LOCUS       NM_016052               7765 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal RNA processing 15 homolog (RRP15), mRNA.
ACCESSION   NM_016052
VERSION     NM_016052.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7765)
  AUTHORS   Deng,Z., Xu,Y., Cai,Y., Lin,W., Zhang,L., Jiang,A., Zhou,Y.,
            Zhao,R., Zhao,H., Liu,Z. and Yan,T.
  TITLE     Inhibition of Ribosomal RNA Processing 15 Homolog (RRP15)
            Suppressed Tumor Growth, Invasion and Epithelial to Mesenchymal
            Transition (EMT) of Colon Cancer
  JOURNAL   Int J Mol Sci 24 (4), 3528 (2023)
   PUBMED   36834940
  REMARK    GeneRIF: Inhibition of Ribosomal RNA Processing 15 Homolog (RRP15)
            Suppressed Tumor Growth, Invasion and Epithelial to Mesenchymal
            Transition (EMT) of Colon Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7765)
  AUTHORS   Dong,Z., Li,J., Dai,W., Yu,D., Zhao,Y., Liu,S., Li,X., Zhang,Z.,
            Zhang,R., Liang,X., Kong,Q., Jin,S., Jiang,H., Jiang,W. and Ding,C.
  TITLE     RRP15 deficiency induces ribosome stress to inhibit colorectal
            cancer proliferation and metastasis via LZTS2-mediated beta-catenin
            suppression
  JOURNAL   Cell Death Dis 14 (2), 89 (2023)
   PUBMED   36750557
  REMARK    GeneRIF: RRP15 deficiency induces ribosome stress to inhibit
            colorectal cancer proliferation and metastasis via LZTS2-mediated
            beta-catenin suppression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7765)
  AUTHORS   Zhao,D., Qian,L., Zhuang,D., Wang,L., Cao,Y., Zhou,F., Zhang,S.,
            Liu,Y., Liang,Y., Zhang,W., Kang,W., Zhang,M., Wang,Y., Zhang,F.,
            Zhang,W., Xiao,J., Xu,G., Lv,Y., Zou,X., Zhuge,Y. and Zhang,B.
  TITLE     Inhibition of ribosomal RNA processing 15 Homolog (RRP15), which is
            overexpressed in hepatocellular carcinoma, suppresses tumour growth
            via induction of senescence and apoptosis
  JOURNAL   Cancer Lett 519, 315-327 (2021)
   PUBMED   34343634
  REMARK    GeneRIF: Inhibition of ribosomal RNA processing 15 Homolog (RRP15),
            which is overexpressed in hepatocellular carcinoma, suppresses
            tumour growth via induction of senescence and apoptosis.
REFERENCE   4  (bases 1 to 7765)
  AUTHORS   Dong,Z., Zhu,C., Zhan,Q. and Jiang,W.
  TITLE     The roles of RRP15 in nucleolar formation, ribosome biogenesis and
            checkpoint control in human cells
  JOURNAL   Oncotarget 8 (8), 13240-13252 (2017)
   PUBMED   28099941
  REMARK    GeneRIF: Data suggest that ribosomal RNA-processing protein 15
            (RRP15) might be a potential target for cancer therapy.
REFERENCE   5  (bases 1 to 7765)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7765)
  AUTHORS   De Marchis,M.L., Giorgi,A., Schinina,M.E., Bozzoni,I. and Fatica,A.
  TITLE     Rrp15p, a novel component of pre-ribosomal particles required for
            60S ribosome subunit maturation
  JOURNAL   RNA 11 (4), 495-502 (2005)
   PUBMED   15769876
  REMARK    GeneRIF: The budding yeast homolog of human RRP15 is required for
            maturation of 60S ribosomal particles
REFERENCE   7  (bases 1 to 7765)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF242786.1, BC020641.1,
            AC096638.2 and AW029169.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016052.3.
            
            Summary: This gene encodes a protein that co-purifies with human
            nucleoli. A similar protein in budding yeast is a component of
            pre-60S ribosomal particles, and is required for the early
            maturation steps of the 60S subunit. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1157409.1,
                                           SRR5189658.93002.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366932.4/ ENSP00000355899.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BF242786.1         8-24
            18-1357             BC020641.1         1-1340
            1358-7393           AC096638.2         38942-44977
            7394-7765           AW029169.1         12-383              c
FEATURES             Location/Qualifiers
     source          1..7765
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..7765
                     /gene="RRP15"
                     /gene_synonym="CGI-115; KIAA0507"
                     /note="ribosomal RNA processing 15 homolog"
                     /db_xref="GeneID:51018"
                     /db_xref="HGNC:HGNC:24255"
                     /db_xref="MIM:611193"
     exon            1..163
                     /gene="RRP15"
                     /gene_synonym="CGI-115; KIAA0507"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..873
                     /gene="RRP15"
                     /gene_synonym="CGI-115; KIAA0507"
                     /note="ribosomal RNA-processing protein 15"
                     /codon_start=1
                     /product="RRP15-like protein"
                     /protein_id="NP_057136.2"
                     /db_xref="CCDS:CCDS1520.2"
                     /db_xref="GeneID:51018"
                     /db_xref="HGNC:HGNC:24255"
                     /db_xref="MIM:611193"
                     /translation="MAAAAPDSRVSEEENLKKTPKKKMKMVTGAVASVLEDEATDTSD
                     SEGSCGSEKDHFYSDDDAIEADSEGDAEPCDKENENDGESSVGTNMGWADAMAKVLNK
                     KTPESKPTILVKNKKLEKEKEKLKQERLEKIKQRDKRLEWEMMCRVKPDVVQDKETER
                     NLQRIATRGVVQLFNAVQKHQKNVDEKVKEAGSSMRKRAKLISTVSKKDFISVLRGMD
                     GSTNETASSRKKPKAKQTEVKSEEGPGWTILRDDFMMGASMKDWDKESDGPDDSRPES
                     ASDSDT"
     exon            164..429
                     /gene="RRP15"
                     /gene_synonym="CGI-115; KIAA0507"
                     /inference="alignment:Splign:2.1.0"
     exon            430..527
                     /gene="RRP15"
                     /gene_synonym="CGI-115; KIAA0507"
                     /inference="alignment:Splign:2.1.0"
     exon            528..729
                     /gene="RRP15"
                     /gene_synonym="CGI-115; KIAA0507"
                     /inference="alignment:Splign:2.1.0"
     exon            730..7765
                     /gene="RRP15"
                     /gene_synonym="CGI-115; KIAA0507"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1214..1219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRP15"
                     /gene_synonym="CGI-115; KIAA0507"
                     /note="hexamer: ATTAAA"
     polyA_site      1233
                     /gene="RRP15"
                     /gene_synonym="CGI-115; KIAA0507"
                     /note="major polyA site"
     regulatory      1339..1344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRP15"
                     /gene_synonym="CGI-115; KIAA0507"
                     /note="hexamer: AATAAA"
     polyA_site      1357
                     /gene="RRP15"
                     /gene_synonym="CGI-115; KIAA0507"
     regulatory      7740..7745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRP15"
                     /gene_synonym="CGI-115; KIAA0507"
                     /note="hexamer: AATAAA"
     polyA_site      7765
                     /gene="RRP15"
                     /gene_synonym="CGI-115; KIAA0507"
ORIGIN      
        1 aggtgacgct tccggcgcag aaaaatggca gccgccgctc cggactcacg tgtgagtgag
       61 gaagaaaacc tgaaaaagac cccaaagaag aagatgaaaa tggtaactgg agccgtagcg
      121 tcggtgctgg aagacgaggc cacagacact tctgatagtg aaggaagctg tggatcggaa
      181 aaggaccact tttattctga tgatgacgca atagaagctg acagtgaggg tgatgctgag
      241 ccctgtgaca aagaaaatga aaatgatgga gaatcaagtg ttgggactaa tatgggctgg
      301 gcagatgcta tggctaaagt cctcaacaag aaaactcctg aaagtaaacc tactattctg
      361 gtcaaaaata agaagctgga aaaggaaaaa gaaaagttaa agcaagaaag actagagaaa
      421 ataaaacagc gtgataagag gctggagtgg gaaatgatgt gcagagtaaa gccagatgtt
      481 gtccaagaca aagagacaga gagaaatctt cagagaattg caacaagggg tgtggtgcaa
      541 ttatttaatg ctgttcagaa acatcaaaag aatgttgatg aaaaggttaa ggaagctgga
      601 agttctatga gaaagcgtgc taagttgata tcaactgttt ccaagaaaga tttcatcagt
      661 gttttgagag ggatggatgg aagtacaaat gagactgctt caagcaggaa gaaaccaaaa
      721 gccaaacaga ctgaagtgaa atcagaagaa ggcccaggtt ggacgatcct acgtgatgat
      781 ttcatgatgg gagcatctat gaaagactgg gacaaggaaa gtgatgggcc agatgacagc
      841 agaccagaat ctgcaagtga ctctgataca taaagcatca taggaaatac aattgcagtc
      901 gttttatttt ttctagaaaa atatgtcatc ctctgatagt tggggaatta taaggatacc
      961 atttgtaaga aagccaaaag acttttgcca gatttcatat ttcccctttt catgtacact
     1021 ttatatatac ttcattaaaa ttatatttta aacccttgta taattttaag cattgttcct
     1081 cagaacattt gtaaaaggat atatttctgc ttgaccagcg agatgtgcat tttgccagga
     1141 tcatattggt catgtctatt ggtgtattat ttcagtatca ccaatgtttt cagaaataca
     1201 gtactaattc atcattaaac tctttgaagt taatattttt ctgccttcta acttatagac
     1261 tcaactatgt atctgtagtt tttgggaatg gttggtgttt tttgctttgt gttgggaagt
     1321 tattgagaaa acctatataa taaaatttaa aattatagtt tttcagattt tgggtcgtga
     1381 ttttagtttt aggtaatctg gaagatatga tttaagaaac aacagatttc aacttttttt
     1441 tttttttttt tttttttttt tttttttttt ttgagacgga gtcttgctct gtggccccgg
     1501 atggaatgca gtggcgtgat ctcggctcac tgcaagcacc gcctcccagg ttcacgccat
     1561 tctcccacct caacctctca agtagctggg actacaggtg cctgccacca cgcccagcta
     1621 attttttgtt tttgtatttt tagtagagac ggggtttcac catgttagcc aggatggtct
     1681 caatctcctg acctcgtgat ccacccgcct cggcctccca aagtgctggg attacaggcg
     1741 tgagccactg cgcccggccc agatttcaac ttttatttta tttcctttca tttattaaat
     1801 aatataaata atgacagatt tattttaggt gttagcctat ttttgcatga gagatttaca
     1861 gaggtggaaa ttctcatgct taacttatgc aatgagacaa tttctcagga agcaagtttg
     1921 acatgcttta gtctctctct tctttttttt cctcccaaat atttgagtta gcttaaattc
     1981 ttttttatgg actgcccaac cagtgaattg atgcacttag acaacaagta atctgcagca
     2041 gaatattgca tccaatttga gacttgattc catattattg ccttaaaggc tattaaattg
     2101 ggtgactttt agtatccagc tgttaaaaag aggaaagact gtttaatatc attccaaaat
     2161 ttttgtgaaa tgtggcccaa gatctaaagt ttttaaggga attattttta ataaatatga
     2221 tctgtccctt tttgaaaagg atccatccct tttcataata aaaataattc cctcctacca
     2281 cccagttgca catacttgca tctgttatgt attgaaggat aatccccccc aaaaaaacta
     2341 tccaagagca gagatgttta tattttgaaa cccatttgag tgttacagta ttatatgact
     2401 aaagctgaat cagtctgtgg cctggtattt gttatcataa aggaagatgt acacctaagg
     2461 tatcaagtgg ttaaaacagc aaagtacaag atgcattttt gtatttattc taacttttga
     2521 acattagtgt ctttcagtat aaataaatgt gaacaaatat acctcagtag taatacagga
     2581 gaactaaata tcctgctata acttaataca gatacatatt tcaatatgac ttaacaaaca
     2641 cacaattttg aaaaaaaaaa aaaaaaagtg cagcaactta aacacatttt tctccccaga
     2701 actaagatta cacttaattt aatttaatgt gtttctgcgt tatactagag ttttgcagga
     2761 atttttctga atagtacatt cacatgatag atacggataa ataccttatt tactaaaatg
     2821 ttttgaaaca tattttatag tccctcattt gatttgaaaa aatttgacaa gatcttcaca
     2881 ttgaaagtaa ggacgagaat atttgcagat ttccttcgtt ccaaaattat tttattccaa
     2941 agaaaaattg agttgccact atcaggaaaa aaaaaatgta tcacttctgt tagaaggcta
     3001 tgaagtatat ataaattata tgacaatttt tatcatatag atttgatatc ttctatgtat
     3061 tcgtattttt gcatcttggg tattaagcaa aataccatat gtataaatat gaaaccagga
     3121 atgtgcatat tttagaaact aattgtgtat cttaagtgaa tgttttgagt agttctgtca
     3181 cccctattct aaatatttta cctacaacat ttaaattatt ctgatatcaa tcagataaat
     3241 aatccgagtg tatttcatct ttctacattg tctttgtggt ttttgtttgt ttgtttttga
     3301 gacggtctca cactgtcacc caggctggag tgcagtggtg caatctcagc tcactgcaac
     3361 ctccacctcc caggttccag ctatcctccc acctcagcct cccaagtagc taggactaca
     3421 ggtgtgcacc accatgccca gctaattttt tgtctttttg atgtagatgg ggttacccca
     3481 tgttgcccag gctggttgtg aactcctgag ctcaagggat ccccccgcct cttgcctccc
     3541 aaagtgcttg gattacaggt gtgagccacc ataccacctg tctttgaatt ttttaacgag
     3601 gggaaagaaa actgcaattc ctgcctcccc atttatttaa acataacacc taggatttta
     3661 tttttggtaa ctacttagaa taatatagta ggttacttat cttcggttag aaagaactat
     3721 ggaaaatagg aaccaataat ttggaagtat tatttcctta tttcatatat agaaataatt
     3781 atcttatttc cttatttcat atatagaata ttctagatac ttggatggct ggggttgatg
     3841 ttcttagtat ttatcatagt ttagcattgg ttgttatttt taagcatcag aatttgaaag
     3901 ccaatgataa tacctgatta ggactgaaaa tagaattatc ttagtagttt agcacttttt
     3961 ataatggagt tggagcactg aatttatttt caaattacct agaattctgc attgctcaaa
     4021 cattattcaa ttgattgcaa aatatacctt ggaaaccctt tggatagaac agttcagagg
     4081 gttaccacta gtacttagag cctaaagtca ctcagtagga ggttctcaaa ggtctatttg
     4141 aaggcaatcc aatttcttta aaataaaata ttttttgcct tttaaaacag atgggtgaag
     4201 aaagggacgt ataaattctg ggaaacctct tatgttttcc tcccatttcc ttctatgtct
     4261 ccattaatgt gctaacttga aggaatttaa cttcaaggaa agttgactga tgaagtttat
     4321 gtagagctgt gaatattata atttgtcaat actttattga taatgttaac tttgttttta
     4381 tttggaaaca ttttttccag ttgaccaaag cagaattcat tctgttcttc cctcaaattc
     4441 atctattagg atcaatgtga ttgacattta tctccactct gcatgtcact gatatggtat
     4501 agacgctata agccctgtag atattatggg tatgaagact atttgaggtg aattggcagt
     4561 gagagcaaat tttggaaaca ggagagagaa ctacttcgtg cctataaaaa gctctctcac
     4621 tccttcccca agaaaacagg agtctgaatt ttggccagct gggtatttga atcttactga
     4681 ctgttgcagc actggtagtc ctggtaaatt ttttcagtgg gcgagctttt ctgaaatttg
     4741 attaaacata ttagtcaagg gaatctgtga atagatttag aagtagaatg tttgaggtgg
     4801 ttgacaagac atttagaatt gtgattaatg ttttaataaa atgctaagtt agaatgaata
     4861 atcataatta tatagatgga agatatattc taacagttct taaataattt tagattctct
     4921 aaatttagag tgttttctag cttagagagc aatattaata ttttttacct agtctactga
     4981 acataatttc agggagttag tatttaggac tttttaccta gagatgcggt aaacctttta
     5041 aatttaaatt tgctttctta aaatacctgt tccaacattg ctcacctttc ttctccctcc
     5101 tttttgccct ctccttcagt gggaggagca catattcagc tttctgttaa acactctttg
     5161 gttttcaact gagtaaggca agcaaggata tatgttagaa gagtgggcat aatactttat
     5221 attaaaatta tagggactaa aagtctaaat cattgctgtc aataggactt tttttgatga
     5281 tggaaataat ttatgtctgt gctgttcaat atggtagcca ctcgcagagg tgactactga
     5341 gcatttcacg tgtggcttgt gatacagagg aactaaattt ttaattttac ttaattactt
     5401 taaattttaa aagttacacg tggctagtgg gtctatccca actatgaaga gaataaagct
     5461 acagagcatc tatctagtct aatgaaacaa cagtgaattt gggaattgta aatctgtctt
     5521 aagctttttc cataaacttt tattgatata atttaggcat atacaaatac tggtgaaatt
     5581 ttattgattg aattattgtt gacttttttt tcagtattta tatttttaaa aagatatgtt
     5641 tctttataat taacttgtat tgtagggtaa ccattgtcct taaatgttaa gccacttagt
     5701 taataacaaa tagcatttgg ttttttagca ttatttatca tctgaggctt tcagaattaa
     5761 tgcaccaaac cttaaatatt tttgttgttc tctaaaagaa tgggtttatg atgcaccaaa
     5821 aggacatttt gagaactgcc ggagcaacag ataccaccat gtaaggagtg aattcccatg
     5881 tttttcactt atatctagag gcctacttat ttaggaggtt tcctaagtaa gtgtatttag
     5941 ttgtaggacc ttagagttgc ctaggtccat tctattctag catatactca acatactgcc
     6001 agagcaaatg taggttgcag attcaggcaa aacacacaca cacacacaca caaaaccctg
     6061 aagagcacaa tgagcattat tagcacagcc aatttaaaat gatgaggtgt taaccacatt
     6121 tgtataaata atagtttctc taaccctgaa tcattatcct gcatttttaa tgcaatcggt
     6181 tcataaacat caaagtgaaa acaccaaatt tgtaagaggt caggaccaac tggggctcta
     6241 aatggagaga cagctgagag ctgtgtccct atgcgtgggt ggccttgcag ctgttgattc
     6301 accctcaggc taccagacag ttgcctcttt gcatttgcag aaccagactt caatcttagg
     6361 taaaaatgta tccctcccat ggacaggaca taaacaatag attgacatca gctctgaaaa
     6421 cagtgcagca gccagactca gcagttgccc tgaaatactg agaagtacca agcataacat
     6481 caagactgtt tctacacaat aatatttgtc tttgtacagc aacactgggt tctcttaagt
     6541 atattataaa tataaaagct caaagtccaa aaggttcaat gtgatgatat ccttctctac
     6601 aaatgccagg aacaccaggg tagattgcat gagacatgac tgccgtatct tggtccttac
     6661 taggattccc aaatatactc cttaataacc agtaaagtta tatttacact ggacatttta
     6721 agaaatacca gtgttcgttg ttagatgaga gacagcataa ttttggaatc acaactgagt
     6781 tcagagttca gttttgagtc ctactagttt tgtttccttg tgtaagtttc ttaacctttg
     6841 taaggctagc atgtaaatca gatacaataa tatatagttc agggtgtaaa gattggatta
     6901 atgtatgcag tgtctatcta gcacagtgcc tgttatgtag tagcgtgtca agagatgttc
     6961 tctcttatgc atttggagga ttaggtgctg cacctatagg tttccattca tttctcatct
     7021 atgtaattct gagtcttcct tttctagata gaattccccc caacaaaaat ttaaagtcta
     7081 acaggtggta ggtgcttatt gaggcccagc aattctactt ctggaaacct tcctcaggaa
     7141 aagattctga tgacagaaaa tgctgtgtga acagtattat atagaattgt ttttaatagc
     7201 aagaaatttt ttaaaactta caagttcagt gatatgagga catttacata aactatcgaa
     7261 ccaccagtct tctgtcaatt ccttttaaaa tgatggttgt gaagactgat gaaaacacag
     7321 tgtcaatgat atgttaactg aaaaagtaag attaaaaaca ttatggatag tataagtttc
     7381 ttaaatgcca acaatgcatg aggtgaatag aataagactt ttttttaaag aatgtaattt
     7441 ttgacagtct gaaaagacag gccttatatt tatattgaga aaaatgatcc tgacatttaa
     7501 tgagacacta aaacagtttt tattttttgc ttacttattc tgttctagaa tccaaactct
     7561 acatactgtt taatagagca ttattgatat tagctgtatt agatgactgt atgaagagtc
     7621 ctgtttgcta gaatcctact ttatctttta agttttgcta attaccctgc aatgaatgtt
     7681 gaacataaaa aatttgactc cctttccatg tgtccactgt ttccttgtgc cttttgatta
     7741 ataaaacttt atttttaagt gagaa
//
