LOCUS       NM_015703               5419 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal RNA processing 7 homolog A (RRP7A), mRNA.
ACCESSION   NM_015703 XM_936245
VERSION     NM_015703.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5419)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   2  (bases 1 to 5419)
  AUTHORS   Farooq,M., Lindbaek,L., Krogh,N., Doganli,C., Keller,C.,
            Monnich,M., Goncalves,A.B., Sakthivel,S., Mang,Y., Fatima,A.,
            Andersen,V.S., Hussain,M.S., Eiberg,H., Hansen,L., Kjaer,K.W.,
            Gopalakrishnan,J., Pedersen,L.B., Mollgard,K., Nielsen,H.,
            Baig,S.M., Tommerup,N., Christensen,S.T. and Larsen,L.A.
  TITLE     RRP7A links primary microcephaly to dysfunction of ribosome
            biogenesis, resorption of primary cilia, and neurogenesis
  JOURNAL   Nat Commun 11 (1), 5816 (2020)
   PUBMED   33199730
  REMARK    GeneRIF: RRP7A links primary microcephaly to dysfunction of
            ribosome biogenesis, resorption of primary cilia, and neurogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5419)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5419)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5419)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 5419)
  AUTHORS   Line,A., Stengrevics,A., Slucka,Z., Li,G., Jankevics,E. and
            Rees,R.C.
  TITLE     Serological identification and expression analysis of gastric
            cancer-associated genes
  JOURNAL   Br J Cancer 86 (11), 1824-1830 (2002)
   PUBMED   12087473
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC073834.1 and AL022316.2.
            
            On Nov 23, 2018 this sequence version replaced NM_015703.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC073834.1, SRR1803611.99604.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323013.7/ ENSP00000321449.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2581              BC073834.1         1-2581
            2582-5419           AL022316.2         137150-139987       c
FEATURES             Location/Qualifiers
     source          1..5419
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..5419
                     /gene="RRP7A"
                     /gene_synonym="BK126B4.3; CGI-96; MCPH28; Rrp7"
                     /note="ribosomal RNA processing 7 homolog A"
                     /db_xref="GeneID:27341"
                     /db_xref="HGNC:HGNC:24286"
                     /db_xref="MIM:619449"
     exon            1..83
                     /gene="RRP7A"
                     /gene_synonym="BK126B4.3; CGI-96; MCPH28; Rrp7"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..853
                     /gene="RRP7A"
                     /gene_synonym="BK126B4.3; CGI-96; MCPH28; Rrp7"
                     /note="gastric cancer antigen Zg14; CTA-126B4.5"
                     /codon_start=1
                     /product="ribosomal RNA-processing protein 7 homolog A"
                     /protein_id="NP_056518.2"
                     /db_xref="CCDS:CCDS14036.1"
                     /db_xref="GeneID:27341"
                     /db_xref="HGNC:HGNC:24286"
                     /db_xref="MIM:619449"
                     /translation="MVARRRKCAARDPEDRIPSPLGYAAIPIKFSEKQQASHYLYVRA
                     HGVRQGTKSTWPQKRTLFVLNVPPYCTEESLSRLLSTCGLVQSVELQEKPDLAESPKE
                     SRSKFFHPKPVPGFQVAYVVFQKPSGVSAALALKGPLLVSTESHPVKSGIHKWISDYA
                     DSVPDPEALRVEVDTFMEAYDQKIAEEEAKAKEEEGVPDEEGWVKVTRRGRRPVLPRT
                     EAASLRVLERERRKRSRKELLNFYAWQHRESKMEHLAQLRKKFEEDKQRIELLRAQRK
                     FRPY"
     exon            84..226
                     /gene="RRP7A"
                     /gene_synonym="BK126B4.3; CGI-96; MCPH28; Rrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            227..352
                     /gene="RRP7A"
                     /gene_synonym="BK126B4.3; CGI-96; MCPH28; Rrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            353..470
                     /gene="RRP7A"
                     /gene_synonym="BK126B4.3; CGI-96; MCPH28; Rrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            471..568
                     /gene="RRP7A"
                     /gene_synonym="BK126B4.3; CGI-96; MCPH28; Rrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            569..767
                     /gene="RRP7A"
                     /gene_synonym="BK126B4.3; CGI-96; MCPH28; Rrp7"
                     /inference="alignment:Splign:2.1.0"
     exon            768..5419
                     /gene="RRP7A"
                     /gene_synonym="BK126B4.3; CGI-96; MCPH28; Rrp7"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1208
                     /gene="RRP7A"
                     /gene_synonym="BK126B4.3; CGI-96; MCPH28; Rrp7"
                     /note="major polyA site"
     polyA_site      2831
                     /gene="RRP7A"
                     /gene_synonym="BK126B4.3; CGI-96; MCPH28; Rrp7"
     regulatory      5401..5406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRP7A"
                     /gene_synonym="BK126B4.3; CGI-96; MCPH28; Rrp7"
                     /note="hexamer: AATAAA"
     polyA_site      5419
                     /gene="RRP7A"
                     /gene_synonym="BK126B4.3; CGI-96; MCPH28; Rrp7"
ORIGIN      
        1 gggtggcaag atggtggcgc gcaggaggaa gtgcgccgcg cgggacccgg aggaccgtat
       61 ccccagccca ctgggctacg cagctattcc aatcaagttc tctgaaaagc aacaggcttc
      121 tcactacctc tatgtgagag cacacggcgt tcgacaaggc accaagtcca cctggcctca
      181 gaagaggact ctttttgtcc tcaatgtgcc cccatactgc acagaggaga gcctgtcccg
      241 cctcctgtcc acctgtggcc tcgtccagtc tgtagagttg caggagaagc cggacctggc
      301 tgagagccca aaggagtcaa ggtcgaagtt ttttcatccc aagccagttc cgggtttcca
      361 ggtagcctat gtggtgttcc agaagccaag tggggtgtca gcggccttgg ccctgaaggg
      421 ccccctgctg gtgtccacag agagccaccc tgtgaagagt ggcattcaca agtggatcag
      481 tgactacgca gactctgtgc ccgaccctga ggccctgagg gtggaagtgg acacgttcat
      541 ggaggcatat gaccagaaga tcgctgagga agaagctaag gccaaggagg aggagggggt
      601 ccctgacgag gagggctggg tgaaggtgac ccgccggggc cggcggcctg tgctcccccg
      661 gactgaggca gccagcttgc gggtgctgga gagggagaga cggaagcgca gccgaaaaga
      721 gctgctcaac ttctacgcct ggcagcatcg agagagcaag atggagcatc tagcgcagct
      781 gcgcaagaag ttcgaggagg acaagcagag gatcgagctg ctgcgggccc agcgcaaatt
      841 ccgaccgtac tgagctgtga gagccgcagt gaatggctgg aggtgcaggg ccaggaggag
      901 gcgaggcagg gcctgcagcg gtctctgaga ggccgagctc tggccaacgg gccccaggtt
      961 gaaggccacc gcgtccaaca gccccatcag agtccacaca ggccaggagg gaaggaccag
     1021 gccacccctc gggtcttgtg cttcagcagt cctggggacc caggcgtgcc gagaggagga
     1081 cttgtccttc ctgcttcttg cctccacacc ctcctctcca ggaccctgga tgaatccgtt
     1141 ctgtgcttcc ttttccctca atgcaaaagc ccttgctggc aacgaaaaag cctcaaaagc
     1201 agtgagaata caagaacctt ttattttcca tccagttggg cagcagggaa aggctaggtg
     1261 ggcccagccc gcccttcctt cctccagctg gctggagatt attagccagg agacagcagc
     1321 cctggaaccc agactctgtc tcccccttga ggtcacagat gttgaagttg gaatctcgct
     1381 ccttcccctg actaccatcc taggctgggc ctcaagacta gtgaggcctg tccccaccat
     1441 ccctggcctt gttgtggggc tcaggaactc agagtcccag tgttgagtct gggagcacta
     1501 ggtcttcata gttccaggcc cagagctaca gctgggctgg gagcgtgtgt gtgcactgta
     1561 agaaggagct gatgatactg gccacgtgct ggggttcgct catgtggaca cagtgattgc
     1621 ctgggacttc cacaaactgg aaccgctgga gaggggaggg ggtgggtagt gagatgtggc
     1681 cagaggagcc tagggagctc catgggcccc ggggtcaggg ccctcccaca gcattccagc
     1741 tccctgcagg tcaggagcgc ctcccacagt gagtttcccc cacactcggc tccttggagc
     1801 cccgacagtc catagcaccc caggagatgt ctaaccttag ggacttggag gcctcccagg
     1861 ggtctaggcc agctgagttg tgaagttgca tggcagggac agggcagggc cgaggccagg
     1921 gttgctgtga ttgtatccga agtagtcctc gtgagaaaag ataatgagat gacgtgagca
     1981 gcctgcagac ttgtgtctgc cttcaagaag ccagacagga aggccctgcc tgccttggct
     2041 ctgacctggc ggccagccag ccagccacag gtgggcttct tccttttgtg gtgacaacgc
     2101 caagaaaact gcagaggccc cagggtcagg tgtaagtggg taggtgacca taaaacacca
     2161 ggtgctccca ggaacccggg caaaggccat ccccacctac agccagcatg cccactggcg
     2221 tgatgggtgc agagggatga ggcagccagg tgttctgctg tggtttggga gcctataaag
     2281 tgagactagg ctgggcatgg tggctcccat ctgcaaaacc agcactttgg gaggccaagg
     2341 tgggcggatc gcctgaggtc aggagtttga gaccagcctg gccaacatgg tgaaccccca
     2401 tctcttaaaa atataaaaat tagctgggca tggtggcagg tgcctgtaat cccagctact
     2461 caggaggctg aggcacgaga gtcgcttgaa cccgggaggt ggaggttaca gtaagctgag
     2521 atcttcccac tgcactccag cctgagcgac agagtgagac tccatctcaa aaaaaaaaaa
     2581 aaagtgtgac tattagctgg gcatgatggc atgcgcctgt agtgccacct actcaggtgg
     2641 ctgaggtggg aggatcattt gagcccagga gtttgaggct gcagtgagct atgactgagc
     2701 ctgagcaaca gaatgagacc ctgtctctca aaaaatgtgg gactgtctct ggcagttggg
     2761 tcacctaatt gtgcctggcc ccaagaagga ggggtgggta cttgaggatg gtaaagaacc
     2821 tccccaccaa aggtctctgt ttcttaaatt ctgattacat gtgtccccag gcctctaggg
     2881 actgatcact ggagcatgag gcctgataga tcctggtggt cacttgttgg gcctgggggc
     2941 agaccagggg tctttcccag tgcatgagaa gagatgggtg aggtgggacc agagtgggcg
     3001 acagtggctg gacaccagct gcctgagccc cgccttacct ctttgagggt ggatttcatt
     3061 gtgtctatca tgaacgacag ggactccttg tcagagtaat tctctcttgg atcaaaatat
     3121 ccgtggactg ctctggaaag tgaggagttg ggggttgttg gggttcatct tagaaccgcc
     3181 tcccagcggt gcccccatcc tgccctgggt tcaggcctct gaggagaaac caaagcctgg
     3241 gctaccccaa ctcccacagc tgggtccctt gaccctgggt tggatttgag gctcagttaa
     3301 tctcagctca cgctcagctg gcacaagcca ggcgcaagca agtgctgaag gcacagcctt
     3361 gctggggcgc agggagttca ggacttggtc acagtcagcc ctgaacagca gagctgggat
     3421 ctgaacaggc gctggagccc acacttgctc tgagagagaa tttatgtctt cacaatcctc
     3481 ccattgaaag tctacaatcc tggccgggta tggtggctca cgcctgtaat cccagcactt
     3541 tgggaggctg aggcgggtgg atcacgaggt caggagatga gaccatcctg gctaacatgg
     3601 tgaaaccctg tctgtactaa aaatacaaaa attagccggg cttggtggtg ggtgcctgta
     3661 gtcccagcta ctccggaggc tgaggcagga gaatggcgtg aacccgggag gcggaccttg
     3721 cagtgagctg agattgcacc actacactcc agcctgggcg acagagccag actccatctc
     3781 aaaaaaaaaa aaaaaaaagt ctacaatccc gtggttttta atacattgag ttgtgagacc
     3841 atcgtcacaa ttacattttc atcaccccca aagaaatcgc aaacctctga gcttacacac
     3901 acacacacac accccacccc cccaccccca acaggcttcc ggtcctgagc aaccatgacc
     3961 tggctttgtc tctgccgtgt gtcctatttg gacttgaacg tgaatgcagc catacaacac
     4021 gtagacggtt gtgtctgact tcatccactt agtgcgatgt tttcaaggct catccatgct
     4081 ggagcccatg tcagtgcttc gtttcttttt atggcttaaa aatcgtctat ggtgggccac
     4141 gcacggtggc tctcgcctgt aatcccaaca ctgggaggcc gaggcaggcg gatcatgagg
     4201 tcaggagatg gagagcagcc tggccaacat ggcgaaacct cgtctctact aaaaatacaa
     4261 aaataagcca ggcgtggtgg cgggcgcctg tagtcccagc tactcgggag gctgaggcag
     4321 gagaatcgtt tgaatccagg aggcagaggt tgcagtgagt cgagactggg ctcactggtt
     4381 atggagcctt acctgggcat gccccccgct gacacctgtg gaaaggcatg ggacagcccc
     4441 ggcccatccc ctgctgcctg agccctcccc tcctctgacc ttcctccttc catgaccctg
     4501 ctgccagggg ggcttcccaa aaaagatctt gagtcttagc gatgtggtcg acacgcagag
     4561 aacttggagc ctcatgccag ggccccctcc cagagattcc tggcgcccat gtctccttgg
     4621 ggggtgactg aaggggatgg gtccagactc acttgatcaa caggacatgg gcctgcagct
     4681 tcctgatgga atgcgcacac agctccctgc tgacgaagtc aatgctgttc tctgcctgca
     4741 gagacaaaaa catggtgaat tctcgtcaca aggcacaggc actctcgtgg gcacgaaacc
     4801 catctctgtt ggggtggcta agccctggcg agggcacctt agccacccac cctgggtctg
     4861 agcccaggac cccacatcac tgcctcatcg aaggctcttt agcccctggt ggccagagac
     4921 tcctgccctc tccaagtctg ttctcccctc ttcctgggct cgtggctacc cagcctgact
     4981 ccatttccaa tactcctttg ccaccaggta tggctgtgtg attaaagtca gagaagtgag
     5041 ttgggccact tttgggcctg gattttagga cttaggtgtg gcccttccac acccctttcc
     5101 cagtccatag gctgcacctc acgctgtccc ctgccagcct gggacaggct tcttgccagg
     5161 agaaagaaac ttgctgggac cacagtgcag gatgggcact ccgtgatggc cccagccagc
     5221 ctcctccgcg gccctgcctg ccctgtcttg tgactgtttt acgtctggat ggcggggatg
     5281 tggccagctt gagtgagatg tgctgtaggt gtgacacgaa gctggatttg gaaaacagca
     5341 tgcaaaataa tgcaatcaag ctttatgttg attacatctt aaatcacatt gtggatgtta
     5401 aataaaaata tgagaagaa
//
