LOCUS       NM_033112               1183 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ribosomal RNA processing 36 (RRP36), transcript
            variant 1, mRNA.
ACCESSION   NM_033112
VERSION     NM_033112.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1183)
  AUTHORS   Gerus,M., Bonnart,C., Caizergues-Ferrer,M., Henry,Y. and
            Henras,A.K.
  TITLE     Evolutionarily conserved function of RRP36 in early cleavages of
            the pre-rRNA and production of the 40S ribosomal subunit
  JOURNAL   Mol Cell Biol 30 (5), 1130-1144 (2010)
   PUBMED   20038530
  REMARK    GeneRIF: studied the orthologue of Rrp36p in HeLa cells, and showed
            that the function of this protein in early cleavages of the
            pre-rRNA has been conserved through evolution in eukaryotes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN311647.1 and BC011933.2.
            
            On Nov 22, 2018 this sequence version replaced NM_033112.3.
            
            Summary: RRP36 functions at an early stage in the processing of 35S
            preribosomal RNA into the mature 18S species (Gerus et al., 2010
            [PubMed 20038530]).[supplied by OMIM, Jul 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.55397.1,
                                           SRR1163658.391116.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244496.6/ ENSP00000244496.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                CN311647.1         27-50
            25-1183             BC011933.2         1-1159
FEATURES             Location/Qualifiers
     source          1..1183
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..1183
                     /gene="RRP36"
                     /gene_synonym="C6orf153; dJ20C7.4"
                     /note="ribosomal RNA processing 36"
                     /db_xref="GeneID:88745"
                     /db_xref="HGNC:HGNC:21374"
                     /db_xref="MIM:613475"
     exon            1..162
                     /gene="RRP36"
                     /gene_synonym="C6orf153; dJ20C7.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..812
                     /gene="RRP36"
                     /gene_synonym="C6orf153; dJ20C7.4"
                     /note="isoform 1 is encoded by transcript variant 1; RNA
                     processing factor; ribosomal RNA processing protein 36
                     homolog; ribosomal RNA processing 36 homolog"
                     /codon_start=1
                     /product="ribosomal RNA processing protein 36 homolog
                     isoform 1"
                     /protein_id="NP_149103.1"
                     /db_xref="CCDS:CCDS34453.1"
                     /db_xref="GeneID:88745"
                     /db_xref="HGNC:HGNC:21374"
                     /db_xref="MIM:613475"
                     /translation="MPGANYRAGAGAGAGARRPRGARDREEDGGGLEPAAVARDLLRG
                     TSNMSFEELLELQSQVGTKTYKQLVAGNSPKKQASRPPIQNACVADKHRPLEMSAKIR
                     VPFLRQVVPISKKVARDPRFDDLSGEYNPEVFDKTYQFLNDIRAKEKELVKKQLKKHL
                     SGEEHEKLQQLLQRMEQQEMAQQERKQQQELHLALKQERRAQAQQGHRPYFLKKSEQR
                     QLALAEKFKELKRSKKLENFLSRKRRRNAGKDRRHLPLSKE"
     exon            163..310
                     /gene="RRP36"
                     /gene_synonym="C6orf153; dJ20C7.4"
                     /inference="alignment:Splign:2.1.0"
     exon            311..377
                     /gene="RRP36"
                     /gene_synonym="C6orf153; dJ20C7.4"
                     /inference="alignment:Splign:2.1.0"
     exon            378..482
                     /gene="RRP36"
                     /gene_synonym="C6orf153; dJ20C7.4"
                     /inference="alignment:Splign:2.1.0"
     exon            483..557
                     /gene="RRP36"
                     /gene_synonym="C6orf153; dJ20C7.4"
                     /inference="alignment:Splign:2.1.0"
     exon            558..675
                     /gene="RRP36"
                     /gene_synonym="C6orf153; dJ20C7.4"
                     /inference="alignment:Splign:2.1.0"
     exon            676..1183
                     /gene="RRP36"
                     /gene_synonym="C6orf153; dJ20C7.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1161..1166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRP36"
                     /gene_synonym="C6orf153; dJ20C7.4"
                     /note="hexamer: CATAAA"
     polyA_site      1183
                     /gene="RRP36"
                     /gene_synonym="C6orf153; dJ20C7.4"
                     /note="major polyA site"
ORIGIN      
        1 gccattcgtc ttccgagcgc tactgccagc tgatgccggg agctaactac cgcgccgggg
       61 ccggggccgg ggccggggcc cgacgtcccc gcggggcccg ggaccgcgag gaggacggcg
      121 ggggcctgga gcccgcggcc gtggcccgcg acctattgag gggcacatct aacatgtcat
      181 ttgaggagct gttggaattg cagagccaag tggggactaa gacgtacaaa caattggtag
      241 ctggaaatag tcctaagaaa caagcttcta gaccacctat ccaaaatgca tgtgttgcag
      301 ataagcacag gcctctggaa atgtcagcca agatccgagt accattttta cgtcaggttg
      361 ttcccattag taaaaaggta gcccgggacc ctcgctttga tgatctgtca ggggaatata
      421 atcctgaggt gtttgacaaa acataccaat tcttgaatga catccgagcg aaagagaaag
      481 agcttgtgaa aaaacagttg aagaagcacc tttcaggaga ggagcatgag aaactgcagc
      541 aactgcttca gcgaatggag cagcaagaaa tggcacagca ggaacgaaag caacagcagg
      601 agctgcacct ggccctgaag caagaacgtc gggctcaggc ccagcagggc catcggccat
      661 acttcctgaa aaaatctgag cagcgccagt tggcactagc tgagaagttc aaggagctga
      721 aacgcagcaa gaaattggag aacttcttga gtcgaaagag gcgacgaaat gcaggcaagg
      781 acaggagaca tctccctttg agcaaagagt aataaggaac tatcctctgc tctgccactg
      841 ccccagggag acatggatct gtgaggacag atttggccac ggctggtttc cgttcaaggg
      901 caaggatcac agctgccctt gaatctcatt gcctcagaga agactagagg gctcttggac
      961 tatccctagg gctacacaag aatagttcag ccttctgcca tgccacacag cctcagcttg
     1021 aatctggttc attgcgtcct cgtgttcttc tctcatcctt gccttaaacc agggattctg
     1081 ataccgaaga agaggggcca atgaaaacca tggagtctgt tcgtgactcc cagggctggg
     1141 acattatgta ggagccactt cataaacatt ctctttactc atc
//
