LOCUS       NM_015179               4396 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ribosomal RNA processing 12 homolog (RRP12),
            transcript variant 1, mRNA.
ACCESSION   NM_015179
VERSION     NM_015179.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4396)
  AUTHORS   Ameismeier,M., Cheng,J., Berninghausen,O. and Beckmann,R.
  TITLE     Visualizing late states of human 40S ribosomal subunit maturation
  JOURNAL   Nature 558 (7709), 249-253 (2018)
   PUBMED   29875412
REFERENCE   2  (bases 1 to 4396)
  AUTHORS   Choi,Y.J., Lee,H.W., Lee,Y.S., Shim da,M. and Seo,S.W.
  TITLE     RRP12 is a crucial nucleolar protein that regulates p53 activity in
            osteosarcoma cells
  JOURNAL   Tumour Biol 37 (4), 4351-4358 (2016)
   PUBMED   26499779
  REMARK    GeneRIF: This study demonstrated that RRP12 was crucial for cell
            survival during cytotoxic stress via the repression of p53
            stability. Thus, targeting RRP12 may enhance chemotherapeutic
            effect in cancers
REFERENCE   3  (bases 1 to 4396)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 4396)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 4396)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   6  (bases 1 to 4396)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 4396)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   8  (bases 1 to 4396)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   9  (bases 1 to 4396)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   10 (bases 1 to 4396)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK022496.1, DA231457.1, BC012745.2 and AK056614.1.
            
            On Jun 28, 2019 this sequence version replaced NM_015179.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012745.2, AK022496.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370992.9/ ENSP00000360031.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AK022496.1         2-52
            52-133              DA231457.1         2-83
            134-3500            BC012745.2         102-3468
            3501-3542           AK056614.1         681-722
            3543-4396           BC012745.2         3511-4364
FEATURES             Location/Qualifiers
     source          1..4396
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..4396
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /note="ribosomal RNA processing 12 homolog"
                     /db_xref="GeneID:23223"
                     /db_xref="HGNC:HGNC:29100"
                     /db_xref="MIM:617723"
     exon            1..248
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..4003
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RRP12-like protein"
                     /codon_start=1
                     /product="RRP12-like protein isoform 1"
                     /protein_id="NP_055994.2"
                     /db_xref="CCDS:CCDS7457.1"
                     /db_xref="GeneID:23223"
                     /db_xref="HGNC:HGNC:29100"
                     /db_xref="MIM:617723"
                     /translation="MGRSGKLPSGVSAKLKRWKKGHSSDSNPAICRHRQAARSRFFSR
                     PSGRSDLTVDAVKLHNELQSGSLRLGKSEAPETPMEEEAELVLTEKSSGTFLSGLSDC
                     TNVTFSKVQRFWESNSAAHKEICAVLAAVTEVIRSQGGKETETEYFAALMTTMEAVES
                     PESLAAVAYLLNLVLKRVPSPVLIKKFSDTSKAFMDIMSAQASSGSTSVLRWVLSCLA
                     TLLRKQDLEAWGYPVTLQVYHGLLSFTVHPKPKIRKAAQHGVCSVLKGSEFMFEKAPA
                     HHPAAISTAKFCIQEIEKSGGSKEATTTLHMLTLLKDLLPCFPEGLVKSCSETLLRVM
                     TLSHVLVTACAMQAFHSLFHARPGLSTLSAELNAQIITALYDYVPSENDLQPLLAWLK
                     VMEKAHINLVRLQWDLGLGHLPRFFGTAVTCLLSPHSQVLTAATQSLKEILKECVAPH
                     MADIGSVTSSASGPAQSVAKMFRAVEEGLTYKFHAAWSSVLQLLCVFFEACGRQAHPV
                     MRKCLQSLCDLRLSPHFPHTAALDQAVGAAVTSMGPEVVLQAVPLEIDGSEETLDFPR
                     SWLLPVIRDHVQETRLGFFTTYFLPLANTLKSKAMDLAQAGSTVESKIYDTLQWQMWT
                     LLPGFCTRPTDVAISFKGLARTLGMAISERPDLRVTVCQALRTLITKGCQAEADRAEV
                     SRFAKNFLPILFNLYGQPVAAGDTPAPRRAVLETIRTYLTITDTQLVNSLLEKASEKV
                     LDPASSDFTRLSVLDLVVALAPCADEAAISKLYSTIRPYLESKAHGVQKKAYRVLEEV
                     CASPQGPGALFVQSHLEDLKKTLLDSLRSTSSPAKRPRLKCLLHIVRKLSAEHKEFIT
                     ALIPEVILCTKEVSVGARKNAFALLVEMGHAFLRFGSNQEEALQCYLVLIYPGLVGAV
                     TMVSCSILALTHLLFEFKGLMGTSTVEQLLENVCLLLASRTRDVVKSALGFIKVAVTV
                     MDVAHLAKHVQLVMEAIGKLSDDMRRHFRMKLRNLFTKFIRKFGFELVKRLLPEEYHR
                     VLVNIRKAEARAKRHRALSQAAVEEEEEEEEEEEPAQGKGDSIEEILADSEDEEDNEE
                     EERSRGKEQRKLARQRSRAWLKEGGGDEPLNFLDPKVAQRVLATQPGPGRGRKKDHGF
                     KVSADGRLIIREEADGNKMEEEEGAKGEDEEMADPMEDVIIRNKKHQKLKHQKEAEEE
                     ELEIPPQYQAGGSGIHRPVAKKAMPGAEYKAKKAKGDVKKKGRPDPYAYIPLNRSKLN
                     RRKKMKLQGQFKGLVKAARRGSQVGHKNRRKDRRP"
     exon            249..478
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            479..562
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            563..639
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            640..745
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            746..862
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            863..998
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1126
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1225
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1317
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1429
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1527
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1642
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1785
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1907
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1972
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2135
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2290
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2358
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2452
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2611
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2692
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2798
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2906
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3064
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            3065..3156
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3324
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3500
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            3501..3626
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            3627..3676
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            3677..3749
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            3750..3817
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            3818..3900
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..4396
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4375..4380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /note="hexamer: AATAAA"
     polyA_site      4396
                     /gene="RRP12"
                     /gene_synonym="KIAA0690"
                     /note="major polyA site"
ORIGIN      
        1 agaagaagag gaagtgaagg ctacagggta tccacgtggg ttctgagcgt gtttctacgt
       61 ccctggaagc cggtcattta agctcattcc tcgccacggc ttagtcaaca tgggtcgctc
      121 gggaaagttg ccttctggtg tctcagctaa gttgaagcgc tggaagaaag gccacagcag
      181 cgacagcaac cccgccatct gccgccaccg tcaggccgcc cgcagccgct tcttcagccg
      241 gccgtcagga aggagtgacc tgacagtcga tgctgtgaag ttacataatg agctgcagtc
      301 agggtccttg cgcttgggca aaagcgaagc cccggagacg cccatggaag aagaggcgga
      361 gctggttctc accgagaagt cctcgggtac cttcctgagt ggcctttccg actgcacaaa
      421 cgtcaccttc agcaaagtac agcgcttctg ggagtccaac tcggctgccc acaaggagat
      481 ctgtgctgtt ctggctgctg tcactgaggt gattcgctcc cagggaggga aggagacgga
      541 gactgagtac ttcgctgctc tgatgacaac aatggaagca gtggagtccc cggagtccct
      601 ggccgccgtt gcttacctgc tgaaccttgt cctgaagcgt gttcccagcc ctgtgcttat
      661 taagaagttc tctgatacct ccaaagcctt catggatatc atgtcagctc aggccagcag
      721 cggctccacc tctgtcctcc gatgggtcct ttcctgcctg gccacccttc tgcggaagca
      781 agacctggag gcctggggct accccgtgac ccttcaggtg taccatgggc tgctgagctt
      841 cacggtgcat cccaagccca agatccggaa ggctgcccag catggagtat gctcagtcct
      901 caagggcagt gaattcatgt ttgaaaaggc ccctgcccat catcctgctg ccatttccac
      961 tgccaagttc tgcatccagg agattgagaa gtctggaggc tccaaggagg ccaccaccac
     1021 gctgcacatg ctgacgctgc tgaaggacct gctgccctgc ttcccggaag gcctggtgaa
     1081 gagctgcagt gagactctcc tcagggtcat gaccttgagc catgtgctgg tgacagcctg
     1141 tgccatgcag gcctttcaca gcctcttcca cgccaggcct ggcctgagca ccctgtcagc
     1201 agagctcaac gcccagatca tcacggccct gtacgactat gttcccagtg agaatgattt
     1261 acaacccctg ctagcctggc ttaaggtcat ggagaaagcc cacatcaacc tggtgaggtt
     1321 gcagtgggac ctggggctag gccacctccc tcgctttttt ggaactgcgg tgacctgcct
     1381 cctttcccca cactcgcaag tgctgactgc tgctacgcag agcctcaagg agatcctgaa
     1441 ggaatgcgtg gctccccaca tggctgacat tggctccgtg acctcctcgg cctcaggccc
     1501 tgcccaatct gttgccaaga tgttcagggc agtggaggag ggcctgacgt acaaattcca
     1561 tgcggcctgg agctccgtgt tgcagctgct gtgtgtcttc ttcgaggcgt gtgggagaca
     1621 ggcccaccct gtgatgagga agtgcctcca gtccctgtgt gacctgcgcc tctcccctca
     1681 tttcccccac acggcggctc ttgaccaggc agtgggggct gcggtgacca gtatgggacc
     1741 tgaggtggtg ctgcaggctg tgcctttgga aattgatggc tctgaggaga ctctggattt
     1801 cccacggagc tggctgctgc ctgtcatccg agaccatgtt caggaaacgc gacttggttt
     1861 tttcaccacc tacttcttgc ccctggctaa caccctgaag agcaaagcca tggacctggc
     1921 tcaggcaggc agcacagtgg aatctaagat ctacgacaca ctccagtggc agatgtggac
     1981 actcctgcct gggttctgca caaggcctac agatgtggcc atctccttca aagggctggc
     2041 acggacgctg ggcatggcca tcagcgagcg tccagacctg agggtcaccg tgtgccaggc
     2101 cctgcgcacc ctcatcacca agggctgcca ggcagaggct gaccgtgctg aagtgagtcg
     2161 ctttgccaag aactttctgc cgatcctctt caacctgtat gggcagcccg tggcagccgg
     2221 ggacactcca gcccctcgcc gggctgtgct ggaaaccatc agaacttacc tcaccatcac
     2281 tgacactcag ttggtgaaca gtctcctgga aaaagccagt gagaaggtgc tcgaccctgc
     2341 cagctctgac tttaccagat tgtctgtcct ggacctggtc gtggccttgg ctccgtgtgc
     2401 tgacgaagct gccatcagta agctatactc caccatccgg ccctacctag agagcaaggc
     2461 ccacggggtg cagaagaagg cctaccgagt gctggaggag gtgtgtgcca gtcctcaggg
     2521 ccccggggcc ctcttcgtgc agagccacct ggaggacctg aagaagacac tgctggactc
     2581 gctgcggagc acctcctcac ccgccaagag gccccgtttg aagtgcctcc tacacatcgt
     2641 gaggaagctc tcagctgaac acaaggagtt catcactgcc ctcatcccag aggtgatcct
     2701 gtgcaccaag gaggtgtcgg tgggcgcacg gaagaacgct tttgcactgc tcgtggagat
     2761 gggccatgct ttcctaaggt ttggctcgaa ccaggaagag gccctgcagt gctacctcgt
     2821 cctgatctac cctggcctgg tgggcgcggt gaccatggtc agctgcagca tcctggccct
     2881 gacccacctc cttttcgagt ttaaaggtct gatggggacc agtacagtgg agcagctgct
     2941 ggagaatgtg tgcctgcttc tggcctcccg cacccgtgac gtggtcaagt ctgcactggg
     3001 cttcatcaag gtggcagtga ctgtcatgga cgtggcgcac ctggccaaac atgtgcagct
     3061 ggtgatggaa gccattggga agctttcaga tgacatgcgg cggcacttcc gcatgaagct
     3121 tcggaacctg ttcaccaagt tcatccgcaa gtttggattt gagctggtga aaaggctgtt
     3181 gcccgaggag taccacagag tcctggtcaa catccggaaa gctgaggccc gggccaagag
     3241 gcaccgagcc ctgagccagg ctgccgtgga ggaggaagaa gaggaggagg aggaggagga
     3301 gcccgcccag ggcaaaggtg acagcattga ggagatttta gctgactcag aggacgagga
     3361 ggacaatgag gaggaggaaa gaagccgagg caaggagcag cggaagctgg cacgacagag
     3421 gagccgggca tggctgaaag agggcggtgg ggacgagccc ctcaacttcc tggatcccaa
     3481 ggtggcccaa cgagtcctgg ccacgcagcc agggccaggc cggggcagga agaaggacca
     3541 cggcttcaag gtgagcgccg atggccggct gatcataagg gaggaggcag acggcaacaa
     3601 gatggaggaa gaggaaggtg ccaaaggcga agatgaagag atggctgacc caatggaaga
     3661 tgtgatcatc aggaataaaa agcaccagaa gctcaagcac cagaaagagg ctgaggagga
     3721 ggagctggag ataccccctc agtaccaagc tggaggctct ggcattcatc gccctgtggc
     3781 caagaaggct atgcctgggg ctgaatacaa ggccaagaaa gcaaaaggtg atgtgaagaa
     3841 gaaaggccgg ccggatccct atgcctacat ccccctcaac agaagcaagc tcaaccgcag
     3901 gaagaagatg aagctgcagg gacagttcaa aggcctggtg aaggctgccc ggcgaggttc
     3961 ccaggtggga cacaaaaacc gcagaaagga tcgtcgaccc tgaggcccag ggcccctggg
     4021 ctgccctgtg gtccagtctg aggccctttc agcccccagg ctgccttgcc accagctcca
     4081 ggtgctcaag attctggcag agcctggact caggatgact tggaactagg gcttggctct
     4141 cagaagtcct ggattttgga aactccaaat ggaatcaccc ttcagagaca tccctggtgc
     4201 ctggagatgg gaatgtggcc tcagtgcctc tgagtaggtg ccatgaggca cctttgcttt
     4261 ctgcccagag tggccatgag caccagaaca gatgatctcc atttccgcca gctgcctgta
     4321 gccacgtggc atcctgcctg tggtctgggt gagatttact gtgaccagat gtagaataaa
     4381 tgtgtctcat cctgca
//
