LOCUS       NM_015324               6559 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal RNA processing 8 (RRP8), mRNA.
ACCESSION   NM_015324
VERSION     NM_015324.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6559)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6559)
  AUTHORS   Waku,T., Nakajima,Y., Yokoyama,W., Nomura,N., Kako,K.,
            Kobayashi,A., Shimizu,T. and Fukamizu,A.
  TITLE     NML-mediated rRNA base methylation links ribosomal subunit
            formation to cell proliferation in a p53-dependent manner
  JOURNAL   J Cell Sci 129 (12), 2382-2393 (2016)
   PUBMED   27149924
  REMARK    GeneRIF: NML depletion increases 60S ribosomal protein L11 (RPL11)
            levels in the ribosome-free fraction and protein levels of p53
            through an RPL11-MDM2 complex, which activates the p53 pathway.
REFERENCE   3  (bases 1 to 6559)
  AUTHORS   Onishi,S., Adnan,E., Ishizaki,J., Miyazaki,T., Tanaka,Y.,
            Matsumoto,T., Suemori,K., Shudou,M., Okura,T., Takeda,H.,
            Sawasaki,T., Yasukawa,M. and Hasegawa,H.
  TITLE     Novel Autoantigens Associated with Lupus Nephritis
  JOURNAL   PLoS One 10 (6), e0126564 (2015)
   PUBMED   26098692
  REMARK    GeneRIF: Among Systemic lupus erythematosus patients, 63.6% and
            45.5% of those with lupus nephritis were positive for anti-RRP8 and
            anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic
            lupus erythematosus patients without nephritis, respectively.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6559)
  AUTHORS   Yang,L., Song,T., Chen,L., Soliman,H. and Chen,J.
  TITLE     Nucleolar repression facilitates initiation and maintenance of
            senescence
  JOURNAL   Cell Cycle 14 (22), 3613-3623 (2015)
   PUBMED   26505814
  REMARK    GeneRIF: Breast tumors without detectable nucleolar NML expression
            had poor survival.
REFERENCE   5  (bases 1 to 6559)
  AUTHORS   Yang,L., Song,T., Chen,L., Kabra,N., Zheng,H., Koomen,J., Seto,E.
            and Chen,J.
  TITLE     Regulation of SirT1-nucleomethylin binding by rRNA coordinates
            ribosome biogenesis with nutrient availability
  JOURNAL   Mol Cell Biol 33 (19), 3835-3848 (2013)
   PUBMED   23897426
  REMARK    GeneRIF: Data indicate that the the nucleomethylin (NML)-SirT1
            interaction was competitively inhibited by rRNA.
REFERENCE   6  (bases 1 to 6559)
  AUTHORS   Murayama,A., Ohmori,K., Fujimura,A., Minami,H., Yasuzawa-Tanaka,K.,
            Kuroda,T., Oie,S., Daitoku,H., Okuwaki,M., Nagata,K., Fukamizu,A.,
            Kimura,K., Shimizu,T. and Yanagisawa,J.
  TITLE     Epigenetic control of rDNA loci in response to intracellular energy
            status
  JOURNAL   Cell 133 (4), 627-639 (2008)
   PUBMED   18485871
REFERENCE   7  (bases 1 to 6559)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 6559)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   9  (bases 1 to 6559)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   10 (bases 1 to 6559)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX417992.2, BC001071.2, AB007869.1, R51624.1 and AC009796.6.
            
            On Nov 22, 2018 this sequence version replaced NM_015324.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB007869.1, SRR1803612.183196.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254605.11/ ENSP00000254605.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BX417992.2         35-69
            36-695              BC001071.2         1-660
            696-1031            AB007869.1         606-941
            1032-1697           BC001071.2         997-1662
            1698-1717           R51624.1           12-31               c
            1718-6559           AC009796.6         138910-143751       c
FEATURES             Location/Qualifiers
     source          1..6559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..6559
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
                     /note="ribosomal RNA processing 8"
                     /db_xref="GeneID:23378"
                     /db_xref="HGNC:HGNC:29030"
                     /db_xref="MIM:615818"
     exon            1..213
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1485
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
                     /note="RRP8 methyltransferase homolog; nucleomethylin;
                     cerebral protein 1; ribosomal RNA processing 8,
                     methyltransferase, homolog"
                     /codon_start=1
                     /product="ribosomal RNA-processing protein 8"
                     /protein_id="NP_056139.1"
                     /db_xref="CCDS:CCDS31411.1"
                     /db_xref="GeneID:23378"
                     /db_xref="HGNC:HGNC:29030"
                     /db_xref="MIM:615818"
                     /translation="MFEEPEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATL
                     RALEAASLSQHPPSLCISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPP
                     CSDSEEEVERKKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWK
                     GSTTNDPPKQSPGSTSPKPPHTLSRKQWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTE
                     KTEVSPVPRTDSHEARAGALRARMAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEA
                     FLLYHRGFQSQVKKWPLQPVDRIARDLRQRPASLVVADFGCGDCRLASSIRNPVHCFD
                     LASLDPRVTVCDMAQVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKPGGLLKVAE
                     VSSRFEDVRTFLRAVTKLGFKIVSKDLTNSHFFLFDFQKTGPPLVGPKAQLSGLQLQP
                     CLYKRR"
     exon            214..577
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
                     /inference="alignment:Splign:2.1.0"
     exon            578..1031
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1161
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1268
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1365
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..6559
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1688..1693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
                     /note="hexamer: AATAAA"
     polyA_site      1709
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
                     /note="major polyA site"
     regulatory      2356..2361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
                     /note="hexamer: AGTAAA"
     polyA_site      2377
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
     regulatory      4767..4772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
                     /note="hexamer: AATAAA"
     polyA_site      4789
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
     regulatory      5767..5772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
                     /note="hexamer: AATAAA"
     polyA_site      5794
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
     regulatory      6537..6542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
                     /note="hexamer: AATAAA"
     polyA_site      6559
                     /gene="RRP8"
                     /gene_synonym="KIAA0409; NML"
ORIGIN      
        1 gtcacgcttt ggtttccggg tcggttctgg caggtctgag cgctccgact tccagaggag
       61 cgctgtgcac gtggagaaga gcggggactc ggcgaccctg ccctcccgac cctcatgttc
      121 gaagagcctg agtgggccga ggcggcccca gtagccgcgg gccttgggcc cgtaatctca
      181 cgacctccgc ctgcggcctc ctcgcaaaac aagggctcca agcgccgcca gctcttggcc
      241 acattacggg ccctagaggc agcatctctt tcccagcatc cccccagcct atgtataagt
      301 gactctgagg aggaggagga ggaaaggaag aagaaatgcc ccaaaaaggc atcatttgcc
      361 agtgcctctg ctgaagtagg gaagaaaggg aagaagaaat gtcaaaaaca gggcccacct
      421 tgcagtgact ctgaggaaga agtagaaagg aagaagaaat gccacaaaca ggctcttgtt
      481 ggcagtgact ctgctgaaga tgagaaaaga aagaggaaat gccagaaaca tgcccctata
      541 aattcagccc agcacctgga caatgttgac caaacaggtc ccaaagcctg gaagggtagt
      601 actacaaatg atccaccaaa gcaaagccct gggtccactt cccctaaacc ccctcataca
      661 ttaagccgca agcagtggcg gaaccggcaa aagaacaaga gaagatgtaa gaacaagttt
      721 cagccacctc aggtgccaga ccaggcccca gctgaggccc ccacagagaa gacagaggtg
      781 tctcctgttc ccaggacaga cagccatgag gctcgggcag gggctttgcg agcccgcatg
      841 gcacagcggc tggatggggc ccgatttcgc tacctcaatg aacagttgta ctcagggccc
      901 agcagtgctg cacagcgtct cttccaggaa gaccctgagg cttttcttct ctaccaccgc
      961 ggcttccaga gccaagtgaa gaagtggcca ctgcagccag tggaccgcat cgccagggat
     1021 cttcgccagc ggcctgcatc cctagtggtg gctgacttcg gctgtgggga ttgccgcttg
     1081 gcttcaagta tccggaaccc tgtgcattgc tttgacttgg cttctctgga ccctagggtc
     1141 actgtgtgtg acatggccca ggttcctctg gaggatgagt ctgtggatgt ggctgtgttt
     1201 tgcctttcac tgatgggaac caacatcagg gacttcctag aggaggcaaa tagagtactg
     1261 aagccagggg gtctcctgaa agtggctgag gtcagcagcc gctttgagga tgttcgaacc
     1321 tttctgcggg ctgtgaccaa gctaggcttc aagattgtct ccaaggacct gaccaacagc
     1381 catttcttct tgtttgattt ccaaaagact gggccccctc tggtagggcc caaggctcag
     1441 ctttcaggcc tgcagcttca gccatgtctc tacaagcgca ggtgacctct ggatcttcct
     1501 tgaaagggga ggcagatctc aaactccagg ctcagaactg tgaagactgt ttccagcctg
     1561 gctgtgagcc aagacctggt tcctggtgga ccctgaggac aaagtgtgat aaaacctctg
     1621 gctcagactt gctctactga aggcttcttg gttataagat gcataaagtc actggggcta
     1681 gctaaacaat aaagagttta ttgtgagaac atggggatat ctgtctcatg acacttcagg
     1741 tgttatgaaa actagatggt ttggaattca aggcatcttt aggttttgct cttctttcca
     1801 actaagaagc cacatggcct tcctgtcctg ccatctccac tctgctgtca tctgatctgt
     1861 ctacagatca gcttcctctg ctcacccata gcttctgctc cttcagcttc agtttgccca
     1921 ggccttcaag gttgcagaca ggcagctgtt gctgtttgac tctgaggcaa ctggttgtcc
     1981 accaacatct tggctcaaga catcagtctg agccaccaac ttgagactgt ttggttgtcc
     2041 ccataccgag catttctagt ggtttatctt tcccctctcc cctcatctcc atttttggaa
     2101 ccatatagca tcaagccact cccaacacct attgtcctgt gggactttgg gatgtatata
     2161 gctgagagca cagattttgg aatcaggtag acctggattt aattcttggc ctgctaccca
     2221 gaggcactta aagtcattta atctctgtat atcacattcc tcatttggaa aatggtagaa
     2281 tttttgtctt gcagggtggt tgtgtgggtt aactggagaa atctgtagcc agggctggga
     2341 acataggagg tgctcagtaa actagctatg actattatgt gttgtaagcc ttattgtttt
     2401 ttgaagatct tccctaggct ggttggaggc tgaggggtaa agaatggatt tgttgactaa
     2461 ggaagcctct gggagaggct agacctttca acaggcctgc ttcataggct atttaatgac
     2521 ttttaataga ttctgagctt ctgtccttgg aggggtagtg agggagctgg gtctctgttc
     2581 ataaacaact tgttgatgcc atgtgggctt gggggcattg ggctgttcat tggcggaaga
     2641 gtctgtccac tatctctgcc ttgcagtgga ctcagatcag catgtcctgg gaaagctata
     2701 ggcaaggtgc tgagggaagg tgagtttgaa tgatagattc taggcctccc ccaaaaggta
     2761 tctgccatgt gcccaggtat aaagatatgg cctcttgtac ttgtttccag gaatacctga
     2821 cagtacccat tgggagatca taggttctat gccctgagcc agttggatgc ctctaataag
     2881 gggatggagg ttttgaaaca ggctgtagtc cagagggcat gtttggaggc tgggctgtga
     2941 atcattaggc aggcactaca cagtgcctct acacgtactg ttctttctgc tggatattca
     3001 tcggactggc agtttgctca tctttccgaa cagcctagtt gtttcctatt ctactcccaa
     3061 agcaaaatca gttcttcatc tgtactctca aagtactatg tgaagagtgc tacttcagct
     3121 tctaaatatt gcattgtgat tcctttgtgc atttggctgc tgttttctca agccatgttt
     3181 atctttgtat tcccggagct tgtcatttga gatatagcca gtgtacttat tcacctaggg
     3241 agagataagg aatgacaggg tccagttgag tgggatagat gagaacaggg gtgttataga
     3301 aacccaggta ctagggcaca agatgagggc actgttgact agtcatgatg gaagaagtag
     3361 gcagacagga gaacttcatt aggtagaatt ggtgggatgt tgaggttggt aagagaggaa
     3421 tctgaagtaa gttccaggtt gctcaactgt gggtaggctg gtgatgccat tcaaagtgtt
     3481 ggattttagg aagtgggaca tgcgtgaaat ctgtgctggg ggtctgggaa tcagcagcct
     3541 agaggtggta attaaagtca gaatagatga gatattcagg gtaagataat gagaagagaa
     3601 aatggctcag aatagaactg aggagcatgt catggatggg taaaggaaaa tgaagcagtg
     3661 aaggtgatgg aagaggagaa ggttcaccca gagatgtagg agtaaaacca ggagagttaa
     3721 tttttttttt tttttttttt taagacagag tcttgctctg tggcccaggc tggaatgcgg
     3781 tggcgtgatc tcaggtcact gaaacctctg cctgctggtt caagcacttc tcctgcctca
     3841 gactcccgag tagctgggaa tacaggcaca tgccaccacg cccagctaat ttttgtattt
     3901 ttagtagtga cggggtttca ccatgttggc caggctggtc tcgaactcct gacctcgagt
     3961 gatcggcctg cctcggcctc ccaaagtgct gggattacag gcatgagcca ctgtgcccag
     4021 ccagtgtttt tttttttttt ttttttatgg gaggatgggc aggttgttag ctgtcgagtg
     4081 ctattgagat gagagagaac tcagaatgca gtggggtaag gattgctgag taatgtggag
     4141 ggcctgtttg aggtaaatgg cagtggtaag aggttgctcc attatgaaag ccctcttcca
     4201 gagttcctga tagggcccca gaagttcatt tctgattgct ttgatttttt ttcaggggag
     4261 caggaagcca gtttatcatt tgagagtgag aataggggag aggaaatatc ttccaggccc
     4321 acagtgcata gaaataccca gtcagggcaa aatgatttat ctgtttacct ctcctcatca
     4381 cttgggccca gagcaatcag cagtgattag gtagagagga gccgagcaga gggaagagca
     4441 taccaatcac tcctcccttt cccagtgcag gctcctagac ttagctgggg cagagctggg
     4501 agaggaaaaa gggatttaaa actgcaacag gtgcagatta ttgttacaca ggattagaca
     4561 ttctaattaa ttgagattat gtttgttcct taaactgatc acaggactat ctattaagaa
     4621 catcacaacc tcgctgcagc ttttctccat agcagggaga gtacctccca gtgaataaaa
     4681 tttggagggt ggtaagagac aagaataaaa ttgggtttgg ttatccgtgc ctcatgcttg
     4741 ttcagcatcc ctttgagagt tctccaaata aatagttact gcttctgcag ttattggtgt
     4801 gctccagctt ctgttcccat aatatagtcc agtcctaagg gaacacagtt ctaaaagaaa
     4861 caacatgatc ttggcagaga caccgctcag ctccaaaccc aaccatttat gtaactgcac
     4921 aaaactctct acagcttttc acagagacca gtaattagaa cctttcatcc cctggtcatc
     4981 ctccttccca ggtgaattct ctgaccagcc atctggtttt aggataccca actcctgcag
     5041 taactgcctt actggtggtc taattgcttc tactcgtgtc cctaaagcaa ttaattttcc
     5101 acacagccat gtgatctttt taaaatgtaa atcagcttat gtcacttctc tgcttaaaat
     5161 ccttcaatgg attctcactg cctcgagaac aaaagacaaa cttttcaggc cccgtgtgat
     5221 cttgcccagg cctccgtcac catcaccatc tgcatcttaa cccactcctc ccctttcaca
     5281 aaactccagc cacacagact tgctttttat tcctcaagct ttccaaactg tttctactga
     5341 gagtctttgc acatgctcca tcttccttga atactctttc cccagtgagc tcattttcat
     5401 cttcctgaat tcataccact attacctttg cttctgtgga agaaactggc cagatgctca
     5461 cccaaatgtc ctctttctgg acacaggtaa actgcatttc ccagctccat gcatctaggc
     5521 ctatgtgagt agttctcaac agtggaaaat gagtggaagt gatgtttcaa tactagacca
     5581 aggcagttaa agggtggctg agccatttcc attattctct tcctccttcc tcttcaaggt
     5641 aaccttgaag cacatgtttt gacggtgatg gagtcatagc atagaagaag tctgaatacc
     5701 tgagttacta tttagggcat aatagctact tgaccaaaaa catccatatt ggactttgaa
     5761 caagaaaata aacttgatta cattctgcta gtgagttttg agggtgtttt agcagttatc
     5821 attatataca ctggatatat cttctatggt atcctgtcca ccttactctt gaccacagta
     5881 ccctctttgt ttccttcagg gtgtttcaga tatttaatta tcttgccaga tgccagtcaa
     5941 cactttcttt ttgtcccatg agtttaaaat caggggaaaa catgtactcc caataggaag
     6001 ttgagatact cttttttttt taaatccgtc attgtgactg tgaccggaaa aacaaatccc
     6061 actaaagaat gtcctaaaca gatgtttttt tttgtcatat aacctggagt taggtgattt
     6121 ggcattggtt ctggagctga aggatgttag ggatgaggtc tctgtagttt tcttgtctca
     6181 tggtcacgaa atgaagtgtt attgattaag cagggatgcc ctacttagta ttagacttct
     6241 tggaagtctc cttaattgcc acagccccta tctttttggc ttcgtttcaa gggtccttct
     6301 acattgttaa tactctggta taaatacgtt ccattattcc ctataacatg actgaaacca
     6361 atctaaagta ttaacatttt aaatatgttt ttgggccaag tgcagtggct cttatctgtg
     6421 atcccagcta ctaggaaggc tgaggtggga ggattgcttg agcccaggaa tttcaggctg
     6481 tagtgagcta tgattgtgcc actgtactcc ggcctggata actgagatcc tgtctcaata
     6541 aataaataaa acaattata
//
