LOCUS       NM_015056               5078 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosomal RNA processing 1B (RRP1B), mRNA.
ACCESSION   NM_015056 XM_371417
VERSION     NM_015056.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5078)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 5078)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5078)
  AUTHORS   Liu,X., Salokas,K., Tamene,F., Jiu,Y., Weldatsadik,R.G., Ohman,T.
            and Varjosalo,M.
  TITLE     An AP-MS- and BioID-compatible MAC-tag enables comprehensive
            mapping of protein interactions and subcellular localizations
  JOURNAL   Nat Commun 9 (1), 1188 (2018)
   PUBMED   29568061
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5078)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   5  (bases 1 to 5078)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5078)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (bases 1 to 5078)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   8  (bases 1 to 5078)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   9  (bases 1 to 5078)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   10 (bases 1 to 5078)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC028386.2, AK056263.1, BX479134.1, AK124620.1, AP001052.1 and
            BE544027.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015056.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.233750.1,
                                           SRR1803614.151588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340648.6/ ENSP00000339145.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-707               BC028386.2         15-721
            708-1367            AK056263.1         680-1339
            1368-1751           BX479134.1         14-397
            1752-2450           BC028386.2         1766-2464
            2451-4069           AK124620.1         2009-3627
            4070-5063           AP001052.1         66869-67862
            5064-5076           AK124620.1         4622-4634
            5077-5078           BE544027.1         538-539
FEATURES             Location/Qualifiers
     source          1..5078
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..5078
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /note="ribosomal RNA processing 1B"
                     /db_xref="GeneID:23076"
                     /db_xref="HGNC:HGNC:23818"
                     /db_xref="MIM:610654"
     exon            1..235
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2382
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /note="RRP1-like protein B; ribosomal RNA processing 1
                     homolog B; protein phosphatase 1, regulatory subunit 136"
                     /codon_start=1
                     /product="ribosomal RNA processing protein 1 homolog B"
                     /protein_id="NP_055871.1"
                     /db_xref="CCDS:CCDS33577.1"
                     /db_xref="GeneID:23076"
                     /db_xref="HGNC:HGNC:23818"
                     /db_xref="MIM:610654"
                     /translation="MAPAMQPAEIQFAQRLASSEKGIRDRAVKKLRQYISVKTQRETG
                     GFSQEELLKIWKGLFYCMWVQDEPLLQEELANTIAQLVHAVNNSAAQHLFIQTFWQTM
                     NREWKGIDRLRLDKYYMLIRLVLRQSFEVLKRNGWEESRIKVFLDVLMKEVLCPESQS
                     PNGVRFHFIDIYLDELSKVGGKELLADQNLKFIDPFCKIAAKTKDHTLVQTIARGVFE
                     AIVDQSPFVPEETMEEQKTKVGDGDLSAEEIPENEVSLRRAVSKKKTALGKNHSRKDG
                     LSDERGRDDCGTFEDTGPLLQFDYKAVADRLLEMTSRKNTPHFNRKRLSKLIKKFQDL
                     SEGSSISQLSFAEDISADEDDQILSQGKHKKKGNKLLEKTNLEKEKGSRVFCVEEEDS
                     ESSLQKRRRKKKKKHHLQPENPGPGGAAPSLEQNRGREPEASGLKALKARVAEPGAEA
                     TSSTGEESGSEHPPAVPMHNKRKRPRKKSPRAHREMLESAVLPPEDMSQSGPSGSHPQ
                     GPRGSPTGGAQLLKRKRKLGVVPVNGSGLSTPAWPPLQQEGPPTGPAEGANSHTTLPQ
                     RRRLQKKKAGPGSLELCGLPSQKTASLKKRKKMRVMSNLVEHNGVLESEAGQPQALGS
                     SGTCSSLKKQKLRAESDFVKFDTPFLPKPLFFRRAKSSTATHPPGPAVQLNKTPSSSK
                     KVTFGLNRNMTAEFKKTDKSILVSPTGPSRVAFDPEQKPLHGVLKTPTSSPASSPLVA
                     KKPLTTTPRRRPRAMDFF"
     exon            236..318
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..376
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..462
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..524
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            525..654
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..719
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..901
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..996
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1094
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1114
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1246
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1971
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2124
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2188
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..5078
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5051..5056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /note="hexamer: ATTAAA"
     polyA_site      5078
                     /gene="RRP1B"
                     /gene_synonym="KIAA0179; Nnp1; NNP1L; PPP1R136; RRP1"
                     /note="major polyA site"
ORIGIN      
        1 ctgtgcagtc gcggcccggg cggacggtgg ctggctgctc cgcagcgctc ggctggctgc
       61 agcggcaccg cgggttgcgc ggccggggat gctccagcgg gcgcgatggc ccccgccatg
      121 cagccggccg agatccaatt tgcccagcgg ctggcgtcca gcgagaaggg catccgggac
      181 cgagcggtga agaagctgcg ccagtacatc agcgtgaaga cgcagaggga gacaggaggt
      241 ttcagtcagg aagaacttct gaaaatctgg aaggggctct tctactgcat gtgggtgcag
      301 gatgaacccc ttctacagga agagctcgcc aacaccattg cacagctagt ccatgctgtt
      361 aacaactcag cggctcaaca cctgttcatt cagacctttt ggcaaaccat gaatcgagaa
      421 tggaaaggaa tagacaggct acgcctggac aaatactata tgctgattcg tctggtcctg
      481 aggcagtcct ttgaagtctt gaagcgaaat ggctgggaag aaagccgaat caaggttttc
      541 ttggatgtcc tgatgaagga ggtcctgtgt cctgagagtc agtctcctaa tggagtgaga
      601 ttccacttca ttgatattta cctggatgaa ctctccaaag tcggggggaa ggagctttta
      661 gcagatcaga atctcaagtt tatcgatcca ttctgcaaaa ttgctgcgaa gacgaaggac
      721 cacaccctgg tacagaccat agctcggggt gtcttcgaag ctatcgtaga tcagtctcct
      781 tttgtgcctg aagagacgat ggaggaacag aagacaaaag tgggtgatgg tgacctctct
      841 gctgaggaga tacctgaaaa tgaggtatcc ttgagaagag ctgtcagtaa aaagaagaca
      901 gcactgggca aaaaccattc cagaaaagat ggactcagtg atgaaagagg aagagatgac
      961 tgtggaacct ttgaggacac agggcccctt ctccagtttg actataaggc tgttgctgat
     1021 cgactcctgg aaatgaccag caggaagaac acgccccact tcaacaggaa gcgcctctcc
     1081 aaactcatca agaaattcca agacctttct gaaggaagca gtatatctca actcagtttt
     1141 gcggaggaca tttctgctga tgaagatgac caaatcctca gtcaaggaaa gcataagaag
     1201 aaaggaaata aacttttaga gaaaactaac ttggaaaagg agaaaggaag cagagtcttt
     1261 tgtgtagagg aagaggacag tgaaagcagt cttcaaaaga gaagaaggaa gaagaagaag
     1321 aagcaccacc tgcagcctga aaatccaggc ccagggggtg cagccccatc cctggaacag
     1381 aaccggggca gggagcccga ggcctctggg ctgaaagccc tgaaggcacg tgtggccgag
     1441 ccaggtgcag aggccacgtc cagcactggg gaggagagtg gctccgagca tcctccagcc
     1501 gtccccatgc acaataaaag gaaacggcca cggaagaaga gcccgagggc ccacagggaa
     1561 atgttggaat cagcagtgtt gcccccagag gacatgtctc agagtggccc gagtggcagt
     1621 catcctcagg gacctagagg gtccccgaca ggtggagccc aactcctaaa aaggaagcgg
     1681 aaacttggag ttgtgcccgt caatggcagt ggcctgtcca cgccggcctg gcctccattg
     1741 cagcaggaag gccctcccac aggccccgca gagggggcga acagccacac cacgctgccc
     1801 cagcgcagga ggctgcagaa aaagaaggca gggcccggca gcctggagct ctgtggcctg
     1861 cccagccaga aaacagcaag tttgaaaaag aggaagaaaa tgagagtgat gtcaaacttg
     1921 gtggagcaca acggggtgct ggagtccgaa gctgggcaac cccaggctct gggaagcagt
     1981 gggacttgca gttccctgaa gaagcagaag ctgagggcag agagcgactt tgtgaagttt
     2041 gacaccccct tcttaccaaa gcccctgttc ttcagaagag ccaagagcag cactgccacc
     2101 caccctccag gccctgccgt ccagctaaac aagacaccat ccagctccaa gaaagtcacc
     2161 tttgggctga acagaaacat gactgccgaa ttcaagaaga cagacaagag tatcttggtc
     2221 agtcccacgg gcccttctcg agtggccttc gaccctgaac agaagcccct ccacggggtg
     2281 ctgaagaccc ccaccagctc acctgccagc tcacccctgg tggccaagaa gcccctgacc
     2341 accacaccaa ggagaaggcc cagggctatg gatttcttct gaggagcagc agagtccctt
     2401 gtaaaagact gcttttgtac agaatgcgct ataaattata cctttaagaa tgtggggcct
     2461 tttttatgat tttgtaagtt cccataagtt gtgtgcacga ggttctgaga gtgcccgcag
     2521 gctgctgcgt cctggcccct ctgtagtggc tgcgggcgtc ttggttgaat cttttgctac
     2581 aaaccatgtt tgcgtttgag ctctccagga ttttacattt ttgggtaacc tcagtgattc
     2641 ccattggtgt aggaaatgag accctctctg aagctgagga gagcacgttg atctgaactt
     2701 taaatcaatc agtgctgctg gcacaatgaa aggtggaact gcacttctgt tgagctctca
     2761 gttctgcgga atttggtact cattaccgta ttcgccgtac taagttggtt tctgttagtc
     2821 ttaacagtct gttttctttt aaaagcatgt agggcttcat tgccatgttc tgtgggtgtt
     2881 tggcaggtta ccgatgggga agattcttgt cacagaatca gcaataccat agtttttcta
     2941 catgtgctca gctgggggtg tggacaggta ggggtgggga aagaagaggc tctgcgttct
     3001 gggggctttt tcttctcctc cccctacccg gtttccctcc ctgttttcct acctctacgg
     3061 caagcccaaa gtgtcttccc gggagcccag cgcagccccc ggctcttacc caggaccccg
     3121 ccccgtgctg agccttctgc tgaggtcctt gcgtggagca cactcattcc tccaagccct
     3181 tgcgctcccg tttctctctc tctccgtcca cgttccagcc gagtcactgc ctgaccggct
     3241 ccatggcagc tccccatctt ccctagaggc tgcctgcgca tctggagcct gcgctccggc
     3301 tcagcgacct ttcctctcaa atgcggaagc gtgcacttac agttcagacc gttctcctgt
     3361 aagttcatta caaacacggg cggaaggcac tcaggctttc gttggagaaa cagaaataag
     3421 gccttctttt gagcagcgat tgctggatca ttgatctgtt tgaggaagtg tctgacctgg
     3481 gcctgagagc tggagaaggt gcagattcaa agtgagcggc tcctgaggag agccgccaag
     3541 gctgctcgcc ttctccgtgg cttccgcagc taccgtctgc acggtgagag ggcacgggca
     3601 cacggttcgg gctggcgtgc agctctccca gccagccacg ctctgctcag gcctggaagt
     3661 gaaagccgcc tccttcccgt tatgcccccc atacaggagc ctcggttttt cagcaaaacg
     3721 cggccagtcc ccttctccac tgctgcctcc cagcagaggg ccccaggatc tccaaggtcc
     3781 cagctatggc tttggacaac gtggcttcgg cccctggggt tgcagagctt gcattgggtt
     3841 tacctcggtc tcattcattc atggagccaa gggtggggtt tcacctgcga acatcagact
     3901 gacttgctgg cgtcaagagc agttgactca ctgatgaagg ccctggtgag gagaaagcac
     3961 tctgttcttc gcctactctg taatcgtttt gtcataatga gccatgaaaa aagtaatgaa
     4021 cttgtgctgt taatcgtcac tgtaatgaga agtcttacgt acaacatagc tgtggtggct
     4081 taatggctgc attagatagg atcctcacat cccattcaga accaaaactg atacagtgaa
     4141 acaattaagg tgagcaaata gttttaactt ttcttttttt tttttaagtt tcattcttcc
     4201 tagaatattt ttctaacaat ttttatttca gctttaaaga tgggtcatat agccaaacgg
     4261 gccatataat ccaacattgt tgagatgtct taggacatct aaggcaaaac tggcacattt
     4321 gttctgcaga ctattgcagg aatgtttttt cctagcattt ctatattatc tgtccattct
     4381 gaggaaccag tgaatgtcct ataaatgcac ctcctgtcaa aaccatgcct gagaggtccc
     4441 ggctgggagt gacagggtgc ttcttagatt ctattggtcc ttctctcatt ctccgaactt
     4501 actccttttt atgggtaagt caactaggtt tacagtccct tatttttaat gcctaagttt
     4561 tgacagcagg aagaaaacaa ttttttaaaa attctcatta catagacgca caagaatatg
     4621 tcacataaag aaaatgtgtt tagaatactg gttttctatt tacgcatgat attttcctaa
     4681 gtaaaattgc caagtggact tggaagtcca gaaaggaaaa taatttaaat taatgctggt
     4741 gatcttaaca atattttgta aaatgatgct tcccccttct ccatggtcta gtcaattttg
     4801 tacaattagg tatctgactt tacaagtttg ttatcctttc taatttttac tgaactgaaa
     4861 gcacaaagaa gactacacag aaaatctgga aacagttgca ggtgttggga ggaagatgaa
     4921 atcgagctgt cttttaactt ttgtatgtgt tttatcagaa tttgctggac tatgctggca
     4981 aggactttgt ttacgatcaa attgtactag tgtctgcagg gtttgtcagt actcgtcaaa
     5041 gccaagtcca attaaaaaaa aaagtctttg ccctccaa
//
