LOCUS       NM_003683               2958 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ribosomal RNA processing 1 (RRP1), mRNA.
ACCESSION   NM_003683
VERSION     NM_003683.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2958)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2958)
  AUTHORS   Yoshikawa,H., Ishikawa,H., Izumikawa,K., Miura,Y., Hayano,T.,
            Isobe,T., Simpson,R.J. and Takahashi,N.
  TITLE     Human nucleolar protein Nop52 (RRP1/NNP-1) is involved in site 2
            cleavage in internal transcribed spacer 1 of pre-rRNAs at early
            stages of ribosome biogenesis
  JOURNAL   Nucleic Acids Res 43 (11), 5524-5536 (2015)
   PUBMED   25969445
  REMARK    GeneRIF: The data suggest that RRP1 is involved not only in
            competitive binding with fibrillarin to C1QBP on 90S but also in
            site 2 cleavage in ITS1 of pre-rRNAs at early stages of human
            ribosome biogenesis.
REFERENCE   3  (bases 1 to 2958)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2958)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 2958)
  AUTHORS   Yoshikawa,H., Komatsu,W., Hayano,T., Miura,Y., Homma,K.,
            Izumikawa,K., Ishikawa,H., Miyazawa,N., Tachikawa,H., Yamauchi,Y.,
            Isobe,T. and Takahashi,N.
  TITLE     Splicing factor 2-associated protein p32 participates in ribosome
            biogenesis by regulating the binding of Nop52 and fibrillarin to
            preribosome particles
  JOURNAL   Mol Cell Proteomics 10 (8), M110.006148 (2011)
   PUBMED   21536856
  REMARK    GeneRIF: p32 is a new rRNA maturation factor involved in the
            remodeling from pre-90S particles to pre-40S and pre-60S particles
            that requires the exchange of FBL for Nop52.
REFERENCE   6  (bases 1 to 2958)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   7  (bases 1 to 2958)
  AUTHORS   Behrends,U., Jandl,T., Golbeck,A., Lechner,B., Muller-Weihrich,S.,
            Schmid,I., Till,H., Berthold,F., Voltz,R. and Mautner,J.M.
  TITLE     Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes
            identified by autologous antibody screening of a pediatric
            neuroblastoma library
  JOURNAL   Int J Cancer 100 (6), 669-677 (2002)
   PUBMED   12209604
  REMARK    GeneRIF: NNP-1 expression in neuroblastoma
REFERENCE   8  (bases 1 to 2958)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   9  (bases 1 to 2958)
  AUTHORS   Savino,T.M., Bastos,R., Jansen,E. and Hernandez-Verdun,D.
  TITLE     The nucleolar antigen Nop52, the human homologue of the yeast
            ribosomal RNA processing RRP1, is recruited at late stages of
            nucleologenesis
  JOURNAL   J Cell Sci 112 (Pt 12), 1889-1900 (1999)
   PUBMED   10341208
REFERENCE   10 (bases 1 to 2958)
  AUTHORS   Jansen,E., Meulemans,S.M., Orlans,I.C. and Van de Ven,W.J.
  TITLE     The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein,
            maps in close proximity to the cystatin B gene within the EPM1 and
            APECED critical region on 21q22.3
  JOURNAL   Genomics 42 (2), 336-341 (1997)
   PUBMED   9192856
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA275615.1, BC000380.2,
            BI223794.1, AI634547.1 and AP001053.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_003683.5.
            
            Summary: The protein encoded by this gene is the putative homolog
            of the yeast ribosomal RNA processing protein RRP1. The encoded
            protein is involved in the late stages of nucleologenesis at the
            end of mitosis, and may be required for the generation of 28S rRNA.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000380.2, SRR3476690.787249.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000497547.2/ ENSP00000417464.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA275615.1         43-55
            14-586              BC000380.2         1-573
            587-670             BI223794.1         1-84
            671-1713            BC000380.2         658-1700
            1714-1767           AI634547.1         14-67               c
            1768-2958           AP001053.1         45949-47139
FEATURES             Location/Qualifiers
     source          1..2958
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..2958
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /note="ribosomal RNA processing 1"
                     /db_xref="GeneID:8568"
                     /db_xref="HGNC:HGNC:18785"
                     /db_xref="MIM:610653"
     exon            1..186
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1439
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /note="Nnp1 homolog, nucleolar protein; protein NNP-1;
                     RRP1-like protein; novel nuclear protein 1; nucleolar
                     protein Nop52; ribosomal RNA processing 1 homolog"
                     /codon_start=1
                     /product="ribosomal RNA processing protein 1 homolog A"
                     /protein_id="NP_003674.1"
                     /db_xref="CCDS:CCDS42951.1"
                     /db_xref="GeneID:8568"
                     /db_xref="HGNC:HGNC:18785"
                     /db_xref="MIM:610653"
                     /translation="MVSRVQLPPEIQLAQRLAGNEQVTRDRAVRKLRKYIVARTQRAA
                     GGFTHDELLKVWKGLFYCMWMQDKPLLQEELGRTISQLVHAFQTTEAQHLFLQAFWQT
                     MNREWTGIDRLRLDKFYMLMRMVLNESLKVLKMQGWEERQIEELLELLMTEILHPSSQ
                     APNGVKSHFIEIFLEELTKVGAEELTADQNLKFIDPFCRIAARTKDSLVLNNITRGIF
                     ETIVEQAPLAIEDLLNELDTQDEEVASDSDESSEGGERGDALSQKRSEKPPAGSICRA
                     EPEAGEEQAGDDRDSGGPVLQFDYEAVANRLFEMASRQSTPSQNRKRLYKVIRKLQDL
                     AGGIFPEDEIPEKACRRLLEGRRQKKTKKQKRLLRLQQERGKGEKEPPSPGMERKRSR
                     RRGVGADPEARAEAGEQPGTAERALLRDQPRGRGQRGARQRRRTPRPLTSARAKAANV
                     QEPEKKKKRRE"
     exon            187..269
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            270..327
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            328..413
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            414..475
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            476..605
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            606..670
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            671..864
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            865..944
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1042
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1062
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1176
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..2958
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1739..1744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /note="hexamer: AATAAA"
     polyA_site      1764
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
                     /note="major polyA site"
     polyA_site      1792
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
     polyA_site      1892
                     /gene="RRP1"
                     /gene_synonym="D21S2056E; NNP-1; NOP52; RRP1A"
ORIGIN      
        1 agtgtgctgg gtaccaggcg actccgggac agggggtctc ggccgtcggc gtcatggttt
       61 cgcgcgtgca gctcccgcct gagatccagc tggctcagcg cctggcgggg aatgagcagg
      121 tgacccggga ccgggcggtg aggaagctcc ggaaatacat cgtcgccagg actcagcggg
      181 ccgcaggtgg ttttacgcac gacgagctgc tgaaggtgtg gaaaggactg ttttattgca
      241 tgtggatgca ggacaagcca ctcctccagg aagaattagg aaggactatt tcccagctcg
      301 ttcatgcttt tcagaccacg gaggcgcagc acctgttcct tcaggccttc tggcagacca
      361 tgaatcgcga gtggacgggc attgacaggc tgcgcctgga taaattctac atgctcatgc
      421 ggatggtcct gaacgagtcc ttgaaggttc tgaagatgca aggctgggaa gaaagacaga
      481 tcgaggagct gctagagctg ctgatgactg agatcctgca ccccagcagc caggccccca
      541 acggtgtgaa gagccacttc atcgagatct tcctggagga gctgaccaaa gtgggcgccg
      601 aggagcttac ggcagaccag aacctgaagt tcatcgaccc cttctgcaga attgctgccc
      661 ggaccaagga ttccttggtt ttgaacaaca tcactcgagg catctttgag acgattgtgg
      721 agcaggcccc gcttgccatt gaagacctcc tgaatgaact ggacacacag gatgaggagg
      781 tggcgtcgga cagtgatgag tcctctgagg gtggtgagcg tggagacgcg ctgtcccaga
      841 agaggtctga gaagccgccc gcaggctcca tctgcagggc tgaacctgag gctggtgagg
      901 agcaggcagg tgacgacagg gacagtggcg gccccgttct ccagtttgac tacgaggcag
      961 ttgctaacag actgtttgaa atggccagcc gccagagcac cccttctcag aacagaaagc
     1021 gtctctacaa agtgatccgg aagctgcagg acctggcagg aggcattttc cctgaagatg
     1081 agatcccaga gaaggcctgc aggcgcctgc ttgaagggag gcggcagaag aagacgaaga
     1141 agcagaagcg tctgctcagg ttgcagcagg agagagggaa aggtgagaag gagcccccga
     1201 gcccgggcat ggagaggaag aggagcagga ggaggggtgt aggggccgac cccgaggcgc
     1261 gggcagaggc tggtgagcag ccaggcacag ctgagcgggc cctgctccga gatcagccca
     1321 ggggccgtgg ccagagaggg gctcgccaga gaaggaggac acctcggccc ctgaccagtg
     1381 cccgagcaaa ggcggccaat gtccaggagc cggagaagaa gaagaaacgc agggagtgat
     1441 gtggccgggc caaggacagg cagggaggga ggccaggcct cgcttgcacc gcgggacgag
     1501 gctgaccggg ctgttctgta gactcaggac cgtggctcca gaactcctgt gccaggcggg
     1561 agggaagggc ggcactggag agatgggccc atcattaggg gccagcatcc caggaactgg
     1621 acctttcccc agagcctccg cctgtggctg tgatgacctt gggccagaag gtcaaactcc
     1681 gaagactgaa actctgcctg cagcaggact ggccgcccct gctgtggggg gttcagaaaa
     1741 taaaatgccg cgcagccctt gccaggggaa gtgtcgcttc aggtgtgtcc tacggacgtg
     1801 tgggaggtgg caggcgccag cctccgagca gtgtggtggt ttatattcat gtttgtggaa
     1861 aaatcttgca agacatttct cctttcacag aactgcccag gtgttaacag ggctgtctgg
     1921 acggggctct tttgcttccc cctcaatctg gggtctagag ttgtgcaagg aattcagctc
     1981 cagtaaggcc tggattgccc ggggtgagcg tgtgtgtggt gggaagacct ggcttccgcg
     2041 agagccttgt tcctggaggc aggagcgccc cgccatcctg ggtacccgcg ggtccgcagg
     2101 ctgcgcacct ctttccctca gccaggtcac cctcagcgtc ctccctgccc ctctcccctt
     2161 cacacctgct ggagcctgtg agggaggtgg cgggtcccca ctgtggcgac ggagagctga
     2221 cagtagccca gggctttcca cctgcatgga acaagggcct gtctgccgcc agcgctgtgg
     2281 ccacagcctg cataggtgac aaggggccgc tgcgttgggt tttgcccgca tcttctgttc
     2341 catgggtgcc cagccagcca ggccgtgtgg gatccagcga gaggccaggg cttggagtgg
     2401 gcctgggacc aggaaggacc tctaggctgt ggctggcctt gtgcagaccc tggactgcat
     2461 ccggttcccc aaagccctgc tgcattcgag tgtcccccaa ccccgggcag gtggcacctg
     2521 gtgacacctc cttcagtccc actcagctgg gcggccgggg caggcttagg gcacagttag
     2581 gggccaagga gagggaaggc cagggcccct gttctagggg ttagggttct ttccccaaag
     2641 gaacttaaaa agacaagcgt ggccaggcac agtggctcac acctgtaatc ccagcacttt
     2701 gggaggccga ggtggccaga tcacctgagg tcaggagttt gagaccagac tgaccaacat
     2761 ggagaaaccc catctctact aaaatacaaa attagccagg cgtggtggca catgcctgta
     2821 atcccagcta ctcgggaggc tgaggcagga gaattgcttg aacctgggag gcagaggttg
     2881 tggtgagcta agatcacgcc attgcactcc agcctgggca acgagaggga aactctgttt
     2941 caaaaaaaaa aaaaaaaa
//
