LOCUS       NM_001033               3142 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens ribonucleotide reductase catalytic subunit M1 (RRM1),
            transcript variant 1, mRNA.
ACCESSION   NM_001033
VERSION     NM_001033.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3142)
  AUTHORS   Lin,X., Tan,Y., Pan,L., Tian,Z., Lin,L., Su,M., Ou,G. and Chen,Y.
  TITLE     Prognostic value of RRM1 and its effect on chemoresistance in
            pancreatic cancer
  JOURNAL   Cancer Chemother Pharmacol 93 (3), 237-251 (2024)
   PUBMED   38040978
  REMARK    GeneRIF: Prognostic value of RRM1 and its effect on chemoresistance
            in pancreatic cancer.
REFERENCE   2  (bases 1 to 3142)
  AUTHORS   Ono,H., Murase,Y., Yamashita,H., Kato,T., Asano,D., Ishikawa,Y.,
            Watanabe,S., Ueda,H., Akahoshi,K., Ogawa,K., Kudo,A., Akiyama,Y.,
            Tanaka,S. and Tanabe,M.
  TITLE     RRM1 is mediated by histone acetylation through gemcitabine
            resistance and contributes to invasiveness and ECM remodeling in
            pancreatic cancer
  JOURNAL   Int J Oncol 62 (4) (2023)
   PUBMED   36866763
  REMARK    GeneRIF: RRM1 is mediated by histone acetylation through
            gemcitabine resistance and contributes to invasiveness and ECM
            remodeling in pancreatic cancer.
REFERENCE   3  (bases 1 to 3142)
  AUTHORS   O'Connor,C.M., Taylor,S.E., Miller,K.M., Hurst,L., Haanen,T.J.,
            Suhan,T.K., Zawacki,K.P., Noto,F.K., Trako,J., Mohan,A.,
            Sangodkar,J., Zamarin,D., DiFeo,A. and Narla,G.
  TITLE     Targeting Ribonucleotide Reductase Induces Synthetic Lethality in
            PP2A-Deficient Uterine Serous Carcinoma
  JOURNAL   Cancer Res 82 (4), 721-733 (2022)
   PUBMED   34921012
  REMARK    GeneRIF: Targeting Ribonucleotide Reductase Induces Synthetic
            Lethality in PP2A-Deficient Uterine Serous Carcinoma.
REFERENCE   4  (bases 1 to 3142)
  AUTHORS   Munoz-Montano,W., Muniz-Hernandez,S., Aviles-Salas,A., Catalan,R.,
            Lara-Mejia,L., Samtani-Bassarmal,S., Cardona,A.F.,
            Mendoza-Desion,J., Hernandez-Cueto,D., Maldonado,A.,
            Baay-Guzman,G., Huerta-Yepes,S. and Arrieta,O.
  TITLE     RRM1 and ERCC1 as biomarkers in patients with locally advanced and
            metastatic malignant pleural mesothelioma treated with continuous
            infusion of low-dose gemcitabine plus cisplatin
  JOURNAL   BMC Cancer 21 (1), 892 (2021)
   PUBMED   34353292
  REMARK    GeneRIF: RRM1 and ERCC1 as biomarkers in patients with locally
            advanced and metastatic malignant pleural mesothelioma treated with
            continuous infusion of low-dose gemcitabine plus cisplatin.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3142)
  AUTHORS   Besse,B., Olaussen,K.A. and Soria,J.C.
  TITLE     ERCC1 and RRM1: ready for prime time?
  JOURNAL   J Clin Oncol 31 (8), 1050-1060 (2013)
   PUBMED   23401439
  REMARK    GeneRIF: RRM1 biomarkers may represent a major step toward
            biology-based prescription of cytotoxic compounds for lung
            neoplasms.
            Review article
REFERENCE   6  (bases 1 to 3142)
  AUTHORS   Pavloff,N., Rivard,D., Masson,S., Shen,S.H. and Mes-Masson,A.M.
  TITLE     Sequence analysis of the large and small subunits of human
            ribonucleotide reductase
  JOURNAL   DNA Seq 2 (4), 227-234 (1992)
   PUBMED   1627826
REFERENCE   7  (bases 1 to 3142)
  AUTHORS   Parker,N.J., Begley,C.G. and Fox,R.M.
  TITLE     Human M1 subunit of ribonucleotide reductase: cDNA sequence and
            expression in stimulated lymphocytes
  JOURNAL   Nucleic Acids Res 19 (13), 3741 (1991)
   PUBMED   1840662
REFERENCE   8  (bases 1 to 3142)
  AUTHORS   Byrne,J. and Smith,P.
  TITLE     Human polymorphic probe pE1.8 detects SacI polymorphism in the
            ribonucleotide reductase M1 subunit gene
  JOURNAL   Hum Genet 87 (3), 376 (1991)
   PUBMED   1677928
REFERENCE   9  (bases 1 to 3142)
  AUTHORS   Mann,G.J., Musgrove,E.A., Fox,R.M. and Thelander,L.
  TITLE     Ribonucleotide reductase M1 subunit in cellular proliferation,
            quiescence, and differentiation
  JOURNAL   Cancer Res 48 (18), 5151-5156 (1988)
   PUBMED   3044582
REFERENCE   10 (bases 1 to 3142)
  AUTHORS   Brissenden,J.E., Caras,I., Thelander,L. and Francke,U.
  TITLE     The structural gene for the M1 subunit of ribonucleotide reductase
            maps to chromosome 11, band p15, in human and to chromosome 7 in
            mouse
  JOURNAL   Exp Cell Res 174 (1), 302-308 (1988)
   PUBMED   3275546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP229960.1, BC006498.2,
            X59617.1, BQ775841.1, CB853003.1 and AC015689.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001033.4.
            
            Summary: This gene encodes the large and catalytic subunit of
            ribonucleotide reductase, an enzyme essential for the conversion of
            ribonucleotides into deoxyribonucleotides. A pool of available
            deoxyribonucleotides is important for DNA replication during S
            phase of the cell cycle as well as multiple DNA repair processes.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.250532.1,
                                           SRR1660803.164459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300738.10/ ENSP00000300738.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BP229960.1         106-160
            56-1063             BC006498.2         1-1008
            1064-2436           X59617.1           1031-2403
            2437-3082           BQ775841.1         17-662              c
            3083-3135           CB853003.1         414-466
            3136-3142           AC015689.12        78306-78312         c
FEATURES             Location/Qualifiers
     source          1..3142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..3142
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /note="ribonucleotide reductase catalytic subunit M1"
                     /db_xref="GeneID:6240"
                     /db_xref="HGNC:HGNC:10451"
                     /db_xref="MIM:180410"
     exon            1..233
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..2593
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /EC_number="1.17.4.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ribonucleotide reductase M1 polypeptide; ribonucleotide
                     reductase, R1 subunit; ribonucleoside-diphosphate
                     reductase large subunit; ribonucleoside-diphosphate
                     reductase subunit M1"
                     /codon_start=1
                     /product="ribonucleoside-diphosphate reductase large
                     subunit isoform 1"
                     /protein_id="NP_001024.1"
                     /db_xref="CCDS:CCDS7750.1"
                     /db_xref="GeneID:6240"
                     /db_xref="HGNC:HGNC:10451"
                     /db_xref="MIM:180410"
                     /translation="MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVI
                     QGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLY
                     NYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKIN
                     GKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSC
                     FLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPML
                     RVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWI
                     PDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYA
                     IIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLA
                     LNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGL
                     ADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGIL
                     QYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNI
                     YTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKT
                     VWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLR
                     TRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS"
     exon            234..322
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..500
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..601
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..661
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..701
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..864
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1006
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1090
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1252
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1332
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1534
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1684
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1906
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..1983
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2119
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2215
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2404
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..3142
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3062..3067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /note="hexamer: AATAAA"
     polyA_site      3086
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /note="major polyA site"
     regulatory      3119..3124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
                     /note="hexamer: TATAAA"
     polyA_site      3142
                     /gene="RRM1"
                     /gene_synonym="PEOB6; R1; RIR1; RR1"
ORIGIN      
        1 ccctttgtgc gtcacgggtg gcgggcgcgg gaaggggatt tggattgttg cgcctctgct
       61 ctgaagaaag tgctgtctgg ctccaactcc agttctttcc cctgagcagc gcctggaacc
      121 taacccttcc cactctgtca ccttctcgat cccgccggcg ctttagagcc gcagtccagt
      181 cttggatcct tcagagcctc agccactagc tgcgatgcat gtgatcaagc gagatggccg
      241 ccaagaacga gtcatgtttg acaaaattac atctcgaatc cagaagcttt gttatggact
      301 caatatggat tttgttgatc ctgctcagat caccatgaaa gtaatccaag gcttgtacag
      361 tggggtcacc acagtggaac tagatacttt ggctgctgaa acagctgcaa ccttgactac
      421 taagcaccct gactatgcta tcctggcagc caggatcgct gtctctaact tgcacaaaga
      481 aacaaagaaa gtgttcagtg atgtgatgga agacctctat aactacataa atccacataa
      541 tggcaaacac tctcccatgg tggccaagtc aacattggat attgttctgg ccaataaaga
      601 tcgcctgaat tctgctatta tctatgaccg agatttctct tacaattact tcggctttaa
      661 gacgctagag cggtcttatt tgttgaagat caatggaaaa gtggctgaaa gaccacaaca
      721 tatgttgatg agagtatctg ttgggatcca caaagaagac attgatgcag caattgaaac
      781 atataatctt ctttctgaga ggtggtttac tcatgcttcg cccactctct tcaatgctgg
      841 taccaaccgc ccacaacttt ctagctgttt tcttctgagt atgaaagatg acagcattga
      901 aggcatttat gacactctaa agcaatgtgc attgatttct aagtctgctg gaggaattgg
      961 tgttgctgtg agttgtattc gggctactgg cagctacatt gctgggacta atggcaattc
     1021 caatggcctt gtaccgatgc tgagagtata taacaacaca gctcgatatg tggatcaagg
     1081 tgggaacaag cgtcctgggg catttgctat ttacctggag ccttggcatt tagacatctt
     1141 tgaattcctt gatttaaaga agaacacagg aaaggaagag cagcgtgcca gagatctttt
     1201 ctttgctctt tggattccgg atctcttcat gaaacgagtg gagactaatc aggactggtc
     1261 tttgatgtgt ccaaatgagt gtcctggtct ggatgaggtt tggggagagg aatttgagaa
     1321 actatatgca agttatgaga aacaaggtcg tgtccgcaaa gttgtaaaag ctcagcagct
     1381 ttggtatgcc atcattgagt ctcagacgga aacaggcacc ccgtatatgc tctacaaaga
     1441 ttcctgtaat cgaaagagca accagcagaa cctgggaacc atcaaatgca gcaacctgtg
     1501 cacagaaata gtggagtaca ccagcaaaga tgaggttgct gtttgtaatt tggcttccct
     1561 ggccctgaat atgtatgtca catcagaaca cacatacgac tttaagaagt tggctgaagt
     1621 cactaaagtc gttgtccgaa acttgaataa aattattgat ataaactact atcctgtacc
     1681 agaggcatgc ctatcaaata aacgccatcg ccccattgga attggggtac aaggtctggc
     1741 agatgctttt atcctgatga gatacccttt tgagagtgca gaagcccagt tactgaataa
     1801 gcagatcttt gaaactattt attatggtgc tctggaagcc agctgtgacc ttgccaagga
     1861 gcagggccca tacgaaacct atgagggctc tccagttagc aaaggaattc ttcagtatga
     1921 tatgtggaat gttactccta cagacctatg ggactggaag gttctcaagg agaagattgc
     1981 aaagtatggt ataagaaaca gtttacttat tgccccgatg cctacagctt ccactgctca
     2041 gatcctgggg aataatgagt ccattgaacc ttacaccagc aacatctata ctcgcagagt
     2101 cttgtcagga gaatttcaga ttgtaaatcc tcacttattg aaagatctta ccgagcgggg
     2161 cctatggcat gaagagatga aaaaccagat tattgcatgc aatggctcta ttcagagcat
     2221 accagaaatt cctgatgacc tgaagcaact ttataaaact gtgtgggaaa tctctcagaa
     2281 aactgttctc aagatggcag ctgagagagg tgctttcatt gatcaaagcc aatctttgaa
     2341 catccacatt gctgagccta actatggcaa actcactagt atgcacttct acggctggaa
     2401 gcagggtttg aagactggga tgtattattt aaggacaaga ccagcggcta atccaatcca
     2461 gttcactcta aataaggaga agctaaaaga taaagaaaag gtatcaaaag aggaagaaga
     2521 gaaggagagg aacacagcag ccatggtgtg ctctttggag aatagagatg aatgtctgat
     2581 gtgtggatcc tgaggaaaga cttggaagag accagcatgt cttcagtagc caaactactt
     2641 cttgagcata gataggtata gtgggtttgc ttgaggtggt aaggctttgc tggaccctgt
     2701 tgcaggcaaa aggagtaatt gatttaaagt actgttaatg atgataatga tttttttttt
     2761 aaactcatat attgggattt tcaccaaaat aatgcttttg aaaaaaagaa aaaaaaaacg
     2821 gatatattga gaatcaaagt agaagtttta ggaatgcaaa ataagtcatc ttgcatacag
     2881 ggagtggtta agtaaggttt catcacccct ttagcactgc ttttctgaag acttcagttt
     2941 tgttaaggag atttagtttt actgctttga ctggtgggtc tctagaagca aaactgagtg
     3001 ataactcatg agaagtactg ataggacctt tatctggata tggtcctata ggttattctg
     3061 aaataaagat aaacatttct aagtgattgt atgagattaa ttttgtcatt tactttcata
     3121 taaaagtcaa atttgaaaaa ca
//
