggga cgacaccaaa gaatggctga ttgaggtgcc
      601 cggcaatgcc gaccccttgg aggaccagtt cgccaagcgg attcaggcca agaaggaaag
      661 ggtggccaag aacgagctga accggctgcg taacctggcc cgcgcgcaca agatgcagct
      721 gcccagcgcg gccggcttgc accctaccgg acaccagagt aaggaggagc tgggccgcgc
      781 catgcaagtg gccaaggtct ccaccgcctc tgtggggcgc tttcaggagc gcctccccaa
      841 ggagaaggtg ccccggggct ccggcaagaa aaggaagttt caaccccttt tcggggactt
      901 tgcagccgag aaaaagaacc agttggagct gcttcgtgtc atgaacagca agaagcctca
      961 gctggatgtg actagggcca ccaataagca gatgagggag gaggaccagg aggaggccgc
     1021 caagaggagg aaaatgagcc agaagggcaa gagaaaggga ggccggcagg ggcctggggg
     1081 caagaggaaa gggggcccgc ccagccaggg agggaagagg aaagggggct tgggaggcaa
     1141 gatgaattct gggccgcctg gcttgggtgg caagagaaaa ggaggacagc gcccaggagg
     1201 aaagaggagg aagtaatagt ttctaactgt cggacccgtc tgtaaaccaa ggactatgaa
     1261 tactaaatgt taagttctag gcaattatac ggggactcag aaggacctgg ccgctgcctt
     1321 cattgagttt aaagggacag gattgccctt ccgtcaagaa agtatgtaag tgttggactg
     1381 cacaaattaa tgtttttccc acaaccgaga ctttggagat taagaactta tttgaggatt
     1441 taagaattag ggaaataatt tggtggaaac cgggaatgag ttctattctt aaacagcctt
     1501 tttttttctt tttaatgttg gatatacggc gaggtagagt tggccatatt tcagagactt
     1561 agattgacgt atatgtttct gcattatttt tacaacaagt ttgtgtatca gagcgggagt
     1621 gcgggggagg gaaagaaaac aaacagtttc agaattgaat aggcaagtga ctgttttaaa
     1681 gattaagtaa taaagatgtc ttatctagtg tgacttttaa
//
